The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study. For the purpose, star-branched poly(lactic acid) and poly(2-methacryloyloxyethyl pho...The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study. For the purpose, star-branched poly(lactic acid) and poly(2-methacryloyloxyethyl phosphorylcholine)(PLA-PMPC)copolymers with umbrella-type AB3,(AB3)_(2), and(AB3)_(3) architecture were synthesized by branching at the PLA core. Micelles self-assembled from these copolymers were used to evaluate the effect of core branching on blood circulation and tumor targeting. The results showed that branching changed the behavior of polymeric self-assembly in solution, thereby changing the size and surface anti-fouling performance of the polymeric micelles. Moreover, star-branched copolymer micelles with a higher branching degree allowed their payload to persist better in blood(half-time prolonged from 7.1, 8.6 to 13.8 h) and for a 1.72-fold higher content at the tumor site. These studies suggest that raising the branching degree of amphiphilic copolymer potentially offers a promising strategy for the design of carriers capable of enhanced circulation and targeting in vivo.展开更多
The design of most water strider robots follows the principle that all supporting legs are in a plane,and each supporting leg bears a certain load and the water strider robot can float on the water.To meet this princi...The design of most water strider robots follows the principle that all supporting legs are in a plane,and each supporting leg bears a certain load and the water strider robot can float on the water.To meet this principle,the number of supporting legs and the spacing between each supporting legs of the water strider robot must be increased,which makes the shape of water strider robots look like octopus.This study proposed a novel water strider robot named 5S-robot,which used five new umbrella-type footpads and a centrifugal pump-based actuating mechanism.Motion analysis model and force analysis model of 5S-robot were built.The general consistency between the results of motion experiments and those of numerical simulation verified the former models.For this 5S-robot,the maximum load of 110.5 g and forward speed of 207.1 mm s^(-1)and rotational speed of 1.22 rad s^(-1)were measured,respectively.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 51773151)。
文摘The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study. For the purpose, star-branched poly(lactic acid) and poly(2-methacryloyloxyethyl phosphorylcholine)(PLA-PMPC)copolymers with umbrella-type AB3,(AB3)_(2), and(AB3)_(3) architecture were synthesized by branching at the PLA core. Micelles self-assembled from these copolymers were used to evaluate the effect of core branching on blood circulation and tumor targeting. The results showed that branching changed the behavior of polymeric self-assembly in solution, thereby changing the size and surface anti-fouling performance of the polymeric micelles. Moreover, star-branched copolymer micelles with a higher branching degree allowed their payload to persist better in blood(half-time prolonged from 7.1, 8.6 to 13.8 h) and for a 1.72-fold higher content at the tumor site. These studies suggest that raising the branching degree of amphiphilic copolymer potentially offers a promising strategy for the design of carriers capable of enhanced circulation and targeting in vivo.
基金financially supported by National Natural Science Foundation of China(No.51975550)Zhejiang Provincial Natural Science Foundation of China(No.LY21E050007)。
文摘The design of most water strider robots follows the principle that all supporting legs are in a plane,and each supporting leg bears a certain load and the water strider robot can float on the water.To meet this principle,the number of supporting legs and the spacing between each supporting legs of the water strider robot must be increased,which makes the shape of water strider robots look like octopus.This study proposed a novel water strider robot named 5S-robot,which used five new umbrella-type footpads and a centrifugal pump-based actuating mechanism.Motion analysis model and force analysis model of 5S-robot were built.The general consistency between the results of motion experiments and those of numerical simulation verified the former models.For this 5S-robot,the maximum load of 110.5 g and forward speed of 207.1 mm s^(-1)and rotational speed of 1.22 rad s^(-1)were measured,respectively.
