Merging Traditional Dwelling Form into Modern Neighborhood—— A Holiday Villa District's Planning and Design in Shanghai

Taking a holiday villa district for example, this paper explored the ways of merging traditional dwelling form into modern neighborhood, in the planning and design of this villa district, external space designs of traditional villages were borrowed to stress the construction of traditional spaces, and the layout of road traffi c. It was elaborated that in the design of Chinese residential buildings, not only should Chinese style be applied in the facade design of dwellings, but also traditional dwelling forms should be merged with modern life, so the essence of traditional resident culture can be demonstrated in modern residential areas.

基于Qform的建筑脚手架连接叉锻压工艺模拟

针对高强度、高可靠建筑零件成形较难的问题,分析了建筑脚手架连接叉的成形工艺。运用有限元软件Qform对其锻压中的辊锻成形进行了模拟,得到辊锻成形过程中不同位置处的等效应力、等效应变。分析了不同辊轮转速与辊轮进给速度对连接叉辊锻等效应力的影响。结果表明：连接叉在辊锻过程中,随着辊轮转速增加,等效应变也随着增加;随着辊轮进给速度的增加,等效应变反而逐渐减小。连接叉辊锻过程中锻件等效应力比较均匀,辊轮转速及进给速度对锻件变形影响较大。

Reliability and validity of the Chinese version of the Readiness for Hospital Discharge Scale-Parent Form in parents of preterm infants

Background: The Readiness for Hospital Discharge Scale (RHDS)-Parent Form shows satisfactory reli-ability and validity to assess the readiness of parents to take care of their children discharged from hospitals in Western countries. However, the reliability and validity of this instrument has not been evaluated in Chinese populations.Objectives: Evaluate the psychometric features of the RHDS-Parent Form among Chinese parents of preterm infants. Methods: The RHDS-Parent Form was translated into a Chinese version following an international in-strument translation guideline. A total of 168 parents with preterm infants were recruited from the neonatal intensive care units of two tertiary-level hospitals in China. The internal consistency of this measure was assessed using the Cronbach's a coefficient;confirmatory factor analysis was conducted to evaluate the construct validity;and Pearson correlation coefficient was used to report the convergent validity. Results: The Chinese version of RHDS (C-RHDS)-Parent Form included 22 items with 4 subscales, ac-counting for 56.71% of the total variance. The C-RHDS-Parent Form and its subscales showed good reliability (Cronbach's a values 0.78-0.92). This measure and its subscales showed positive correlations with the score of Quality of Discharge Teaching Scale. Conclusion: The factor structure of C-RHDS-Parent Form is partially consistent with the original English version. Future studies are needed to explore the factors within this measure before it is widely used in Chinese clinical care settings.

Hierarchy of mesenchymal stem cells: Comparison of multipotentmesenchymal stromal cells with fibroblast colony forming units

The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units (CFU-F). The aim of this study was to compare the main characteristics of MMSC and CFU-F derived from the bone marrow of 24 healthy donors. Growth and differentiation parameters, as well as relative expression levels of different genes were analyzed in MMSC and CFU-F. MMSC were cultivated for 5 passages. CFU-F concentration was determined for each bone marrow sample. The data obtained demonstrated the heterogeneity and hierarchical organization of both studied populations of stromal precursor cells-MMSC and CFU-F. These two types of stromal precursor cells turned to be different in most parameters studied. Altogether MMSC seemed to be more immature cells than CFU-F and took up the higher position in hierarchical tree of mesenchymal stem cells. The rate of differentiation and proliferative potential decreased with the donor’s age in both populations MMSC and CFU-F.

Direct Infection of Colony Forming Unit-Megakaryocyte by Human Cytomegalovirus Contributes the Pathogenesis of Idiopathic Thrombocytopenic Purpura

Human cytomegalovirus （HCMV） late mRNA expression in megakaryoblast and in turn the pathogenesis of idiopathic thrombocytopenic purpura （ITP） patients with HCMV infection, and effectiveness of ganciclovir were investigated. Colony forming unit-megakaryocytes （CFU-MK） of 46 ITP patients with HCMV infection were incubated from patients＇ bone marrow mononuclear cells （MNC）. Reverse transcriptase-polymerase chain reaction （RT-PCR） was subsequently used for CFU-MK for HCMV-late mRNA detection, Ganciclovir therapy was given to both HCMV-late mRNA positive and negative groups for comparison of therapeutic effectiveness, The results in 19 of 46 CFU-MK culture cells specimens with positive HCMV-DNA by PCR or positive CMV-IgM by enzyme linked immunosorbent assay （ELISA） in the correspondent serum of peripheral blood were positive for HCMV-late mRNA, Sixteen out of 19 patients with positive HCMV-late mRNA CFU-MK had a positive response to ganciclovir. Amongst 27 patients with negative HCMV-late mRNA CFU-MK, only 4 positive responders to ganciclovir therapy were observed. Curative effectiveness of ganciclovir in HCMV-late mRNA positive group was significantly higher than that in HCMV-late mRNA negative group （P〈0.01）, It was suggested that HCMV could directly infect CFU-MK, which might be one of the mechanisms responsible for HCMV related ITE The ganci- clovir is an effective therapy in resulting in the increases in thrombocyte in the ITP patients whose HCMV- late mRNA was positive in their CFU-MK.

Machine learning for enumeration of cell colony forming units

As one of the most widely used assays in biological research,an enumeration of the bacterial cell colonies is an important but time-consuming and labor-intensive process.To speed up the colony counting,a machine learning method is presented for counting the colony forming units(CFUs),which is referred to as CFUCounter.This cellcounting program processes digital images and segments bacterial colonies.The algorithm combines unsupervised machine learning,iterative adaptive thresholding,and local-minima-based watershed segmentation to enable an accurate and robust cell counting.Compared to a manual counting method,CFUCounter supports color-based CFU classification,allows plates containing heterologous colonies to be counted individually,and demonstrates overall performance(slope 0.996,SD 0.013,95%CI:0.97–1.02,p value<1e-11,r=0.999)indistinguishable from the gold standard of point-and-click counting.This CFUCounter application is open-source and easy to use as a unique addition to the arsenal of colony-counting tools.

Research of CBR, DM and smart algorithms based design methods for high-rise building structure form-selection

First, the high-rise building structure design process is divided into three relevant steps, that is, scheme generation and creation, performance evaluation, and scheme optimization. Then with the application of relational database, the case database of high-rise structures is constructed, the structure form-selection designing methods such as the smart algorithm based on CBR, DM, FINS, NN and GA is presented, and the original forms system of this method and its general structure are given. CBR and DM are used to generate scheme candidates; FINS and NN to evaluate and optimize the scheme performance; GA to create new structure forms. Finally, the application cases are presented, whose results fit in with the real project. It proves by combining and using the expert intelligence, algorithm intelligence and machine intelligence that this method makes good use of not only the engineering project knowledge and expertise but also much deeper knowledge contained in various engineering cases. In other words, it is because the form selection has a strong background support of vast real cases that its results prove more reliable and more acceptable. So the introduction of this method provides an effective approach to improving the quality, efficiency, automatic and smart level of high-rise structures form selection design.

Structural form selection of the high-rise buildingwith the improved BP neural network

As civil engineering technology development,the structural form selection is more and more critical in design of high-rise buildings.However,structural form selection involves expertise knowledge and changes with the environment which makes the task arduous.An approach utilizing improved back propagation(BP)neural network optimized by the Levenberg-Marquardt(L-M)algorithm is proposed to extract the main controlling factors of structural form selection.Then,an intelligent expert system with artificial neural network is constructed to design high-rise buildings structure effectively.The experiment tests the model in 15 well-known architecture samples and get the prediction accuracy of 93.33%.The results show that the method is feasible and can help designers select the appropriate structural form.

The weak form market efficiency investigation of American, European and Asian stock markets

This paper investigates the empirical validity of the Weak Form Efficient Market Hypothesis for American, European and Asian stock markets. Random Walk Hypothesis is used to prove weak form efficiency in American, European and Asian stock indices. ADF and PP Unit Root Tests have been used to test unit root in time series of daily data of American, European and Asian stock indices. Results show that sample of stock markets are weak-form efficient in terms of the Random Walk Hypothesis.

The Effects of Building Form on Microclimate and Outdoor Thermal Comfort in a Tropical City

The urban microclimate has direct implications with regards to thermal comfort indoors as well as outdoors. In the tropics, the outdoor thermal comfort conditions during daytime are often far above acceptable comfort standards due to intense solar radiation and high solar elevations. This study aims to know effects of simple and fundamental building forms on microclimate and outdoor thermal comfort in a high dense tropical city, focusing on Dhaka, Bangladesh as a study city. Investigations are carried out on existing area and model areas with modified building forms （in respect of height and shape） on the microclimate as well as on outdoor thermal comfort during daytime in summer. This study has demonstrated that the model using less ground coverage and higher buildings can offer a better thermal climate than the models using maximum ground coverage in a high-density tropical city.

Analysis on Pore-Forming Pouring Pile Construction Technology of House Building Project

Compared with the in-place pile, the pore-forming pouring pile is more simple and convenient, with a wider range of construction. In the actual construction process, it is able to pass through complex bottom layer and water layer underground without very high requirements in equipment. The actual bearing capacity of single pile is very strong, so that it can be better to adapt to the actual needs of different scales or the different geological conditions in building. And it has been promoted and used greatly in building construction work [1]. This paper introduces the concept of the pore-forming pouring pile technology, analyzes the pore-forming construction technology and the pile construction technology, then talks about prevention problems of the pore-forming pouring pile construction in House Building Project, at last draws a conclusion that the pore-forming pouring pile technology is the most basic construction technology and is the most effective and convenient way of construction.

RESIDENTIAL LIFE CYCLE ASSESSMENT MODELING: COMPARATIVE CASE STUDY OF INSULATING CONCRETE FORMS AND TRADITIONAL BUILDING MATERIALS

Innovative,sustainable construction products are emerging in response to market demands.One potential product,insulating concrete forms(ICFs),offers possible advantages in energy and environmental performance when compared with traditional construction materials.Even though ICFs are in part derived from a petroleum-based product,the benefits in the use phase outweigh the impacts of the raw material extraction and manufacturing phase.This paper quantitatively measures ICFs’performance through a comparative life cycle assessment of wall sections comprised of ICF and traditional wood-frame.The life cycle stages included raw materials extraction and manufacturing,construction,use and end of life for a 2,450 square foot house in Pittsburgh,Pennsylvania.Results showed that even though building products such as ICFs are energy intensive to produce and thus have higher environmental impacts in the raw materials extraction and manufacturing phase,the use phase dominated in the life cycle.For the use phase,the home constructed of ICFs consumed 20 percent less energy when compared to a traditional wood-frame structure.The results of the impact assessment show that ICFs have higher impacts over wood homes in most impact categories.The high impacts arise from the raw materials extraction and manufacturing phase of ICFs.But there are a number of embedded unit processes such as disposal of solid waste and transport of natural gas that contribute to this high impact and identifying the top unit process and substance contributors to the impact category is not intuitive.Selecting different unit processes or impact assessment methods will yield dissimilar results and the tradeoffs associated with every building product should be considered after studying the entire life cycle in detail.

Neuronal-like cell differentiation of non-adherent bone marrow cell-derived mesenchymal stem cells

Non-adherent bone marrow cell-derived mesenchymal stem cells from C57BL/6J mice were sepa- rated and cultured using the ＂pour-off＂ method. Non-adherent bone marrow cell-derived mesen- chymal stem ceils developed colony-forming unit-fibroblasts, and could be expanded by supple- mentation with epidermal growth factor. Immunocytochemistry showed that the non-adherent bone marrow cell-derived mesenchymal stem cells exposed to basic fibroblast growth factor/epidermal growth factor/nerve growth factor expressed the neuron specific markers, neurofilament-200 and NeuN, in vitro. Non-adherent bone marrow cell-derived mesenchymal stem cells from 13-galactosidase transgenic mice were also transplanted into focal ischemic brain （right corpus striatum） of C57BL/6J mice. At 8 weeks, cells positive for LacZ and 13-galactosidase staining were observed in the ischemic tissues, and cells co-labeled with both 13-galactosidase and NeuN were seen by double immunohistochemical staining. These findings suggest that the non-adherent bone marrow cell-derived mesenchymal stem cells could differentiate into neuronal-like cells in vitro and in vivo.

HYGROTHERMAL PERFORMANCE ASSESSMENT OF ICF WALLS WITH DIFFERENT MOISTURE CONTROL STRATEGIES AND WALL DESIGNS

The initial high moisture content of concrete and the low vapor permeability of insu-lation layers on both sides of the concrete complicate the drying process of Insulated Concrete Forms(ICF).In order to facilitate the moisture transport and enhance the drying process,different moisture control stratcgics and wall designs can be implc-mented.The application of an air and vapor barrier is one of the most common moisture control stratcgics.In this paper,the impact of vapor permcance of an air and vapor barriers on the hygrothermal performance of an ICF wall in three differ cnt cold and wet climates is examined using a validated Hcat-Air-Moisture transfer model.The hygrothermal performance of an ICF wall assembly with different types of barriers and locations in the wall system for scveral wall designs is invcstigated.Results indicate that a smaller thickness of insulation on the outside facilitates remov-ing the moisture towards the outside and installing low permcance air/vapor barrier systems on the outside prohibits drying and drives the moisture to the inside.Our findings also show that with the proper sclection of insulation thickncss and vapor control stratcgy moisture-related problems can be avoided.

新型都市工业:形成原因、内涵特征与发展策略

新型都市工业作为一种产业新形态,是新质生产力的都市空间产业表现。在总结提炼新型都市工业基本内涵的基础上,从产业空间形态、产业行业形态、发展体系、微观运行主体、区域产业属性和区域产业治理方式六个方面阐述了其主要特征。围绕现阶段产城人融合发展态势,我国各级政府应以形成新型都市工业发展共识为基础,重构或调整多种利益关系,重新配置都市工业资源,加快数智化转型,充实高端生产性服务业,加快新型基础设施建设,塑造工业与社区新型关系,推动试点示范。

模块化冷弯薄壁型钢结构体系低层村镇住宅设计研究

在传统冷弯薄壁型钢结构体系的基础上,从模块化、装配化角度出发,提出了一种适用于低层村镇住宅的新型结构体系——模块化冷弯薄壁型钢结构体系。首先,简述了墙体模块单元的构成,给出了7种通用标准化墙体模块单元,并介绍了基于通用标准化模块单元的村镇模块化户型构建原则及过程;其次,详述了便于快速装配安装的标准墙体单元间模块化连接方式,对模块连接节点进行了受力分析及数值模拟,并给出了模块化冷弯薄壁型钢结构体系构建的原则;最后,重点介绍了适用于所有冷弯薄壁型钢结构体系的抗剪墙长简化设计方法以及基于模块化冷弯薄壁结构体系的抗剪墙长设计方法,并通过实际案例详述了墙长确定过程,同时对比了不同计算方法的抗剪墙长,进一步验证了所提出的抗剪墙长简化设计方法的可行性。结果表明:所提出的模块化冷弯薄壁型钢结构体系可大幅提高冷弯薄壁型钢结构低层村镇住宅的工业化和产品化水平,大幅缩减了工期;所提出的抗剪墙长简化设计方法可显著降低设计门槛,便于该类体系的推广应用。

含跟网和构网型新能源发电单元的混联电力系统暂态同步稳定分析

在新能源发电单元与同步发电机共同接入的混联电力系统中,不同同步方式新能源间,新能源与同步发电机间耦合复杂,深刻影响系统的暂态同步稳定性。为揭示电网对称短路故障下不同发电单元间的动态耦合机理及其对系统暂态同步稳定性的作用机制,该文首先建立故障条件下混联系统的暂态稳定分析数学模型。随后,利用空间矢量图示法与相平面法分析跟网型新能源发电单元注入电流、锁相环参数以及构网型新能源发电单元有功控制环参数等因素对混联系统内各发电单元暂态同步稳定性的影响规律,并据此给出系统控制器参数的设计原则。最后,通过不同工况下的仿真验证理论分析的正确性。

基于肠道菌群平衡分析微生态制剂联合浙贝黄芩汤对急性淋巴细胞白血病大剂量化疗后患者的临床影响

目的探讨微生态制剂联合浙贝黄芩汤对急性淋巴细胞白血病(ALL)大剂量化疗后患者粒细胞集落刺激因子受体(G-CSFR)、粒单系集落形成单位(CFU-GM)、肠道菌群及红系爆式集落形成单位(BFU-E)的影响。方法选取延安大学附属医院2019年6月至2022年12月收治的ALL患者130例作为研究对象,根据治疗方法将患者分为A组、B组、C组,3组患者均接受大剂量化疗,化疗结束48 h后A组患者实施常规治疗,B组患者单纯浙贝黄芩汤治疗,C组给予微生态制剂联合浙贝黄芩汤治疗,治疗12 d后,对3组患者G-CSFR、CFU-GM、BFU-E表达情况及血细胞数量进行检测。结果治疗后,C组血红蛋白、白细胞、血小板[(79±6)g/L、(3.8±0.4)×10^(9)/L、(66.4±3.6)×10^(9)/L]与A组[(59±7)g/L、(3.2±0.4)×10^(9)/L、(52.6±2.8)×10^(9)/L]、B组[(61±7)g/L、(3.1±0.3)×10^(9)/L、(52.8±2.6)×10^(9)/L]对比,差异有统计学意义(P<0.05)。C组G-CSFR(5.35±0.16)pg/ml和白细胞介素-11受体(IL-11R)(6.38±0.54)μg/kg水平均高于A组[(2.23±0.13)pg/ml和(1.49±0.24)μg/kg]和B组[(2.31±0.16)pg/ml和(2.31±0.49)μg/kg]差异有统计学意义(P<0.05)。治疗后,C组患者7 d CFU-GM(18.5±6.0)个和14 d BFU-E(83.5±7.5)个高于A组[7 d CFU-GM(9.5±2.0)个和14 d BFU-E(59.5±6.5)个]和B组[7 d CFU-GM(12.0±6.5)个和14 d BFU-E(63.5±5.0)个],差异有统计学意义(P<0.05)。7 d后,C组双歧杆菌(12.56±3.25)lgCFU/g、乳酸杆菌(13.56±2.58)lgCFU/g、肠杆菌(5.12±1.45)lgCFU/g、肠球菌(5.14±0.58)lgCFU/g高于A组[(9.26±1.03)lg CFU/g、(8.65±0.84)lg CFU/g、(8.08±0.64)lgCFU/g、(8.15±0.46)lgCFU/g]和B组[(11.35±1.36)lg CFU/g、(12.43±1.14)lgCFU/g、(6.49±0.55)lgCFU/g、(6.66±0.43)lgCFU/g],差异有统计学意义(P<0.05)。结论微生态制剂联合浙贝黄芩汤治疗可以有效提高ALL大剂量化疗后患者的G-CSFR、CFU-GM、BFU-E水平,可能更好地改善化疗引起的患者骨髓抑制情况,改善肠道菌群,具有临床研究价值。

江西天井式民居生态适宜性探究

江西地区传统天井式民居具有良好的生态适宜性,在漫长的岁月中形成一套人与自然相和谐的共处模式。文章选取典型案例进行实地测绘、建模,借助Ecotect、Phoenics以及Energy Plus软件进行模拟分析,比较天井式民居与现代民居的光环境、风环境及能耗,验证天井式民居宜居性特征,分析天井式民居生态适宜性的优势与短板,并提出提高现代乡土民居生态适宜性的设计策略,以期为现代建筑的被动式节能技术提供优化思路。

基于风环境响应的可变建筑表皮设计策略研究

与传统静态建筑表皮相比,可变建筑表皮因具有动态适应性能够更好地适应室外环境变化。而在现有的研究中,对基于风环境响应的可变建筑表皮的研究较少。通过案例研究,将基于风环境响应的可变建筑表皮分为可变通风表皮、风动幕墙两类。可变通风表皮可以对室外环境因素进行实时响应以降低建筑能耗并提高室内舒适度,在国家大力提倡“碳达峰、碳中和”的政策背景下,可以更好地满足低碳建筑要求。风动幕墙可以与风环境互动创造灵动的立面效果,提高立面视觉美学。分别从响应因子、运动方式的角度对两类表皮的设计策略进行梳理,为之后基于风环境响应的可变建筑表皮的设计及应用提供参考。