Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes...Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.展开更多
目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速...目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速成像技术检测颈动脉脉搏波传导速度(pulse wave velocity,PWV),包括收缩期起始(beginning of the systole,BS)时及收缩期结束(ending of the systole,ES)时的PWV;应用DDMX-100脉象仪检测桡动脉脉象参数,包括h1、h3、h4、h5、h3/h1、h4/h1、h5/h1、w1、w2、w1/t、w2/t;分析两组数据,并采用Spearman非参数法对两种技术参数进行相关性分析。结果:原发性高血压组h1、h3、h3/h1、h4/h1、w2/t增高,h5/h1降低(P <0.05)。BS和ES时,高血压组的PWV均显著高于对照组(P <0.01)。对照组BS、ES时的PWV与h3/h1、h4/h1呈正相关(P <0.05),原发性高血压组BS、ES时的PWV与h4、h3/h1、h4/h1呈正相关(P <0.05)。结论:原发性高血压患者脉象参数与极速成像技术参数间具有良好的相关性,进一步完善了脉象的客观化研究。展开更多
目的评估联合应用极速成像技术与脉象仪检测冠心病患者动脉弹性的价值。方法联合应用超声极速成像技术与脉象仪对44例冠心病患者及40例健康人(对照组)分别行颈动脉脉搏波传导速度(PWV,pulse wave velocity)及桡动脉脉象参数的检测。检...目的评估联合应用极速成像技术与脉象仪检测冠心病患者动脉弹性的价值。方法联合应用超声极速成像技术与脉象仪对44例冠心病患者及40例健康人(对照组)分别行颈动脉脉搏波传导速度(PWV,pulse wave velocity)及桡动脉脉象参数的检测。检测颈动脉脉搏波传导速度使用的是法国Supersonic Aixplorer彩超仪所配备的极速成像技术,包括两个参数:即收缩期起始时的PWV-BS(BS,beginning of the systole)及收缩期结束时的PWV-ES(ES,ending of the systole);检测桡动脉脉象参数使用的是DDMX--100脉象仪,包括诸多参数,如h1、h3/h1、h4/h1、h5/h1、h3、h4、h5、t、w1、w1/t、w2、w2/t等;冠心病组及对照组数据采用SPSS 18.0统计软件进行组间数据分析对比,同一观察对象的两种技术参数的相关性分析采用Spearman非参数法进行。结果冠心病组的PWV-BS、PWV-ES均高于对照组(P <0.05)。冠心病组h3、h4、h3/h1、h4/h1均高于对照组(P <0.05)。冠心病组PWV-BS、PWV-ES与h3、h3/h1、h4/h1呈正相关(P <0.05),对照组PWV-BS、PWV-ES与h3/h1、h4/h1呈正相关(P <0.05)。结论联合应用极速成像技术与脉象仪能够客观评估冠心病患者的动脉弹性功能,为临床综合评估冠心病患者动脉弹性提供新方法。冠心病患者诸多脉象参数与极速成像技术参数PWV-BS、PWV-ES间呈现出了很好的相关性,进而拓展和完善了脉象客观化领域的研究。展开更多
基金Training Program for Young Qhuang Scholars[Chinese Medicine Education Letter(2022)No.256]Key Research and Development Program of Anhui Province(No.202204295107020001)+1 种基金Anhui Young Leaders Reserve Talent Project[No.4,Middle Development(2022)]National Natural Science Foundation of China(No.81973825,82104783)。
文摘Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.
文摘目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速成像技术检测颈动脉脉搏波传导速度(pulse wave velocity,PWV),包括收缩期起始(beginning of the systole,BS)时及收缩期结束(ending of the systole,ES)时的PWV;应用DDMX-100脉象仪检测桡动脉脉象参数,包括h1、h3、h4、h5、h3/h1、h4/h1、h5/h1、w1、w2、w1/t、w2/t;分析两组数据,并采用Spearman非参数法对两种技术参数进行相关性分析。结果:原发性高血压组h1、h3、h3/h1、h4/h1、w2/t增高,h5/h1降低(P <0.05)。BS和ES时,高血压组的PWV均显著高于对照组(P <0.01)。对照组BS、ES时的PWV与h3/h1、h4/h1呈正相关(P <0.05),原发性高血压组BS、ES时的PWV与h4、h3/h1、h4/h1呈正相关(P <0.05)。结论:原发性高血压患者脉象参数与极速成像技术参数间具有良好的相关性,进一步完善了脉象的客观化研究。
文摘目的评估联合应用极速成像技术与脉象仪检测冠心病患者动脉弹性的价值。方法联合应用超声极速成像技术与脉象仪对44例冠心病患者及40例健康人(对照组)分别行颈动脉脉搏波传导速度(PWV,pulse wave velocity)及桡动脉脉象参数的检测。检测颈动脉脉搏波传导速度使用的是法国Supersonic Aixplorer彩超仪所配备的极速成像技术,包括两个参数:即收缩期起始时的PWV-BS(BS,beginning of the systole)及收缩期结束时的PWV-ES(ES,ending of the systole);检测桡动脉脉象参数使用的是DDMX--100脉象仪,包括诸多参数,如h1、h3/h1、h4/h1、h5/h1、h3、h4、h5、t、w1、w1/t、w2、w2/t等;冠心病组及对照组数据采用SPSS 18.0统计软件进行组间数据分析对比,同一观察对象的两种技术参数的相关性分析采用Spearman非参数法进行。结果冠心病组的PWV-BS、PWV-ES均高于对照组(P <0.05)。冠心病组h3、h4、h3/h1、h4/h1均高于对照组(P <0.05)。冠心病组PWV-BS、PWV-ES与h3、h3/h1、h4/h1呈正相关(P <0.05),对照组PWV-BS、PWV-ES与h3/h1、h4/h1呈正相关(P <0.05)。结论联合应用极速成像技术与脉象仪能够客观评估冠心病患者的动脉弹性功能,为临床综合评估冠心病患者动脉弹性提供新方法。冠心病患者诸多脉象参数与极速成像技术参数PWV-BS、PWV-ES间呈现出了很好的相关性,进而拓展和完善了脉象客观化领域的研究。
