基于Needs甲基化法枸杞多糖指纹图谱的建立

目的多糖是枸杞中主要的活性成分,各产地间枸杞多糖的结构和含量均有差异。目前枸杞多糖的质量控制方法大多都通过单糖组成构建指纹图谱,但仅通过单糖指纹图谱对枸杞多糖进行质量控制,并不能系统地对不同产地的枸杞多糖进行质量控制。因此,我们在单糖指纹图谱的基础上,利用Needs甲基化法确定枸杞多糖的糖残基连接方式,建立Needs甲基化法枸杞多糖指纹图谱,实现对不同产地枸杞的质量控制。方法通过水提醇沉法获得枸杞多糖,并采用Needs甲基化、完全酸水解、硼氢化钠还原及乙酰化等方法结合GC-MS测定枸杞多糖的糖残基连接方式。结果将18批枸杞多糖的糖残基连接方式色谱图导入《中药色谱指纹图谱相似度评价系统》(2004版)构建出指纹图谱,并结合多种化学计量法评价不同产地间枸杞多糖的差异。相似度计算结果发现,除西藏自治区三批枸杞多糖相似度0.551-0.569,其余15批样品相似度均0.929以上。糖残基连接方式色谱图共标定了16个共有峰,指认了其中10个共有峰,分别为TArap、T-Araf、T-Xylp、1,2-Arap、1,3-Rhap、1,5-Araf、T-Glcp、T-Galp、1,4-Glcp、1,6-Galp。HCA、PCA和PLS-DA分析结果将18批次不同产地的枸杞多糖分为3类,并筛选出了3个标志性成分,分别为T-Araf、1,5-Araf和T-Glcp,以此来判断不同产地间枸杞多糖的差异性。结论首次建立了18批枸杞多糖的Needs甲基化法指纹图谱,为枸杞多糖质量控制提供实验数据参考,进一步证明了多糖在中药质量控制中的作用。

Hepatitis B Surface Antigen and Hepatitis C Virus Antibodies among Drug Users in Burkina Faso

Introduction: The epidemiology of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis B and C viruses among drug users in Burkina Faso. Methodology: This was a cross-sectional biological and behavioral survey conducted between June and August 2022, among drug users in Ouagadougou and Bobo Dioulasso, the two main cities of Burkina Faso. A respondent-driven sampling (RDS) was used to recruit drug users. Hepatitis B surface antigen was determined using lateral flow rapid test kits and antibodies to hepatitis C virus in serum determined using an Enzyme-Linked Immunosorbent Assay. Data were entered and analyzed using Stata 17 software. Weighted binary logistic regression was used to identify the associated factors of hepatitis B and C infections and a p-value Results: A total of 323 drug users were recruited with 97.5% males. The mean age was 32.7 years old. The inhaled or smoked mode was the most used by drug users. The adjusted hepatitis B and hepatitis C prevalence among study participants were 11.1% and 2.3% respectively. The marital status (p = 0.001), and the nationality (p = 0.011) were significantly associated with hepatitis B infection. The type of drug used was not significantly associated with hepatitis B infection or hepatitis C infection. Conclusion: The prevalence of HBsAg and anti-HCV antibodies among DUs are comparable to those reported in the general population in Burkina Faso. This result suggests that the main routes of contamination by HBV and HCV among DUs are similar to those in the population, and could be explained by the low use of the injectable route by DUs in Burkina Faso.

Multimodal emotion recognition in the metaverse era:New needs and transformation in mental health work

This editorial comments on an article recently published by López del Hoyo et al.The metaverse,hailed as"the successor to the mobile Internet",is undoubtedly one of the most fashionable terms in recent years.Although metaverse development is a complex and multifaceted evolutionary process influenced by many factors,it is almost certain that it will significantly impact our lives,including mental health services.Like any other technological advancements,the metaverse era presents a double-edged sword for mental health work,which must clearly understand the needs and transformations of its target audience.In this editorial,our primary focus is to contemplate potential new needs and transformation in mental health work during the metaverse era from the pers-pective of multimodal emotion recognition.

The Oral Health Status of Person with Special Needs in Kumasi

Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in Kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in June-July 2022. Dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in Kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.

Evaluation of an Autonomous Vehicle User Interface for Sensory Impaired Users

Autonomous vehicles (AVs) hold immense promises in revolutionizing transportation, and their potential benefits extend to individuals with impairments, particularly those with vision and hearing impairments. However, the accommodation of these individuals in AVs requires developing advanced user interfaces. This paper describes an explorative study of a multimodal user interface for autonomous vehicles, specifically developed for passengers with sensory (vision and/or hearing) impairments. In a driving simulator, 32 volunteers with simulated sensory impairments, were exposed to multiple drives in an autonomous vehicle while freely interacting with standard and inclusive variants of the infotainment and navigation system interface. The two user interfaces differed in graphical layout and voice messages, which adopted inclusive design principles for the inclusive variant. Questionnaires and structured interviews were conducted to collect participants’ impressions. The data analysis reports positive user experiences, but also identifies technical challenges. Verified guidelines are provided for further development of inclusive user interface solutions.

Reform of the Irrigation Sector and Creation of Functional and Sustainable Irrigation Water Users Associations (AUEI) in Niger: Capitalization of the Experience of the Konni AHA

During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to cooperatives concerned. Due to lack of financial resources, but also because of poor management, everywhere in Niger we are witnessing an accelerated deterioration of the irrigation infrastructure of hydro-agricultural developments. Institutional studies carried out on this situation led the State of Niger to initiate a reform of the governance of hydro-agricultural developments, by streng-thening the status of ONAHA, by creating an Association of Irrigation Water Users (AUEI) and by restructuring the old cooperatives. Indeed, this research aims to analyze the creation of functional and sustainable Irrigation Water User Associations (AUEI) in Niger in a context of reform of the irrigation sector, and based on the experience of the Konni AHA. It is based on a methodological approach which takes into account documentary research and the collection of data from 115 farmers, selected by reasoned choice and directly concerned by the management of the irrigated area. The data collected was analyzed and the results were analyzed using the systemic approach and the diagnostic process. The results show that the main mission of the AUEI is to ensure better management of water, hydraulic equipment and infrastructure on the hydro-agricultural developments of Konni. The creation of the Konni AUEI was possible thanks to massive support from the populations and authorities in the implementation process. After its establishment, the AUEI experienced a certain lethargy for some time due to the rehabilitation work of the AHA but currently it is functional and operational in terms of associative life and governance. Thus, the constraints linked to the legal system, the delay in the completion of the work, the uncertainties of access to irrigation water but also the problems linked to the change in mentality of certain ONAHA agents constitute the challenges that must be resolved in the short term for the operationalization of the Konni AUEI.

Design Method for Optimizing the Interactive Interface of Live Broadcasting Platform for the Elderly Users

In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interaction design mode used is still mainly based on the interaction mode for young groups,and is not designed for elderly users.Therefore,a design method for optimizing the interaction interface of live broadcasting platform for elderly users was proposed in this study.Firstly,the case study method and Delphi expert survey method were used to determine the design needs of elderly users and the design mode was analysed.Secondly,the orthogonal design principle was used to design a test sample of the interactive interface of live broadcasting platform applicable for the elderly users,and then a user evaluation system was established to calculate the weights of the design elements using hierarchical analysis,and then the predictive relationship between the design mode of the interactive interface of live broadcasting platform and the elderly users was established by Quantitative Theory I.Finally,Genetic Algorithm was applied to generate the optimized design scheme.The results showed that the design method based on the Genetic Algorithm and the combination of Quantitative Theory can scientifically and effectively optimize the design of the interactive interface of the live broadcasting platform for the elderly users,and improve the experience of the elderly users.

An Empirical Study on Foreign Language Majors’Needs for Ideological and Political Education Elements in Chinese Universities

The paper takes 2076 undergraduate students majoring in foreign languages from 15 Chinese universities as the research subjects to investigate their demand for ideological and political education elements in foreign language courses.The results show that:(1)Students have high needs for ideological and political education elements in foreign language courses;(2)There are differences in students’needs for ideological and political education elements across different dimensions.Students have higher demand for dimensions such as personal qualities,cultural literacy,moral cultivation,and patriotism,while their demand for dimensions related to constitutional law and political identity is relatively low.Therefore,foreign language majors in Chinese universities should optimize the supply of ideological and political education elements in their courses according to students’needs,and improve the effectiveness of moral education in these courses.

Supportive care needs of women with gynecologic cancer and factors affecting in Turkiye: a cross sectional study

Background:Identifying and managing patients'supportive care needs is an essential component of health care.The cancer patients'needs are multidimensional and it is important to identify these needs.This study was conducted to assess supportive care needs of women with gynecologic cancer and affecting factors.Methods:This cross-sectional study consisted of 98 women with gynecologic cancer.The data of the study was gathered using“Personal Information Form”and the“James Supportive Care Screening”.Results:The most frequently reported unmet needs of gynecologic cancer patients were emotional issues,including uncertainty(87.6%),fears(85.7%),feeling down(86.7%),worry(87.6%),loss of interest in usual activities(73.3%)and physical symptoms including fatigue/lack of energy(81.9%),weakness(81.9%),lack of appetite(76.2%).The most frequently reported social/practical problems was transportation problems(50%).The mean scores for JSCS was 29.72±15.57.There were a statistically significant difference was found only between family type,stage of the disease,and time of diagnosis,and the total mean scores of the JSCS(p<0.05).Conclusion:It has been determined that patients with gynecological cancer mostly experience emotional and physical problems.Health professionals working in the oncology unit should be aware of unmet needs.Certain programs and services to address the identified unmet needs should be provided.

Research on Learner Needs Analysis and Listening Activities

Listening is the primary method to access language information.It is an essential part of L2(second language)teaching but also the most difficult skill to master for L2 learners.Based on this,it is necessary to analyze learners’needs in listening.This article aims to conduct a needs analysis of a selected learner from Iraq and describe course material selection and design.Methods including questionnaires,interviews,and observation were used to collect data.Additionally,targeted 60-minute online listening activities were designed.It was found that listening activities can improve both listening and speaking skills.Thus,language teaching should be student-oriented,and subsequent course materials and activity design should be selected based on the analysis of students’needs.

Analysis of the Brand Visual Needs System from the Perspective of Contemporary Market Demands

Brand visual design is not only an essential bridge for companies to convey their ideas and values but also a key factor in shaping the brand image and enhancing market competitiveness.However,a pervasive concern has arisen in society that many recent graduates in brand design and visual design cannot immediately meet the demands of the design industry.Despite attempts by scholars to reform courses and teaching philosophies,there are still significant shortcomings and gaps.Therefore,based on market orientation and supply-demand concepts,this study collected in-depth recruitment demands for brand design from 74 companies and conducted systematic summarization and analysis.It synthesized a demand model consisting of three major modules and 55 content points required by companies for brand design students.Based on these demands,adjustments and plans were made to the curriculum content,aiming to construct a teaching system that not only meets market demands but also enhances students’comprehensive qualities.The goal is to cultivate more outstanding talents capable of quickly adapting to and excelling in brand design work.

Core competencies and perceived training needs of nurses in the background of Internet plus nursing service:a qualitative descriptive study

Background:The Internet plus nursing service program is being piloted in China,which has become a new home nursing service model led by nurses.To enable safe and effective homecare service delivery,nurses working in the program need a high level of competency.However,the content of these core competencies and the training needs of nurses for Internet plus nursing services are still unknown.Aim:To describe nurses’perceptions of core competencies and training needs to work in the Internet plus nursing service program,thereby providing a reference for the development of training programs.Methods:A qualitative descriptive study using semi-structured interviews was conducted on 15 nurses with experience of working in the Internet plus nursing service program.Interviews were audio-recorded and transcribed verbatim,and the data were analyzed using thematic analysis.Results:Core competencies involved comprehensive assessment competence,direct care practice competence,health education and consulting competence,risk estimation and response competence,and communication competence.Training needs involved complex operational items,knowledge of chronic disease management,professional communication,risk identification and response,nursing standards,norms,and procedures,and utilization of information technology.Conclusions:The training system may be developed based on nurses’core competencies and their training needs to promote professional development of the Internet plus nursing service.

Research on Training Needs,Training Transfer,and Training Effectiveness of In-Service Teachers in Local Normal Colleges

This study aims to understand the in-service training needs,training transfer,and training effectiveness of teachers in local normal universities in China,while also proposing a continuous professional development plan for teachers.Descriptive research methods were employed,with questionnaires serving as the primary data collection tool.The survey revealed that the educational background of teachers in local normal universities is characterized by an unreasonable distribution of academic qualifications,with a shortage of teachers holding postgraduate and higher degrees.Additionally,the training effectiveness for female teachers was found to be lower than that of male teachers.There is a lack of personalization in training needs,which tends to be more generalized.The transfer effect of training is moderate,and there is a need for further enhancement at the behavioral level of training effectiveness.A continuous professional development plan for teachers has been formulated to improve training effectiveness and promote professional development.

Research on the Status Quo and Improvement Needs of Foreign Language Teachers’ Teaching Competence in Curriculum-Based Ideological Education in Xinjiang Colleges and Universities

This study investigated the status quo and further improvement needs of foreign language teachers’teaching competence in curriculum-based ideological education(CIE)in Xinjiang colleges and universities.The results show that the teachers’teaching competence in CIE is generally good,with the“cultivating quality”being the highest and the“scientific research quality”the lowest;there still exist several problems,such as teachers’lack of theoretical knowledge in CIE,lack of teaching resources,and insufficient abilities in teaching design and research.It is hoped that with the support and efforts from university administrations,teachers can improve their teaching competence in CIE through various approaches adopted and multiple measures taken,thus optimizing their teaching effectiveness,promoting the construction of CIE in Xinjiang colleges and universities in the new era,and contributing to Xinjiang’s high-quality development.

Education of Hospitalized Diabetic Patients: Analysis of Training Needs among Nurses in a Lebanese Hospital - A Secondary Publication

The design of diabetes inpatient educational preparation should be based on the needs of the nurses involved in terms of skills in this area. The objective of this qualitative study is to identify the preparatory needs of nurses working in the medical and surgical units of a Lebanese hospital in terms of Survival Skills Education for Hospitalized Diabetic Patients (SSEHDP). Method: The focus group method is used for data collection using a semi-structured interview guide. The needs expressed by the thirty-two participating nurses were classified into categories of the competency framework for providing self-management education to diabetic patients proposed by the American Diabetes Association. Results: By focusing on the themes of an SSEHDP, a list of preparatory needs was drawn up. The needs identified and analyzed are then translated into general and specific learning objectives for educational preparation. Conclusion: The needs analysis is only the first step in a work that will ideally continue into the implementation and eventual evaluation of an educational program developed to help nurses acquire skills in the education of diabetic patients.

The Intersection of Privacy by Design and Behavioral Economics: Nudging Users towards Privacy-Friendly Choices

This paper conducts a comprehensive review of existing research on Privacy by Design (PbD) and behavioral economics, explores the intersection of Privacy by Design (PbD) and behavioral economics, and how designers can leverage “nudges” to encourage users towards privacy-friendly choices. We analyze the limitations of rational choice in the context of privacy decision-making and identify key opportunities for integrating behavioral economics into PbD. We propose a user-centered design framework for integrating behavioral economics into PbD, which includes strategies for simplifying complex choices, making privacy visible, providing feedback and control, and testing and iterating. Our analysis highlights the need for a more nuanced understanding of user behavior and decision-making in the context of privacy, and demonstrates the potential of behavioral economics to inform the design of more effective PbD solutions.

Enable Excel-Based Basic Cybersecurity Features for End Users by Using Python-Excel Integration

In the digital age, the global character of the Internet has significantly improved our daily lives by providing access to large amounts of knowledge and allowing for seamless connections. However, this enormously interconnected world is not without its risks. Malicious URLs are a powerful menace, masquerading as legitimate links while holding the intent to hack computer systems or steal sensitive personal information. As the sophistication and frequency of cyberattacks increase, identifying bad URLs has emerged as a critical aspect of cybersecurity. This study presents a new approach that enables the average end-user to check URL safety using Microsoft Excel. Using the powerful VirusTotal API for URL inspections, this study creates an Excel add-in that integrates Python and Excel to deliver a seamless, user-friendly interface. Furthermore, the study improves Excel’s capabilities by allowing users to encrypt and decrypt text communications directly in the spreadsheet. Users may easily encrypt their conversations by simply typing a key and the required text into predefined cells, enhancing their personal cybersecurity with a layer of cryptographic secrecy. This strategy democratizes access to advanced cybersecurity solutions, making attentive digital integrity a feature rather than a daunting burden.

Chinese Web users' daily image needs and seeking behavior in a Q&A community

Purpose： In order to further the understanding of Chinese Web users＇ image-seeking behavior, this study explores the kinds of images that Chinese Web users seek online and how they express their requests.Design/methodology/approach： We used five pairs of simulated keywords to collect 893 image-seeking questions from Baidu Zhidao. Then, we revised the subject category of questions to analyze popular image needs. In addition, we conducted content analysis and descriptive statistical analysis to identify image-seeking motivations and image features used in the requests in terms of the two theories of image feature classification and image use. Findings： Among the 893 questions, the image searches for entertainment accounted for 47.59%, more than the searches for professional knowledge （37.40%） and personal daily activities （15.01%）. With regard to motivation, over 60% of the questions were identified as used for learning, which is well over the proportion of questions used for illustrating. Thus, these questions requested images as sources of data rather than sources of objects. Non-visual features （47.58%） were used most frequently in question descriptions, slightly higher than semantic features （45.96%）. Users who lacked domain knowledge tended to use general words rather than specific words to describe their requests. However, not many users used syntactic featm＇es when seeking images. Nevertheless, most of the users had a fairly clear idea about what the target image should look like. Research limitations： We studied only one question and answer （Q＆A） community using five pairs of simulated keywords. Practical implications： The findings should be helpful in strengthening the functionality of Q＆A systems, promoting the theories of image feature classification, and shedding light on information literacy training.Originality/value： This study is one of the first research efforts that discusses Chinese Web users＇ daily image searches and querying behavior in natural language in a Q＆A community, which should help to further the understanding of the principles of image-seeking behavior among Chinese Web users.

Clothing Needs for Wheelchair Users: A Systematic Literature Review

The aim of this study was to identify the clothing needs of wheelchair users using relevant literatures in a global scale and to design a method to classify the clothing needs into a unified system, in order to generate a map of wheelchair users’ clothing needs with the information from multiple resources. The paper reviewed the previous studies about clothing needs and preference of wheelchair users. A three-tier screening was designed to extract main findings from the relevant literature. Content analysis and statistical analysis were used to integrate the information and identify implications. Information was categorized to represent the attributes of the clothing needs. The paper provides comprehensive insights about the specific barriers and abstract demands about the clothing needs of wheelchair users regarding their preference for apparel products. Eight essential attributes relating to the clothing needs of wheelchair users were identified: functional needs, fit attribute fabric and fiber, safety issue, aesthetic needs, expressive needs, quality of life, and extrinsic attributes. The attributes were classified into two general domains, reflecting the physical challenges and psychological desires of wheelchair users.

A study of changing information needs of contemporary public library users in China

Public libraries should be vigilant and responsive to the ever changing information needs of their clientele functioning in a society undergoing through rapid change due to technological innovations. China is currently experiencing a social and technological transformation of great magnitude in terms of metamorphosing itself from a traditional society to one that is driven by information technologies. Our research study, taking this proposition into account, did a questionnaire survey on 954 library information users at five major public libraries. This research study has discovered that the information needs of public library users today reflect some of the peculiar characteristics of their society in changing times which is driven largely by the rapid development and application of new information technologies. It shows that there is a newly added demand emphasis on certain categories of library resources and services by the Chinese reading public. Our research findings have identified such needs basically in the following five functional areas of public libraries, namely, 1) Increased demands for economic resources, 2) rising expectations for more effective and efficient library services, 3) a convenient location and an amicable environment congenial to learning, 4) a suitable place for engaging in intellectual dialogues and in socialization, and 5) a few other technological amenities and information technology-based digital resources and facilities in addition to a rich repository of library materials in print format. Finally, our paper concludes its discussion with a few observation remarks about the changing trend of public libraries' visions, missions and operations vis-à-vis a contextual background of the ever heightened public expectations for getting quality information services in a timely manner in order for them to function effectively in an information-oriented society such as that of ours today.