The Drosophila adult neuromuscular junction as a model for unravelling amyloid peptide influence on synapse dynamics

Amyloid peptide（Aβ）oligomers are considered one of the primary causal factors for the synaptic loss characteristic of Alzheimer’s disease（AD）（Karran and De Strooper,2016）.However,Aβis generated in normal brains and accumulates at synaptic sites,which raises the question whether Aβplays a physiological role in synapses.

Unraveling complexity of interconnected regulatory circuits in lipid metabolism

In this issue of Journal of Biomedical Research,3review articles are published that cover a broad range of topics addressing current understanding on regulation of nutrient metabolism through protein phosphatases,homeostatic regulation of cellular lipid droplets by small GTPases,and mechanisms by which hepatic assembly and secretion of triglyceride-rich lipoproteins are regulated.

Unraveling the Holiday Train Rush

ID verification seeks to streamline railway-ticketing system HAVING not spent the Spring Festival with her family for two years, Li Li,26,had been eager to go home in northeast China＇s Heilongjiang Province to spend the Spring Festival, which fell on January 23 this year,with her parents.But the greatest difficulty before her was how to get the train ticket to her hometown.

Unraveling electrolyte solvation architectures for high-performance lithium-ion batteries

The design of advanced electrolytes hinges critically on a comprehensive comprehension of lithium-ion migration mechanisms within these electrochemical systems. Fluorination generally improves the stability and reduces the reactivity of organic compounds, making them potentially suitable for use in harsh conditions such as those found in a battery electrolyte. However,the specific properties, such as the solvation power, diffusivity, ion mobility, and so forth, would depend on the exact nature and extent of the fluorination. In this work, we introduce a theoretical framework designed to facilitate the autonomous creation of electrolyte molecular structures and craft methodologies to compute transport coefficients, providing a physical interpretation of fluoride systems. Taking fluorinated-1,2-diethoxyethanes as electrolyte solvents, we present and analyze the relationship between the electronic properties and atomic structures, and further correlate these properties to the transport coefficients, resulting in a good alignment with the experimental diffusion behaviors and Li-solvation structures. The insights derived from this research contribute to the methodological basis for high-throughput evaluation of prospective electrolyte systems, and consequently, propose strategic directions for the improvement of electrochemical cycle characteristics. This comprehensive exploration of the transport mechanisms enhances our understanding, offering avenues for further advancements in the field of lithium-ion battery technology.

Unraveling Iterative Control Structures from Business Processes

Iterative control structures allow the repeated execution of tasks,activities or sub-processes according to the given conditions in a process model.Iterative control structures can significantly increase the risk of triggering temporal exceptions since activities within the scope of these control structures could be repeatedly executed until a predefined condition is met.In this paper,we propose two approaches to unravel iterative control structures from process models.The first approach unravels loops based on zero-one principle.The second approach unravels loops based on branching probabilities assigned at split gateways.The proposed methods can be used to unfold structured loops,nested loops and crossing loops.Since the unfolded model does not contain any iterative control structures,it can be used for further analysis by process designers during the modeling phase.The proposed methods are implemented based on workflow graphs,and therefore they are compatible with modeling languages such as Business Process Modelling Notation(BPMN).In the experiments,the execution behavior of unfolded process models is compared against the original models based on the concept of runs.Experimental results reveal that runs generated from the original models can be correctly executed in the unfolded BPMN models that do not contain any loops.

Unraveling salt stress signaling in plants

Salt stress is a maior environmental factor limiting plant growth and productivity. A better understanding of the mechanisms mediating salt resistance will help researchers design ways to improve crop performance under adverse environmental conditions. Salt stress can lead to ionic stress, osmotic stress and secondary stresses, particularly oxidative stress, in plants. Therefore, to adapt to salt stress, plants rely on signals and pathways that re-establish cellular ionic, osmotic, and reactive oxygen species （ROS） homeostasis. Over the past two decades, genetic and biochemical analyses have revealed several core stress signaling pathways that participate in salt resistance. The Salt Overly Sensitive signaling pathway plays a key role in maintaining ionic homeostasis, via extruding sodium ions into the apoplast. Mitogenactivated protein kinase cascades mediate ionic, osmotic, and ROS homeostasis. SnRK2 （sucrose nonfermenting l-related protein kinase 2） proteins are involved in maintaining osmotic homeostasis. In this review, we discuss recent progress in identifying the components and pathways involved in the plant＇s response to salt stress and their regulatory mechanisms. We also review progress in identifying sensors involved in salt-induced stress signaling in plants.

Foreword： varicocele - unraveling the enigma

It was more than 40 years ago, as a first-year Urology resident, that I performed my first varicocele ligation （a palomo procedure under the watchful eye and able hands of my staff physician. I dutifully read all I could the night before the procedure and became familiar with the names of Barfield, Macomber and Sanders, Tulloch, MacLeod, Ivanissevich, Palomo, Amelar and Dubin and others who had written about varicoceles being associated with abnormal semen parameters and a potentially surgically correctable cause of male infertility.

Economic Globalization Unraveled

In a book titled The World Is Flat, author Thomas Friedman postulates how the emergence of Asian powers, which have bridged gaps between developed and developing countries, pose a threat to the United States. China's celebrated economist Cheng Siwei, also Vice Chairman of the Standing Committee of the National People's Congress, is quick to point out that Friedman's theory, one held by many Americans, is biased. Cheng argues that the world has been unevenly developed, and is far from a point of equality. His keynote speech delivered at a forum in Beijing, in which he shares his views about the essence of economic globalization, follows:

Plot Unravels

An investigation suggests the July 5 riot in Urumqi was organized and linked to terrorist groups Although alerted to a possible protest beforehand, the government of Urumqi did not expect the demonstration on July 5 to escalate into a murderous rampage with brutality, the likes of which the city had never seen, officials said.