“Diabegon”, a safe and effective polyherbal therapy for type 2 diabetes mellitus

AIM: To investigate the antihyperglycemic, antihyperlipidemic and antioxidant functions of a polyherbal formulation, "Diabegon", in human subjects with type 2 diabetes mellitus.METHODS: A total of 33 human subjects with type 2 diabetes mellitus were recruited for the study and all anthropological and biochemical parameters were recorded at the time of registration. The subjects were given hot water extract obtained from 10 gm of "Diabegon" powder, "Diabegon kwath", on an empty stomach everyday in the morning under personal supervision for 6 mo. The therapeutic functions of the "Diabegon kwath" was assessed by monitoring the blood glucoselevels at monthly intervals and glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney function markers at three monthly intervals in the study subjects. RESULTS: Daily administration of hot water extract of "Diabegon" regularly for 6 mo resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high density lipoprotein cholesterol levels with concomitant decreases in total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein. A significant improvement in glycosuria and proteinuria was also observed. Also, the subjects exhibited a significant improvement in enzymatic and nonenzymatic biochemical markers of oxidative stress. The kidney and liver functions remained normal and in fact improved in many subjects.CONCLUSION: The study which is first of its kind, advocates "Diabegon kwath" as a safe and effective Ayurvedic therapy for the treatment of human type 2 diabetes mellitus and further placebo controlled trial may substantiate the therapeutic efficacy of the formulation.

自拟降脂茶治疗高脂血症的临床研究

目的观察自拟降脂茶治疗痰浊阻遏型高脂血症的临床疗效.方法选择2023年3月-10月南昌市人民医院门诊治疗的高脂血症患者100例作为研究对象,按随机数字表法分为治疗组和对照组各50例.对照组嘱患者适量饮食及运动.治疗组在对照组同样饮食及运动的基础上给予自拟降脂茶治疗.比较两组患者治疗前后小血脂、中医症状积分、体重、血压、BMI、残余胆固醇、血常规、肝肾功水平,并记录不良反应.结果血脂疗效方面,治疗组总有效率为86%,高于对照组的42%,P<0.05,两组比较,差异有统计学意义,治疗组的治疗效果明显优于对照组;血糖调节方面,治疗组总有效率为20%,对照组总有效率为28%,P>0.05,两组比较,差异无统计学意义,两组对血糖治疗效果相当;中医症状疗效方面,治疗组总有效率为94%,明显高于对照组的16%,P<0.05,两组比较,差异有统计学意义,治疗组的治疗效果明显优于对照组.体重疗效方面,治疗组显效率为50%,高于对照组的16%,P<0.05,两组比较,差异有统计学意义,治疗组的治疗效果明显优于对照组.治疗组治疗后血压、BMI、RC平均值均低于治疗前,P<0.05,差异均有统计学意义;对照组治疗前后血压、BMI、RC比较,P>0.05,差异均无统计学意义,治疗组疗效优于对照组.结论自拟降脂茶不仅可以良好地降低患者的血脂、体重水平,降低心脑血管疾病的发生风险,还可以明显改善患者的不适症状,且没有出现副作用,值得临床推广.

利用体外脂解模型评价Ⅰ型脂质制剂

以吲哚美辛为模型药物,分别以中链混合甘油酯CapmulMCM和长链极性油LabrafilM1944CS为Ⅰ型脂质制剂,利用体外脂解模型研究药物的肠道分配和增溶作用。结果发现,脂质制剂消化后水性分散相对吲哚美辛的增溶能力较强;脂解程度和速度与脂质辅料的结构有关,长链极性油脂质溶液消化后分配进入水性分散相的药物比中链混合甘油酯少,不利于吸收;脂质制剂消化后水性分散相中药物浓度随载药率提高呈现线性增加。研究结果提示,在筛选脂质制剂的处方时,需考虑脂解程度和速率可能对药物吸收产生的不利影响;脂质混悬液比载药量低的脂质溶液可能更有利于药物吸收。体外脂解模型能为Ⅰ型脂质制剂的处方筛选和评价以及体内外相关性研究提供依据。