Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

AIM: To evaluate the potential of Polysol, a newly developed preservation solution, in cold storage of small bowel grafts, compared with the current standards, University of Wisconsin solution (UW), Celsior and histidine-tryptophan-ketoglutarate solution (HTK). METHODS: Male Wistar rats were used as donors. Small bowels were retrieved, flushed and then stored in the respective 4 solutions for 18 h at 4℃. Functional integrity of the grafts was evaluated by isolated reperfusion with oxygenated Krebs-Henseleit buffer at 37℃ for 30 min in all 4 groups. RESULTS: Polysol preservation exhibited the highest tissue ATP concentration and the lowest release of LDH. Malondialdehyde, an index for tissue lipid peroxidation, was also the lowest in Polysol. Tissue oxygen consumption was significantly higher in Polysol than in the others. Of interest, UW-storage promoted 10-fold higher apoptosis than in the others. Moreover, electron microscopy revealed that the mucosal villi/micro-villi formation and the cell organelles, including mitochondria, were both significantly better preserved in Polysol, while deleterious alterations were apparent in the others, most notably in UW. Although Celsior and HTK exhibited the better trend of results than UW in some parameters, but could not reach the over-all superiority to UW.CONCLUSION: Cold storage using Polysol resulted in significantly better integrity and function of small bowel grafts than UW. Hence, Polysol may be a novel alternative for the small bowel preservation.

Evaluation of IGL-1 preservation solution using an orthotopic liver transplantation model

AIM： To compare, in a pig the protective effect of UW liver transplantation model, with that of IGL-1, a highsodium preservation solution containing polyethylene glycol （PEG） as an oncotic supply. METHODS： All livers were harvested and grafted orthotopically according to standard techniques. The livers were washed out and preserved for 7 h in IGL-1 （n = 6） or in UW solution （n = 7） at 4℃. In a sham group （n = 4）, the livers underwent a 60-min warm ischemia at 37℃. The hepatocellular injury was assessed in organ preservation solution washed out from the graft at the end of ischemic storage （before revascularization）, and in serum 2 h after reperfusion and daily for up to 6 d. RESULTS： Livers preserved in IGL-1 solution released markedly less AST than that preserved in the UW solution before and after revascularization （P 〈 0.05）. Besides, the activity of creatine kinase-BB, a marker of sinusoidal lining cells injury, was higher in the UW group than in the IGL-1 group （P 〈 0.05）. Histological results showed less necrotic regions in livers preserved in IGL-1 solution; however, no difference was observed for inflammation. CONCLUSION： IGL-1 liquid effectively protects parenchymal and non-parenchymal cells against preservation-reperfusion injuries.

On the Fifth-Order Stokes Solution for Steady Water Waves

This paper presents a universal fifth-order Stokes solution for steady water waves on the basis of potential theory. It uses a global perturbation parameter, considers a depth uniform current, and thus admits the flexibilities on the definition of the perturbation parameter and on the determination of the wave celerity. The universal solution can be extended to that of Chappelear （1961）, confirming the correctness for the universal theory. Furthermore, a particular fifth-order solution is obtained where the wave steepness is used as the perturbation parameter. The applicable range of this solution in shallow depth is analyzed. Comparisons with the Fourier approximated results and with the experimental measurements show that the solution is fairly suited to waves with the Ursell number not exceeding 46.7.

On the universal third order Stokes wave solution

This paper presents a universal third-order Stokes solution with uniform current. This solution is derived on the basis of potential theory by expanding the free surface and potential function in Fourier series and determining the Fourier coefficients by solving a set of nonlinear algebraic equations through the Taylor expansion and perturbation method. The universal solution is expressed upon the still water depth with the still water level as datum and retains a global perturbation parameter. The wave set-up term generated by the self-interaction of oscillatory waves is explicitly included in the free surface function. With the use of different definitions for the wave celerity, different water levels as the datum, different non-dimensional variables as the perturbation parameter, and different treatments for the total head, the universal solution can be reduced to the existing various Stokes solutions, thus explaining the reasons and the physical significance of different non-periodic terms in them, such as the positive or negative constant term in the free surface expression and the time-or space-proportional term in the potential function.

Potential Impact of Mobile Phone Charger Standardization in China

The standardization of mobile phone charger is proceeding steadily in Europe. This paper makes a quantitative analysis on the potential impact of this move in China. The demands for mobile handset and phone charger in China after the introduction of standardization are predicted based on Bass diffusion model. The results indicate that the standardization would have little influence on mobile phone producers, but may charger makers face a fierce turbulence. Standardization would not only reduce the size of charger market, but also change the stable demand to a fluctuating pattern. Standardization of mobile phone charger can contribute to green economy greatly and provide the ICT industry a directive signal for green innovation in the future. Finally, suggestions for policy makers are provided based on the analysis.