In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpasse...In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpassed 0.5 million units,展开更多
The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Man...The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Many Southeast Asian countries are blessed with an abundance of natural resources.Singapore has positioned itself as one of the region’s largest commodity trading hubs offering tax-friendly incentives,transparent financial and legal sectors,excellent infrastructure and a skilled workforce.These factors have enabled Singa-展开更多
On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on t...On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on the historic importance of the event in an exclusive interview with China Tibet magazine. Excerpts follow:展开更多
IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and...IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and restaurant employees, employers, valued customers and the local people who make travel and tourism possible. The hotel and restaurant industry is united in its support of a rapid recovery and seeks ways of identifying展开更多
Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf population.This genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmento...Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf population.This genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular areflexia.Among the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset RP.USH type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high frequencies.Conversely,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of life.The dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with society.To date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and CLRN1.These genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional loss.Although non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating USH.Regarding drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in USH.Simultaneously,CI has proven to be critical in the restoration of hearing.This review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et al.Diagnosis and current treatments of USH WJO https://www.wjgnet.com 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and improving patient prognosis.展开更多
文摘In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpassed 0.5 million units,
文摘The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Many Southeast Asian countries are blessed with an abundance of natural resources.Singapore has positioned itself as one of the region’s largest commodity trading hubs offering tax-friendly incentives,transparent financial and legal sectors,excellent infrastructure and a skilled workforce.These factors have enabled Singa-
文摘On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on the historic importance of the event in an exclusive interview with China Tibet magazine. Excerpts follow:
文摘IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and restaurant employees, employers, valued customers and the local people who make travel and tourism possible. The hotel and restaurant industry is united in its support of a rapid recovery and seeks ways of identifying
文摘Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf population.This genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular areflexia.Among the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset RP.USH type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high frequencies.Conversely,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of life.The dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with society.To date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and CLRN1.These genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional loss.Although non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating USH.Regarding drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in USH.Simultaneously,CI has proven to be critical in the restoration of hearing.This review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et al.Diagnosis and current treatments of USH WJO https://www.wjgnet.com 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and improving patient prognosis.
