Clinical application of flexible ureteroscopic sheath with controllable intraluminal pressure in treating ureteral stones

Objective:The purpose of the study was to assess the clinical efficacy and safety of a combined perfusion suction platform with pressure feedback control function and an ureteroscopic suction sheath that can measure the ureteropelvic pressure in implementing lithotripsies.Methods:Fifty-two patients who underwent lithotripsy under intelligent monitoring of ureteral intraluminal pressure from June 2016 to January 2018 were retrospectively recruited.The inclusion standard was stone diameter>1.5 cm but<2.5 cm.After the 12/14 Fr suction sheath was placed,manometer interface and suction interface of the sheath were connected to the platform via the pressure sensor and suction tube,respectively.The ureteroscope was connected to the platform perfusion pump,and the crushed stones were aspirated out under negative pressure.Results:According to the location of the stone,21(40.4%)cases were classified as upper ureteral stones,19(36.5%)were midureteral stones,and 12(23.1%)were lower ureteral stones.Forty-seven patients underwent successful primary sheath placement and lithotripsy with a mean operative time of 34.5(standard deviation 18.3)min.Retrograde stone migration did not occur.There were eight patients with hematuria postoperatively.Serious complication was 1.9% with one case of ureteral perforation.Stone clearance was 95.7% at Day 1e2 postoperatively,and 100% at Day 30 postoperatively.Conclusion:Ureteroscopic lithotripsy with intelligent pressure control using our device improved the efficiency of the lithotripsy and rate of stone clearance.The safety of the operation can be ensured.It is worth popularization and application in clinical practice.

Extracorporeal shock-wave versus pneumatic ureteroscopic lithotripsy in treatment of lower ureteral calculi

Aim: To compare the efficacy and complications of extracorporeal shock-wave lithotripsy (SWL) and pneumatic ureteroscopic lithotripsy (URS) in the treatment of lower ureteral calculi. Methods: From August 1997 to June 1999, 210 patients with calculi in the distal third of the ureter were treated with SWL and the other 180 with URS. The stones were fragmented with either HB-ESWL-V lithotripter or JML-93 pneumatic lithotripter through Wolf 7.5～9.0 Fr ureteroscope. The outcome was assessed in terms of stone clearance rate, re-treatment rate and complication incidence. Results: The stone clearance rate was 78.1% with SWL and 93.3 % with URS (P<0.05). SWL had a re-treatment rate of 11.9 %, vs 2.2 % in the URS group (P<.05). URS caused ureteral perforation in 3.3% of patients, while it was 0 with SWL (P<0.05). The differences in the incidence of other complications such as infection and stricture between the two groups were insignificant. Conclusion: Though the selection of these two options depends on equipments available and the expertise of the operator, we recommend URS as the optimal treatment for distal ureteral calculi. (Asian J Andro12002 Dec, 4: 303-305)

Role of Removing Stasis and Reducing Heat Formula in Clearance of Proximal Ureteral Calculi after Ureteroscopic Ho:YAG Laser Lithotripsy: A Prospective Randomized Study

Objective To prospectively evaluate the efficacy of Removing Stasis and Reducing Heat Formula in accelerating calculus clearance and improving lower urinary tract symptoms of patients with proximal ureteral calculi after ureteroscopic Ho:YAG laser lithotripsy. Methods A total of 138 patients with proximal ureteral calculi underwent ureteroscopic Ho:YAG laser lithotripsy by a single endocrinologist. Stone size varied from 10 to 15 mm. After operation, the patients were randomly divided into three groups: the control group(group A), tamsulosin group(group B), and Removing Stasis and Reducing Heat Formula group(group C). The treatment lasted for 4 weeks or until stone clearance. The primary and secondary outcomes of the three groups at follow-up were assessed. Results Of the 131 patients available for follow-up, 44 cases were in the group A, 45 in the group B, and 42 in the group C, respectively. The stone free rate at 2 weeks in the groups B and C were significantly higher than that in the group A(95.56%, 97.62% vs. 79.55%; all P<0.05). The ureteral colic rate and mean time of fragment expulsion were significantly reduced in the groups B(4.44% and 7.86±4.99 days) and C(2.43% and 6.76±4.37 days) compared with the group A(22.73% and 11.54±9.89 days, all P<0.05). On the day of double-J ureteric stent removal, the group C differed significantly from the group A in the total International Prostate Symptom Score, irritative subscore, obstructive subscore, and quality of life score(all P<0.05). Conclusion Removing Stasis and Reducing Heat Formula in the medical expulsive therapy might be an effective modality for patients with calculus in the proximal uretera after ureteroscopic Ho:YAG laser lithotripsy.

Ureteroscopic Holmium:YAG Laser Lithotripsy for Managing Ureteral Calculi (A Report of 168 Cases)

Summary: The effectiveness and safety of ureteroscopic holmium:YAG laser lithotripsy for managing ureteral calculi was evaluated. Ureteroscopic holmium:YAG laser lithotripsy was performed in 168 ureteral calculi (upper 27 cases, middle 33 cases and lower 108 cases). The results showed that the stone-free rate was 92.6 % in the upper ureteral calculi, 93.9 % in the middle ureteral calculi and 94.4 % in the lower ureteral calculi, respectively. The complication rate was 4.8 % (8 cases). It was suggested that ureteroscopic holmium:YAG laser lithotripsy is a highly effective and safe treatment modality for managing ureteral calculi.

Comparison of the trauma between combined retrograde intrarenal surgery and mini-percutaneous nephrolithotomy for upper ureteral calculi

Objective: To compare the trauma between combined retrograde intrarenal surgery and mini-percutaneous nephrolithotomy for upper ureteral calculi. Methods: Patients with upper ureteral calculi who received lithotripsy in Pengzhou Hospital of Traditional Chinese Medicine between February 2015 and March 2017 were selected and randomly divided into two groups;RIRS group received combined retrograde intrarenal surgery and the Mini-PCNL group received mini-percutaneous nephrolithotomy. 3 d after surgery;the contents of liver and kidney function indexes and stress hormones in serum as well as the expression of CD4+T cell transcription factors in peripheral blood were measured. Results: Serum ALT;AST;γ-GT;BUN and Cr contents of RIRS group 3 d after surgery were not significantly different from those of Mini-PCNL group;and HO-1;ET-1;ACTH;Cor and YKL-40 contents in serum as well as RORγt and T-bet mRNA expression in peripheral blood were significantly lower than those of Mini-PCNL group while Gata-3 and Foxp3 mRNA expression in peripheral blood were higher than those of Mini-PCNL group. Conclusion: Combined retrograde intrarenal surgery for upper ureteral calculi activates less stress response and inflammatory response than mini-percutaneous nephrolithotomy.

The role of ureteroscopy for treatment of staghorn calculi: A systematic review

Objective:To define the role of ureteroscopy for treatment of staghorn calculi.Methods:A systematic review was conducted using the Scopus and Medline databases.Original articles and systematic reviews were selected according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.Only studies relating to the role of ureteroscopy for treatment of staghorn calculi were included.Results:In five studies on ureteroscopic monotherapy,stone-free rate(SFR)ranged from 33%to 93%,with a maximum four ureteroscopy sessions per patient and no major complications.Endoscopic combined intrarenal surgery(ECIRS)was compared with percutaneous nephrolithotomy(PNL)in two studies and reached significantly higher SFR(88%e91%vs.59%e65%)and lower operative times(84e110 min vs.105e129 min).The role of salvage ureteroscopy for residual stones after primary PNL has been highlighted by two studies with a final SFR of 83%e89%.One study reported on the feasibility of ureteroscopy for ureteral stones and same-session PNL for contralateral staghorn calculi,with a SFR of 92%.Conclusion:Ureteroscopy plays a pivotal role in the setting of a combined approach to staghorn calculi.Ureteroscopy is also particularly suitable for clearance of residual stones.In specific cases,ureteroscopy may become the sole applicable therapeutic option to staghorn calculi.Technological advances and refinement of techniques suggest a major role of ureteroscopy for staghorn calculi treatment in close future.

Rigid ureteroscopy in prone split-leg position for fragmentation of female ureteral stones:A case report

BACKGROUND Ureteroscopy is widely used in the treatment of ureteral stones due to the increased morbidity of turolithiasis.This is the first report of a case of ureteral calculi treated with rigid ureteroscopy in the modified prone split-leg position.CASE SUMMARY A 62-year-old Asian woman was diagnosed with a ureteral stone and underwent extracorporeal shock wave lithotripsy twice.However,the abdominal computer tomography scan showed persistent calculi on the right lower ureter.Her left hip movement was limited because of a left femoral neck fracture that did not receive proper treatment in a timely manner.She was unable to undergo surgery in the lithotomy position and refused to accept flexible ureteroscopy treatment.Therefore,rigid ureteroscopy was performed with her in the modified prone split-leg position.The ureteral calculi were successfully fragmented.CONCLUSION It is feasible to treat lower ureteral calculi in women in the prone split-leg position with the implementation of rigid ureteroscopy.

Ureteroscopy and stones:Current status and future expectations

Urolithaisis is becoming an ever increasing urological,nephrological and primary care problem.With a lifetime prevalence approaching 10% and increasing morbidity due to stone disease,the role of ureteroscopy and stone removal is becoming more important.We discuss the current status of stone disease and review the ever increasing role that ureteroscopy has to play in its management.We discuss technological advances that have been made in stone management and give you an overview of when,how and why ureteroscopy is the most common treatment option for stone management.We touch on the role of robotic ureteroscopy and the future of ureteroscopy in the next 10 years.

输尿管软镜下钬激光碎石治疗输尿管上段结石并发输尿管狭窄的危险因素分析

目的探讨输尿管软镜下钬激光碎石治疗输尿管上段结石并发输尿管狭窄的危险因素。方法选取输尿管上段结石患者988例,根据手术设备不同分为软镜组和硬镜组,比较两组皮质醇(Cor)、C反应蛋白(CRP)水平。软镜组根据术后有无并发输尿管狭窄分为狭窄组和非狭窄组,采用多因素Logistic回归分析输尿管狭窄的危险因素。结果两组术后Cor、CRP水平均高于术前,且软镜组低于同时间硬镜组(P<0.05)。软镜组输尿管狭窄发生率为5.60%。病程、结石直径、结石嵌顿和输尿管损伤是并发输尿管狭窄的独立危险因素(P<0.05)。结论输尿管软镜对该类患者机体应激反应影响更小,且病程、结石直径、结石嵌顿及输尿管损伤是并发输尿管狭窄的独立危险因素。

输尿管硬镜联合软镜碎石取石术治疗老年输尿管结石的临床效果及术后发生全身炎症反应综合征的危险因素

目的探讨输尿管硬镜联合输尿管软镜碎石取石术(FURL)治疗老年输尿管结石(UC)的临床效果及术后全身炎症反应综合征(SIRS)发生的危险因素。方法选取2018年1月至2022年12月在郑州市第三人民医院接受治疗的老年UC患者共计200例,以随机数字表法分为研究组(n=100)与对照组(n=100),对照组采用半硬性输尿管镜治疗,研究组采用输尿管硬镜联合FURL治疗,对两组一期清石率、围手术期指标及排尿功能进行比较,并统计术后SIRS发生情况,进行单因素分析与多因素Logistic回归分析以明确术后SIRS发生的危险因素。结果研究组一期清石率较对照组更高,术中出血量更少,血尿持续时间更短,但手术时间、住院时间更长,差异均有统计学意义(P<0.05);与术后1个月相比,两组术后3个月最大尿流量(Qmax)增加,国际前列腺症状评分量表(IPSS)评分下降,差异均有统计学意义(P<0.05),且研究组术后1个月、3个月的Qmax较对照组更高,IPSS评分更低,差异均有统计学意义(P<0.05);100例患者中,10例发生SIRS,发生率为10.00%;发生组术前白细胞计数(WBC)≥10×10~9/L、术前因结石发热、术中尿液浑浊与脓苔的患者比例较未发生组更高,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,术前因结石发热(OR=4.213)、术前WBC≥10×10~9/L(OR=2.122)、术中尿液浑浊与脓苔(OR=3.616)是输尿管硬镜联合FURL术后SIRS发生的独立危险因素,差异有统计学意义(P<0.05)。结论输尿管硬镜联合FURL应用于老年UC患者中,能够促进一期清石率提高及术中出血量减少,缩短血尿持续时间,提高排尿功能,但会延长手术时间、住院时间;术前WBC≥10×10~9/L、术前因结石发热、术中尿液浑浊与脓苔均为术后SIRS发生的危险因素。

球囊扩张技术在儿童输尿管镜钬激光碎石术进镜困难时的应用

目的探讨儿童输尿管镜钬激光碎石术进镜困难时应用球囊扩张技术的有效性及安全性。方法回顾性分析2020年3月~2023年10月23例(25侧)输尿管镜钬激光碎石术中应用球囊扩张技术的资料。进镜困难时,经输尿管镜工作通道置入输尿管扩张球囊导管对管腔狭小部位进行扩张,进镜置入钬激光光纤,粉末化结石。结果本组23例(25侧)输尿管结石,行输尿管扩张球囊导管扩张输尿管共26处,扩张部位为输尿管膀胱壁内段23处,输尿管下段3处,扩张后输尿管Ⅰ级损伤23处,Ⅱ级损伤3处。球囊扩张后继续碎石成功23侧,失败2侧。均未出现与输尿管球囊扩张相关并发症。拔除双J管时间26~45 d,(33.5±5.2)d,在此期间尿路感染5例。拔除双J管后2周内复查泌尿系超声,结石均排出,均无肾积水。随访6~24个月,平均13.7月,均无输尿管狭窄表现。结论输尿管镜进镜困难时经工作通道使用输尿管扩张球囊导管进行扩张安全、有效。

输尿管软镜与硬镜下钬激光碎石术治疗复杂性输尿管上段结石患者的效果比较

目的:比较输尿管软镜与硬镜下钬激光碎石术治疗复杂性输尿管上段结石患者的效果。方法:回顾性分析2021年7月至2023年2月该院收治的188例复杂性输尿管上段结石患者的临床资料,根据手术方法不同将其分为软镜组(n=94)和硬镜组(n=94)。软镜组给予输尿管软镜下钬激光碎石术治疗,硬镜组予以输尿管硬镜下钬激光碎石术治疗。比较两组围术期指标水平,手术前后氧化应激指标[皮质醇(Cor)、肾上腺素(E)、去甲肾上腺素(NE)]水平,以及并发症发生率。结果:软镜组手术时间、住院时间均短于硬镜组,术中出血量少于硬镜组,碎石成功率高于硬镜组,结石上移率低于硬镜组,差异均有统计学意义(P<0.05);术后3 d,两组E、NE、Cor水平均高于术前,但软镜组低于硬镜组,差异有统计学意义(P<0.05);软镜组并发症发生率为4.26%(4/94),低于硬镜组的12.77%(12/94),差异有统计学意义(P<0.05)。结论:输尿管软镜下钬激光碎石术治疗复杂性输尿管上段结石患者可提高碎石成功率,改善围术期指标水平,减轻机体氧化应激反应,降低结石上移率和并发症发生率,效果优于输尿管硬镜下钬激光碎石术治疗。

经皮肾镜联合输尿管软镜取石术治疗输尿管结石合并同侧肾结石的效果研究

目的分析经皮肾镜联合输尿管软镜取石术(RIRS)治疗输尿管结石合并同侧肾结石的应用优势。方法选取2020年1月—2023年1月150例输尿管结石合并同侧肾结石患者,随机分为2组各75例,肾镜组行经皮肾镜取石术(PCNL),双镜组采用PCNL联合RIRS。比较2组围术期指标、术后并发症发生率、术后视觉模拟评分法(VAS)评分及尿液代谢异常发生率,术前及术后神经源炎症反应指标[神经生长因子(NGF)、前列腺素E_(2)(PGE_(2))、C反应蛋白(CRP)、P物质(SP)]、肾功能指标[血清肌酐(Cr)、尿素(UREA)、肾损伤分子-1(KIM-1)、中性粒细胞明胶酶相关载脂蛋白(NGAL)]。结果双镜组手术时间、住院天数短于肾镜组,术中出血量低于肾镜组,术后3 d、术后1个月结石清除率高于肾镜组(P<0.01)。双镜组术后并发症发生率为2.67%(2/75)低于肾镜组的12.00%(9/75)(P<0.05)。双镜组术后6、12、24、48 h VAS评分低于肾镜组(P<0.05)。双镜组术后24、48 h NGF、PGE_(2)、CRP及SP均低于肾镜组(P<0.05)。术后1周、2周双镜组Cr、UREA、KIM-1及NGAL低于肾镜组(P<0.05)。双镜组术后2周高尿酸尿症、高草酸尿症、低枸橼酸尿症、高钙尿症及低镁尿症发生率均较肾镜组低(P<0.05)。结论PCNL联合RIRS治疗输尿管结石合并同侧肾结石患者可优化手术操作,抑制神经源炎症反应,减轻术后疼痛与肾功能损伤,且能提高结石清除率,降低并发症风险,改善尿液代谢状态。

分析钬激光手术对输尿管结石并发息肉患者的治疗效果及复发情况

目的分析钬激光手术对输尿管结石并发息肉患者的治疗效果及复发情况。方法收集2020年2月至2023年2月期间在我院就诊的输尿管结石并发息肉患者100例中随机选取,分为对照组(n=50)和实验组(n=50)。对照组采用传统的开放式手术进行治疗。实验组采用钬激光手术进行治疗。对比两组患者手术时间、失血量以及住院天数。对比两组患者在治疗前后的血肌酐(Scr)以及血尿素氮(BUN)水平的变化。对比两组患者的手术成功率,并发症发生率和术后6个月的复发率。使用Logistics回归分析来探究影响患者术后复发的危险因素。结果实验组患者手术时间、失血量以及住院天数显著低于对照组患者(P<0.001)实验组患者术后Scr和BUN与对照组相比明显降低(P<0.05)。实验组患者术后成功率与对照组相比不存在统计学差异(P>0.05)。但是实验组患者术后并发症发生率与术后6个月复发率显著低于对照组患者(P>0.05)。Logistic回归分析结果显示饮食习惯和手术方案是影响患者输尿管结石复发的危险因素。结论钬激光手术是治疗输尿管结石和输尿管息肉的有效方法,它不仅能提高患者的生活质量,减少患者的痛苦,还能降低术后并发症的发生和疾病的复发率。

输尿管软镜与输尿管硬镜下钬激光碎石术治疗老年输尿管上段结石的效果分析

探究输尿管软镜与输尿管硬镜下钬激光碎石术治疗老年输尿管上段结石的效果.以贵州省疾病预防控制中心于2021年1月-2021年11月收治的82例存在输尿管上段结石的老年患者为研究对象,采用随机抽签法将其分为对照组、试验组两组,每组各41例.对照组使用输尿管硬镜,试验组使用输尿管软镜,对比两组患者围术期指标、治疗效果、并发症发生情况.结果显示,试验组各围术期指标均优于对照组(P<0.05);试验组结石一次性清除率高于对照组(P<0.05);试验组二次清石率和疾病复发率低于对照组(P<0.05);试验组并发症总发生率为7.32%(3/41),对照组并发症总发生率为24.39%(10/41),试验组并发症总发生率低于对照组(P<0.05).研究发现,钬激光碎石术治疗存在输尿管上段结石的老年患者,采取输尿管软镜干预更具优势,安全系数更高,具有推广价值.

输尿管软镜与输尿管硬镜联合拦截网篮钬激光碎石术治疗输尿管上段结石的随机对照临床研究

目的:分析输尿管软镜钬激光碎石术与输尿管硬镜联合拦截网篮钬激光碎石术治疗输尿管上段结石的临床效果。方法:选取2021年10月至2023年4月上海中医药大学附属上海市中西医结合医院收治的直径>10 mm的输尿管上段结石92例,随机分入软镜组46例和硬镜组46例,软镜组接受输尿管软镜钬激光碎石术,硬镜组接受输尿管硬镜联合拦截网篮钬激光碎石术。将两组患者根据肾下极水平线分为上部、下部亚组,比较整体及亚组间的手术成功率、手术时间、严重并发症和1个月结石清除率、3个月结石清除率。结果:两组手术成功率比较:整体上软镜组(95.7%)明显高于硬镜组(80.4%);分亚组比较,软镜上部组(96.0%)明显高于硬镜上部组(70.8%),软镜下部组(95.2%)与硬镜下部组(90.9%)比较无统计学差异(P>0.05)。两组手术成功患者手术时间比较:整体及分亚组比较,软镜组均明显长于硬镜组(P均<0.05)。两组严重并发症比较:整体及分亚组比较,软镜组与硬镜组差异均无统计学意义(P>0.05)。两组1个月结石清除率比较:整体上软镜组(84.1%)与硬镜组(67.6%)差异无统计学意义(P>0.05);分亚组比较,软镜上部组(83.3%)明显高于硬镜上部组(52.9%),软镜下部组(85.0%)与硬镜下部组(80.0%)无统计学差异(P>0.05)。两组3个月结石清除率比较:整体及分亚组比较,软镜组与硬镜组均无统计学差异(P>0.05)。结论:输尿管软镜与输尿管硬镜钬激光碎石术均为相对安全的手术方式。对于肾下极水平以上的输尿管上段结石,软镜钬激光碎石术的手术成功率和1个月结石清除率高于输尿管硬镜联合拦截网篮碎石术,是该部位更优的手术方式。对于肾下极以下的输尿管上段结石,软镜碎石和硬镜联合拦截网篮碎石的手术效果无明显差异,但硬镜手术时间更短。

单侧输尿管上段结石输尿管硬镜钬激光碎石失败危险因素研究

目的探讨单侧输尿管上段结石输尿管硬镜钬激光碎石失败危险因素。方法选取2012年1月至2021年9月于内蒙古自治区人民医院行输尿管硬镜钬激光碎石术治疗单侧输尿管上段结石患者852例,其中术后1周评估碎石失败72例(碎石失败组),其余患者均碎石成功(碎石成功组)。分析患者临床资料,采用多因素Logistic回归模型分析影响因素。结果碎石失败组左侧结石比例、多发结石比例、入镜困难比例、结石停留时间≥6周比例均高于碎石成功组,结石CT值和结石停留时间≥2周比例均低于碎石成功组,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析结果显示入镜困难是本组患者中输尿管硬镜钬激光碎石失败的独立危险因素(比值比=2.64,95%置信区间:1.75~3.64,P=0.02)。结论输尿管硬镜钬激光碎石术治疗单侧输尿管上段结石成功率较高,入镜困难是导致碎石失败的独立危险因素。

输尿管软镜联合柔性可弯曲输尿管导引鞘在肾结石患者中的应用

目的探讨输尿管软镜联合柔性可弯曲输尿管导引鞘在肾结石患者中的应用价值。方法选择2022年1月至12月赣南医学院第三附属医院收治的40例肾结石患者作研究对象,按照随机数字表法分为对照组和观察组,每组各20例。两组均行输尿管软镜碎石术,对照组采用非可弯曲输尿管导引鞘,观察组采用柔性可弯曲输尿管导引鞘。比较两组的结石清除率、手术指标、疼痛程度、负性情绪、生活质量、并发症发生率。结果观察组术后1d及术后1个月的结石清除率均高于对照组,差异有统计学意义(P<0.05)。观察组的手术时间短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。术前,两组患者的疼痛程度、负性情绪、生活质量评分比较,差异无统计学意义(P>0.05);观察组术后3d的疼痛视觉模拟评分法(VAS)评分低于对照组,术后1个月的抑郁自评量表(SDS)、焦虑自评量表(SAS)评分低于对照组,术后1个月的世界卫生组织生活质量测定量表简表(WHOQOL-BREF)中社会关系、生理健康、心理健康、周围环境维度评分均高于对照组,差异有统计学意义(P<0.05)。观察组的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论输尿管软镜联合柔性可弯曲输尿管导引鞘较非可弯曲输尿管导引鞘在缩短手术时间、减少术中出血量等方面优势明显,利于提高结石清除率,降低并发症发生风险,减轻患者疼痛、负性情绪,改善生活质量。

二期电子输尿管软镜激光碎石术治疗输尿管上段结石及肾结石的效果

目的:分析二期电子输尿管软镜激光碎石术治疗输尿管上段结石及肾结石的效果。方法:选取2021年1月—2023年6月庆阳市人民医院需采取二期手术治疗的200例输尿管上段结石及肾结石患者为研究对象。依据数字排列法将患者分为观察组和对照组,各100例。对照组采用经皮肾镜碎石激光碎石术,观察组采用电子输尿管软镜激光碎石术。比较两组结石治疗效果、手术相关指标、肾功能指标、炎症指标、术后并发症。结果:两组术后3 d、7 d结石清除率、再次手术率比较,差异无统计学意义(P>0.05)。观察组术中失血量、术后24 h视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,手术时间长于对照组,差异有统计学意义(P<0.05)。观察组术后24 h血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)、β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)低于对照组,差异有统计学意义(P<0.05)。观察组术后24 h白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:二期经皮肾镜激光碎石术与电子输尿管软镜激光碎石术治疗输尿管上段结石及肾结石效果均较好,后者具有更好的手术安全性,术中失血量少,术后VAS评分低,且对肾功能、炎症指标影响小,有助于减少手术损伤。

输尿管硬镜联合输尿管软镜钬激光碎石术治疗复杂性输尿管上段结石的效果分析

目的:分析输尿管硬镜联合输尿管软镜钬激光碎石术治疗复杂性输尿管上段结石的效果。方法:选取2020年3月—2022年12月同济赤壁医院收治的70例复杂性输尿管上段结石患者作研究对象,采用随机数字表法分为对照组与观察组,各35例。对照组实施输尿管硬镜钬激光碎石术,观察组在对照组基础上联合输尿管软镜钬激光碎石术。比较两组围术期指标、炎性指标、并发症发生情况。结果:观察组手术时间长于对照组,碎石时间短于对照组,术中出血量少于对照组,下床活动时间早于对照组,差异有统计学意义(P<0.001)。术前,两组白细胞计数(WBC)、中性粒细胞计数(NE)、血清降钙素原(PCT)水平比较,差异无统计学意义(P>0.05);术后7 d,两组WBC、NE、PCT水平高于术前,但观察组低于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P=0.022)。结论:输尿管硬镜联合输尿管软镜钬激光碎石术治疗复杂性输尿管上段结石的效果显著,可缩短碎石时间,减少术中出血量,减轻炎性反应,促进患者术后恢复,减少术后并发症。