Objective:To compare conventional surgery and ultrasound guided foam sclerotherapy for primary superficial venous insufficiency(SVI)with respect to obliteration of superficial venous system,clinical outcome and cost.M...Objective:To compare conventional surgery and ultrasound guided foam sclerotherapy for primary superficial venous insufficiency(SVI)with respect to obliteration of superficial venous system,clinical outcome and cost.Methods:The study was conducted between September 2005 and March 2006,in Surgery department of Christian Medical College Hospital,Vellore.All patients with symptomatic primary venous insufficiency of lower limbs requiring definitive management were randomized to conventional surgery(n=30)or ultrasound guided foam sclerotherapy(n=30).Obliteration of superficial venous system at 3 months,clinical outcome and costs were registered.Results:Superficial venous system was obliterated in all the patients of both the groups at 3 months.Improvement in clinical scores and complication rates was similar in both the groups.The foam sclerotherapy group had less analgesic requirement,earlier return to work and lower cost.Conclusion:Foam sclerotherapy is a cheaper alternative to surgery for primary venous insufficiency with respect to early measures of clinical outcome.展开更多
Polidocanol is the most widely used Sclerotherapy in European and American countries. It is affordable, easy to use and apply, and has high efficiency. The purpose of this paper is to give an overview of the recent ba...Polidocanol is the most widely used Sclerotherapy in European and American countries. It is affordable, easy to use and apply, and has high efficiency. The purpose of this paper is to give an overview of the recent basics of the Sclerotherapy, chemistry and formulation, clinical applications, and side-effects and complications of Polidocanol, and to discuss the Polidocanol as the safety and efficacy of Sclerotherapy.展开更多
目的探讨原发性大隐静脉曲张传统开放性手术与激光治疗联合泡沫硬化术对机体免疫系统的影响。方法按照手术方式将104例择期行大隐静脉曲张手术的患者分为激光治疗联合泡沫硬术组(MIS组,53例)和传统开放性手术组(OS组,51例)。分别于术前...目的探讨原发性大隐静脉曲张传统开放性手术与激光治疗联合泡沫硬化术对机体免疫系统的影响。方法按照手术方式将104例择期行大隐静脉曲张手术的患者分为激光治疗联合泡沫硬术组(MIS组,53例)和传统开放性手术组(OS组,51例)。分别于术前和术后24 h采集2组静脉血测定超氧化物岐化酶(SOD)、IL-1β、IL-6、IL-8、IL-10、TNF-α、干扰素-γ(IFN-γ)水平。采用流式细胞术检测T淋巴细胞亚群及自然杀伤细胞(NK)的比例变化。采用单细胞测序(scRNA-seq)技术检测外周血免疫细胞差异基因表达。结果MIS组术后IL-1β、IL-8水平较术前高(P均<0.05),术前与术后的SOD、IL-6、IL-10、TNF-α、IFN-γ水平比较差异无统计学意义(P均>0.05);OS组上述指标术前与术后比较差异均有统计学意义(P均<0.05)。MIS组术前与术后T淋巴细胞亚群及NK比例比较差异均无统计学意义(P均>0.05);OS组术后24 h CD8^(+)T细胞比例升高,NK比例降低(P均<0.05)。术后24 h外周血免疫细胞表达差异基因功能富集分析提示OS组术后缺氧应答、IFN应答及NF-κB等炎症通路较MIS组上调。结论大隐静脉曲张激光治疗联合泡沫硬化术对机体系统免疫炎症及缺氧反应影响较小,能够更好地维持机体的免疫平衡,较大程度保留机体原有免疫系统抵御微生物入侵的能力。展开更多
文摘Objective:To compare conventional surgery and ultrasound guided foam sclerotherapy for primary superficial venous insufficiency(SVI)with respect to obliteration of superficial venous system,clinical outcome and cost.Methods:The study was conducted between September 2005 and March 2006,in Surgery department of Christian Medical College Hospital,Vellore.All patients with symptomatic primary venous insufficiency of lower limbs requiring definitive management were randomized to conventional surgery(n=30)or ultrasound guided foam sclerotherapy(n=30).Obliteration of superficial venous system at 3 months,clinical outcome and costs were registered.Results:Superficial venous system was obliterated in all the patients of both the groups at 3 months.Improvement in clinical scores and complication rates was similar in both the groups.The foam sclerotherapy group had less analgesic requirement,earlier return to work and lower cost.Conclusion:Foam sclerotherapy is a cheaper alternative to surgery for primary venous insufficiency with respect to early measures of clinical outcome.
文摘Polidocanol is the most widely used Sclerotherapy in European and American countries. It is affordable, easy to use and apply, and has high efficiency. The purpose of this paper is to give an overview of the recent basics of the Sclerotherapy, chemistry and formulation, clinical applications, and side-effects and complications of Polidocanol, and to discuss the Polidocanol as the safety and efficacy of Sclerotherapy.
文摘目的探讨原发性大隐静脉曲张传统开放性手术与激光治疗联合泡沫硬化术对机体免疫系统的影响。方法按照手术方式将104例择期行大隐静脉曲张手术的患者分为激光治疗联合泡沫硬术组(MIS组,53例)和传统开放性手术组(OS组,51例)。分别于术前和术后24 h采集2组静脉血测定超氧化物岐化酶(SOD)、IL-1β、IL-6、IL-8、IL-10、TNF-α、干扰素-γ(IFN-γ)水平。采用流式细胞术检测T淋巴细胞亚群及自然杀伤细胞(NK)的比例变化。采用单细胞测序(scRNA-seq)技术检测外周血免疫细胞差异基因表达。结果MIS组术后IL-1β、IL-8水平较术前高(P均<0.05),术前与术后的SOD、IL-6、IL-10、TNF-α、IFN-γ水平比较差异无统计学意义(P均>0.05);OS组上述指标术前与术后比较差异均有统计学意义(P均<0.05)。MIS组术前与术后T淋巴细胞亚群及NK比例比较差异均无统计学意义(P均>0.05);OS组术后24 h CD8^(+)T细胞比例升高,NK比例降低(P均<0.05)。术后24 h外周血免疫细胞表达差异基因功能富集分析提示OS组术后缺氧应答、IFN应答及NF-κB等炎症通路较MIS组上调。结论大隐静脉曲张激光治疗联合泡沫硬化术对机体系统免疫炎症及缺氧反应影响较小,能够更好地维持机体的免疫平衡,较大程度保留机体原有免疫系统抵御微生物入侵的能力。
