In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-...In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-scale fuzzy entropy(RCMFE)is proposed.First,CS is used to denoise the HIFU echo signals.Then the multi-scale fuzzy entropy(MFE)and RCMFE of the denoised HIFU echo signals are calculated.This study analyzed 90 cases of HIFU echo signals,including 45 cases in normal status and 45 cases in denatured status,and the results show that although both MFE and RCMFE can be used to identify denatured tissues,the intra-class distance of RCMFE on each scale factor is smaller than MFE,and the inter-class distance is larger than MFE.Compared with MFE,RCMFE can calculate the complexity of the signal more accurately and improve the stability,compactness,and separability.When RCMFE is selected as the characteristic parameter,the RCMFE difference between denatured and normal biological tissues is more evident than that of MFE,which helps doctors evaluate the treatment effect more accurately.When the scale factor is selected as 16,the best distinguishing effect can be obtained.展开更多
This article studies the feasibility of noninvasive temperature estimation by detecting echo-strain including thermal expansion in therapeutic ultrasound treatment. This technique evaluates distributions of echo-strai...This article studies the feasibility of noninvasive temperature estimation by detecting echo-strain including thermal expansion in therapeutic ultrasound treatment. This technique evaluates distributions of echo-strain and temperature inside the tissue by detecting echo signals pre- and post-heating, in combination with the temperature dependence of sound speed and thermal expansion. In the computer simulation and experimental study, echo signals pre- and post- heating are acquired and then the temperature elevation is evaluated by correlation analysis. Results demonstrate that this technique can effectively extend the measured temperature range up to 75℃ with an accuracy of±2 ℃.展开更多
Bubbly flows appear in many different industrial fields and the measurement of bubble sizes is crucial for understanding phase interactions. The ultrasound pulse echo can be used for a non-intrusive measurement of the...Bubbly flows appear in many different industrial fields and the measurement of bubble sizes is crucial for understanding phase interactions. The ultrasound pulse echo can be used for a non-intrusive measurement of the bubble surface position in one dimension even when there is no optical access to the bubble. A simultaneous measurement from two opposing directions gives the bubble size but has been performed only on single bubbles. This work applies the tracking technique, which allows a simultaneous measurement of multiple bubbles. The performance of the bubble size measurement was tested experimentally by comparing ultrasonic results with the sizes measured by a high-speed camera and also with metal cylinders. Possible sources of measurement uncertainty were analysed and discussed. The tested range of bubble sizes was up to 10 mm and the void fraction was lower than 1.25%.展开更多
目的探究经颅黑质超声在帕金森病(Parkinson’s disease,PD)中的诊断价值及不同黑质(substantia nigra,SN)回声患者的临床特征。方法选取2020年10月至2023年1月宜春市中医院收治的60例PD患者纳入研究组,另选取同期于本院接受健康检查的6...目的探究经颅黑质超声在帕金森病(Parkinson’s disease,PD)中的诊断价值及不同黑质(substantia nigra,SN)回声患者的临床特征。方法选取2020年10月至2023年1月宜春市中医院收治的60例PD患者纳入研究组,另选取同期于本院接受健康检查的60名正常者纳入对照组,两组均予以经颅黑质超声检查。比较两组研究对象的SN高回声面积、双侧SN高回声总面积与中脑总面积的比值(ratio of total area of hyperechoic substantia nigra to total area of mesencephalon,S/M),统计经颅黑质超声诊断PD的阳性率。根据SN回声强度,将PD患者分成PD-SN-组、PD-SN+组,比较不同SN回声患者的临床特征。结果研究组患者的SN高回声面积、S/M均显著高于对照组(P<0.05);经颅黑质超声检查显示PD-SN-者10例,PD-SN+者50例,经颅黑质超声诊断PD的阳性率为83.33%(50/60)。PD-SN+组与PD-SN-组患者的性别、年龄、H-Y分期、发病年龄、简易精神状态检查量表评分及蒙特利尔认知评估量表评分比较,差异均有统计学意义(P<0.05)。结论经颅黑质超声能更好地帮助临床筛查和发现PD,提高PD阳性检出率。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774088 and 11474090)。
文摘In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-scale fuzzy entropy(RCMFE)is proposed.First,CS is used to denoise the HIFU echo signals.Then the multi-scale fuzzy entropy(MFE)and RCMFE of the denoised HIFU echo signals are calculated.This study analyzed 90 cases of HIFU echo signals,including 45 cases in normal status and 45 cases in denatured status,and the results show that although both MFE and RCMFE can be used to identify denatured tissues,the intra-class distance of RCMFE on each scale factor is smaller than MFE,and the inter-class distance is larger than MFE.Compared with MFE,RCMFE can calculate the complexity of the signal more accurately and improve the stability,compactness,and separability.When RCMFE is selected as the characteristic parameter,the RCMFE difference between denatured and normal biological tissues is more evident than that of MFE,which helps doctors evaluate the treatment effect more accurately.When the scale factor is selected as 16,the best distinguishing effect can be obtained.
基金Project supported by the National Natural Science Foundation of China （Grant No 10474044） and the Program for New Century Excellent Talents in University of China （CNCET）.
文摘This article studies the feasibility of noninvasive temperature estimation by detecting echo-strain including thermal expansion in therapeutic ultrasound treatment. This technique evaluates distributions of echo-strain and temperature inside the tissue by detecting echo signals pre- and post-heating, in combination with the temperature dependence of sound speed and thermal expansion. In the computer simulation and experimental study, echo signals pre- and post- heating are acquired and then the temperature elevation is evaluated by correlation analysis. Results demonstrate that this technique can effectively extend the measured temperature range up to 75℃ with an accuracy of±2 ℃.
文摘Bubbly flows appear in many different industrial fields and the measurement of bubble sizes is crucial for understanding phase interactions. The ultrasound pulse echo can be used for a non-intrusive measurement of the bubble surface position in one dimension even when there is no optical access to the bubble. A simultaneous measurement from two opposing directions gives the bubble size but has been performed only on single bubbles. This work applies the tracking technique, which allows a simultaneous measurement of multiple bubbles. The performance of the bubble size measurement was tested experimentally by comparing ultrasonic results with the sizes measured by a high-speed camera and also with metal cylinders. Possible sources of measurement uncertainty were analysed and discussed. The tested range of bubble sizes was up to 10 mm and the void fraction was lower than 1.25%.
文摘目的探究经颅黑质超声在帕金森病(Parkinson’s disease,PD)中的诊断价值及不同黑质(substantia nigra,SN)回声患者的临床特征。方法选取2020年10月至2023年1月宜春市中医院收治的60例PD患者纳入研究组,另选取同期于本院接受健康检查的60名正常者纳入对照组,两组均予以经颅黑质超声检查。比较两组研究对象的SN高回声面积、双侧SN高回声总面积与中脑总面积的比值(ratio of total area of hyperechoic substantia nigra to total area of mesencephalon,S/M),统计经颅黑质超声诊断PD的阳性率。根据SN回声强度,将PD患者分成PD-SN-组、PD-SN+组,比较不同SN回声患者的临床特征。结果研究组患者的SN高回声面积、S/M均显著高于对照组(P<0.05);经颅黑质超声检查显示PD-SN-者10例,PD-SN+者50例,经颅黑质超声诊断PD的阳性率为83.33%(50/60)。PD-SN+组与PD-SN-组患者的性别、年龄、H-Y分期、发病年龄、简易精神状态检查量表评分及蒙特利尔认知评估量表评分比较,差异均有统计学意义(P<0.05)。结论经颅黑质超声能更好地帮助临床筛查和发现PD,提高PD阳性检出率。
