Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years.Chemotherapy alone is difficult to benefit the surviv...Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years.Chemotherapy alone is difficult to benefit the survival of patients with advanced oral and maxillofacial malignancy.Ultrasound hyperthermia is a new and effective treatment for malignant tumor,which is developing rapidly in addition to conventional treatment.However,at present,ultrasound hyperthermia has not been widely used in the treatment of oral and maxillofacial malignancy.Therefore,formation of a guideline on ultrasound hyperthermia for oral and maxillofacial malignancy is mandatory,in order to promote and standardize the clinical practice of ultrasound hyperthermia in this field,and improve the long-term survival rate and quality of life of patients.展开更多
Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasi...Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency(PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.展开更多
Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid t...Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.展开更多
This paper deals with the temperature correlation of gray scale of B-mode ultrasound image from heated tissue. In this study, many in-vitro fresh pig livers are heated in a temperature range from 28 ℃ to 45℃, from w...This paper deals with the temperature correlation of gray scale of B-mode ultrasound image from heated tissue. In this study, many in-vitro fresh pig livers are heated in a temperature range from 28 ℃ to 45℃, from which a series of B-mode ultrasonic images of livers were obtained. The gray-value is evaluated from the ultrasound images respectively. A correlation of the mean gray value of the selected regions (12×12 pixels) in B-mode ultrasonic images of liver and its temperature was pointed out. And the experiment results agreed the evaluation well. And it is possible to monitor the tissue temperature changing in hyperthermia using this correlation.展开更多
文摘Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years.Chemotherapy alone is difficult to benefit the survival of patients with advanced oral and maxillofacial malignancy.Ultrasound hyperthermia is a new and effective treatment for malignant tumor,which is developing rapidly in addition to conventional treatment.However,at present,ultrasound hyperthermia has not been widely used in the treatment of oral and maxillofacial malignancy.Therefore,formation of a guideline on ultrasound hyperthermia for oral and maxillofacial malignancy is mandatory,in order to promote and standardize the clinical practice of ultrasound hyperthermia in this field,and improve the long-term survival rate and quality of life of patients.
基金the National Natural Science Foundation of China(No.30800246)the Shanghai Key Technologies R&D Program of China(No.09441900500)the Research Program of Shanghai Education Commission(No.14CXY05)
文摘Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging(MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency(PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.
基金Project supported by the National Basic Research Program of China (Grant No. 2011CB707900)the National Natural Science Foundation of China (Grant Nos. 11074123, 10974095, 10904068, and 10204014)+2 种基金the Fundamental Research Funds for the Central Universities of China (Grant Nos. 111602040 and 1095020409)the Natural Science Foundation of Jiangsu Province of China (Grant No. BK2011812)the Priority Academic Program Development of Jiangsu Higher Educaton Institutions of China
文摘Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.
基金The research was supported by National Nature Science Foundation (30470450) Education Committee Foundation( KP0608200201 ) Elitist Foundation( KW5800200351 ) from Beijing City,China.
文摘This paper deals with the temperature correlation of gray scale of B-mode ultrasound image from heated tissue. In this study, many in-vitro fresh pig livers are heated in a temperature range from 28 ℃ to 45℃, from which a series of B-mode ultrasonic images of livers were obtained. The gray-value is evaluated from the ultrasound images respectively. A correlation of the mean gray value of the selected regions (12×12 pixels) in B-mode ultrasonic images of liver and its temperature was pointed out. And the experiment results agreed the evaluation well. And it is possible to monitor the tissue temperature changing in hyperthermia using this correlation.
