The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patient...The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex.展开更多
A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain mo...A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain morphology in patients with low back pain or neck and upper back pain, we investi- gated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry. A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain. In these patients, there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens, right pallidum, right caudate nucleus, and left amygdala. In upper back pain patients, reduced cortical gray matter volume was found in the left precentral and left postcen- tral cortices. Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients. Subcortical gray matter volume in- creases are found only in patients with low back pain.展开更多
目的 探讨基于视听觉和运动反馈的脑机接口(BCI)结合经颅直流电刺激(tDCS)对脑卒中患者上肢功能的疗效。方法 2023年3月至10月,徐州医科大学附属徐州康复医院和徐州市中心医院住院的脑卒中患者45例,随机分为BCI组、tDCS组和联合组,每组1...目的 探讨基于视听觉和运动反馈的脑机接口(BCI)结合经颅直流电刺激(tDCS)对脑卒中患者上肢功能的疗效。方法 2023年3月至10月,徐州医科大学附属徐州康复医院和徐州市中心医院住院的脑卒中患者45例,随机分为BCI组、tDCS组和联合组,每组15例。3组均接受常规康复治疗,BCI组增加BCI,tDCS组增加tDCS治疗,联合组先行tDCS治疗,然后立即进行BCI,共4周。治疗前后采用Fugl-Meyer评定量表上肢部分(FMA-UE)、上肢动作研究量表(ARAT)和改良Barthel指数(MBI)进行评定,测量脑电图δ-α比(DAR)和功率比指数(PRI)。结果 治疗后,3组FMA-UE、ARAT和MBI评分均较治疗前显著提高(|t|> 5.350, P <0.001),联合组最优(F>3.366, P <0.05),DAR和PRI均较治疗前显著减小(|t|> 2.208, P <0.05),联合组最优(F> 5.224, P <0.01)。结论 基于视听觉和运动反馈的BCI结合tDCS可进一步改善脑卒中患者上肢运动功能,提高日常生活活动能力。展开更多
基金supported by the National Natural Science Foundationof China,No.30973165
文摘The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex.
基金supported partially by two grants from the National Natural Science Foundation of China,No.30870686 and 81371530
文摘A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain morphology in patients with low back pain or neck and upper back pain, we investi- gated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry. A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain. In these patients, there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens, right pallidum, right caudate nucleus, and left amygdala. In upper back pain patients, reduced cortical gray matter volume was found in the left precentral and left postcen- tral cortices. Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients. Subcortical gray matter volume in- creases are found only in patients with low back pain.
文摘目的 探讨基于视听觉和运动反馈的脑机接口(BCI)结合经颅直流电刺激(tDCS)对脑卒中患者上肢功能的疗效。方法 2023年3月至10月,徐州医科大学附属徐州康复医院和徐州市中心医院住院的脑卒中患者45例,随机分为BCI组、tDCS组和联合组,每组15例。3组均接受常规康复治疗,BCI组增加BCI,tDCS组增加tDCS治疗,联合组先行tDCS治疗,然后立即进行BCI,共4周。治疗前后采用Fugl-Meyer评定量表上肢部分(FMA-UE)、上肢动作研究量表(ARAT)和改良Barthel指数(MBI)进行评定,测量脑电图δ-α比(DAR)和功率比指数(PRI)。结果 治疗后,3组FMA-UE、ARAT和MBI评分均较治疗前显著提高(|t|> 5.350, P <0.001),联合组最优(F>3.366, P <0.05),DAR和PRI均较治疗前显著减小(|t|> 2.208, P <0.05),联合组最优(F> 5.224, P <0.01)。结论 基于视听觉和运动反馈的BCI结合tDCS可进一步改善脑卒中患者上肢运动功能,提高日常生活活动能力。
