Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

Detection Algorithm of Laboratory Personnel Irregularities Based on Improved YOLOv7

Due to the complex environment of the university laboratory,personnel flow intensive,personnel irregular behavior is easy to cause security risks.Monitoring using mainstream detection algorithms suffers from low detection accuracy and slow speed.Therefore,the current management of personnel behavior mainly relies on institutional constraints,education and training,on-site supervision,etc.,which is time-consuming and ineffective.Given the above situation,this paper proposes an improved You Only Look Once version 7(YOLOv7)to achieve the purpose of quickly detecting irregular behaviors of laboratory personnel while ensuring high detection accuracy.First,to better capture the shape features of the target,deformable convolutional networks(DCN)is used in the backbone part of the model to replace the traditional convolution to improve the detection accuracy and speed.Second,to enhance the extraction of important features and suppress useless features,this paper proposes a new convolutional block attention module_efficient channel attention(CBAM_E)for embedding the neck network to improve the model’s ability to extract features from complex scenes.Finally,to reduce the influence of angle factor and bounding box regression accuracy,this paper proposes a newα-SCYLLA intersection over union(α-SIoU)instead of the complete intersection over union(CIoU),which improves the regression accuracy while increasing the convergence speed.Comparison experiments on public and homemade datasets show that the improved algorithm outperforms the original algorithm in all evaluation indexes,with an increase of 2.92%in the precision rate,4.14%in the recall rate,0.0356 in the weighted harmonic mean,3.60%in the mAP@0.5 value,and a reduction in the number of parameters and complexity.Compared with the mainstream algorithm,the improved algorithm has higher detection accuracy,faster convergence speed,and better actual recognition effect,indicating the effectiveness of the improved algorithm in this paper and its potential for practical application in laboratory scenarios.

A Novel Foreign Object Detection Method in Transmission Lines Based on Improved YOLOv8n

The rapid pace of urban development has resulted in the widespread presence of construction equipment andincreasingly complex conditions in transmission corridors. These conditions pose a serious threat to the safeoperation of the power grid.Machine vision technology, particularly object recognition technology, has beenwidelyemployed to identify foreign objects in transmission line images. Despite its wide application, the technique faceslimitations due to the complex environmental background and other auxiliary factors. To address these challenges,this study introduces an improved YOLOv8n. The traditional stepwise convolution and pooling layers are replacedwith a spatial-depth convolution (SPD-Conv) module, aiming to improve the algorithm’s efficacy in recognizinglow-resolution and small-size objects. The algorithm’s feature extraction network is improved by using a LargeSelective Kernel (LSK) attention mechanism, which enhances the ability to extract relevant features. Additionally,the SIoU Loss function is used instead of the Complete Intersection over Union (CIoU) Loss to facilitate fasterconvergence of the algorithm. Through experimental verification, the improved YOLOv8n model achieves adetection accuracy of 88.8% on the test set. The recognition accuracy of cranes is improved by 2.9%, which isa significant enhancement compared to the unimproved algorithm. This improvement effectively enhances theaccuracy of recognizing foreign objects on transmission lines and proves the effectiveness of the new algorithm.

SPRING FESTIVAL CELEBRATIONS BUILD A GLOBAL CULTURAL COMMUNITY

As the Year of the Dragon draws close,the Chinese worldwide,as well as the countries and groups sharing the festival,are gearing up to celebrate the most important social event in the Chinese lunar calendar.For the Chinese,the Spring Festival,or the Chinese New Year,is far more than an occasion for merrymaking.It’s a time for family reunion and the beginning of a new start filled with hope.So the celebrations are also a prayer for peace,prosperity,health,longevity,good luck,and even a bumper harvest.

Chinese New Year Folk Activities in Gansu Promoting Tourism Economy to Heat Up Again

The Chinese New Year is the most solemn traditional festival of the Chinese nation,which is a folk festival integrating the old and the new,praying for auspiciousness,family reunion,celebration and entertainment,and carrying rich historical and cultural heritage.

The Volga River Is Russia’s Lifeline and in Need of Maintenance, Mitigation and Restoration

The Volga River flows entirely through Russia and the watershed includes three of the country’s ten largest cities. The river is the longest in Europe and western Russia’s principal waterway. The Volga River basin is home to approximately half of Russia’s population and occupies almost two-fifth of European Russia. It covers much of the Volga region and stretches 3530 kilometers from its source in the Valdai Hills to the Caspian Sea, the world’s largest inland water body. Its economic, cultural, and historic importance makes it one of the world’s greatest rivers. The Volga basin makes up 8 percent of the Russian territory. Stalingrad, located on the banks of the Volga River, has been described as the site of the greatest de-feat in the history of the German Army. It is often identified as the turning point on the Eastern Front of WWII, in the war against Germany, and in the entire WWII. The meeting point of the Eurasian Civilization was historically the Volga River. The river has some of the world’s largest reservoirs and is a major source of livelihood for millions of people. Many factories and cities empty their waste including sewage, industrial waste, fertilizers, and pesticides into the Volga River. Pollutants tend to settle in the reservoirs and contain several meters of heavily contaminated muck. The primary objectives are to assess lessons learned, manage, and restore the Volga River system lifeline in Russia.

教室里的团聚

A classroom of high school students helped their teacher welcome her overseas soldier son back after being apart for over five years,and it had us in tears.A video of the reunion has caught the attention of more than 40 million people.It shows the son wearing his military uniform and carrying flowers and a sign that reads,“Im home.”When his mother walks into the class,he hides behind the door and then sneaks behind a whiteboard so the students can prime her for the big secret.

A Construction Method of Arbitrary-Length Polar Codes

To remove the restriction on code length of polar codes,this paper proposes a construction scheme,called stepwise polar codes,which can gen-erate arbitrary-length polar codes.The stepwise polar codes are generated by sub-polar codes with different code lengths.To improve coding performance,sub-polar codes are united by polarization effect priority algorithm,which can reduce the number of in-completely polarized channels.Then,the construction method of the generator matrix of the stepwise po-lar code is presented.Furthermore,we prove that the proposed scheme has lower decoding complexity than punctured,multi-kernel polar codes.Simulation results show that the proposed method can achieve similar decoding performance compared with the conventional punctured polar codes,rate-compatible punctured polar code,PC-short and asymmetric polar codes(APC)when code length N=48 and 72,respectively.

Tax avoidance and earnings management:a neural network approach for the largest European economies

In this study,we investigate the relationship between tax avoidance and earnings management in the largest five European Union economies by using artificial neural network regressions.This methodology allows us to deal with nonlinearities detected in the data,which is the principal contribution to the previous literature.We ana-lyzed Compustat data for Germany,the United Kingdom,France,Italy,and Spain for the 2006–2015 period,focusing on discretionary accruals.We considered three tax avoidance measures,two based on the effective tax rate(ETR)and one on book-tax differences(BTD).Our results indicate the presence of nonlinear patterns and a posi-tive,statistically significant relationship between discretionary accruals and both ETR indicators implying that when companies resort to earnings management,a larger tax-able income—and thus higher ETR and lesser tax avoidance–would ensue.Hence,as also highlighted by the fact that discretionary accruals do not appear to affect BTD,our evidence does not suggest that companies are exploiting tax manipulation to reduce their tax payments;thus,the gap between accounting and taxation seems largely unaf-fected by earnings management.

Open banking and inclusive finance in the European Union:perspectives from the Dutch stakeholder ecosystem

In the European Union(EU),the revised Payment Services Directive(PSD2)aims to provide more convenient and customized financial products through open banking(OB)platforms.However,little attention has been paid to the role of OB in improving the financial well-being of the growing number of the EU’s underserved groups,which currently constitute approximately a quarter of its population.This study examines how the PSD2 and OB impact inclusive finance in the EU based on the perspectives of the Netherlands’ecosystem,one of the leaders in the EU’s financial technology(FinTech)landscape.A fundamental distinction can be drawn between the OB users and the ecosystem’s players.Regarding the impact of financial services on the users’inclusivity,while the PSD2 strengthens the infrastructure necessary for financial inclusion,many challenges remain,mainly because it was not designed for this purpose.This study identifies several areas of improvement that include adjustments to the know your customer and anti-money laundering processes for underserved customers,innovative ways to communicate the PSD2’s potential,and the regulation of technology providers’activities to build trust.Meanwhile,from the ecosystem’s position,there is a need to strengthen and improve microfinance regulation according to the opportunities provided by the PSD2 to support microfinance institutions(MFIs)in scaling up and reaching underserved clients across borders with innovative services.OB improvements can also be achieved by organizations formed by MFIs and FinTechs in collaboration with banks.Such hybrid institutions will combine the best features of each of them:knowledge of the needs of local underserved clients from MFIs,technological innovations from FinTechs,and large and trusted customer bases,infrastructures,and access to institutional investments and governments from banks.Finally,an EU inclusive OB sector depends on the centrality of trusted regulators as coordination bodies.The PSD2 requires adjustments for underserved populations’specific needs.OB improvements can be achieved by organizations formed by MFIs and Fin-Techs in collaboration with banks.Regulated technical service providers(TSPs)are crucial to building trust and customer adoption in OB.The European Banking Authority(EBA)may function as coordination body to design inclusive rules by engaging with OB stakeholders.As inclusive finance moves into open-finance and data eras,an increasing regulatory complexity and scope will require networks of innovative and trusted regulators.

乌克兰危机下欧盟的发展前景

The Ukraine crisis,which broke out in early 2022,is the most significant geopolitical event to affect Europe since the end of the Cold War.It will have a great impact on the development prospects of the European Union(EU),including significantly altering the EU’s economic development and operation logics,with a more serious longterm impact than the previous debt crisis.The conflict has interrupted the EU strategic autonomy process and made its prospects even bleak.It has given new impetus to integration and,at the same time,has strengthened the negative factors impeding integration within the EU.The Ukraine crisis will further weaken the strength and international influence of the EU and accelerate the marginalization of the EU on the global geopolitical landscape;it may also kill its geopolitical aspiration of becoming a pole in the world’s balance of power.This is not conducive to a multipolar world order or the containment of hegemonism and power politics.However,these outcomes are not inevitable.If the lessons of the Ukraine crisis are properly reflected,and the EU is united,more open toward,and more inclusive with the world,it may have a brighter future.

Comments from the Editor in Chief

With the bell of the New Year,we are about to bid farewell to the unforgettable 2022 and usher in a hopeful 2023.At this moment of saying goodbye to the old year and welcoming the new year,on behalf of Shanxi Medical Periodical Press,I would like to pay tribute to the leaders at all levels who have supported and encouraged us for a long time,and to the authors and readers who trust and care about us;I also would like to express my gratitude to the well-known experts,editorial board members,and reviewers at home and abroad who have helped and accompanied us along the way,and to the colleagues who have helped each other under the pandemic situation.I would like to extend my sincere appreciation and warmest New Year greetings to all of you.Finally,I wish you all good luck in the Year of Rabbit,good health,great progresses in work,and a happy family reunion!

Sunflower Seed Seller Extraordinaire

Former street peddler Nian Guangjiu is indisputably recognized as an iconic figure from the early years of China’s reform and opening-up.THE lead-up to the 2023 Chinese New Year,as the nation happily set about purchasing foods and gifts in preparation for their grand Spring Festival family reunions.

The Revolution’s Result: The Change of Cuban-American Relations During the 1959-1962 Period

Cuban-American relations have become one of the most attractive bilateral relations since the Cold War era.With historical methods and international relations theory,this paper aims to discuss the Cuban Revolution and the change of Cuban-American relations through two issues.One is the Cuban Revolution and the gradual rupture of traditional Cuban-American ties,demonstrating that since Castro’s radical reform of nationalization deeply violated the economic interests of the United States,conflicts and confrontations had already been incurred.At the same time,with Moscow’s intervention,the Cuban Revolution gradually became complicated and sensitive to deal with from Washington’s perspective.The other one is the evolution of confrontation between the Castro revolutionary regime and the United States government during the 1959-1962 period.The Bay of Pigs Invasion rapidly caused political tensions in Cuban-American relations,and soon,the Cuban Missile Crisis institutionalized the escalating confrontation and deeply worsened bilateral relations.As a result,the Castro regime had no choice but to rely on Soviet assistance to maintain a delicate balance with the United States for several decades,which indicated the tragedy of the small nations’destiny.

中秋节庆典

1 As the second most important festival in China,the MidAutumn Festival is celebrated in many traditional ways.Here are some of the most popular traditional celebrations.Enjoying a dinner with family 2 The roundness of the moon represents the reunion of the family in Chinese minds.Families will have dinner together on the evening of the MidAutumn Festival.The public holiday(usually 3 days)is mainly for Chinese people working in different places to have enough time to reunite.Those staying too far away from their parents􀆳homes usually get together with friends.

Research on the Regulatory Framework of Advanced Therapies in the European Union and the United States

Objective To study the regulatory framework of advanced therapies in the European Union and the United States,and to provide reference for the regulation of cell-and gene-based therapeutic products in China.Methods The legal and regulatory documents,annual reports,work information and related literature published on the websites of the FDA and European Medicines Agency(EMA)were reviewed to analyze the regulatory models of advanced therapies in the European Union and the United States.Results and Conclusion the United States and the European Union have carried out a lot of work in the classification standards of advanced therapies,policy formulation and accelerated listing procedures.Therefore,they have established a relatively mature regulatory system.China can learn from their experience and continuously improve the regulatory system to help the sustainable development of gene and cell therapy industry.

Sowing Seeds of Su%ciency

Sia Evelyne Koudounon was amazed by how China handles rice-related operations during her visit to Zhejiang Province in east China in June.As head of a farmers’union of a village called Guegueckoce in Guinea,she was invited to China under an exchange programme for rice value chain.

旗山矿月饼

Mooncakes stands for reunion in China.In the Mid-Autumn Festival,people enjoy kinds of delicious mooncakes.Some prefer Suzhou-style mooncakes,some like Cantonese-style mooncakes.My favorite is Qishan mooncakes.You may wonder why I like Qishan mooncakes best.Now let me tell you.In the beginning,Qishan mooncakes were first created in the 1960s to improve the life of the workers at the Qishan mine in the Mid-Autumn Festival.The dining hall of the Qishan mine created different kinds of tastes.The coal workers could buy them from the dining hall.Unexpectedly,the mooncakes were quite popular among the workers then.They were proud to give such nice food as a gift to their relatives.As a result,Qishan mine was determined to set up a company to produce mooncakes in order to meet the needs of consumers.It turned out to be a big success.

Research on the Interior Decoration Characteristics of Peking Union Medical College Phase I Project

Peking Union Medical College was founded in the late Qing Dynasty and the early Republic of China.Since then,society and politics have been rapidly changing,and its architectural aesthetics reflect the idea of advocating the West and inheriting tradition.Through research and actual investigation,this paper summarizes the current status of its building from two aspects,interior decoration art and interior decoration technology,analyzes the interior decoration characteristics of Peking Union Medical College Phase I Project,and records the archives of Peking Union Medical College’s decoration technology.

构件化WebGIS及其缓存框架

介绍并分析了一个多层次的构件化WebGIS系统———Geo Union的体系结构、构件功能划分以及Web应用模式 为了改善Geo Union的性能 ,引入了空间缓存框架 ,并将其分为三个层次 :空间数据库缓存、网络空间缓存和空间数据代理服务器 空间数据库缓存是为了提高空间数据库的读取效率 ;网络空间缓存是为了提高单个用户或局域网用户的空间数据读取效率 ;