Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a＂breakthrough drug＂for the treatment of dep...Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a＂breakthrough drug＂for the treatment of depression because of its very high selectivity as a serotonin reuptake inhibitor and because it presented a lower side-effectprofile than previous drugs （Wong et al., 2005）.展开更多
Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been im...Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been implicated in the physiopathology of a wide range of neurological and psychiatric disorders, from acute brain damage such as traumatic brain injury, ischemia as well as chronic condi- tions like epilepsy, depression and neurodegenerative pathologies such as Huntington＇s, Parkinson＇s and Alzheimer＇s diseases. Exces- sive stimulation of glutamatergic receptors, mainly N-methyl-D-as- partate （NMDA） receptors （NMDAR）, can have numerous adverse effects on the cell viability, including increased nitric oxide release （NO）, activation of proteases, increased production of reactive oxygen （ROS） and nitrogen （RNS） species and massive influx of calcium ions （Ca2＋）, resulting in cell death. Thus, the use of strategies that modulate the excitotoxic cell damage represents a perspective for the treatment of diseases such as Parkinson＇s and Alzheimer＇s diseases, ischemia, traumatic brain injury （TBI） and seizures.展开更多
Xi Jinping thought for international strategy is an important part of Xi Jinping thought for governing the country, including a concept of era themes, the international pattern, China's self positioning, and inter...Xi Jinping thought for international strategy is an important part of Xi Jinping thought for governing the country, including a concept of era themes, the international pattern, China's self positioning, and international standing, and aspects of diplomatic goals, foreign policy and strategy. The lofty goal of Xi Jinping thought for international strategy is to realize peaceful development and win-win cooperation between China and the rest of the world. Around this goal, Xi Jinping proposes to build a community of shared destiny for mankind, and the Belt and Road Initiative strategy, adhere to the peripheral diplomacy concept of amity, sincerity, benefits and inclusiveness, build a new-type major-countries relations, establish a new security concept, and adhere to the positive outlook on rights and interests and outlook on scientific development, and make a strategic blueprint for the world development, build new-type international relations, and cultivate common values.展开更多
基金Agencia Nacional de Investigación e Innovación (ANII,Fondo Clemente Estable,FCE_6834 to FMR)Programa de Desarollo de las Ciencias Basicas,Pedeciba,Uruguay
文摘Fluoxetine hydrochloride,better known for its commercial name Prozac,is one of the most widely prescribed antidepressant drugs all over the world.This drug was considered a＂breakthrough drug＂for the treatment of depression because of its very high selectivity as a serotonin reuptake inhibitor and because it presented a lower side-effectprofile than previous drugs （Wong et al., 2005）.
基金grants from CNPq (Universal 2012 INCT-Excitotoxicity and Neuroprotection)+1 种基金FAPESC (NENASC/PRONEX)CAPES (PVE 052/2012) to C.I.T
文摘Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been implicated in the physiopathology of a wide range of neurological and psychiatric disorders, from acute brain damage such as traumatic brain injury, ischemia as well as chronic condi- tions like epilepsy, depression and neurodegenerative pathologies such as Huntington＇s, Parkinson＇s and Alzheimer＇s diseases. Exces- sive stimulation of glutamatergic receptors, mainly N-methyl-D-as- partate （NMDA） receptors （NMDAR）, can have numerous adverse effects on the cell viability, including increased nitric oxide release （NO）, activation of proteases, increased production of reactive oxygen （ROS） and nitrogen （RNS） species and massive influx of calcium ions （Ca2＋）, resulting in cell death. Thus, the use of strategies that modulate the excitotoxic cell damage represents a perspective for the treatment of diseases such as Parkinson＇s and Alzheimer＇s diseases, ischemia, traumatic brain injury （TBI） and seizures.
文摘Xi Jinping thought for international strategy is an important part of Xi Jinping thought for governing the country, including a concept of era themes, the international pattern, China's self positioning, and international standing, and aspects of diplomatic goals, foreign policy and strategy. The lofty goal of Xi Jinping thought for international strategy is to realize peaceful development and win-win cooperation between China and the rest of the world. Around this goal, Xi Jinping proposes to build a community of shared destiny for mankind, and the Belt and Road Initiative strategy, adhere to the peripheral diplomacy concept of amity, sincerity, benefits and inclusiveness, build a new-type major-countries relations, establish a new security concept, and adhere to the positive outlook on rights and interests and outlook on scientific development, and make a strategic blueprint for the world development, build new-type international relations, and cultivate common values.
