Objective: To assess the possible role of human Urotensin-II (hU-II), a vaso active peptide, in the pathophysiology of preeclampsia-eclampsia prospectively. Study design: Sixty subjects, 30 with a diagnosis of preecla...Objective: To assess the possible role of human Urotensin-II (hU-II), a vaso active peptide, in the pathophysiology of preeclampsia-eclampsia prospectively. Study design: Sixty subjects, 30 with a diagnosis of preeclampsia-eclampsia (g roup I) and 30 control subjects (group II), who had been admitted between Januar y, 2002 and December, 2002, were taken into the study. Patients in group I had a n increase in blood pressure after 28th week of gestation, without any history o f hypertensive disease and/or preeclampsia or eclampsia. hU-II levels were asse ssed using a radioimmunoassay method. Results: No statistically significant diff erence in terms of age, gestational age, gravidity, abortion and parity was dete cted among groups (P >0.05). Plasma hU-II levels in the preeclampsia-eclampsia and control groups were 10.11 ±5.94 pg/mL and 3.93 ±1.73 pg/mL, respectively. Difference between plasma hU-II levels of the two groups was found to be stati stically significant (P < .00001). Also there was correlation between hU-II lev els and mean arterial pressures in both groups (r = 0.73, P < 0.0001 and r = 0.7 2, P < 0.0001 for groups I and II, respectively). Conclusion: Results of our stu dy strongly suggest an important role for hU-II in the pathophysiology of preec lampsia-eclampsia. Further studies concerning placenta and cord blood samples w ill more clearly elucidate the role of Urotensin-II in the pathogenesis of pree clampsia-eclampsia, and its feto-maternal effects.展开更多
目的:探讨蚌埠市汉族人群尾加压素Ⅱ(UⅡ)基因多态性以及与2型糖尿病(T2DM)和肥胖的相关性。方法:随机选择蚌埠市汉族人群T2DM患者105例(其中肥胖组53例,非肥胖组52例),非糖尿病(ND组)114例(其中肥胖组55例,非肥胖组59例),采用聚合酶链...目的:探讨蚌埠市汉族人群尾加压素Ⅱ(UⅡ)基因多态性以及与2型糖尿病(T2DM)和肥胖的相关性。方法:随机选择蚌埠市汉族人群T2DM患者105例(其中肥胖组53例,非肥胖组52例),非糖尿病(ND组)114例(其中肥胖组55例,非肥胖组59例),采用聚合酶链反应-限制性片断多态性及凝胶电泳方法分析UⅡ基因第4外显子89位点由Ser置换成Asn的变异,即S89N。结果:野生型Ser/Ser基因型频率在ND组为64.9%,T2DM组为52.4%;突变型Asn/Asn基因型频率在ND组为5.3%,T2DM组为16.2%,差异均有统计学意义(P<0.05);UⅡ基因型S89N与T2DM有一定关系(P<0.01),而与肥胖无明显关系(P>0.05)。T2DM组各基因型间空腹葡萄糖、餐后2 h血糖、空腹胰岛素、餐后2 h胰岛素、胰岛素抵抗指数、胰岛素敏感数、三酰甘油差异均有统计学意义(P<0.05～P<0.01);空腹C肽和餐后2 h C肽在Asn/Asn基因型与其他2种基因型差异均有统计学意义(P<0.01);其余指标各基因型间差异均无统计学意义(P>0.05)。结论:蚌埠市汉族人群UⅡ基因S89N多态性与T2DM有明显相关性,与肥胖无相关性。展开更多
文摘Objective: To assess the possible role of human Urotensin-II (hU-II), a vaso active peptide, in the pathophysiology of preeclampsia-eclampsia prospectively. Study design: Sixty subjects, 30 with a diagnosis of preeclampsia-eclampsia (g roup I) and 30 control subjects (group II), who had been admitted between Januar y, 2002 and December, 2002, were taken into the study. Patients in group I had a n increase in blood pressure after 28th week of gestation, without any history o f hypertensive disease and/or preeclampsia or eclampsia. hU-II levels were asse ssed using a radioimmunoassay method. Results: No statistically significant diff erence in terms of age, gestational age, gravidity, abortion and parity was dete cted among groups (P >0.05). Plasma hU-II levels in the preeclampsia-eclampsia and control groups were 10.11 ±5.94 pg/mL and 3.93 ±1.73 pg/mL, respectively. Difference between plasma hU-II levels of the two groups was found to be stati stically significant (P < .00001). Also there was correlation between hU-II lev els and mean arterial pressures in both groups (r = 0.73, P < 0.0001 and r = 0.7 2, P < 0.0001 for groups I and II, respectively). Conclusion: Results of our stu dy strongly suggest an important role for hU-II in the pathophysiology of preec lampsia-eclampsia. Further studies concerning placenta and cord blood samples w ill more clearly elucidate the role of Urotensin-II in the pathogenesis of pree clampsia-eclampsia, and its feto-maternal effects.
文摘目的:探讨蚌埠市汉族人群尾加压素Ⅱ(UⅡ)基因多态性以及与2型糖尿病(T2DM)和肥胖的相关性。方法:随机选择蚌埠市汉族人群T2DM患者105例(其中肥胖组53例,非肥胖组52例),非糖尿病(ND组)114例(其中肥胖组55例,非肥胖组59例),采用聚合酶链反应-限制性片断多态性及凝胶电泳方法分析UⅡ基因第4外显子89位点由Ser置换成Asn的变异,即S89N。结果:野生型Ser/Ser基因型频率在ND组为64.9%,T2DM组为52.4%;突变型Asn/Asn基因型频率在ND组为5.3%,T2DM组为16.2%,差异均有统计学意义(P<0.05);UⅡ基因型S89N与T2DM有一定关系(P<0.01),而与肥胖无明显关系(P>0.05)。T2DM组各基因型间空腹葡萄糖、餐后2 h血糖、空腹胰岛素、餐后2 h胰岛素、胰岛素抵抗指数、胰岛素敏感数、三酰甘油差异均有统计学意义(P<0.05～P<0.01);空腹C肽和餐后2 h C肽在Asn/Asn基因型与其他2种基因型差异均有统计学意义(P<0.01);其余指标各基因型间差异均无统计学意义(P>0.05)。结论:蚌埠市汉族人群UⅡ基因S89N多态性与T2DM有明显相关性,与肥胖无相关性。
