Objective: To investigate the effect of flexible ureteroscope lithotripsy and percutaneous nephrolithotomy on levels of serum inflammatory factors, oxidative stress and stress hormone in patients with renal calculi. M...Objective: To investigate the effect of flexible ureteroscope lithotripsy and percutaneous nephrolithotomy on levels of serum inflammatory factors, oxidative stress and stress hormone in patients with renal calculi. Methods: A total of 97 cases of renal calculi patients were chosen as the research objects, based on the random data table, they were divided into the control group (n=49) and the observation group (n=48), patients in the control group underwent percutaneous nephrolithotomy (PCNL) treatment, while the observation group patients were treated with flexible ureteroscope lithotripsy (FURL), before and after 1 d ,the levels of inflammatory factors [interleukin-10 (IL-10), C reactive protein (CRP), white blood cell (WBC)], stress hormone [cortisol (COR), adrenocorticotropic hormone (ACTH), norepinephrine (NE)] and oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD) ] of the two groups were compared. Results: There were no significant differences in IL-10, CRP, WBC, COR, ACTH, NE, MDA and SOD levels between the two groups preoperative;Compared with the preoperative level in the group, the 1 d post-operation levels of IL-10, CRP, WBC, COR, ACTH, NE and MDA in the two groups were significantly increased, and the level of the observation group was significantly lower than that in the control group;The levels of SOD in the two groups 1 d post-operation were significantly lower than those in the same group preoperative, and the control group (85.65±9.95) U/mL was significantly lower than that of the control group (94.71±7.63) U/mL. Conclusion: Compared with percutaneous nephrolithotomy, flexible ureteroscopic lithotripsy for renal calculi is less stressful and more favorable for postoperative recovery, has an important clinical value.展开更多
目的研究输尿管镜碎石术(URL)与经皮肾镜碎石术(PCNL)治疗输尿管上段复杂性结石的手术疗效及对C反应蛋白(CRP)、血红蛋白(Hb)水平的影响。方法选取我院2013年4月—2016年4月220例输尿管上段复杂性结石患者为研究对象,将纳入患者按随机...目的研究输尿管镜碎石术(URL)与经皮肾镜碎石术(PCNL)治疗输尿管上段复杂性结石的手术疗效及对C反应蛋白(CRP)、血红蛋白(Hb)水平的影响。方法选取我院2013年4月—2016年4月220例输尿管上段复杂性结石患者为研究对象,将纳入患者按随机数表法分为URL组与PCNL组,每组110例。URL组采用URL治疗,PCNL采用PCNL治疗,比较两组应激指标、血红蛋白、术中指标、结石清除率、术后恢复指标、术后并发症。结果URL组术后3 d CRP、Hb、术中出血量、住院时间分别为(20.20±6.54)mg/L、(119.43±19.21)g/L、(32.33±7.84)ml、(5.81±1.59)d与PCNL组的(23.15±6.29)mg/L、(104.39±21.81)g/L、(48.49±9.21)ml、(7.47±1.82)d比较差异有统计学意义(P<0.05)。PCNL组1次清石成功率、1个月内结石清除率分别为91.8%、96.4%显著高于URL组的79.1%、86.4%(P<0.05)。结论 PCNL较URL具有更佳清石效果,但可能造成较重手术创伤。应根据患者身体、经济、个人意愿等进行综合考量,选择合理手术方案。展开更多
文摘Objective: To investigate the effect of flexible ureteroscope lithotripsy and percutaneous nephrolithotomy on levels of serum inflammatory factors, oxidative stress and stress hormone in patients with renal calculi. Methods: A total of 97 cases of renal calculi patients were chosen as the research objects, based on the random data table, they were divided into the control group (n=49) and the observation group (n=48), patients in the control group underwent percutaneous nephrolithotomy (PCNL) treatment, while the observation group patients were treated with flexible ureteroscope lithotripsy (FURL), before and after 1 d ,the levels of inflammatory factors [interleukin-10 (IL-10), C reactive protein (CRP), white blood cell (WBC)], stress hormone [cortisol (COR), adrenocorticotropic hormone (ACTH), norepinephrine (NE)] and oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD) ] of the two groups were compared. Results: There were no significant differences in IL-10, CRP, WBC, COR, ACTH, NE, MDA and SOD levels between the two groups preoperative;Compared with the preoperative level in the group, the 1 d post-operation levels of IL-10, CRP, WBC, COR, ACTH, NE and MDA in the two groups were significantly increased, and the level of the observation group was significantly lower than that in the control group;The levels of SOD in the two groups 1 d post-operation were significantly lower than those in the same group preoperative, and the control group (85.65±9.95) U/mL was significantly lower than that of the control group (94.71±7.63) U/mL. Conclusion: Compared with percutaneous nephrolithotomy, flexible ureteroscopic lithotripsy for renal calculi is less stressful and more favorable for postoperative recovery, has an important clinical value.
文摘目的探讨输尿管软镜碎石取石术(flexible ureteroscopic lithotripsy,fURL)术前预置双J管对肾结石患者疗效的影响。方法回顾性分析2021年9月至2022年3月安徽医科大学第一附属医院收治的180例行fURL肾结石患者的临床资料。对照组(n=100)术前未预置输尿管支架,研究组(n=80)术前2周预置双J管。比较两组围手术期临床指标、视觉模拟评分法(visual analogue scale,VAS)、威斯康辛生活质量问卷(the Wisconsin Stone Quality of Life questionnaire,WISQOL)评分。结果对照组术后出现输尿管黏膜损伤3例,持续高热2例,研究组无并发症发生,对照组并发症发生率高于研究组,差异有统计学意义(P<0.05);对照组术前尿白细胞计数、初始尿培养阳性率、术前膀胱过度活动症(overactive bladder,OAB)发生率、一次输尿管通道鞘(ureteral access sheath,UAS)置入率均低于研究组,差异有统计学意义(P<0.05)。术后,对照组VAS评分低于研究组,WISQOL评分高于研究组,差异均有统计学意义(P<0.05);两组精力、睡眠、工作和家庭、对于出行和亲密行为的关注评分差值比较,差异无统计学意义(P>0.05);对照组营养和药物治疗、症状、总体情绪评分差值均高于研究组,差异有统计学意义(P<0.05)。结论术前预置双J管能够提高fURL中一次UAS置入成功率,但会降低患者生活质量,增加OAB和尿路感染发生率,且需承担额外的术前置双J管手术风险和费用。
文摘目的研究输尿管镜碎石术(URL)与经皮肾镜碎石术(PCNL)治疗输尿管上段复杂性结石的手术疗效及对C反应蛋白(CRP)、血红蛋白(Hb)水平的影响。方法选取我院2013年4月—2016年4月220例输尿管上段复杂性结石患者为研究对象,将纳入患者按随机数表法分为URL组与PCNL组,每组110例。URL组采用URL治疗,PCNL采用PCNL治疗,比较两组应激指标、血红蛋白、术中指标、结石清除率、术后恢复指标、术后并发症。结果URL组术后3 d CRP、Hb、术中出血量、住院时间分别为(20.20±6.54)mg/L、(119.43±19.21)g/L、(32.33±7.84)ml、(5.81±1.59)d与PCNL组的(23.15±6.29)mg/L、(104.39±21.81)g/L、(48.49±9.21)ml、(7.47±1.82)d比较差异有统计学意义(P<0.05)。PCNL组1次清石成功率、1个月内结石清除率分别为91.8%、96.4%显著高于URL组的79.1%、86.4%(P<0.05)。结论 PCNL较URL具有更佳清石效果,但可能造成较重手术创伤。应根据患者身体、经济、个人意愿等进行综合考量,选择合理手术方案。
