In evolutionary games,most studies on finite populations have focused on a single updating mechanism.However,given the differences in individual cognition,individuals may change their strategies according to different...In evolutionary games,most studies on finite populations have focused on a single updating mechanism.However,given the differences in individual cognition,individuals may change their strategies according to different updating mechanisms.For this reason,we consider two different aspiration-driven updating mechanisms in structured populations:satisfied-stay unsatisfied shift(SSUS)and satisfied-cooperate unsatisfied defect(SCUD).To simulate the game player’s learning process,this paper improves the particle swarm optimization algorithm,which will be used to simulate the game player’s strategy selection,i.e.,population particle swarm optimization(PPSO)algorithms.We find that in the prisoner’s dilemma,the conditions that SSUS facilitates the evolution of cooperation do not enable cooperation to emerge.In contrast,SCUD conditions that promote the evolution of cooperation enable cooperation to emerge.In addition,the invasion of SCUD individuals helps promote cooperation among SSUS individuals.Simulated by the PPSO algorithm,the theoretical approximation results are found to be consistent with the trend of change in the simulation results.展开更多
To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic upd...To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic update mechanism of SI based on spectrum opportunity incentive is established, in which spectrum users are encouraged to actively assist the database to update SI in real time. Secondly, the information update contribution(IUC) of spectrum opportunity is defined to describe the cost of accessing spectrum opportunity for heterogeneous spectrum users, and the profit of SI update obtained by the database from spectrum allocation. The process that the database determines the IUC of spectrum opportunity and spectrum user selects spectrum opportunity is mapped to a Hotelling model. Thirdly, the process of determining the IUC of spectrum opportunities is further modelled as a Stackelberg game by establishing multiple virtual spectrum resource providers(VSRPs) in the database. It is proved that there is a Nash Equilibrium in the game of determining the IUC of spectrum opportunities by VSRPs. Finally, an algorithm of determining the IUC based on a genetic algorithm is designed to achieve the optimal IUC. The-oretical analysis and simulation results show that the proposed method can quickly find the optimal solution of the IUC, and ensure that the spectrum resource provider can obtain the optimal profit of SI update.展开更多
Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with me...Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with medically unexplained symptoms.Based on the previous work,this review aims to comprehensively synthesise updated evidence related to SSD from recent years in English publications and,more extensively,from data published in Chinese language journals.The scoping review update was based on an earlier scoping review and included Chinese language publication data from China National Knowledge Internet(CNKI),WANFANG and WEIPU between January 2013 and May 2022 and data from PubMed,PsyclNFO,and Cochrane Library between June 2020 and May 2022.Initially,2984 articles were identified,of which 63 full texts were included for analysis.In China,SSD is mainly applied in scientific research,but it also shows good predictive validity and clinical application potential.The mean frequency of SSD was 4.5%in the general population,25.2%in the primary care population and 33.5%in diverse specialised care settings.Biological factors,such as brain region changes and heart rate variability,are associated with the onset of sSD.Psychological impairment related to somatic symptoms is the best predictor of prognosis.While adolescent SSD is significantly associated with family function,SSD overall is associated with an increased dysfunction of cognition and emotion,decreased quality of life,and high comorbidity with anxiety and depressive disorders.Further research is needed on suicide risk and cultural and gender-related issues.Updating the data of Chinese language studies,our research enriches the evidence-based findings related to the topics addressed in the text sections of the SSD chapter of DSM-5.However,research gaps remain about SSD reliability,population-based prevalence,suicide risk,and cultural and gender-related issues.展开更多
To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottle...To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottlenecked by the constrained cross-rack bandwidth.Various techniques have been proposed in the literature to improve network bandwidth efficiency,including delta transmission,relay,and batch update.These techniques were largely proposed individually previously,and in this work,we seek to use them jointly.To mitigate the cross-rack update traffic,we propose DXR-DU which builds on four valuable techniques:(i)delta transmission,(ii)XOR-based data update,(iii)relay,and(iv)batch update.Meanwhile,we offer two selective update approaches:1)data-deltabased update,and 2)parity-delta-based update.The proposed DXR-DU is evaluated via trace-driven local testbed experiments.Comprehensive experiments show that DXR-DU can significantly improve data update throughput while mitigating the cross-rack update traffic.展开更多
Multiple failure modes tend to be identified in the reliability analysis of a redundant truss structure.This identification process involves updating the model for identifying the next potential failure members.Herein...Multiple failure modes tend to be identified in the reliability analysis of a redundant truss structure.This identification process involves updating the model for identifying the next potential failure members.Herein we intend to update the finite element model automatically in the identification process of failure modes and further perform the system reliability analysis efficiently.This study presents a framework that is implemented through the joint simulation of MATLAB and APDL and consists of three parts:reliability index of a single member,identification of dominant failure modes,and system-level reliability analysis for system reliability analysis of truss structures.Firstly,RSM(response surface method)combines with a constrained optimization model to calculate the reliability indices ofmembers.Then theβ-unzipping method is adopted to identify the dominant failuremodes,and the system function in MATLAB,as well as the EKILL command in APDL,is used to facilitate the automatic update of the finite element model and realize load-redistribution.Besides,the differential equivalence recursion algorithmis performed to approximate the reliability indices of failuremodes efficiently and accurately.Eventually,the PNET(probabilistic network evaluation technique)is used to calculate the joint failure probability as well as the system reliability index.Two illustrative examples demonstrate the accuracy and efficiency of the proposed system reliability analysis framework through comparison with corresponding references.展开更多
The interactions between players of the prisoner's dilemma game are inferred using observed game data.All participants play the game with their counterparts and gain corresponding rewards during each round of the ...The interactions between players of the prisoner's dilemma game are inferred using observed game data.All participants play the game with their counterparts and gain corresponding rewards during each round of the game.The strategies of each player are updated asynchronously during the game.Two inference methods of the interactions between players are derived with naive mean-field(n MF)approximation and maximum log-likelihood estimation(MLE),respectively.Two methods are tested numerically also for fully connected asymmetric Sherrington-Kirkpatrick models,varying the data length,asymmetric degree,payoff,and system noise(coupling strength).We find that the mean square error of reconstruction for the MLE method is inversely proportional to the data length and typically half(benefit from the extra information of update times)of that by n MF.Both methods are robust to the asymmetric degree but work better for large payoffs.Compared with MLE,n MF is more sensitive to the strength of couplings and prefers weak couplings.展开更多
In the traditional incremental analysis update(IAU)process,all analysis increments are treated as constant forcing in a model’s prognostic equations over a certain time window.This approach effectively reduces high-f...In the traditional incremental analysis update(IAU)process,all analysis increments are treated as constant forcing in a model’s prognostic equations over a certain time window.This approach effectively reduces high-frequency oscillations introduced by data assimilation.However,as different scales of increments have unique evolutionary speeds and life histories in a numerical model,the traditional IAU scheme cannot fully meet the requirements of short-term forecasting for the damping of high-frequency noise and may even cause systematic drifts.Therefore,a multi-scale IAU scheme is proposed in this paper.Analysis increments were divided into different scale parts using a spatial filtering technique.For each scale increment,the optimal relaxation time in the IAU scheme was determined by the skill of the forecasting results.Finally,different scales of analysis increments were added to the model integration during their optimal relaxation time.The multi-scale IAU scheme can effectively reduce the noise and further improve the balance between large-scale and small-scale increments in the model initialization stage.To evaluate its performance,several numerical experiments were conducted to simulate the path and intensity of Typhoon Mangkhut(2018)and showed that:(1)the multi-scale IAU scheme had an obvious effect on noise control at the initial stage of data assimilation;(2)the optimal relaxation time for large-scale and small-scale increments was estimated as 6 h and 3 h,respectively;(3)the forecast performance of the multi-scale IAU scheme in the prediction of Typhoon Mangkhut(2018)was better than that of the traditional IAU scheme.The results demonstrate the superiority of the multi-scale IAU scheme.展开更多
With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes ...With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes are also very frequent.However,no matter what changes,the network must ensure the correct conditions,such as isolating tenants from each other or guaranteeing essential services.Once changes occur,it is necessary to verify the after-changed network.Whereas,for the verification of large-scale network configuration changes,many current verifiers show poor efficiency.In order to solve the problem ofmultiple global verifications caused by frequent updates of local configurations in large networks,we present a fast configuration updates verification tool,FastCUV,for distributed control planes.FastCUV aims to enhance the efficiency of distributed control plane verification for medium and large networks while ensuring correctness.This paper presents a method to determine the network range affected by the configuration change.We present a flow model and graph structure to facilitate the design of verification algorithms and speed up verification.Our scheme verifies the network area affected by obtaining the change of the Forwarding Information Base(FIB)before and after.FastCUV supports rich network attributes,meanwhile,has high efficiency and correctness performance.After experimental verification and result analysis,our method outperforms the state-of-the-art method to a certain extent.展开更多
GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdevel...GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis of the pathology results in inadequate classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to point out updated national and international practice protocols of diagnosis of GTD, through an integrative review. Seven articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized (usually one month for Partial Hydatidiform Mole six months for Complete Hydatidiform Mole and one year for Gestational Trophoblastic Neoplasia). Unfortunately, regarding the diagnosis of MH, the guidelines of some countries show the absence or difficulty of access to the karyotype test and ploid p57 or pelvic ultrasound accompanying the uterine curettage, contrary to what is proposed by the IFGO guideline. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of recurrence, morbidity and mortality, especially in less developed countries.展开更多
Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with d...Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed.展开更多
In this special issue of the Journal of Sport and Health Science,analyses of the most recent national prevalence estimates from the 2016 Physical Activity and Fitness in China—The Youth Study(PAFCTYS)are presented.Th...In this special issue of the Journal of Sport and Health Science,analyses of the most recent national prevalence estimates from the 2016 Physical Activity and Fitness in China—The Youth Study(PAFCTYS)are presented.These include the prevalence of moderate-to-vigorous physical activity(MVPA)。展开更多
Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bon...Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard.展开更多
Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and cont...Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and control. Since the national program of cancer registry was launched by the Ministry of Health of China in 2008, the National Central Cancer Registry (NCCR) has been releasing the cancer incidence and mortality based on the data collected from cancer registries supported by the program. The cancer statistics provide current data from registered areas and aims to accurately reflect the cancer burden and epidemic in China. In 2014, the NCCR collected data for calendar year 2011 from 234 registries. After comprehensive quality' evaluation, data from 177 registries have been selected as sources of the reports reflecting cancer incidence and mortaliD, in the registration areas in 2011. These reports are the updated cancer statistics so far, covering much more registries and a hig population.展开更多
Hepatocellular carcinoma(HCC) is one of the commonest malignant tumours in the East. Although the management of HCC in the West is mainly based on the Barcelona Clinic for Liver Cancer staging, it is considered too co...Hepatocellular carcinoma(HCC) is one of the commonest malignant tumours in the East. Although the management of HCC in the West is mainly based on the Barcelona Clinic for Liver Cancer staging, it is considered too conservative by Asian countries where the number of HCC patients is huge. Scientific and clinical advances were made in aspects of diagnosis, staging, and treatment of HCC. HCC is well known to be associated with cirrhosis and the treatment of HCC must take into account the presence and stage of chronic liver disease. The major treatment modalities of HCC include:(1) surgical resection;(2) liver transplantation;(3) local ablation therapy;(4) transarterial locoregional treatment; and(5) systemic treatment. Among these, resection, liver transplantation and ablation therapy for small HCC are considered as curative treatment. Portal vein embolisation and the associating liver partition with portal vein ligation for staged hepatectomy may reduce dropout in patients with marginally resectable disease but the midterm and long-term results are still to be confirmed. Patient selection for the best treatment modality is the key to success of treatment of HCC. The purpose of current review is to provide a description of the current advances in diagnosis, staging, preoperative liver function assessment and treatment options for patients with HCC in the east.展开更多
The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 c...The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 cases in human was reported to the World Health Organization(WHO)by the Chinese Health Authorities[1].By 3 February 2020,a total of 17391 cases have been confirmed globally with 2838 new cases(China:17238;2831 new cases and 361 deaths;Outside China:153 with 7 new cases and 1 death from 23 countries)[1].展开更多
基金Project supported by the Doctoral Foundation Project of Guizhou University(Grant No.(2019)49)the National Natural Science Foundation of China(Grant No.71961003)the Science and Technology Program of Guizhou Province(Grant No.7223)。
文摘In evolutionary games,most studies on finite populations have focused on a single updating mechanism.However,given the differences in individual cognition,individuals may change their strategies according to different updating mechanisms.For this reason,we consider two different aspiration-driven updating mechanisms in structured populations:satisfied-stay unsatisfied shift(SSUS)and satisfied-cooperate unsatisfied defect(SCUD).To simulate the game player’s learning process,this paper improves the particle swarm optimization algorithm,which will be used to simulate the game player’s strategy selection,i.e.,population particle swarm optimization(PPSO)algorithms.We find that in the prisoner’s dilemma,the conditions that SSUS facilitates the evolution of cooperation do not enable cooperation to emerge.In contrast,SCUD conditions that promote the evolution of cooperation enable cooperation to emerge.In addition,the invasion of SCUD individuals helps promote cooperation among SSUS individuals.Simulated by the PPSO algorithm,the theoretical approximation results are found to be consistent with the trend of change in the simulation results.
文摘To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic update mechanism of SI based on spectrum opportunity incentive is established, in which spectrum users are encouraged to actively assist the database to update SI in real time. Secondly, the information update contribution(IUC) of spectrum opportunity is defined to describe the cost of accessing spectrum opportunity for heterogeneous spectrum users, and the profit of SI update obtained by the database from spectrum allocation. The process that the database determines the IUC of spectrum opportunity and spectrum user selects spectrum opportunity is mapped to a Hotelling model. Thirdly, the process of determining the IUC of spectrum opportunities is further modelled as a Stackelberg game by establishing multiple virtual spectrum resource providers(VSRPs) in the database. It is proved that there is a Nash Equilibrium in the game of determining the IUC of spectrum opportunities by VSRPs. Finally, an algorithm of determining the IUC based on a genetic algorithm is designed to achieve the optimal IUC. The-oretical analysis and simulation results show that the proposed method can quickly find the optimal solution of the IUC, and ensure that the spectrum resource provider can obtain the optimal profit of SI update.
文摘Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with medically unexplained symptoms.Based on the previous work,this review aims to comprehensively synthesise updated evidence related to SSD from recent years in English publications and,more extensively,from data published in Chinese language journals.The scoping review update was based on an earlier scoping review and included Chinese language publication data from China National Knowledge Internet(CNKI),WANFANG and WEIPU between January 2013 and May 2022 and data from PubMed,PsyclNFO,and Cochrane Library between June 2020 and May 2022.Initially,2984 articles were identified,of which 63 full texts were included for analysis.In China,SSD is mainly applied in scientific research,but it also shows good predictive validity and clinical application potential.The mean frequency of SSD was 4.5%in the general population,25.2%in the primary care population and 33.5%in diverse specialised care settings.Biological factors,such as brain region changes and heart rate variability,are associated with the onset of sSD.Psychological impairment related to somatic symptoms is the best predictor of prognosis.While adolescent SSD is significantly associated with family function,SSD overall is associated with an increased dysfunction of cognition and emotion,decreased quality of life,and high comorbidity with anxiety and depressive disorders.Further research is needed on suicide risk and cultural and gender-related issues.Updating the data of Chinese language studies,our research enriches the evidence-based findings related to the topics addressed in the text sections of the SSD chapter of DSM-5.However,research gaps remain about SSD reliability,population-based prevalence,suicide risk,and cultural and gender-related issues.
基金supported by Major Special Project of Sichuan Science and Technology Department(2020YFG0460)Central University Project of China(ZYGX2020ZB020,ZYGX2020ZB019).
文摘To achieve the high availability of health data in erasure-coded cloud storage systems,the data update performance in erasure coding should be continuously optimized.However,the data update performance is often bottlenecked by the constrained cross-rack bandwidth.Various techniques have been proposed in the literature to improve network bandwidth efficiency,including delta transmission,relay,and batch update.These techniques were largely proposed individually previously,and in this work,we seek to use them jointly.To mitigate the cross-rack update traffic,we propose DXR-DU which builds on four valuable techniques:(i)delta transmission,(ii)XOR-based data update,(iii)relay,and(iv)batch update.Meanwhile,we offer two selective update approaches:1)data-deltabased update,and 2)parity-delta-based update.The proposed DXR-DU is evaluated via trace-driven local testbed experiments.Comprehensive experiments show that DXR-DU can significantly improve data update throughput while mitigating the cross-rack update traffic.
基金support from the National Key R&D Program of China(Grant Nos.2021YFB2600605,2021YFB2600600)the Overseas Scholar Program in the Hebei Province(C20190514)+1 种基金from the State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Project(ZZ2020-20)from the Youth Foundation of Hebei Science and Technology Research Project(QN2018108).
文摘Multiple failure modes tend to be identified in the reliability analysis of a redundant truss structure.This identification process involves updating the model for identifying the next potential failure members.Herein we intend to update the finite element model automatically in the identification process of failure modes and further perform the system reliability analysis efficiently.This study presents a framework that is implemented through the joint simulation of MATLAB and APDL and consists of three parts:reliability index of a single member,identification of dominant failure modes,and system-level reliability analysis for system reliability analysis of truss structures.Firstly,RSM(response surface method)combines with a constrained optimization model to calculate the reliability indices ofmembers.Then theβ-unzipping method is adopted to identify the dominant failuremodes,and the system function in MATLAB,as well as the EKILL command in APDL,is used to facilitate the automatic update of the finite element model and realize load-redistribution.Besides,the differential equivalence recursion algorithmis performed to approximate the reliability indices of failuremodes efficiently and accurately.Eventually,the PNET(probabilistic network evaluation technique)is used to calculate the joint failure probability as well as the system reliability index.Two illustrative examples demonstrate the accuracy and efficiency of the proposed system reliability analysis framework through comparison with corresponding references.
基金supported by the National Natural Science Foundation of China(Grant Nos.11705079 and 11705279)the Scientific Research Foundation of Nanjing University of Posts and Telecommunications(Grant Nos.NY221101 and NY222134)the Science and Technology Innovation Training Program(Grant No.STITP 202210293044Z)。
文摘The interactions between players of the prisoner's dilemma game are inferred using observed game data.All participants play the game with their counterparts and gain corresponding rewards during each round of the game.The strategies of each player are updated asynchronously during the game.Two inference methods of the interactions between players are derived with naive mean-field(n MF)approximation and maximum log-likelihood estimation(MLE),respectively.Two methods are tested numerically also for fully connected asymmetric Sherrington-Kirkpatrick models,varying the data length,asymmetric degree,payoff,and system noise(coupling strength).We find that the mean square error of reconstruction for the MLE method is inversely proportional to the data length and typically half(benefit from the extra information of update times)of that by n MF.Both methods are robust to the asymmetric degree but work better for large payoffs.Compared with MLE,n MF is more sensitive to the strength of couplings and prefers weak couplings.
基金jointly sponsored by the Shenzhen Science and Technology Innovation Commission (Grant No. KCXFZ20201221173610028)the key program of the National Natural Science Foundation of China (Grant No. 42130605)
文摘In the traditional incremental analysis update(IAU)process,all analysis increments are treated as constant forcing in a model’s prognostic equations over a certain time window.This approach effectively reduces high-frequency oscillations introduced by data assimilation.However,as different scales of increments have unique evolutionary speeds and life histories in a numerical model,the traditional IAU scheme cannot fully meet the requirements of short-term forecasting for the damping of high-frequency noise and may even cause systematic drifts.Therefore,a multi-scale IAU scheme is proposed in this paper.Analysis increments were divided into different scale parts using a spatial filtering technique.For each scale increment,the optimal relaxation time in the IAU scheme was determined by the skill of the forecasting results.Finally,different scales of analysis increments were added to the model integration during their optimal relaxation time.The multi-scale IAU scheme can effectively reduce the noise and further improve the balance between large-scale and small-scale increments in the model initialization stage.To evaluate its performance,several numerical experiments were conducted to simulate the path and intensity of Typhoon Mangkhut(2018)and showed that:(1)the multi-scale IAU scheme had an obvious effect on noise control at the initial stage of data assimilation;(2)the optimal relaxation time for large-scale and small-scale increments was estimated as 6 h and 3 h,respectively;(3)the forecast performance of the multi-scale IAU scheme in the prediction of Typhoon Mangkhut(2018)was better than that of the traditional IAU scheme.The results demonstrate the superiority of the multi-scale IAU scheme.
基金supported by the Fundamental Research Funds for the Central Universities(2021RC239)the Postdoctoral Science Foundation of China(2021 M690338)+3 种基金theHainan Provincial Natural Science Foundation of China(620RC562,2019RC096,620RC560)the Scientific Research Setup Fund of Hainan University(KYQD(ZR)1877)the Program of Hainan Association for Science and Technology Plans to Youth R&D Innovation(QCXM201910)the National Natural Science Foundation of China(61802092,62162021).
文摘With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes are also very frequent.However,no matter what changes,the network must ensure the correct conditions,such as isolating tenants from each other or guaranteeing essential services.Once changes occur,it is necessary to verify the after-changed network.Whereas,for the verification of large-scale network configuration changes,many current verifiers show poor efficiency.In order to solve the problem ofmultiple global verifications caused by frequent updates of local configurations in large networks,we present a fast configuration updates verification tool,FastCUV,for distributed control planes.FastCUV aims to enhance the efficiency of distributed control plane verification for medium and large networks while ensuring correctness.This paper presents a method to determine the network range affected by the configuration change.We present a flow model and graph structure to facilitate the design of verification algorithms and speed up verification.Our scheme verifies the network area affected by obtaining the change of the Forwarding Information Base(FIB)before and after.FastCUV supports rich network attributes,meanwhile,has high efficiency and correctness performance.After experimental verification and result analysis,our method outperforms the state-of-the-art method to a certain extent.
文摘GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis of the pathology results in inadequate classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to point out updated national and international practice protocols of diagnosis of GTD, through an integrative review. Seven articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized (usually one month for Partial Hydatidiform Mole six months for Complete Hydatidiform Mole and one year for Gestational Trophoblastic Neoplasia). Unfortunately, regarding the diagnosis of MH, the guidelines of some countries show the absence or difficulty of access to the karyotype test and ploid p57 or pelvic ultrasound accompanying the uterine curettage, contrary to what is proposed by the IFGO guideline. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of recurrence, morbidity and mortality, especially in less developed countries.
文摘Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed.
文摘In this special issue of the Journal of Sport and Health Science,analyses of the most recent national prevalence estimates from the 2016 Physical Activity and Fitness in China—The Youth Study(PAFCTYS)are presented.These include the prevalence of moderate-to-vigorous physical activity(MVPA)。
文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard.
文摘Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and control. Since the national program of cancer registry was launched by the Ministry of Health of China in 2008, the National Central Cancer Registry (NCCR) has been releasing the cancer incidence and mortality based on the data collected from cancer registries supported by the program. The cancer statistics provide current data from registered areas and aims to accurately reflect the cancer burden and epidemic in China. In 2014, the NCCR collected data for calendar year 2011 from 234 registries. After comprehensive quality' evaluation, data from 177 registries have been selected as sources of the reports reflecting cancer incidence and mortaliD, in the registration areas in 2011. These reports are the updated cancer statistics so far, covering much more registries and a hig population.
文摘Hepatocellular carcinoma(HCC) is one of the commonest malignant tumours in the East. Although the management of HCC in the West is mainly based on the Barcelona Clinic for Liver Cancer staging, it is considered too conservative by Asian countries where the number of HCC patients is huge. Scientific and clinical advances were made in aspects of diagnosis, staging, and treatment of HCC. HCC is well known to be associated with cirrhosis and the treatment of HCC must take into account the presence and stage of chronic liver disease. The major treatment modalities of HCC include:(1) surgical resection;(2) liver transplantation;(3) local ablation therapy;(4) transarterial locoregional treatment; and(5) systemic treatment. Among these, resection, liver transplantation and ablation therapy for small HCC are considered as curative treatment. Portal vein embolisation and the associating liver partition with portal vein ligation for staged hepatectomy may reduce dropout in patients with marginally resectable disease but the midterm and long-term results are still to be confirmed. Patient selection for the best treatment modality is the key to success of treatment of HCC. The purpose of current review is to provide a description of the current advances in diagnosis, staging, preoperative liver function assessment and treatment options for patients with HCC in the east.
文摘The year 2020 was welcomed and characterized with a report of pneumonia of unknown etiology,which occurred primarily in Wuhan City of Hubei Province of China.Between 31 December 2019 and 3 January 2020,a total of 44 cases in human was reported to the World Health Organization(WHO)by the Chinese Health Authorities[1].By 3 February 2020,a total of 17391 cases have been confirmed globally with 2838 new cases(China:17238;2831 new cases and 361 deaths;Outside China:153 with 7 new cases and 1 death from 23 countries)[1].