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Novel Application of Vacuum Sealing Drainage with Continuous Irrigation of Potassium Permanganate for Managing Infective Wounds of Gas Gangrene 被引量:14
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作者 胡宁 吴星火 +7 位作者 刘融 杨述华 黄玮 蒋电明 吴强 夏天 邵增务 叶哲伟 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第4期563-568,共6页
Summary: Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputa- tion. The aim ... Summary: Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputa- tion. The aim of the present study was to use vacuum sealing drainage (VSD) with continuous irrigation of potassium permanganate to manage infective wounds of gas gangrene and observe its clinical effi- cacy. A total of 48 patients with open traumatic gas gangrene infection were included in this study. Am- putations were done for 27 patients, and limb salvage procedures were performed for the others. After amputation or aggressive debridement, the VSD system, including polyvinyl alcohol (PVA) foam dress- ing and polyurethane (PU) film, with continuous irrigation of 1:5000 potassium permanganate solutions, was applied to the wounds. During the follow-up, all the patients healed without recurrence within 8-18 months. There were four complications. Cardiac arrest during amputation surgery occurred in one pa- tient who suffered from severe septic shock. Emergent resuscitation was performed and the patient re- turned to stable condition. One patient suffered from mixed infection of Staphylococcal aureus, and a second-stage debridement was performed. One patient suffered from severe pain of the limb after the debridement. Exploratory operation was done and the possible reason was trauma of a local peripheral nerve. Three cases of crush syndrome had dialysis treatment for concomitant renal failure. In conclusion, VSD can convert open wound to closed wound, and evacuate necrotic tissues. Furthermore, potassium permanganate solutions help eliminate anaerobic microenviroument and achieve good therapeutic effect on gas gangrene and mixed infection. VSD with continuous irrigation of potassium permanganate is a novel, simple and feasible alternative for severe traumatic open wounds with gas gangrene infection. 展开更多
关键词 vacuum sealing drainage potassium permanganate IRRIGATION gas gangrene TRAUMA
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Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs 被引量:11
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作者 Shuai Wei Wei Wang +9 位作者 Li Li Hao-Ye Meng Chun-Zhen Feng Yu-Ying Dong Xi-Chi Fang Qi-Qiang Dong Wen Jiang Hai-Li Xin Zhan-Zhen Li Xin Wang 《Military Medical Research》 SCIE CSCD 2021年第4期510-522,共13页
Background:Vacuum sealing drainage(VSD)and epidermal growth factor(EGF)both play an important role in the treatment of wounds.This study aims to explore the effects of the combination of VSD and EGF on wound healing a... Background:Vacuum sealing drainage(VSD)and epidermal growth factor(EGF)both play an important role in the treatment of wounds.This study aims to explore the effects of the combination of VSD and EGF on wound healing and the optimal concentration and time of EGF.Methods:We tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations(0,1,5,10,and 100ng/ml)and different EGF action times(2,10,and 30min).A full-thickness skin defect model was established using male,30-week-old Bama pigs.The experiment included groups as follows:routine dressing change after covering with sterile auxiliary material(Control),continuous negative pressure drainage of the wound(VSD),continuous negative pressure drainage of the wound and injection of EGF 10min followed by removal by continuous lavage(V+E 10min),and continuous negative pressure drainage of the wound and injection of EGF 30min followed by removal by continuous lavage(V+E 30min).The wound healing rate,histological repair effect and collagen deposition were compared among the four groups.Results:An EGF concentration of 10ng/ml and an action time of 10min had optimal effects on the proliferation and migration capacities of HaCaT and L929 cells.The drug dispersion effect was better than drug infusion after bolus injection effect,and the contact surface was wider.Compared with other groups,the V+E 10min group promoted wound healing to the greatest extent and obtained the best histological score.Conclusions:A recombinant human epidermal growth factor(rhEGF)concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in vitro.VSD combined with rhEGF kept in place for 10min and then washed,can promote wound healing better than the other treatments in vitro. 展开更多
关键词 vacuum sealing drainage Epidermal growth factor Skin wound healing Full-thickness skin defect
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Salvage of vascular graft infections via vacuum sealing drainage and rectus femoris muscle flap transposition: A case report 被引量:3
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作者 Peng Zhang Fu-Lin Tao +2 位作者 Qing-Hu Li Dong-Sheng Zhou Fan-Xiao Liu 《World Journal of Clinical Cases》 SCIE 2021年第10期2296-2301,共6页
BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical situation.The aim of this report is to illustrate the novel vacuum sealing drainage(VSD)technique and rectus... BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical situation.The aim of this report is to illustrate the novel vacuum sealing drainage(VSD)technique and rectus femoris muscle flap transposition for vascular graft infections,and to evaluate the prospective of future testing of this surgical procedure.CASE SUMMARY We report the case of a 32-year-old male patient,who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure.Using the VSD and muscle flap transposition,the groin wound and vascular graft infection were finally treated successfully.CONCLUSION Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure,especially in consideration of treatable conditions. 展开更多
关键词 Vascular graft INFECTION Muscle flap transposition Rectus femoris muscle flap vacuum sealing drainage Case report TRAUMA
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Application of vacuum sealing drainage technique in poor healing wounds after heart valve surgery 被引量:5
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作者 黄志锋 陈华德 +7 位作者 郑少逸 赖文 廖路妹 刘族安 卞徽宁 孙传伟 李汉华 马亮华 《South China Journal of Cardiology》 CAS 2013年第2期122-126,共5页
Background: Poor healing wounds or postoperative infection after open-heart surgery are most commonly seen, especially in secondary surgery for heart diseases, with an incidence rate of 2.2% after a valve replacement... Background: Poor healing wounds or postoperative infection after open-heart surgery are most commonly seen, especially in secondary surgery for heart diseases, with an incidence rate of 2.2% after a valve replacement surgery. If not treated in time or the infection progresses, it can lead to sternal infection, even mediastinal and pericardial infection, causing a higher mortality rate. It becomes a really troublesome and complicated case when a poor healing occurs in midsternal incision after the heart valve surgery and a higher medical cost may be needed. Methods From January 2009 to February 2013, 162 patients who underwent heart valve surgery through midsternal incision approach and had a poor healing of wound were observed for prospective randomized controlled trial. The patients were randomly assigned to a vacuum sealing drainage group (n = 81) who received vacuum sealing drainage for healing of the wound or a control group (n = 81) who received traditional treating for the infected wound. Their therapeutic effects, healing time and treatment costs, etc were compared. Results Two patients from the vacuum sealing drainage group came back to hospital for repair due to dehiscence of the incision after discharge, and no patient died. Six patients from the control group came back to hospital for repair due to dehiscence of the incision after discharge, two came back to hospital for surgery due to chronic osteomyelitis, and one patient died two weeks later after surgery due to severe chest infection. Wound healing time for vacuum sealing drainage group was 14.6 ± 3.6 days, which was significantly shorter than that of the control group (21.2 ± 7.8 days, P 〈 0.05), while the medical costs showed no significant difference between the two groups (P 〉 0.05). Seventy-eight patients (96.29%) in the vacuum sealing drainage group showed a good healing of the wound and sternum after a six-month follow-up. Conclusion The use of vacuum sealing drainage technique in poor-healing wounds after heart valve surgery through midsternal incision approach could achieve good therapeutic efficacy, with shorter wound healing time and similar costs as traditional treatment. 展开更多
关键词 vacuum sealing drainage heart valve heart operation poor healing wounds
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Vacuum sealing drainage technique in the treatment of poor healing wounds after heart valve surgery:experience in cardiac nursing 被引量:1
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作者 WU Hong-mei HUANG Zhi-feng +7 位作者 ZHENG Shao-yi LAI Wen LIU Zu-an BIAN Hui-ning SUN Chuan-wei LI Han-hua MA Liang-hua CHEN Han-xi 《South China Journal of Cardiology》 CAS 2014年第4期279-281,共3页
Background Poor wound healing or postoperative infection after open-heart surgery is most commonly seen. If not treated in time or the infection progresses, it can lead to sternal infection, even mediastinal and peric... Background Poor wound healing or postoperative infection after open-heart surgery is most commonly seen. If not treated in time or the infection progresses, it can lead to sternal infection, even mediastinal and pericardial infection, causing a higher mortality rate. Vacuum sealing drainage (VSD) is a new technology to promote wound healing. We studied the use of VSD technique in poor wound healing after heart valve surgery to see if it could achieve good therapeutic efficacy. Methods From 2013 October to 2014 October in Guang- dong General Hospital, 86 cases of the application of vacuum sealing drainage technique in the treatment of cardiac nonunion after valve replacement in patients with nursing observation. The treatment time, death rate and infection rate, etc were compared. Results Wound healing time of 86 patients receiving vacuum sealing drainage was 14.6 ± 3.6 days, and no patient died. Two patients came back to hospital for repair due to dehis- cence of the incision after discharge. Conclusion Nursing observation and drainage management were the key of VSD. VSD technique is worthy to be popularized clinically. 展开更多
关键词 vacuum sealing drainage NURSING heart valve surgery
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Vacuum-sealed casting process under pressure
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作者 LI Chen-xi GUO Tai-ming +1 位作者 WU Chun-jing WANG Hong 《China Foundry》 SCIE CAS 2006年第3期190-194,共5页
A new casting method, the vacuum-sealed mold casting under pressure, has been developed, and thin wall iron castings with high precision and smooth surface have been produced successfully with this casting method. The... A new casting method, the vacuum-sealed mold casting under pressure, has been developed, and thin wall iron castings with high precision and smooth surface have been produced successfully with this casting method. The experimental results show that the liquid iron has a very excellent filling ability because a high negative pressure is formed in the mold cavity during filling process. The vacuum-sealed mold under pressure has very high compressive strength greater than 650 kPa, which is 3-4 times as high as that of the molds produced by high-pressure molding process or vacuum-sealed molding process. 展开更多
关键词 CASTING PROCESS vacuum-sealed MOLD PRESSURE CASTING
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四妙勇安汤负压滴灌治疗湿热内蕴型糖尿病足伴严重下肢缺血患者的临床观察
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作者 刘皓 李树森 +2 位作者 吴广迎 冯军 姚书格 《世界中西医结合杂志》 2024年第8期1582-1586,1591,共6页
目的观察四妙勇安汤负压滴灌治疗湿热内蕴型糖尿病足伴严重下肢缺血患者的临床疗效。方法选取2021年6月—2023年10月期间邢台医学高等专科学校附属二院收治的糖尿病足(Diabetic foot,DF)伴严重下肢缺血(Critial limb ischemia,CLI)患者6... 目的观察四妙勇安汤负压滴灌治疗湿热内蕴型糖尿病足伴严重下肢缺血患者的临床疗效。方法选取2021年6月—2023年10月期间邢台医学高等专科学校附属二院收治的糖尿病足(Diabetic foot,DF)伴严重下肢缺血(Critial limb ischemia,CLI)患者60例,采用随机数表法分为对照组和观察组,每组各30例,术前WIFI分级评估,进行相应的血管腔内治疗,血运重建成功后,分别行坏疽趾或趾列开放性切除或溃疡清创术,其中对照组术后采用负压封闭引流(VSD)进行治疗,观察组术后采用四妙勇安汤负压滴灌治疗,1周后拆除VSD敷料查看创面情况,创面内组织细菌培养阴性后,行创面修复,直至创面愈合,分别检测治疗1、2周后血清C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT),治疗2周后创面细菌转阴率;检测治疗2周后经皮氧分压(Transcutaneous oxygen pressure,T_(C)PO_(2))及踝肱指数(Ankle-brachialindex,ABI)、创面愈合时间及不良反应。结果治疗后观察组总有效率90.00%(27/30)明显高于对照组80.00%(24/30),差异有统计学意义(P<0.05)。治疗后两组患者CRP、PCT水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组CRP、PCT水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组创面细菌转阴率90%(27/30)明显高于对照组70%(21/30),差异有统计学意义(P<0.05)。治疗后两组患者T_(C)PO_(2)水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组T_(C)PO_(2)水平明显高于对照组,差异有统计学意义(P<0.05),观察组ABI指数与对照组比较,治疗前后差异无统计学意义(P>0.05)。治疗后观察组创面愈合时间(28.63±5.30)d明显优于对照组(40.87±5.14)d,差异有统计学意义(P<0.05)。治疗期间,两组患者均无过敏、肿胀、感染加重等不良反应发生。结论四妙勇安汤负压滴灌治疗糖尿病足伴严重下肢缺血腔内治疗术后湿热内蕴型可有效控制感染,改善局部微循环,缩短创面愈合时间,具有临床应用及推广价值。 展开更多
关键词 四妙勇安汤 灌洗 负压封闭引流 糖尿病足 重症肢体缺血
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Research on the Encapsulation Device for Lunar Samples
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作者 Yonggang Du Chunyong Wang +3 位作者 Haoling Li Ying Zhou Ming Ji Xuesong Wang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期104-117,共14页
The encapsulation of lunar samples is a core research area in the third phase of the Chinese Lunar Exploration Program.The seal assembly,opening and closing mechanism(OCM),and locking mechanism are the core components... The encapsulation of lunar samples is a core research area in the third phase of the Chinese Lunar Exploration Program.The seal assembly,opening and closing mechanism(OCM),and locking mechanism are the core components of the encapsulation device of the lunar samples,and the requirements of a tight seal,lightweight,and low power make the design of these core components difficult.In this study,a combined sealing assembly,OCM,and locking mechanism were investigated for the device.The sealing architecture consists of rubber and an Ag-In alloy,and a theory was built to analyze the seal.Experiments of the electroplate Au coating on the knife-edge revealed that the hermetic seal can be significantly improved.The driving principle for coaxial double-helical pairs was investigated and used to design the OCM.Moreover,a locking mechanism was created using an electric initiating explosive device with orifice damping.By optimizing the design,the output parameters were adjusted to meet the requirements of the lunar explorer.The experimental results showed that the helium leak rate of the test pieces were not more than 5×10^(-11) Pa·m^(3)·s^(-1),the minimum power of the OCM was 0.3 W,and the total weight of the principle prototype was 2.9 kg.The explosive driven locking mechanism has low impact.This investigation solved the difficulties in achieving tight seal,light weight,and low power for the lunar explorer,and the results can also be used to explore other extraterrestrial objects in the future. 展开更多
关键词 Lunar samples ENCAPSULATION vacuum seal MECHANISM
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归因分析理论下护理流程再造对骨折负压封闭引流术术后患者的恢复影响
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作者 罗美凤 《中国医药指南》 2024年第8期56-58,共3页
目的 分析归因分析理论下护理流程再造对骨折负压封闭引流术(VSD)术后患者恢复的影响。方法 选取我院2022年2月至2023年3月收治的82例骨折VSD术后患者,随机分为参照组和试验组,每组各41例,参照组采用一般性护理干预,试验组采用归因分析... 目的 分析归因分析理论下护理流程再造对骨折负压封闭引流术(VSD)术后患者恢复的影响。方法 选取我院2022年2月至2023年3月收治的82例骨折VSD术后患者,随机分为参照组和试验组,每组各41例,参照组采用一般性护理干预,试验组采用归因分析理论下护理流程再造模式,对比两组骨折VSD术后患者二期植皮天数、创面缩小面积、平均骨折愈合时间、住院时间和并发症发生率及两组疼痛评分、焦虑评分改善情况。结果 试验组二期植皮天数、平均骨折愈合时间、住院时间明显短于参照组(P <0.05),创面缩小面积明显大于参照组(P <0.05);试验组骨折患者疼痛评分、焦虑评分改善情况明显优于参照组(P <0.05),并发症发生率低于参照组(P <0.05)。结论 归因分析理论下护理流程再造对骨折VSD术后患者恢复具有良好的应用效果,更有利于缩短患者恢复时间,改善患者疼痛程度和焦虑心理,减少并发症发生。 展开更多
关键词 归因分析理论 护理流程再造 骨折 负压封闭引流术
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自体富血小板血浆联合负压封闭引流对糖尿病足溃疡患者创面愈合情况的影响
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作者 刘晶 阎红云 王曦晨 《当代医学》 2024年第2期24-28,共5页
目的探究自体富血小板血浆联合负压封闭引流对糖尿病足溃疡患者创面愈合情况的影响。方法选取2018年1月至2020年12月大连大学附属中山医院收治的100例Wagner 2~4级糖尿病足溃疡患者作为研究对象,使用抽签法分为对照组与研究组,每组50例... 目的探究自体富血小板血浆联合负压封闭引流对糖尿病足溃疡患者创面愈合情况的影响。方法选取2018年1月至2020年12月大连大学附属中山医院收治的100例Wagner 2~4级糖尿病足溃疡患者作为研究对象,使用抽签法分为对照组与研究组,每组50例。对照组采用常规方案治疗,研究组采用自体富血小板血浆联合负压封闭引流治疗。比较两组临床疗效、瘙痒评分、疼痛评分[数字评分法(NRS)]、肉芽组织血管生成因子[碱性成纤维细胞生长因子(bFCF)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)]水平、临床指标、血糖指标[空腹血糖(FPG)、糖化血红蛋白Alc(HbAlc)、餐后2 h血糖(2 h PBG)]、胰岛素水平[空腹胰岛素(FIns)、稳态模型评估-胰岛素抵抗指数(HOMA-IR)]。结果研究组治疗总有效率为98.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,两组瘙痒评分、NRS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组bFCF、EGF、VEGF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组创面愈合时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组FPG、HbAlc、2 h PBG、HOMA-IR水平均低于治疗前,FIns水平均高于治疗前,且研究组FPG、HbAlc、2 h PBG、HOMA-IR水平均低于对照组,FIns高于对照组,差异有统计学意义(P<0.05)。结论自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡效果显著,可促进患者创面愈合,改善患者临床症状,值得临床推广应用。 展开更多
关键词 自体富血小板血浆 负压封闭引流 糖尿病足溃疡 创面愈合
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The Application of Bilayer Artificial Dermis Combined with VSD Technology in Chronic Wounds
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作者 Xianjin Dong Huasong Luo 《Journal of Biosciences and Medicines》 2024年第3期238-244,共7页
Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD... Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD) technology in the treatment of chronic wounds. Method: From June 2021 to December 2023, our hospital treated 24 patients with chronic skin tissue wounds on their limbs using a novel tissue engineering product, the bilayer artificial dermis, in combination with VSD technology to repair the wounds. The bilayer artificial dermis protects subcutaneous tissue, blood vessels, nerves, muscles, and tendons, and also promotes the growth of granulation tissue and blood vessels to aid in wound healing when used in conjunction with VSD technology for wound dressing changes in chronic wounds. Results: In this study, 24 cases of chronic wounds with exposed bone or tendon larger than 1.0 cm2 were treated with a bilayer artificial skin combined with VSD dressing after wound debridement. The wounds were not suitable for immediate skin grafting. At 2 - 3 weeks post-treatment, good granulation tissue growth was observed. Subsequent procedures included thick skin grafting or wound dressing changes until complete wound healing. Patients were followed up on average for 3 months (range: 1 - 12 months) post-surgery. Comparative analysis of the appearance, function, skin color, elasticity, and sensation of the healed chronic wounds revealed superior outcomes compared to traditional skin fl repairs, resulting in significantly higher satisfaction levels among patients and their families. Conclusion: The application of bilayer artificial dermis combined with VSD technology for the repair of chronic wounds proves to be a viable method, yielding satisfactory therapeutic effects compared to traditional skin flap procedures. 展开更多
关键词 Bilayer Artificial Dermis vacuum sealing Drainage (VSD) Chronic Wounds Wound Healing APPLICATION
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孟加拉滨海相复杂互层地基真空预压加固特性研究
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作者 胡小波 王海燕 +1 位作者 康湘龙 贾涛 《水运工程》 2024年第5期207-214,共8页
针对孟加拉国某港口工程真空预压加固中遇到的透水性较差的黏土层和透水性较好的砂土层反复交互出现,可能存在边界透水透气、地基固结规律复杂难以预测、地基加固效果难以预测等问题。依托工程的试验区块及典型施工区块,研究黏土搅拌桩... 针对孟加拉国某港口工程真空预压加固中遇到的透水性较差的黏土层和透水性较好的砂土层反复交互出现,可能存在边界透水透气、地基固结规律复杂难以预测、地基加固效果难以预测等问题。依托工程的试验区块及典型施工区块,研究黏土搅拌桩的密封墙密封效果、透水层对固结速度理论计算的影响、复杂互层场地加固后的物理力学特性改变等。主要采用试验检测和试验实测数据与理论计算数据对比分析的方法,对表层沉降-时程曲线、孔隙水压力消散曲线、加固前后的SPT指标、压缩性指标等比较研究。结果表明:黏土密封墙在粉砂地层具有良好的适应性,透水性砂层的存在对于实际场地固结的影响远小于理论或者理想边界条件下的试验,真空预压对于复杂互层地基具有较好的加固效果等。对于在复杂互层地基上的真空预压法加固设计具有一定的参考意义。 展开更多
关键词 复杂互层地基 真空预压加固 黏土密封墙
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铀矿实物地质资料保护技术探究——以铀矿岩心保护为例
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作者 田宇 刘丹 陈江源 《铀矿地质》 CAS CSCD 2024年第5期1014-1018,共5页
岩心是铀矿资源勘查和开发中重要的数据来源,其对于研究矿床成因、预测矿床分布、评价矿产资源量和开采等具有重要意义。文章深入探究了岩心的保护技术,分析了目前常见的保护方法——石蜡封护法、树脂浇筑法以及真空包覆法的优缺点及对... 岩心是铀矿资源勘查和开发中重要的数据来源,其对于研究矿床成因、预测矿床分布、评价矿产资源量和开采等具有重要意义。文章深入探究了岩心的保护技术,分析了目前常见的保护方法——石蜡封护法、树脂浇筑法以及真空包覆法的优缺点及对铀矿岩心的适用性。研究结果表明,石蜡封护法、树脂浇筑法和真空包覆法均可用于铀矿岩心保护,应根据实际需要选择最适合的方法,真空包覆法在铀矿实物地质资料保护中的实用性更强,应加强这一方法的应用研究。 展开更多
关键词 铀矿岩心 保护技术 石蜡封护法 树脂浇筑法 真空包覆法
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脐带间充质干细胞移植联合负压封闭引流技术治疗糖尿病足溃疡的疗效观察 被引量:1
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作者 王小飞 高素文 张贞 《安徽医药》 CAS 2024年第4期777-781,I0004,共6页
目的 观察脐带间充质干细胞移植(UCMSCs)联合负压封闭引流技术(VSD)治疗糖尿病足溃疡(DFU)的疗效。方法纳入2020年5月至2022年5月邯郸市中心医院收治的86例DFU病人,根据随机数字表法分为引流组(43例)和联合组(43例)。其中引流组给予VSD... 目的 观察脐带间充质干细胞移植(UCMSCs)联合负压封闭引流技术(VSD)治疗糖尿病足溃疡(DFU)的疗效。方法纳入2020年5月至2022年5月邯郸市中心医院收治的86例DFU病人,根据随机数字表法分为引流组(43例)和联合组(43例)。其中引流组给予VSD,联合组给予UCMSCs联合VSD。比较两组创面愈合时间及创面愈合率,足部相关指标[足背动脉血管内径、血流速度、踝肱指数(ABI)],周围血管恢复情况[密歇根神经体征评分(MNSI)、CT血管造影(CTA)检查],炎症指标[C反应蛋白(CRP)、白细胞(WBC)、中性粒细胞百分比(NEU%)],肾功能(尿酸、肌酐)及临床疗效。结果 联合组创面愈合率[(68.42±6.95)%比(52.78±5.35)%]明显高于引流组(P<0.05),创面愈合时间[(27.34±2.76)d比(31.46±3.25)d]明显低于引流组(P<0.05);引流组和联合组治疗后足背动脉血管内径[(1.95±0.21)mm比(1.86±0.17)mm,(2.10±0.35)mm比(1.82±0.15)mm]、ABI(0.87±0.26比0.61±0.15,0.75±0.21比0.64±0.17)均明显升高(P<0.05),且与引流组比较,联合组明显升高(P<0.05);与治疗前比较,引流组和联合组治疗后足背动脉血流速度[(47.35±4.75)cm/s比(52.75±5.32)cm/s,(41.78±4.27)cm/s比(52.14±5.26)cm/s]、MNSI评分(4.68±0.51比5.74±0.61,4.12±0.42比5.89±0.65)、CRP[(35.78±3.62)mg/L比(41.78±4.25)mg/L,(29.36±3.02)mg/L比(2.14±4.31)mg/L]、WBC[(7.58±0.79)×10^(9)/L比(9.45±1.06)×10^(9)/L,(6.42±0.67)×10^(9)/L比(9.12±1.01)×10^(9)/L]、NEU%[(64.31±6.53)%比(69.72±7.02)%,(58.14±5.86)%比(70.54±7.11)%]水平均明显降低(P<0.05),且与引流组比较,联合组明显降低(P<0.05);联合组总有效率(95.35%)明显高于引流组(72.09%),联合组临床疗效优于引流组(Z=2.09,P<0.05)。结论UCMSCs联合VSD治疗DFU可有效减轻炎症反应,改善临床症状,促进创面恢复,效果较好。 展开更多
关键词 糖尿病足 溃疡 负压封闭引流技术 脐带间充质干细胞 疗效
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负压封闭引流联合威伐光治疗难愈性创面的临床效果观察 被引量:1
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作者 郭忠梁 刘元媛 +2 位作者 刘应平 王静 徐敏 《医药前沿》 2024年第8期6-9,共4页
目的:观察负压封闭引流(VSD)联合威伐光(wIRA)治疗难愈性创面的临床效果。方法:选取2020年1月—2023年1月遂宁市中心医院收治的64例难愈性创面患者,按住院顺序排列,分为试验组和对照组,每组32例。试验组清创术后实施VSD+wIRA治疗,对照... 目的:观察负压封闭引流(VSD)联合威伐光(wIRA)治疗难愈性创面的临床效果。方法:选取2020年1月—2023年1月遂宁市中心医院收治的64例难愈性创面患者,按住院顺序排列,分为试验组和对照组,每组32例。试验组清创术后实施VSD+wIRA治疗,对照组清创术后实施换药治疗。观察两组肉芽生长速度、创面愈合速度、治疗时间以及临床换药次数。结果:试验组治疗第7天创面肉芽生长情况评分高于对照组,差异有统计学意义(P<0.05);试验组行Ⅱ期手术闭合创面的时间短于对照组,差异有统计学意义(P<0.05);试验组行Ⅱ期手术术前1d创面肉芽组织生长情况评分低于对照组,差异有统计学意义(P<0.05);试验组换药次数少于对照组,差异有统计学意义(P<0.05)。结论:VSD技术联合wIRA治疗难愈性创面的疗效确切,能缩短病程,是一种较理想的治疗方式。 展开更多
关键词 负压封闭引流 难愈创面 威伐光
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福尼尔坏疽负压清创治疗并阴囊重建一例
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作者 辜祖玄 姚海军 +6 位作者 潘惟昕 郑大超 谢敏凯 万祥 倪剑书 曾文锋 王忠 《海南医学》 CAS 2024年第11期1654-1657,共4页
福尼尔(Fournier)坏疽是一种罕见且进展迅速的生殖器和会阴组织坏死性筋膜炎,该病起病急、病程短、发展快,严重者向盆腔和下腹壁蔓延,病死率高,为泌尿生殖系统的急重症之一。早期治疗是防治Fournier坏疽的关键。Fournier坏疽治疗有清创... 福尼尔(Fournier)坏疽是一种罕见且进展迅速的生殖器和会阴组织坏死性筋膜炎,该病起病急、病程短、发展快,严重者向盆腔和下腹壁蔓延,病死率高,为泌尿生殖系统的急重症之一。早期治疗是防治Fournier坏疽的关键。Fournier坏疽治疗有清创后缝合、重建和负压吸引等治疗方式。本病例通过VSD负压吸引以及局部清创缝合,应用常规抗生素的方式进行治疗,效果显著,预后良好。 展开更多
关键词 福尼尔坏疽 负压封闭引流技术 清创 阴囊重建
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老年营养风险指数、血清25羟维生素D水平与糖尿病足溃疡VSD治疗效果的关系
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作者 白顺宁 曹尚鹏 +4 位作者 李康 丁俊杰 张斌杰 周飞 高慧 《山东医药》 CAS 2024年第16期19-23,共5页
目的探讨老年营养风险指数(GNRI)、血清25羟维生素D[25(OH)D]水平与糖尿病足溃疡(DFU)患者负压封闭引流(VSD)治疗效果的关系。方法选取接受VSD术的DFU患者106例为DFU组,根据VSD治疗效果分为无效组(27例)和有效组(79例);同期另选取55例单... 目的探讨老年营养风险指数(GNRI)、血清25羟维生素D[25(OH)D]水平与糖尿病足溃疡(DFU)患者负压封闭引流(VSD)治疗效果的关系。方法选取接受VSD术的DFU患者106例为DFU组,根据VSD治疗效果分为无效组(27例)和有效组(79例);同期另选取55例单纯2型糖尿病(T2DM)患者为单纯T2DM组,55名健康体检志愿者为对照组。计算GNRI,检测血清25(OH)D。用多因素Logistic回归分析DFU患者VSD治疗效果的影响因素,受试者工作特征曲线分析GNRI联合血清25(OH)D对DFU患者VSD治疗效果的评估价值。结果DFU组、单纯T2DM组、对照组GNRI、血清25(OH)D水平比较差异均有统计学意义(P均<0.05),三组GNRI、血清25(OH)D水平依次降低(P均<0.05)。Wagner分级4级、HbA1c升高为DFU患者VSD治疗无效的独立危险因素(P均<0.05),踝肱指数、GNRI、25(OH)D升高为DFU患者VSD治疗有效的独立保护因素(P均<0.05)。GNRI联合血清25(OH)D水平评估DFU患者VSD治疗效果的曲线下面积为0.879,大于二者单独评估的0.800、0.879(P均<0.05)。结论GNRI、血清25(OH)D水平低的DFU患者VSD治疗效果差,二者联合对DFU患者VSD治疗效果的评估价值较高。 展开更多
关键词 糖尿病足溃疡 老年营养风险指数 25羟维生素D 负压封闭引流 治疗效果
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微骨窗骨搬移联合负压封闭引流治疗糖尿病足:双中心回顾性队列研究
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作者 刘俊鹏 杜心如 +4 位作者 要星晨 徐子彧 裴福春 张林 赵会 《实用医学杂志》 CAS 北大核心 2024年第18期2590-2596,共7页
目的 评估微骨窗胫骨横向骨搬移(tibial transverse transport, TTT)的疗效,并探讨其与负压封闭引流(vacuum sealing drainage, VSD)联合治疗的潜在益处。方法 回顾分析自2020年7月至2022年12月收治的Wagner分级≥2级的糖尿病足患者资... 目的 评估微骨窗胫骨横向骨搬移(tibial transverse transport, TTT)的疗效,并探讨其与负压封闭引流(vacuum sealing drainage, VSD)联合治疗的潜在益处。方法 回顾分析自2020年7月至2022年12月收治的Wagner分级≥2级的糖尿病足患者资料。依据治疗方案的差异,将患者分为三组:VSD治疗(VSD组)、微骨窗TTT治疗(TTT组)以及微骨窗TTT联合VSD治疗(联合组)。进行为期1年的随访。记录并比较三组患者的一般资料、术前及术后3个月的溃疡面积、踝肱指数、疼痛目测类比评分,以及术后1年内溃疡复发、手术并发症以及截肢情况。结果 共纳入VSD组患者43例,TTT组43例,联合组42例。三组患者的基线资料差异无统计学意义(P> 0.05)。与TTT组相比,VSD组患者的溃疡愈合时间更长,术后3个月时患者的疼痛评分更高,踝肱指数更低(P <0.05),溃疡面积更大(P=0.029),1年溃疡复发率更高(P=0.021)。与TTT组相比,联合组患者的溃疡愈合时间更短(P=0.046)。术后3个月时溃疡面积(P=0.362)、疼痛评分(P=0.932)、踝肱指数(P=0.671)以及1年溃疡复发率(P=0.710)差异均无统计学意义。结论 微骨窗TTT在促进溃疡愈合,缓解疼痛,改善下肢血运方面的效果明显优于VSD。在应用微骨窗TTT的基础上加用VSD可以进一步缩短伤口愈合时间,降低患者和医护的创面护理负担。 展开更多
关键词 糖尿病足 胫骨横向骨搬移 负压封闭引流 血管再生 清创术
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自体富血小板血浆联合封闭负压引流治疗胫前慢性难愈性创面的临床疗效观察
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作者 浦飞飞 赵晓龙 +3 位作者 杨林 刘伟 冯晶 夏平 《生物骨科材料与临床研究》 CAS 2024年第2期57-60,共4页
目的 研究应用自体富血小板血浆(platelet-rich plasma, PRP)联合持续封闭负压引流(vacuum sealing drainage, VSD)治疗胫前慢性难愈性创面患者的临床治疗效果。方法 选择2018年1月至2022年12月武汉市第一医院收治的胫前慢性难愈性创面... 目的 研究应用自体富血小板血浆(platelet-rich plasma, PRP)联合持续封闭负压引流(vacuum sealing drainage, VSD)治疗胫前慢性难愈性创面患者的临床治疗效果。方法 选择2018年1月至2022年12月武汉市第一医院收治的胫前慢性难愈性创面患者40例,按随机数字表法分为PRP+VSD组和VSD组,每组20例。PRP+VSD组采用PRP联合VSD治疗,VSD组采用VSD治疗。比较两组患者的住院时间、抗菌药物使用时间、创面愈合时间、医疗费用和创面愈合情况。结果 两组患者均获随访,PRP+VSD组随访时间2~12个月(平均3.72个月),VSD组随访时间3~14个月(平均4.25个月)。PRP+VSD组的住院时间、抗菌药物使用时间、创面愈合时间均低于VSD组(P<0.05)。PRP+VSD组医疗费用高于VSD组,但两组比较差异无统计学意义(P>0.05)。PRP+VSD组20例患者创面全部愈合,其中16例患者一次性愈合,4例患者经过2次PRP+VSD治疗后愈合。VSD组9例患者一次性愈合,其余11例患者均经多次清创和VSD治疗才使创面完全愈合。结论 自体PRP联合VSD治疗胫前慢性难愈性创面可缩短创面愈合时间、患者住院时间和抗菌药物使用时间,降低二次手术率。自体PRP联合VSD是治疗胫前慢性难愈性创面的有效方法,为慢性难愈性创面的修复治疗提供了临床指导。 展开更多
关键词 慢性难愈性创面 胫前 富血小板血浆 封闭负压引流
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负压封闭吸引对结核术后难愈性创面中相关因子表达及预后的研究
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作者 张磊 秦学博 +3 位作者 段小亮 李建行 陈亮 李义帅 《临床肺科杂志》 2024年第2期167-171,共5页
目的探讨应用负压封闭引流(VSD)治疗结核术后出现难愈性创面的患者,研究其相关因子的表达及预后。方法选取2016年1月-2022年5月我院胸外科结核术后出现伤口愈合不良的患者76例,按数字表格法分为观察组和对照组,每组38例,观察组接受VSD治... 目的探讨应用负压封闭引流(VSD)治疗结核术后出现难愈性创面的患者,研究其相关因子的表达及预后。方法选取2016年1月-2022年5月我院胸外科结核术后出现伤口愈合不良的患者76例,按数字表格法分为观察组和对照组,每组38例,观察组接受VSD治疗,对照组接受外科换药治疗,在治疗前和治疗后第7天用ELISA法测定血清中TNF-α、IL-4、IL-8、IL-10的含量和伤口肉芽组织中TGF-β1、VEGF、HIF-1α的含量及伤口愈合拆线时间。结果比较两组治疗前TNF-α、IL-4、IL-8、IL-10及TGF-β1、VEGF、HIF-1α水平,差异无统计学意义(P>0.05)。治疗后第7天检测,TNF-α、IL-8较治疗前均降低,其中观察组较对照组降低更明显(P<0.05);IL-4、IL-10较治疗前均升高,其中观察组较对照组升高更明显(P<0.05);TGF-β1、VEGF较治疗前均升高,其中观察组较对照组升高更明显(P<0.05);HIF-1α较治疗前均降低,其中观察组较对照组降低更明显(P<0.05)。观察组愈合拆线时间较对照组明显缩短,差异有统计学意义(P<0.05)。结论应用VSD治疗结核术后出现的难愈性创面,可以减轻炎症反应,促进增殖、修复,加速创面愈合。 展开更多
关键词 负压封闭吸引 结核术后 难愈性创面 炎症因子 创面愈合 结核外科
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