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Roof collapse mechanism of weak surrounding rock for deep-buried tunnels under high geostress conditions
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作者 ZHANG Qi GUO Xiaokang +2 位作者 YAN Zhiguo LEI Zhongdai SHEN Yixin 《Journal of Mountain Science》 SCIE CSCD 2024年第7期2408-2426,共19页
High geostress,a typical attribute of tunnels located at significant depths,is crucial in causing stress-induced failure and influencing the stability of the tunnel crown.This study developed an analytical method for ... High geostress,a typical attribute of tunnels located at significant depths,is crucial in causing stress-induced failure and influencing the stability of the tunnel crown.This study developed an analytical method for the failure mechanism that occurs in deep-buried tunnel roofs,taking into account the influence of geostress.The limit analysis theory was utilized for deriving analytical solutions about the geometry of the collapsing surface and the limit supporting pressure.The collapsing surface obtained by the analytical solution was validated by the findings of the physical model test,which shows a high level of agreement with the actual one.An extensive investigation was done to explore the effects of the lateral pressure coefficients,the tunnel buried depth,the geological conditions of the surrounding rock,the long-short axis ratio,and the size of the tunnel profile.The findings indicate that an increase in the lateral pressure coefficient from 0.5 to 1.5 results in a reduction in the height of the collapsing zone by 2.08 m and the width of the collapsing zone by 1.15 m,while simultaneously increases the limit supporting pressure by 18.9%.The proposed upper bound method accurately determines the limit supporting pressure and the geometry of the collapsing surface,which aligns well with the results acquired through numerical modelling and on-site monitoring in actual engineering applications.The proposed analytical method can serve as a reference for similar crown failure issues of deep-buried tunnels. 展开更多
关键词 Geostress deep-buried tunnels Collapse mechanism Pressure arch Limit analysis HoekBrown criterion
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Fisher discriminant analysis model and its application for prediction of classification of rockburst in deep-buried long tunnel 被引量:10
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作者 ZHOU Jian SHI Xiu-zhi +2 位作者 DONG Lei HU Hai-yan WANG Huai-yong 《Journal of Coal Science & Engineering(China)》 2010年第2期144-149,共6页
A Fisher discriminant analysis (FDA) model for the prediction of classification of rockburst in deep-buried long tunnel was established based on the Fisher discriminant theory and the actual characteristics of the p... A Fisher discriminant analysis (FDA) model for the prediction of classification of rockburst in deep-buried long tunnel was established based on the Fisher discriminant theory and the actual characteristics of the project. First, the major factors of rockburst, such as the maximum tangential stress of the cavern wall σθ, uniaxial compressive strength σc, uniaxial tensile strength or, and the elastic energy index of rock Wet, were taken into account in the analysis. Three factors, Stress coefficient σθ/σc, rock brittleness coefficient σc/σt, and elastic energy index Wet, were defined as the criterion indices for rockburst prediction in the proposed model. After training and testing of 12 sets of measured data, the discriminant functions of FDA were solved, and the ratio of misdiscrimina- tion is zero. Moreover, the proposed model was used to predict rockbursts of Qinling tunnel along Xi'an-Ankang railway. The results show that three forecast results are identical with the actual situation. Therefore, the prediction accuracy of the FDA model is acceptable. 展开更多
关键词 deep-buried tunnel ROCKBURST CLASSIFICATION Fisher discriminant analysis model
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Comparison of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting 被引量:5
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作者 卢文波 李鹏 +2 位作者 陈明 周创兵 舒大强 《Journal of Central South University》 SCIE EI CAS 2011年第5期1709-1718,共10页
The measured data of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting were analyzed by Fourier Transform and Wavelet Transform,and the characteristics of vibrations ind... The measured data of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting were analyzed by Fourier Transform and Wavelet Transform,and the characteristics of vibrations induced under these two circumstances were studied.It is concluded that with the similar rock condition and drilling-blasting parameters,vibration induced by bench blasting in deep-buried cavern has a higher main frequency and more scattered energy distribution than that in open pit.The vibration induced by bench blasting in open pit is mainly originated from the blast load,while the vibration induced by bench blasting in deep-buried cavern is the superposition of vibrations induced by blast load and transient release of in-situ stress.The vibration induced by transient release of in-situ stress increases with the stress level. 展开更多
关键词 deep-buried cavem open pit blasting vibration power spectra time-energy density in-situ stress
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Mechanical Properties of Deep-buried Marble Material Under Loading and Unloading Tests 被引量:2
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作者 李新平 ZHAO Hang +1 位作者 WANG Bin XIAO Taoli 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第3期514-520,共7页
The mechanical properties are essentially different when rock material is subjected to loading or unloading conditions. In this study, loading and unloading tests with various confining pressures are conducted to inve... The mechanical properties are essentially different when rock material is subjected to loading or unloading conditions. In this study, loading and unloading tests with various confining pressures are conducted to investigate the mechanical properties of marble material samples taken from the deep diversion tunnels of Jinping II Hydropower Station. The stress-strain relationship, failure characteristics and strength criterion are compared and analyzed based on the experiment results. The results show: in the loading and unloading test, peak strength, lateral strain, axial strain and plastic deformation increase significantly as the confining pressure increases. Lateral strain increased significantly and obvious lateral dilatancy can be observed to the change of confining pressure; The fracture mode is mainly the single shear fracture for the triaxial compression test and post-peak test, angle between the failure surface and the ends of the rock material becomes smaller as the confining pressure increases. Hock-Brown strength criterion reflects the strength characteristics of marble material under two different unloading conditions, and has some supplementary effects to the rock material of mechanical field. 展开更多
关键词 deep-buried material loading and unloading tests mechanical properties strength criterion shear fracture
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Dissolution mechanism of a deep-buried sandstone reservoir in a deep water area:A case study from Baiyun Sag,Zhujiang River(Pearl River)Mouth Basin 被引量:1
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作者 Jihua Liao Keqiang Wu +3 位作者 Lianqiao Xiong Jingzhou Zhao Xin Li Chunyu Zhang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第3期151-166,共16页
Dissolution mechanism and favorable reservoir distribution prediction are the key problems restricting oil and gas exploration in deep-buried layers.In this paper,the Enping Formation and Zhuhai Formation in Baiyun Sa... Dissolution mechanism and favorable reservoir distribution prediction are the key problems restricting oil and gas exploration in deep-buried layers.In this paper,the Enping Formation and Zhuhai Formation in Baiyun Sag of South China Sea was taken as a target.Based on the thin section,scanning electron microscopy,X-ray diffraction,porosity/permeability measurement,and mercury injection,influencing factors of dissolution were examined,and a dissolution model was established.Further,high-quality reservoirs were predicted temporally and spatially.The results show that dissolved pores constituted the main space of the Paleogene sandstone reservoir.Dissolution primarily occurred in the coarse-and medium-grained sandstones in the subaerial and subaqueous distributary channels,while dissolution was limited in fine-grained sandstones and inequigranular sandstones.The main dissolved minerals were feldspar,tuffaceous matrix,and diagenetic cement.Kaolinization of feldspar and illitization of kaolinite are the main dissolution pathways,but they occur at various depths and temperatures with different geothermal gradients.Dissolution is controlled by four factors,in terms of depositional facies,source rock evolution,overpressure,and fault activities,which co-acted at the period of 23.8–13.8 Ma,and resulted into strong dissolution.Additionally,based on these factors,high-quality reservoirs of the Enping and Zhuhai formations are predicted in the northern slope,southwestern step zone,and Liuhua uplift in the Baiyun Sag. 展开更多
关键词 dissolution mechanism deep-buried reservoir diagenesis evolution reservoir prediction deep water region Baiyun Sag
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Numerical simulation of zonal disintegration of surrounding rock in the deep-buried chamber 被引量:1
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作者 Yukai Wang Xiaoli Liu Yanlin Xiong 《Deep Underground Science and Engineering》 2022年第2期174-182,共9页
Zonal disintegration is the phenomenon of cyclical rupture zone and nonrupture zone in the surrounding rock of a deep-buried chamber,which is different from that of a shallow chamber.Based on the finite difference sof... Zonal disintegration is the phenomenon of cyclical rupture zone and nonrupture zone in the surrounding rock of a deep-buried chamber,which is different from that of a shallow chamber.Based on the finite difference software FLAC3D,the numerical simulation of surrounding rock with different mechanical parameters was conducted by using the SU model(Bilinear Strain-Softening Ubiquitous-Joint).The influences of buried depth,cohesion,and internal friction angle of surrounding rock on zonal disintegration were analyzed to reveal the influence law.The results show that:(1)after the chamber excavation,multiple rupture zones gradually extend from the chamber surface or adjacent periphery to the deep surrounding rock.In the extension process,a single rupture zone may be forked into two or even multiple rupture zones,which cross each other and form the zonal disintegration zone.(2)Zonal disintegration is affected by bothσ(in situ stress)and U_(cs)(uniaxial compression strength).Smaller U_(cs)and largerσwill lead to zonal disintegration.(3)The zoning fracture is not obvious in the case ofσ≤U_(cs).In the reverse case,zoning fracture appears remarkably in the surrounding rock around the chamber.These results reveal the influence law of zonal disintegration and provide theoretical support for the design of deep-buried chambers. 展开更多
关键词 deep-buried chamber numerical simulation SU model uniaxial compression strength zonal disintegration
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Analytical solution for steady seepage into a circular deep-buried mountain tunnel with grouted zone in anisotropic strata
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作者 YAN Qi-xiang ZHANG Tian +2 位作者 ZHANG Chuan GUO De-ping QING Song-yong 《Journal of Mountain Science》 SCIE CSCD 2022年第10期2987-2998,共12页
Due to the existence of a large number of discontinuous fractures and interfaces in tunnel surrounding rocks,the groundwater inflow into tunnel generally presents significant anisotropy.Therefore,it is of great signif... Due to the existence of a large number of discontinuous fractures and interfaces in tunnel surrounding rocks,the groundwater inflow into tunnel generally presents significant anisotropy.Therefore,it is of great significance to consider the anisotropic permeability when dealing with water gushing-induced engineering accidents in water-rich mountain tunnels with large burial depth.In this study,based on the complex variable method and the seepage flow theory,a theoretical model of water inflow into a deep-buried circular tunnel in a fully saturated,anisotropic and semi-infinite aquifer is developed.The influence of grouted zone,initial support and secondary lining is fully considered.By comparison to the existing analytical methods and numerical results,the reliability of this proposed analytical solution is well validated.It is indicated from the parametric study that the groundwater inflow into tunnel presents an upward trend with an increasing value of the strata permeability in the vertical direction.Moreover,the water inflow rate and the total water head decrease with the growth of the thickness of grouting circle.It is suggested that reasonable grouting thickness and permeability should be controlled to enhance the grouting effect.This study provides a practical method for estimating the water inflow into a deep-buried,grouted and lined mountain tunnel considering the anisotropic strata permeability. 展开更多
关键词 deep-buried tunnel Analytical solution Groundwater inflow Anisotropic strata Conformal mapping Grouted zone
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Experimental study on similarity materials for soft rock of deep-buried tunnels
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作者 ZHAO Yu PENG Hai-you 《Journal of Coal Science & Engineering(China)》 2011年第2期124-127,共4页
When every parameter is properly scaled down in accordance with some similarity coefficients, it is possible to study the physical-mechanical properties of rock mass with a scale model. To identify the key mechanisms ... When every parameter is properly scaled down in accordance with some similarity coefficients, it is possible to study the physical-mechanical properties of rock mass with a scale model. To identify the key mechanisms of soft rock in deep buried tunnels, the proper sand, binder and ratio were selected. During the process, the model manufacture technology was introduced and typical tests were done and the results were presented. The physical and meehanieal properties effects caused by each composition were discussed. It is shown that the physical and mechanical properties of chosen ratio material such as uniaxial compressive strength tests, elasticity modulus, tensile strength, internal frictional angle, and Poisson's ratio meet with similarity relationship well. The physical and mechanical properties of deep soft rock are simulated successfully. 展开更多
关键词 similarity materials deep-buried tunnel soft rock
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Forecasting of water yield of deep-buried iron mine in Yanzhou, Shandong
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作者 WANG Ye ZHANG Qiu-lan +1 位作者 WANG Shi-chang SHAO Jing-li 《Journal of Groundwater Science and Engineering》 2015年第4期342-351,共10页
This paper compares analytical and numerical methods by taking the forecasting of water yield of deep-buried iron mine in Yanzhou, Shandong as an example. Regarding the analytical method, the equation of infinite and ... This paper compares analytical and numerical methods by taking the forecasting of water yield of deep-buried iron mine in Yanzhou, Shandong as an example. Regarding the analytical method, the equation of infinite and bilateral water inflow boundary is used to forecast the water yield, and in the case of numerical simulation, we employed the GMS software to establish a model and further to forecast the water yield. On the one hand, through applying the analytical method, the maximum water yield of mine 1 500 m deep below the surface was calculated to be 13 645.17 m3/d; on the other hand, through adopting the numerical method, we obtained the predicted result of 3 816.16 m3/d. Meanwhile, by using the boundary generalization in the above-mentioned two methods, and through a comparative analysis of the actual hydro-geological conditions in this deep-buried mine, which also concerns the advantages and disadvantages of the two methods respectively, this paper draws the conclusion that the analytical method is only applicable in ideal conditions, but numerical method is eligible to be used in complex hydro-geological conditions. Therefore, it is more applicable to employ the numerical method to forecast water yield of deep-buried iron mine in Yanzhou, Shandong. 展开更多
关键词 Analytical method Numerical simulation Forecasting of water yield Yanzhou deep-buried iron mine
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Stress wave propagation and incompatible deformation mechanisms in rock discontinuity interfaces in deep-buried tunnels
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作者 Cong Zhang Zhende Zhu +2 位作者 Shanyong Wang Xuhua Ren Chong Shi 《Deep Underground Science and Engineering》 2022年第1期25-39,共15页
Complex weak structural planes and fault zones induce significant heterogeneity,discontinuity,and nonlinear characteristics of a rock mass.When an earthquake occurs,these characteristics lead to extremely complex seis... Complex weak structural planes and fault zones induce significant heterogeneity,discontinuity,and nonlinear characteristics of a rock mass.When an earthquake occurs,these characteristics lead to extremely complex seismic wave propagation and vibrational behaviors and thus pose a huge threat to the safety and stability of deep buried tunnels.To investigate the wave propagation in a rock mass with different structural planes and fault zones,this study first introduced the theory of elastic wave propagation and elastodynamic principles and used the Zoeppritz equation to describe wave field decomposition and develop a seismic wave response model accordingly.Then,a physical wave propagation model was constructed to investigate seismic waves passing through a fault,and dynamic damage was analyzed by using shaking table tests.Finally,stress wave attenuation and dynamic incompatible deformation mechanisms in a rock mass with fault zones were explored.The results indicate that under the action of weak structural planes,stress waves appear as a complex wave field decomposition phenomenon.When a stress wave spreads to a weak structural plane,its scattering may transform into a tensile wave,generating tensile stress and destabilizing the rock mass;wave dynamic energy is absorbed by a low-strength rock through wave scattering,which significantly weakens the seismic load.Wave propagation accelerates the initiation and expansion of internal defects in the rock mass and leads to a dynamic incompatible deformation.This is one of the main causes for large deformation and even instability within rock masses.These findings provide an important reference and guide with respect to stability analysis of rock mass with weak structural planes and fault zones. 展开更多
关键词 deep-buried tunnels fractured rock mass incompatible deformation mechanism rock interfaces stress wave propagation model
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GamBro AK 200 ULTRA S透析机无技术错误代码指向的维修案例解析
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作者 陈凯 郦超 王侃 《北京生物医学工程》 2024年第6期656-656,共1页
GamBro AK 200 ULTRA S透析机是百特金宝公司生产的双泵透析机,以血液透析滤过功能为特色,兼备血液透析、血液滤过的功能。通常,操作人员在使用过程中的操作失误,会以报警提示的形式呈现,操作人员根据报警提示的引导,即可快速更正操作,... GamBro AK 200 ULTRA S透析机是百特金宝公司生产的双泵透析机,以血液透析滤过功能为特色,兼备血液透析、血液滤过的功能。通常,操作人员在使用过程中的操作失误,会以报警提示的形式呈现,操作人员根据报警提示的引导,即可快速更正操作,报警提示普遍与操作失误相关,然而,也有掩藏在“报警提示”表面下的特殊故障,本文对一例该类特殊故障的检修进行解析。 展开更多
关键词 GamBro AK 200 ultra S血液透析滤过机 加热装置 特殊故障 维修案例
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Comparative impact behaviours of ultra high performance concrete columns reinforced with polypropylene vs steel fibres
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作者 Thong M.Pham Harrison Hyde +4 位作者 Maw K.Kaung Yan Zhuge Duong T.Tran Des Vlietstra Tung M.Tran 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第10期138-153,共16页
Polypropylene(PP) fibres have primarily used to control shrinkage cracks or mitigate explosive spalling in concrete structures exposed to fire or subjected to impact/blast loads, with limited investigations on capacit... Polypropylene(PP) fibres have primarily used to control shrinkage cracks or mitigate explosive spalling in concrete structures exposed to fire or subjected to impact/blast loads, with limited investigations on capacity improvement. This study unveils the possibility of using PP micro-fibres to improve the impact behaviour of fibre-reinforced ultra-high-performance concrete(FRUHPC) columns. Results show that the addition of fibres significantly improves the impact behaviour of FRUHPC columns by shifting the failure mechanism from brittle shear to favourable flexural failure. The addition of steel or PP fibres affected the impact responses differently. Steel fibres considerably increased the peak impact force(up to 18%) while PP micro-fibres slightly increased the peak(3%-4%). FRUHPC significantly reduced the maximum midheight displacement by up to 30%(under 20°impact) and substantially improved the displacement recovery by up to 100%(under 20° impact). FRUHPC with steel fibres significantly improved the energy absorption while those with PP micro-fibres reduced the energy absorption, which is different from the effect of PP-macro fibre reported in the literature. The optimal fibre content for micro-PP fibres is 1% due to its minimal fibre usage and low peak and residual displacement. This study highlights the potential of FRUHPC as a promising material for impact-resistant structures by creating a more favourable flexural failure mechanism, enhancing ductility and toughness under impact loading, and advancing the understanding of the role of fibres in structural performance. 展开更多
关键词 ultra high-performance concrete Steel fibre Polypropylene micro-fibre Fibre volume fraction Impact loading Pendulum tests COLUMNS
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CO_(2) mineralization by typical industrial solid wastes for preparing ultrafine CaCO_(3): A review
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作者 Run Xu Fuxia Zhu +8 位作者 Liang Zou Shuqing Wang Yanfang Liu Jili Hou Chenghao Li Kuntong Song Lingzhao Kong Longpeng Cui Zhiqiang Wang 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第11期1679-1697,共19页
Mineral carbonation is a promising CO_(2) sequestration strategy that can utilize industrial wastes to convert CO_(2) into high-value CaCO_(3).This review summarizes the advancements in CO_(2) mineralization using typ... Mineral carbonation is a promising CO_(2) sequestration strategy that can utilize industrial wastes to convert CO_(2) into high-value CaCO_(3).This review summarizes the advancements in CO_(2) mineralization using typical industrial wastes to prepare ultrafine CaCO_(3).This work surveys the mechanisms of CO_(2) mineralization using these wastes and its capacities to synthesize CaCO_(3),evaluates the effects of carbonation pathways and operating parameters on the preparation of CaCO_(3),analyzes the current industrial application status and economics of this technology.Due to the large amount of impurities in solid wastes,the purity of CaCO_(3) prepared by indirect methods is greater than that prepared by direct methods.Crystalline CaCO_(3) includes three polymorphs.The polymorph of CaCO_(3) synthesized by carbonation process is determined the combined effects of various factors.These parameters essentially impact the nucleation and growth of CaCO_(3) by altering the CO_(2) supersaturation in the reaction system and the surface energy of CaCO_(3) grains.Increasing the initial pH of the solution and the CO_(2)flow rate favors the formation of vaterite,but calcite is formed under excessively high pH.Vaterite formation is favored at lower temperatures and residence time.With increased temperature and prolonged residence time,it passes through aragonite metastable phase and eventually transforms into calcite.Moreover,polymorph modifiers can decrease the surface energy of CaCO_(3) grains,facilitating the synthesis of vaterite.However,the large-scale application of this technology still faces many problems,including high costs,high energy consumption,low calcium leaching rate,low carbonation efficiency,and low product yield.Therefore,it is necessary to investigate ways to accelerate carbonation,optimize operating parameters,develop cost-effective agents,and understand the kinetics of CaCO_(3) nucleation and crystallization to obtain products with specific crystal forms.Furthermore,more studies on life cycle assessment(LCA)should be conducted to fully confirm the feasibility of the developed technologies. 展开更多
关键词 Industrial solid wastes Resource utilization Mineral carbonation ultrafine CaCO_(3) Carbon emission reduction
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Spatiotemporal mapping of(ultra‐)mafic magmatic mine areas:Implications of economic and political realities in China
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作者 Heling Li Liang Tang +3 位作者 Tim T.Werner Zhengmeng Hou Fan Meng Jingjing Li 《Deep Underground Science and Engineering》 2024年第1期91-102,共12页
The spatiotemporal extension/expansion of mine areas is affected by multiple factors.So far,very little has been done to examine the interaction between mine areas and political or economic realities.The(ultra‐)mafic... The spatiotemporal extension/expansion of mine areas is affected by multiple factors.So far,very little has been done to examine the interaction between mine areas and political or economic realities.The(ultra‐)mafic magmatic mines in China played a specific role in supporting national development and providing an ideal research subject for monitoring their interrelationship.In this study,remote sensing and mining‐related GIS data were used to identify and analyze 1233(ultra‐)mafic magmatic mine area polygons in China,which covered approximately 322.96 km2 of land and included a V–Ti–Fe mine,a copper–nickel mine,a chromite mine,an asbestos mine,and a diamond mine.It was found that(1)the areal expansion of mines is significantly related to the mine types,perimeter,topography,and population density.(2)The mine area variation also reflects market and policy realities.The temporal expansion of the mine area from 2010 to 2020 followed an S‐shaped pattern(with the turning point occurring in 2014),closely related to iron overcapacity and tightened mining policies.(3)The complexity(D)of the mine area may reflect mine design and excavation practices.To be specific,lower D indicates early‐stage or artisanal/small‐scale mining,whereas higher D represents large‐scale mining.This study demonstrates that the detailed mapping of mine land can serve as an indicator to implement miningrelated market and policy changes.The(ultra‐)mafic mines area data set can be accessed at https://zenodo.org/record/7636616#.Y-p0uXaZOa0. 展开更多
关键词 complexity mine area mining and socioeconomic interaction spatiotemporal distribution (ultra‐)mafic magmatic mine
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Xpert MTB/RIF Ultra在儿童结核诊断中的应用价值
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作者 王小杰 周正 《医药前沿》 2024年第18期23-26,共4页
目的:探讨Xpert MTB/RIF Ultra在儿童结核诊断中的应用价值。方法:选取2010年1月—2022年12月山东省公共卫生临床中心收治的150例患儿作为研究对象。根据临床综合诊断确诊结果将结核病感染患儿纳入试验组(n=100),将非结核病感染患儿纳... 目的:探讨Xpert MTB/RIF Ultra在儿童结核诊断中的应用价值。方法:选取2010年1月—2022年12月山东省公共卫生临床中心收治的150例患儿作为研究对象。根据临床综合诊断确诊结果将结核病感染患儿纳入试验组(n=100),将非结核病感染患儿纳入对照组(n=50)。计算不同标本类型的敏感度、特异度、阴性预测值、阳性预测值和准确度,评价Xpert MTB/RIF Ultra检出利福平(RIF)耐药性的效能。结果:Xpert MTB/RIF Ultra的检测所有标本总敏感度为77.00%,特异度为96.00%;合并肺内标本敏感度为92.85%,特异度为96.29%,其中肺内标本中肺泡灌洗液敏感度最高为100.00%;合并肺外标本敏感度为77.55%,特异度为95.65%,其中肺外标本中淋巴结敏感度最高为100.00%。结论:不同标本类型中Xpert MTB/RIF Ultra对儿童结核的检出率差异较大,在诊断肺内结核标本时,检测肺泡灌洗液标本价值最高,在诊断肺外结核标本时,检测淋巴结标本价值最高。 展开更多
关键词 儿童 结核 Xpert MTB/RIF ultra 标本
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Xpert MTB/RIF Ultra对结核性脑膜炎的早期诊断价值
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作者 杨元利 张永峰 杨翰 《陕西医学杂志》 CAS 2024年第4期544-547,568,共5页
目的:评价Xpert MTB/RIF Ultra(Ultra)对结核性脑膜炎(TBM)的早期诊断价值。方法:对79例患者的临床资料进行分析,用Ultra、Xpert MTB/RIF(Xpert)、宏基因测序(mNGS)和分枝杆菌培养(MGIT)检测脑脊液(CSF)中的结核分枝杆菌。在临床诊断的... 目的:评价Xpert MTB/RIF Ultra(Ultra)对结核性脑膜炎(TBM)的早期诊断价值。方法:对79例患者的临床资料进行分析,用Ultra、Xpert MTB/RIF(Xpert)、宏基因测序(mNGS)和分枝杆菌培养(MGIT)检测脑脊液(CSF)中的结核分枝杆菌。在临床诊断的基础上,分析各方法的检测性能和利福平药物敏感性。结果:Ultra的敏感度(56.4%)、曲线下面积(AUC值)和Kappa值(0.521)均高于MGIT(20%、0.600、0.236)、Xpert(40%、0.700、0.236)和mNGS(32.7%、0.664、0.352)。在31例Ultra阳性病例中,24例对利福平敏感,7例耐药性不确定。结论:与其他方法相比,Ultra检测脑脊液中结核分枝杆菌具有较高的敏感性。因此,Ultra可用于TBM的早期诊断。 展开更多
关键词 脑脊液 诊断 结核性脑膜炎 Xpert MTB/RIF Xpert MTB/RIF ultra 宏基因测序
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Anisotropy of Trabecular Bone from Ultra-Distal Radius Digital X-Ray Imaging: Effects on Bone Mineral Density and Age
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作者 Jian-Feng Chen 《Open Journal of Radiology》 2024年第1期14-23,共10页
Background: When applied to trabecular bone X-ray images, the anisotropic properties of trabeculae located at ultra-distal radius were investigated by using the trabecular bone scores (TBS) calculated along directions... Background: When applied to trabecular bone X-ray images, the anisotropic properties of trabeculae located at ultra-distal radius were investigated by using the trabecular bone scores (TBS) calculated along directions parallel and perpendicular to the forearm. Methodology: Data from more than two hundred subjects were studied retrospectively. A DXA (GE Lunar Prodigy) scan of the forearm was performed on each subject to measure the bone mineral density (BMD) value at the location of ultra-distal radius, and an X-ray digital image of the same forearm was taken on the same day. The values of trabecular bone score along the direction perpendicular to the forearm, TBS<sub>x</sub>, and along the direction parallel to the forearm, TBS<sub>y</sub>, were calculated respectively. The statistics of TBS<sub>x</sub> and TBS<sub>y</sub> were calculated, and the anisotropy of the trabecular bone, which was defined as the ratio of TBS<sub>y</sub> to TBS<sub>x</sub> and changed with subjects’ BMD and age, was reported and analyzed. Results: The results show that the correlation coefficient between TBS<sub>x</sub> and TBS<sub>y</sub> was 0.72 (p BMD and age was reported. The results showed that decreased trabecular bone anisotropy was associated with deceased BMD and increased age in the subject group. Conclusions: This study shows that decreased trabecular bone anisotropy was associated with decreased BMD and increased age. 展开更多
关键词 ANISOTROPY Trabecular Bone Score Bone Mineral Density ultra-Distal Radius Digital X-Ray Image
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Xpert MTB/RIF Ultra检测脑脊液对结核性脑膜炎的诊断价值 被引量:9
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作者 黄麦玲 孙晴 +6 位作者 王桂荣 李文胜 杜亚东 蔡宝云 黄海荣 李琦 初乃惠 《中国防痨杂志》 CAS CSCD 2021年第7期670-676,共7页
目的评估超敏结核分枝杆菌和利福平耐药基因(Xpert MTB/RIF Ultra,简称"Xpert Ultra")检测脑脊液(cerebral spinal fluid,CSF)对结核性脑膜炎(tuberculous meningitis,TBM)的诊断价值。方法连续纳入2017年1月至2018年12月首... 目的评估超敏结核分枝杆菌和利福平耐药基因(Xpert MTB/RIF Ultra,简称"Xpert Ultra")检测脑脊液(cerebral spinal fluid,CSF)对结核性脑膜炎(tuberculous meningitis,TBM)的诊断价值。方法连续纳入2017年1月至2018年12月首都医科大学附属北京胸科医院就诊的疑似TBM患者189例,依据入组标准最终纳入151例,其中临床诊断TBM患者106例(包括32例确诊、55例很可能,19例可能),非TBM患者45例。收集所有患者的CSF,评价抗酸染色涂片镜检、BACTEC MGIT 960培养(简称"MGIT 960培养")、GeneXpert MTB/RIF(简称"Xpert")和Xpert Ultra检测CSF对TBM的诊断效能。结果以临床诊断为参考标准,Xpert Ultra对106例临床诊断TBM患者检测的敏感度[(44.3%,47/106)]明显高于Xpert[24.5%(26/106)],差异有统计学意义(χ^(2)=16.000,P<0.01);对76例行CSF培养的TBM患者的检测敏感度[44.7%(34/76)]明显高于MGIT 960培养[18.4%(14/76)],差异有统计学意义(χ^(2)=12.893,P<0.01)。纳入Xpert Ultra检测结果后,诊断TBM的确诊率从30.2%(32/106)上升至50.0%(53/106)。Xpert Ultra对62例培养阴性患者的阳性检出率[38.7%(24/62)]明显高于Xpert[21.0%(13/62)],差异有统计学意义(χ^(2)=7.692,P=0.003)。Xpert和Xpert Ultra对接受抗结核治疗TBM患者CSF的阳性检出率[分别为13.3%(8/60)和20.0%(12/60)]均明显低于未接受抗结核治疗患者[分别为39.1%(18/46)和76.1%(35/46)],差异均有统计学意义(χ^(2)=9.360,P=0.002;χ^(2)=33.189,P<0.01);且Xpert Ultra对未接受抗结核治疗的TBM患者的阳性检出率明显高于Xpert(χ^(2)=15.059,P<0.01)。Xpert Ultra和Xpert同时检出利福平耐药者1例,利福平敏感者5例,与表型药物敏感性试验结果一致。结论 Xpert Ultra检测CSF诊断TBM的敏感度明显高于Xpert和MGIT 960培养;且在培养阴性的TBM患者中,Xpert Ultra阳性检出率明显优于Xpert。Xpert Ultra可快速诊断TBM,值得临床推广应用。 展开更多
关键词 Xpert MTB/RIF ultra 结核 脑膜 诊断 对比研究
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Ultra Q:YAG与传统Nd:YAG激光玻璃体消融术治疗飞蚊症的疗效比较 被引量:6
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作者 唐莉 赵玥 +2 位作者 姜静 蒋沁 王成虎 《国际眼科杂志》 CAS 北大核心 2021年第11期1957-1961,共5页
目的:通过观察Ultra Q∶YAG玻璃体消融术治疗飞蚊症的长期效果,评价Ultra Q:YAG较传统Nd∶YAG激光的治疗优势。方法:回顾性分析2018-05/2020-01于我院确诊为玻璃体混浊并接受激光玻璃体消融术治疗的112例130眼患者的临床资料。所有患者... 目的:通过观察Ultra Q∶YAG玻璃体消融术治疗飞蚊症的长期效果,评价Ultra Q:YAG较传统Nd∶YAG激光的治疗优势。方法:回顾性分析2018-05/2020-01于我院确诊为玻璃体混浊并接受激光玻璃体消融术治疗的112例130眼患者的临床资料。所有患者均接受了激光玻璃体消融术治疗,根据不同治疗方法分为A、B两组,A组(60例70眼)接受Ultra Q∶YAG玻璃体消融术治疗;B组(52例60眼)接受传统Nd∶YAG激光治疗。根据患者玻璃体混浊的形态将A、B组各分为两亚组:其中A1组45例52眼和B1组30例38眼,玻璃体混浊形态多为Weiss环、絮状、致密膜状;A2组15例18眼和B2组22例22眼,玻璃体混浊形态多为细点状、丝状、网状。比较治疗前后的BCVA,治疗次数差异及主觉症状改善情况。结果:BCVA:治疗前A1组和A2组、B1组和B2组、A组和B组均无差异(P>0.05);A组和B组在治疗后2wk,1mo时均有差异(P<0.001),A1组和A2组在治疗后1、6、12mo均有差异(P=0.019、0.042、<0.001)。A组患者治疗后的主觉症状改善程度优于B组(P=0.006)。A1组治疗后的主觉症状改善程度优于A2组(P<0.001)。Ultra Q∶YAG比传统Nd∶YAG激光所需的激光治疗次数少(P<0.001)。同一种激光方法,不同玻璃体混浊形态,治疗次数无差异(P>0.05)。结论:Ultra Q∶YAG较传统Nd∶YAG激光进行玻璃体消融治疗飞蚊症,更易于操作、更安全、具有更好的主觉症状改善,尤其是对于伴有Weiss环、絮状、致密膜状混浊物的患者。 展开更多
关键词 ultra Q∶YAG Nd∶YAG激光 玻璃体消融术 飞蚊症
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Xpert MTB/RIF Ultra在结核分枝杆菌及利福平耐药检测中的价值 被引量:7
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作者 王伟 李静 +4 位作者 李铮 杨晶 苑星 张国龙 陈会会 《检验医学》 CAS 2019年第8期742-745,共4页
目的通过与Xpert MTB/RIF比较,评价Xpert MTB/RIF Ultra在结核分枝杆菌及利福平耐药检测中的价值。方法选取出现肺结核症状的患者,根据是否确诊肺结核以及治疗情况分为结核检测组(CDG)和耐药结核组(DRG)。分别采用Xpert MTB/RIF和Xpert ... 目的通过与Xpert MTB/RIF比较,评价Xpert MTB/RIF Ultra在结核分枝杆菌及利福平耐药检测中的价值。方法选取出现肺结核症状的患者,根据是否确诊肺结核以及治疗情况分为结核检测组(CDG)和耐药结核组(DRG)。分别采用Xpert MTB/RIF和Xpert MTB/RIF Ultra检测2组患者的痰标本,以MGIT960液体培养作为参考方法,比较2种方法在结核分枝杆菌及利福平耐药检测中的敏感性和特异性。结果Xpert MTB/RIF Ultra在结核分枝杆菌检测中的敏感性(96.1%)高于Xpert MTB/RIF(85.2%),特异性相同;Xpert MTB/RIF Ultra在抗酸染色涂片阴性患者的结核病检测中敏感性(75.5%)明显高于Xpert MTB/RIF(22.6%)。结论Xpert MTB/RIF Ultra在结核病患者尤其是在抗酸染色涂片阴性患者结核病检测中的价值优于Xpert MTB/RIF。 展开更多
关键词 Xpert MTB/RIF ultra Xpert MTB/RIF 结核分枝杆菌 利福平 耐药
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