期刊文献+
共找到1,139篇文章
< 1 2 57 >
每页显示 20 50 100
精液优化处理后DNA碎片指数与IVF-ET胚胎质量及妊娠结局的关系
1
作者 杨洪毅 刘艳 +2 位作者 许宁 李刚 金海霞 《郑州大学学报(医学版)》 CAS 北大核心 2024年第5期664-668,共5页
目的:评估经密度梯度离心联合上游法优化处理后的精子DNA碎片指数(DFI)与辅助生殖体外受精-胚胎移植(IVF-ET)胚胎质量及妊娠结局的关系。方法:回顾性分析2022年4月至12月在郑州大学第一附属医院生殖医学中心因单纯输卵管因素行IVF-ET的... 目的:评估经密度梯度离心联合上游法优化处理后的精子DNA碎片指数(DFI)与辅助生殖体外受精-胚胎移植(IVF-ET)胚胎质量及妊娠结局的关系。方法:回顾性分析2022年4月至12月在郑州大学第一附属医院生殖医学中心因单纯输卵管因素行IVF-ET的257个周期,比较男方精液优化前后精液参数和精子DFI;按优化后精子DFI将其分为高DFI组(DFI>5)与低DFI组(DFI≤5),比较两组的胚胎发育及妊娠结局;根据临床妊娠情况分为妊娠组与非妊娠组、持续妊娠组及早期流产组,比较精子DFI情况。结果:与处理前相比,精液优化处理后前向运动精子及正常形态精子百分比提高,精子DFI下降(P<0.001)。精子优化处理后高DFI组的早期流产率高于低DFI组(P<0.05)。105例临床妊娠周期中早期流产组精液优化处理前、后DFI均高于持续妊娠组(P<0.05)。结论:密度梯度离心联合上游优化处理是一种有效的精液制备方法,可提高精子前向运动能力和正常形态精子比例,降低精子DFI;优化后精子高DFI可能增加临床妊娠后早期流产的风险。 展开更多
关键词 精子DNA碎片指数 密度梯度离心联合上游法 ivf-et 胚胎质量 妊娠结局
下载PDF
Effect of internet multiple linkage mode-based extended care combined with in-hospital comfort care on colorectal cancer patients undergoing colostomy 被引量:1
2
作者 Li Xu Mei-Zhen Zhou 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第9期1959-1968,共10页
BACKGROUND Patients with colorectal cancer may need postoperative nursing to improve prognosis,and conventional nursing is not effective.Clinical research is needed to explore nursing methods that can more effectively... BACKGROUND Patients with colorectal cancer may need postoperative nursing to improve prognosis,and conventional nursing is not effective.Clinical research is needed to explore nursing methods that can more effectively improve postoperative conditions on colorectal cancer patients undergoing colostomy.AIM To explore the effect of internet multiple linkage mode-based extended care combined with in-hospital comfort care on colorectal cancer patients undergoing colostomy.METHODS Data from 187 patients with colostomy treated in our hospital from May 2019 to March 2022 were collected and divided into three groups,A(n=62),B(n=62)and C(n=63),according to different intervention methods.Group A received internet multiple linkage mode-based extended care combined with in-hospital comfort care.Group B received internet multiple linkage mode-based extended care.Group C received usual care intervention.Complications were compared among the three groups.The stoma self-efficacy scale,Hamilton Anxiety Scale,RESULTS The complication rate of group A,B and C(16.13%,20.97%and 60.32%,respectively)was significantly different(all P<0.05).The incidence of complications in groups A and B was lower than that in group C,and there was no significant difference between groups A and B(P>0.05).After intervention,the scores of ostomy care,social contact,diet choice,confidence in maintaining vitality,confidence in self-care of ostomy,confidence in sexual life,confidence in sexual satisfaction and confidence in physical labor in the three groups were all higher than before intervention,and the scores of groups A and B were higher than those of group C,with statistical significance(P<0.05).The Hamilton Anxiety Scale and Hamilton Depression Scale scores of the three groups after intervention were lower than those before intervention.The scores of groups A and B were lower than those of group C,and the score of group A was lower than that of group B,all with statistical significance(all P<0.05).There was a statist-ically significant difference in cancer-induced fatigue among the three groups(P<0.05).After intervention,the scores of physical health,psychological health,social health and mental health of the three groups were lower than before the intervention.The scores of group A and B were lower than that of group C;and the score of group A was lower than that of group B,all with statistical significance(all P<0.05).CONCLUSION Internet multiple linkage mode-based extended care combined with in-hospital comfort care can effectively improve self-efficacy,bad mood,cancer-related fatigue and life quality of colorectal cancer patients undergoing colostomy. 展开更多
关键词 Internet multiple linkage mode Extended care In-hospital comfort care Colorectal cancer patients Patients undergoing colostomy
下载PDF
不孕症患者IVF-ET助孕后自然流产的相关因素分析
3
作者 姜璎钊 邹雅琴 +1 位作者 屈艳阳 陈洁 《生殖医学杂志》 CAS 2024年第10期1346-1350,共5页
目的分析不孕症患者IVF-ET助孕后自然流产的相关因素。方法回顾性分析2022年7月至2023年6月在中国医学科学院北京协和医院首次接受IVF-ET助孕并临床妊娠的357例不孕症患者的临床资料,按照是否出现自然流产情况分为未流产组(n=312)和流产... 目的分析不孕症患者IVF-ET助孕后自然流产的相关因素。方法回顾性分析2022年7月至2023年6月在中国医学科学院北京协和医院首次接受IVF-ET助孕并临床妊娠的357例不孕症患者的临床资料,按照是否出现自然流产情况分为未流产组(n=312)和流产组(n=45),比较两组患者的基础临床资料、男方精液参数、疾病史/既往史、IVF-ET相关资料等临床资料,基于Logistic回归模型分析自然流产的相关因素。结果应用Logistic回归模型分析发现,年龄≥35岁、体质量指数(BMI)>24 kg/m^(2)、男方精子活力为D级、男方精子浓度≤15×10^(6)/ml、男方精子DNA碎片指数>20%、人工流产史>3次、自然流产史>3次、宫腔操作史>2次、有子宫肌瘤患病史、移植胚胎质量为C级是不孕症患者IVF-ET后自然流产的危险因素(OR>1,P<0.05)。结论不孕症患者的年龄大、BMI高、人工/自然流产次数多、宫腔操作次数多、有子宫肌瘤患病史和移植胚胎质量差可增加IVF-ET助孕后自然流产的风险,且男方精子活力差、浓度低和男方精子DNA碎片指数大也会加大IVF-ET后自然流产的风险。 展开更多
关键词 不孕症 ivf-et 自然流产 相关因素 LOGISTIC回归模型
下载PDF
1例遗传性易栓症患者行IVF-ET助孕治疗的护理
4
作者 郑湘琼 吴嘉齐 +3 位作者 马肇华 柯玩娜 吕燕君 李庆妮 《当代护士(上旬刊)》 2024年第1期113-116,共4页
总结1例遗传性易栓症患者行IVF-ET助孕治疗的护理经验。护理要点包括静脉血栓风险评估、健康教育、预防护理、皮肤管理、加强心理支持、延续性护理等。经过精心的治疗及护理后,患者在IVF-ET助孕治疗过程中未发生静脉血栓栓塞。
关键词 遗传性易栓症 ivf-et助孕 护理
下载PDF
章勤治疗围IVF-ET期经验举隅
5
作者 钱海墨 章勤 《浙江中医杂志》 2024年第8期670-671,共2页
介绍章勤对体外受精与胚胎移植(IVF-ET)围手术期中医药调治经验:术前倡导辨病辨证,溯源求因;术中配合西医治疗,中西合璧;移植之际或孕后力求蓝田种玉、固冲安胎。
关键词 ivf-et 中医药疗法 章勤 名医经验
下载PDF
针灸在IVF-ET周期中辅助治疗薄型子宫内膜(肾阳虚证)不孕患者的临床应用研究
6
作者 江亮 王安 +2 位作者 胥杜鹃 姚文亮 万懿婷 《现代诊断与治疗》 CAS 2024年第4期479-481,共3页
目的 探讨针灸在IVF-ET周期中辅助治疗薄型子宫内膜(肾阳虚证)不孕患者的临床应用效果。方法 选取2022年2月至2023年11月本院生殖科就诊的60例行IVF-ET治疗的薄型子宫内膜(肾阳虚证)不孕患者,随机数字表法分为观察组和对照组,各30例。... 目的 探讨针灸在IVF-ET周期中辅助治疗薄型子宫内膜(肾阳虚证)不孕患者的临床应用效果。方法 选取2022年2月至2023年11月本院生殖科就诊的60例行IVF-ET治疗的薄型子宫内膜(肾阳虚证)不孕患者,随机数字表法分为观察组和对照组,各30例。对照组给予戊酸雌二醇片口服治疗,观察组于月经第5天在对照组治疗基础上加用针刺和艾灸治疗。对比两组治疗前及治疗3个月经周期后子宫内膜厚度,对比两组治疗后胚胎移植成功率和妊娠成功率。结果 治疗后,观察组子宫内膜厚度显著优于对照组,差异有统计学意义(P<0.05)。观察组胚胎移植成功率、妊娠成功率均高于对照组,但差异无统计学意义(P>0.05)。结论 针灸在IVF-ET周期中辅助治疗薄型子宫内膜(肾阳虚证)不孕患者,可显著改善患者子宫内膜厚度,但可能因样本量过少,在胚胎移植成功率和妊娠成功率方面比较差异不显著,需进一步研究。 展开更多
关键词 针刺 艾灸 ivf-et 薄型子宫内膜 肾阳虚证
下载PDF
补肾调周法论治IVF-ET薄型子宫内膜不孕症临证体会
7
作者 董雨萌 殷燕云 寇玉佳 《山西中医》 2024年第8期69-70,共2页
IVF-ET薄型子宫内膜不孕症病机关键为肾精亏虚,血行不畅,瘀阻胞络,胞络失养。治疗上,多以补肾调周为治疗大法,提出分期论治的观点,注重清心滋肾,健脾疏肝以调经,从而提高移植成功率。
关键词 不孕症 补肾调周 薄型子宫内膜 ivf-et
下载PDF
TNF-α、IL-17与PCOS不孕患者IVF-ET助孕结局的关系及交互作用分析
8
作者 陈晨 《新疆医科大学学报》 CAS 2024年第9期1237-1241,1247,共6页
目的探讨肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)与多囊卵巢综合征(PCOS)不孕患者体外受精-胚胎移植(IVF-ET)助孕结局的关系及其交互作用。方法回顾性分析2022年1月至2023年12月北京市大兴区人民医院收治的126例PCOS不孕患者的... 目的探讨肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)与多囊卵巢综合征(PCOS)不孕患者体外受精-胚胎移植(IVF-ET)助孕结局的关系及其交互作用。方法回顾性分析2022年1月至2023年12月北京市大兴区人民医院收治的126例PCOS不孕患者的临床资料,患者均给予IVF-ET治疗,将IVF-ET 35 d后患者宫内妊娠且有胎心搏动者纳入临床妊娠组,否则纳入未妊娠组。分析影响PCOS不孕患者IVF-ET助孕结局的因素,分析TNF-α与IL-17的交互作用对PCOS不孕患者IVF-ET助孕结局的影响,分析TNF-α、IL-17对PCOS不孕患者IVF-ET助孕结局的预测价值。结果临床妊娠患者62例,未妊娠患者64例。Logistic回归分析显示优质胚胎率(OR=0.331,95%CI:0.148~0.738)、TNF-α水平(OR=3.494,95%CI:1.438~8.491)、IL-17水平(OR=3.144,95%CI:1.281~7.569)是影响PCOS不孕患者IVF-ET助孕结局的因素(P<0.05)。TNF-α与IL-17对PCOS不孕患者IVF-ET助孕结局存在正向交互作用,两者交互助孕结局效应为两者单独作用之和的1.384倍(95%CI:1.012~1.894)。ROC曲线分析显示,TNF-α、IL-17及两者联合预测PCOS不孕患者IVF-ET助孕结局的AUC分别为0.713(95%CI:0.610~0.816)、0.707(95%CI:0.594~0.821)、0.883(95%CI:0.815~0.952)。结论TNF-α、IL-17与PCOS不孕患者IVF-ET助孕结局有关,二者在不良助孕结局中具有正向交互作用,其联合预测助孕结局效能良好。 展开更多
关键词 多囊卵巢综合征(PCOS) 肿瘤坏死因子-α(TNF-α) 白细胞介素-17(IL-17) 体外受精-胚胎移植(ivf-et) 助孕结局
下载PDF
LH在多囊卵巢综合征患者行IVF-ET中的研究进展
9
作者 侯美艳 王流林 +1 位作者 胥琴 转黎 《临床医学进展》 2024年第3期354-359,共6页
多囊卵巢综合征(PCOS)是一种常见的内分泌紊乱性疾病,常发生在育龄期女性中。PCOS可以引起排卵障碍、卵巢多囊样改变等,是女性不孕的主要原因之一,严重影响女性的生殖健康。PCOS患者主要通过促排卵治疗,而对于反复促排卵失败的患者,往... 多囊卵巢综合征(PCOS)是一种常见的内分泌紊乱性疾病,常发生在育龄期女性中。PCOS可以引起排卵障碍、卵巢多囊样改变等,是女性不孕的主要原因之一,严重影响女性的生殖健康。PCOS患者主要通过促排卵治疗,而对于反复促排卵失败的患者,往往需要辅助生殖技术助孕治疗。黄体生成素(LH)可以调节卵泡发育,促进卵子成熟,是衡量卵巢功能的重要指标。现就LH在PCOS患者行体外受精–胚胎移植(IVF-ET)中的应用作一综述。 展开更多
关键词 多囊卵巢综合征(PCOS) 促黄体生成素(LH) 体外受精–胚胎移植(ivf-et)
下载PDF
Clinical Effects of the Follicular Phase Long Regimen and Luteal Phase Long Regimen on Ovulation Induction in IVF-ET Treatment: A Meta-Analysis
10
作者 Zhouxiang Chen Mingyu Ouyang 《Journal of Clinical and Nursing Research》 2024年第5期114-123,共10页
Objective:To systematically evaluate the clinical effects of the follicular phase long regimen and the luteal phase long regimen on ovulation induction in IVF-ET treatment.Methods:Databases including PubMed,Embase,Coc... Objective:To systematically evaluate the clinical effects of the follicular phase long regimen and the luteal phase long regimen on ovulation induction in IVF-ET treatment.Methods:Databases including PubMed,Embase,Cochrane Library,CNKI,Chinese Biomedical Literature(CBM),VIP,Wanfang,and others were searched up to January 2021.Clinical studies on ovulation induction using the follicular phase long regimen and luteal phase long regimen in IVF-ET treatment were identified.Literature screening,data extraction,and quality evaluation were conducted based on inclusion and exclusion criteria.Meta-analysis was performed using RevMan 5.3 software.Results:After screening,a total of 11 studies were included,comprising 21,544 patients:9,974 in the follicular phase long regimen group and 11,570 in the luteal phase long regimen group.The meta-analysis results were as follows:(1)The number of Gn days and the total amount of Gn in the follicular phase long regimen were higher than those in the luteal phase long regimen(P<0.05);(2)The number of eggs obtained in the follicular phase long regimen was higher than that in the luteal phase long regimen(P<0.05).There were no significant differences in the rate of embryo optimization and cycle cancellation between the two groups(P>0.05);(3)The embryo implantation rate and clinical pregnancy rate in the follicular phase long regimen were higher than those in the luteal phase long regimen(P<0.05),while the abortion rate in the follicular phase long regimen was lower than that in the luteal phase long regimen(P<0.05).Conclusion:Compared to the luteal phase long regimen,the follicular phase long regimen involves more Gn days and a higher total amount of Gn.The optimal embryo rate and cycle cancellation rate were similar between the regimens,but the follicular phase long regimen resulted in more eggs,significantly improved the implantation and clinical pregnancy rates,and reduced the abortion rate.However,these conclusions require further validation through more multicenter,large-sample RCT studies. 展开更多
关键词 In vitro fertilization and embryo transfer(ivf-et) Follicular phrase long regimen Luteal phase long regimen META-ANALYSIS
下载PDF
Psychological preparation practices for children undergoing medical procedures in Japan and Germany 被引量:2
11
作者 Naomi Matsumori Michael Isfort 《Open Journal of Nursing》 2013年第2期281-286,共6页
The present study aimed to clarify the current status and awareness of psychological preparation for children undergoing medical procedures in pediatric nursing in Japan as compared with that in Germany. An original q... The present study aimed to clarify the current status and awareness of psychological preparation for children undergoing medical procedures in pediatric nursing in Japan as compared with that in Germany. An original questionnaire about the current status and awareness of psychological preparation for children in hospitals was distributed by mail to nurses’ working on Japanese pediatric wards in 2010. The same questionnaire, translated into German, was distributed to nurses working on German pediatric wards via the internet in 2010. A large majority of respondents strongly agreed that children have a right to informed consent. German nurses expressed a longer-term viewpoint on the effects of preparation than Japanese nurses. Japanese nurses recognized a greater need for improvement in their duties than German nurses. The results suggest that we should consider our own country’s nursing practices and need for improvement, but also learn from studies of other countries to address each culture and medical situation appropriately. 展开更多
关键词 PSYCHOLOGICAL Preparation CHILDREN undergoing Medical Procedures PEDIATRIC NURSING Japan GERMANY
下载PDF
辅酶Q10对卵巢低反应患者IVF-ET卵巢反应性和妊娠结局的改善效果 被引量:2
12
作者 齐山芹 闻姬 《现代妇产科进展》 北大核心 2023年第2期123-126,共4页
目的:评估辅酶Q10对既往卵巢低反应(POR)患者卵巢反应性和妊娠结局的改善效果。方法:选取2021年8月至2022年4月在山东中医药大学第二附属医院生殖医学科进行控制性促排卵(COH)、胚胎植入失败或因无可用胚胎取消移植的POR患者35例。下一... 目的:评估辅酶Q10对既往卵巢低反应(POR)患者卵巢反应性和妊娠结局的改善效果。方法:选取2021年8月至2022年4月在山东中医药大学第二附属医院生殖医学科进行控制性促排卵(COH)、胚胎植入失败或因无可用胚胎取消移植的POR患者35例。下一COH周期前给予辅酶Q10预处理2个月,以相同方案再次进行控制性促排卵,比较两个周期卵巢反应、胚胎学结果及妊娠率。选择同期同年龄段、预期卵巢反应正常、初次进行IVF的患者35例作为对照组。结果:较前一周期,辅酶Q10组的获卵数、MⅡ卵数、受精卵数、可用胚胎数及MⅡ卵率、受精率、胚胎种植率、临床妊娠率均显著提高,差异有统计学意义(P<0.05)。辅酶Q10组与对照组的获卵数、MⅡ卵数、受精卵数、优胚数等比较,差异有统计学意义(P<0.05);两组的早期流产率、临床妊娠率比较差异无统计学意义(P>0.05)。结论:辅酶Q10可显著改善既往无可移植胚胎或胚胎植入失败史POR患者的卵巢储备和刺激反应性,增加获卵数和优质胚胎数,但仍显著低于同年龄段预期卵巢反应正常患者。此外,辅酶Q10能显著提高POR患者临床妊娠率。 展开更多
关键词 辅酶Q10 ivf-et 卵巢低反应 卵巢刺激反应性 妊娠结局
下载PDF
生长激素添加对高龄卵巢储备功能减退患者IVF-ET妊娠结局的疗效研究 被引量:5
13
作者 周虹雨 谢宝国 +2 位作者 吴亚妹 冯玉莹 卢伟英 《中国生育健康杂志》 2023年第3期234-238,共5页
目的探究生长激素添加对于高龄卵巢储备功能减退(DOR)患者首次IVF-ET结局的影响。方法本研究回顾性分析了从2019年5月至2020年12月在海南医学院第一附属医院生殖中心进行IVF-ET患者的资料,纳入研究对象236人并同时满足高龄(35岁≤~<4... 目的探究生长激素添加对于高龄卵巢储备功能减退(DOR)患者首次IVF-ET结局的影响。方法本研究回顾性分析了从2019年5月至2020年12月在海南医学院第一附属医院生殖中心进行IVF-ET患者的资料,纳入研究对象236人并同时满足高龄(35岁≤~<40岁)和DOR的诊断标准。按照促排卵过程中是否添加生长激素(GH)将患者分为两组:118例单用促性腺激素(Gn)为对照组,118例为Gn+GH组,收集两组研究对象的获卵数、可利用胚胎数、优质胚胎率、着床率、临床妊娠率等相关妊娠结局数据并对其进行研究。结果两组病人年龄、不孕时间、体质指数(BMI)、窦卵泡数(AFC)、性激素程度、抗缪勒氏管激素(AMH)值进行对比无统计学差异(P>0.05)。两组研究对象Gn总使用计量、使用时间、扳机日P水平、扳机日子宫内膜厚度、2PN受精率、平均移植胚胎数、周期取消率等指标进行对比,无统计学差异(P>0.05)。Gn+GH组获卵数、可利用胚胎数、优质胚胎率明显优于对照组(P<0.05)。Gn+GH组着床率以及妊娠率大于对照组,但经过统计学分析后无差异性(P>0.05)。结论针对高龄(35岁≤~<40岁)卵巢储备功能减退患者,在促排卵过程中使用生长激素能够增加获卵数、可利用胚胎数以及提高优质胚胎率。 展开更多
关键词 卵巢储备功能减退(DOR) 生长激素(GH) 体外授精-胚胎移植(ivf-et) 临床妊娠率
下载PDF
The psychological trajectory from diagnosis to approaching end of life in patients undergoing hemodialysis in China: A qualitative study
14
作者 Hong-yan Niu Jin-feng Liu 《International Journal of Nursing Sciences》 2017年第1期29-33,共5页
Background: In China,the number of patients diagnosed with end-stage renal disease has increased rapidly in recent years.Patients undergoing dialysis treatment often experience psychosocial challenges,such as death an... Background: In China,the number of patients diagnosed with end-stage renal disease has increased rapidly in recent years.Patients undergoing dialysis treatment often experience psychosocial challenges,such as death anxiety,which may potentially cause patients to withdraw from treatment.Nephrology nurses and other practitioners who provide direct care to patients undergoing hemodialysis must understand how these challenges are perceived by patients and affect their daily lives.Aim: This article investigated the psychological trajectory and life experiences of hemodialysis patients to provide complementary guidance for nurses and healthcare practitioners.Method: This study utilized a qualitative descriptive phenomenological design.Data were collected by conducting semistructured interviews and analyzed by content analysis.Data were collected through indepth interviews from May to December 2014.The questions were designed to reveal the life experiences and perspectives of hemodialysis patients.Participants were selected by convenience sampling approach and recruited from outpatients receiving treatment in a blood-purification center in Jiangsu Province,China.Results: Twenty-three participants were recruited.Three stages were extracted from the interview data:(1) afraid stage,(2) adapted stage,and (3) depression stage.Accordingly,three corresponding stages of physiological status were identified: (1) induced stage,(2) stable stage,and (3) severe complications or approaching-end-of-life stage.Conclusions: Patients undergoing dialysis exhibited differing psychological statuses at different physical stages.Thus,nurses must assess the psychophysiological symptoms of patients and design individual care plans for each stage.Future studies should focus on developing stage-specific nursing-care protocols. 展开更多
关键词 Patients undergoing hemodialysis Psychological trajectory Qualitative research
下载PDF
疏肝滋肾方对肝肾亏虚型卵巢储备功能下降患者性激素水平及IVF-ET治疗结局的影响
15
作者 康华 郝镁娟 +2 位作者 郭礼尚 王旭初 马建新 《天津中医药》 CAS 2023年第12期1506-1510,共5页
[目的]探讨疏肝滋肾方对肝肾亏虚型卵巢储备功能下降患者性激素水平及体外受精-胚胎移植(IVF-ET)治疗结局的影响。[方法]选择2020年11月—2021年11月于河北省沧州中西医结合医院治疗的98例卵巢储备功能下降患者,按照随机数字表法随机分... [目的]探讨疏肝滋肾方对肝肾亏虚型卵巢储备功能下降患者性激素水平及体外受精-胚胎移植(IVF-ET)治疗结局的影响。[方法]选择2020年11月—2021年11月于河北省沧州中西医结合医院治疗的98例卵巢储备功能下降患者,按照随机数字表法随机分组,49例患者为西医组,给予IVF-ET治疗,49例患者为疏肝滋肾方组,在西医组基础上给予患者疏肝滋肾方治疗,比较两组患者治疗前后性激素水平[促卵泡刺激素(FSH)、黄体生成素(LH)]及生长分化因子-9(GDF-9)、抗苗勒氏管激素(AMH)、Toll样受体2(TLR2)水平,卵巢状态[卵巢动脉收缩期峰值流速(PSV)、卵巢窦卵泡数(AFC)];比较治疗前后中医证候评分;记录两组患者促性腺激素(Gn)使用剂量、成熟卵率(MII卵率)、获取卵泡个数、受精率、临床妊娠率、流产率及不良反应。[结果]治疗后,疏肝滋肾方组患者LH、FSH含量显著低于西医组、AMH含量显著高于西医组,差异有统计学意义(P<0.05);疏肝滋肾方组患者TLR2含量显著低于西医组、GDF-9水平显著高于西医组,差异有统计学意义(P<0.05);疏肝滋肾方组PSV、AFC显著高于西医组,差异有统计学意义(P<0.05);疏肝滋肾方组中医证候评分显著低于西医组,差异有统计学意义(P<0.05);疏肝滋肾方组Gn使用剂量较西医组少、获取卵泡个数较西医组多,差异有统计学意义(P<0.05),疏肝滋肾方组受精率、MII卵率、临床妊娠率较西医组高,差异有统计学意义(P<0.05),两组流产率比较,差异无统计学意义(P>0.05),治疗期间两组患者均无明显不良反应产生。[结论]疏肝滋肾方治疗肝肾亏虚型卵巢储备功能下降患者,可调节患者性激素水平,抑制机体炎症,改善卵巢微环境,提升卵巢储备功能,缓解临床症状,减少Gn使用剂量,提升受精率、MII卵率、临床妊娠率,改善IVF-ET治疗结局。 展开更多
关键词 疏肝滋肾方 卵巢储备功能下降 卵巢微环境 卵巢储备功能 ivf-et治疗结局
下载PDF
Impact of early intensive rehabilitation care in patients undergoing cardiac surgery in a single center:a quasi-experimental study
16
作者 Lin Zhao Qingyin Li +3 位作者 Chunying Huo Yunxia Hao Li Shi Lin Liu 《中国循环杂志》 CSCD 北大核心 2018年第S01期173-173,共1页
Objective To evaluate the impact of early intensive rehabilitation care in adults undergoing cardiac surgery.Methods This was a quasi-experimental study using assessor blinding in 252 cardiac surgery patients recruite... Objective To evaluate the impact of early intensive rehabilitation care in adults undergoing cardiac surgery.Methods This was a quasi-experimental study using assessor blinding in 252 cardiac surgery patients recruited from Fuwai Hospital.Participants awaiting cardiac surgery were divided into the experiment group and the control group.The control group received routine rehabilitation care postoperatively,including the exercise training,deep breathing exercises,nutrition direction,medication instruction,psychological education,pain management and sleep conditioning. 展开更多
关键词 ADULTS undergoing cardiac surgery EARLY INTENSIVE REHABILITATION CARE ROUTINE REHABILITATION CARE postoperatively
下载PDF
滋阴疏肝汤干预调控HPO轴改善高龄DOR患者IVF-ET助孕结局临床观察
17
作者 赵新伟 马建新 +3 位作者 赵静淳 李小玉 郝镁娟 郭锐利 《辽宁中医药大学学报》 CAS 2023年第11期88-92,共5页
目的观察滋阴疏肝汤对高龄卵巢储备功能低下(DOR)患者HPO轴及IVF-ET助孕结局的影响。方法选择2019年5月—2022年3月于河北省沧州中西医结合医院就诊的DOR患者92例,按照就诊先后顺序随机分为对照组与观察组各46例。对照组常规行体外受精... 目的观察滋阴疏肝汤对高龄卵巢储备功能低下(DOR)患者HPO轴及IVF-ET助孕结局的影响。方法选择2019年5月—2022年3月于河北省沧州中西医结合医院就诊的DOR患者92例,按照就诊先后顺序随机分为对照组与观察组各46例。对照组常规行体外受精-胚胎移植术(IVF-ET),观察组于IVF-ET术前预处理2个月,给予滋阴疏肝汤口服,每日1剂,早晚各1次,连续服用2个月后常规行IVF-ET。观察评定两组的临床疗效,比较两组治疗前后的卵巢储备功能指标,包括血清基础性激素水平(FSH、LH、E2、P、AMH及FSH/LH比值)和卵巢间质动脉血流信号值(PSV、EDV、PI及RI)。比较两组的促排卵情况(Gn总量、促排天数、获卵率、成熟卵率、受精率、卵裂率及优质胚胎率)和IVF-ET结局指标(胚胎种植率、临床妊娠率)。结果观察组治疗后的总有效率95.45%显著高于对照组80.00%(P<0.05)。两组患者治疗后的FSH、LH、E2水平及FSH/LH比值、PI、RI值,均显著低于治疗前(P<0.05),观察组的FSH、E2水平及FSH/LH比值、PI、RI值均显著低于对照组(P<0.05);两组患者的P、AMH、PSV、EDV值均显著高于治疗前(P<0.05),观察组的P、PSV、EDV值则显著高于对照组(P<0.05),两组间LH和AMH值相比较,差异无统计学意义(P>0.05)。两组间Gn总量、促排天数和卵裂率相比,差异无统计学意义(P>0.05);观察组的获卵数、成熟卵数、受精率、优质胚胎率和胚胎种植率、临床妊娠率,均显著高于对照组(P<0.05)。结论滋阴疏肝汤治疗高龄卵巢储备功能低下(DOR)患者疗效显著,可明显改善患者的卵巢储备功能和IVF-ET助孕结局,该作用可能是通过调控HPO轴实现的。 展开更多
关键词 滋阴疏肝汤 基础性激素 卵巢间质动脉血流信号 ivf-et 助孕结局
下载PDF
Tumor cells undergoing direct lineage conversion to neurons: unnatural but useful?
18
作者 Yang-yang Jiang Min Wei Heng-zhu Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第2期334-336,共3页
Dear Editor, In 2011, Son et al. (2011) reported that the forced expression of selected transcription factors is sufficient to convert mouse and human fibroblasts into induced motor neurons (iMNs). The authors use... Dear Editor, In 2011, Son et al. (2011) reported that the forced expression of selected transcription factors is sufficient to convert mouse and human fibroblasts into induced motor neurons (iMNs). The authors used three factors (Ascll, Brn2, and Mytll) to convert fibroblasts into neuronal-like ceils. After confirming that the cells had neuronal morphology, but with absence of motor neuron markers, eight candidate transcription factors were added, which participate in various stages of motor neuron specification. As expected, a significant number of motor cells emerged with known characteristics of cultured embryonic motor neurons. 展开更多
关键词 cell NSCs unnatural but useful Tumor cells undergoing direct lineage conversion to neurons BDNF
下载PDF
Safety and efficacy of trimodality therapy in patients undergoing extrapleural pneumonectomy
19
作者 Servet Blükbas 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第2期130-131,共2页
Malignant pleural mesothelioma (MPM) is a rare but rapidly deadly disease (1). Macroscopic complete resection (MCR) is the goal of surgery (2). MCR seems to have the most significant impact on survival in pati... Malignant pleural mesothelioma (MPM) is a rare but rapidly deadly disease (1). Macroscopic complete resection (MCR) is the goal of surgery (2). MCR seems to have the most significant impact on survival in patients undergoing multimodality treatment for MPM. The role of surgical resection in the management of MPM remains controversial. The selection criterion to perform either extrapleural pneumonectomy (EPP) or extended/radical pleurectomy/ decortication (PD) rely not only on the cardio-pulmonary status of the patient, tumor stage and intraoperative findings but is strongly dependent also on surgeons' decision and philosophy. This is reflected by a recent survey of opinions and beliefs among 802 thoracic surgeons, in which EPP was believed to be more effective than PD (3). Nonetheless, either surgery might achieve MCR. 展开更多
关键词 Safety and efficacy of trimodality therapy in patients undergoing extrapleural pneumonectomy MPM
下载PDF
GnRH Antagonist Protocol: Is It Optimal for All Patients of Different Ages Undergoing <i>In Vitro</i>Fertilization and Embryo Transfer?
20
作者 Weijie Xing Haiyan Lin Qingxue Zhang 《Advances in Sexual Medicine》 2017年第4期153-160,共8页
Background: To assess the effect of these two protocols in patients of different ages. Methods: 1923 in vitro fertilization and embryo transfer (IVF-ET) cycles were divided into two groups: a GnRH-ant protocol group a... Background: To assess the effect of these two protocols in patients of different ages. Methods: 1923 in vitro fertilization and embryo transfer (IVF-ET) cycles were divided into two groups: a GnRH-ant protocol group and GnRH-a long protocol group, and then every group were subdivided into four age ranges. The general materials and IVF outcomes were compared. Results: The incidence of OHSS fluctuated from 0% to 2.37% with GnRH-ant protocol, which was significantly lower than another (P P Conclusion: The antagonist protocol should be considered in patients with a high ovarian response (e.g., PCOS patients) to avoid OHSS. Older patients (>35 years) could be treated with the antagonist protocol. 展开更多
关键词 GNRH AGONIST GNRH ANTAGONIST ivf-et
下载PDF
上一页 1 2 57 下一页 到第
使用帮助 返回顶部