Applying ultrasound （US） to drug delivery and disease therapy is important work. Sonodynamic therapy （SDT）-a comprehensive therapy using US and a sonosensitizer-exhibits antineoplasfic activity in many tumors. In ...Applying ultrasound （US） to drug delivery and disease therapy is important work. Sonodynamic therapy （SDT）-a comprehensive therapy using US and a sonosensitizer-exhibits antineoplasfic activity in many tumors. In this stud）5 we investigated the feasibility of using a new sonosensitizer （sinoporphyrin sodium, DVDMS） loaded into liposome-microbubble complexes （DLMBs） as a possible candidate to enhance SDT against breast cancer. DLMBs were synthesized via the biofin-avidin linkage and confirmed to have good US response. US-induced cavitation played a key role to trigger a boosted payload release from DLMBs and improve the cellular uptake and intratumoral diffusion of DVDMS to realize better SDT effect. The combination of DLMBs and US treatment resulted in significant changes to cell morpholog34 mitochondria damage, and cell apoptosis in vitro. In vivo, the combined treatment markedly inhibited tumor growth, which appeared to result from increased apoptosis and reduced proliferation activity. The significant increase in the antitumor effect of DLMBs plus US suggests their potential use as a new approach to promote the killing activity of SDT against breast cancer.展开更多
文摘Applying ultrasound （US） to drug delivery and disease therapy is important work. Sonodynamic therapy （SDT）-a comprehensive therapy using US and a sonosensitizer-exhibits antineoplasfic activity in many tumors. In this stud）5 we investigated the feasibility of using a new sonosensitizer （sinoporphyrin sodium, DVDMS） loaded into liposome-microbubble complexes （DLMBs） as a possible candidate to enhance SDT against breast cancer. DLMBs were synthesized via the biofin-avidin linkage and confirmed to have good US response. US-induced cavitation played a key role to trigger a boosted payload release from DLMBs and improve the cellular uptake and intratumoral diffusion of DVDMS to realize better SDT effect. The combination of DLMBs and US treatment resulted in significant changes to cell morpholog34 mitochondria damage, and cell apoptosis in vitro. In vivo, the combined treatment markedly inhibited tumor growth, which appeared to result from increased apoptosis and reduced proliferation activity. The significant increase in the antitumor effect of DLMBs plus US suggests their potential use as a new approach to promote the killing activity of SDT against breast cancer.
