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Forensic Validation Studies of a Novel 35-InDel Multiplex Polymerase Chain Reaction System
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作者 Tong Xie Hui Xu +5 位作者 Congying Zhao Yating Fang Yongsong Zhou Qiong Lan Chunmei Shen Bofeng Zhu 《Journal of Forensic Science and Medicine》 2023年第4期303-308,I0004-I0011,共14页
Background:A difficulty associated with forensic applications is the detection of degraded biological materials.Due to the large amplicon sizes of short tandem repeat alleles,valid genotyping results cannot be obtaine... Background:A difficulty associated with forensic applications is the detection of degraded biological materials.Due to the large amplicon sizes of short tandem repeat alleles,valid genotyping results cannot be obtained from degraded biological materials.Recently,insertion/deletion(InDel)polymorphisms have been used in forensic applications for their widespread distributions in the human genome,short amplicon sizes,and low mutation rates.Purpose:Human identification InDel panels have mostly been designed for European populations.Therefore,our laboratory independently developed a multiplex polymerase chain reaction(PCR)system with 35 polymorphic InDel loci to be used for human identification in China.Forensic validation studies were conducted on this novel 35-InDel multiplex PCR system.Methods:The 35 InDel loci were screened in the database,and then used with the traditional PCR amplification and capillary electrophoresis platform combined with five-color fluorescence parallel detection technology.Validation studies were performed on this novel panel,including accuracy,repeatability and reproducibility,species specificity,sensitivity,stability,forensic case sample detection,and mixture studies.In addition,forensic efficiency assessments were conducted in populations from different continents.Results:The data of validated studies indicated that the novel 35-InDel panel was accurate,stable,and efficient for forensic purposes.For human identification,the cumulative power of discrimination values for the these 35 InDel loci in East Asian,South Asian,European,American,and African populations were 0.999999999999995,0.999999999999995,0.999999999999971,0.9999999999999960,and 0.999999999998166,respectively.Conclusions:In this study,a set of 35 InDel loci were conducted in a multiplex amplification system for human identification of degraded DNA sample,and this new assay was efficient and stable.The present results suggested that the 35-InDel panel was a reliable tool for forensic use and could be efficiently used for human identification in the East Asian populations. 展开更多
关键词 35-InDel panel human identification insertion/deletion polymorphism validation study
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Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China 被引量:11
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作者 Xiao-Ping Tian Ying Li +6 位作者 Fan-Rong Liang Guo-Jie Sun Jie Yan Xiao-Rong Chang Ting-Ting Ma Shu-Yuan Yu Xu-Guang Yang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第25期3173-3177,共5页
AIM: To assess the reliability and validity of the translated version of Nepean Dyspepsia Index (NDI) in Chinese patients with documented functional dyspepsia (FO). METHODS: The translation process included forw... AIM: To assess the reliability and validity of the translated version of Nepean Dyspepsia Index (NDI) in Chinese patients with documented functional dyspepsia (FO). METHODS: The translation process included forward translation, back translation, pretest and cross-cultural adaptation. Reliability and validity of the translated version were examined by asking 300 subjects to complete the Chinese version of the NDI. The mean age of subjects was 39.24 years and 68.7% of the subjects were women. Internal consistency analysis with Cronbach's α was performed to test the reliability. Correlation analysis was used to assess the content validity. Factor analysis and structural equation models were used to assess the construct validity. RESULTS: The Cronbach's α coefficients ranged 0.833-0.960, well above the acceptable level of 0.70. Correlation analysis showed that each item had a strong correlation with the corresponding domain, but a weak correlation with other domains. Confirmatory factor analysis indicated that the comparative fit index was 0.94, higher than the acceptable level of 0.90.CONCLUSION: The Chinese version of the NDI is a reliable and valid scale for measuring health-related quality of life and disease severity in Chinese patients with FD. 展开更多
关键词 Nepean Dyspepsia Index Functional dyspepsia Health-related quality of life validation studies Questionaires
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Validity and Reliability of a Mental Health Recovery Checklist for Young Adults
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作者 Brianna Cerrito Jamie Xiao +2 位作者 Amie DiTomasso Amanda Fialk Jocelyn Bolin 《International Journal of Mental Health Promotion》 2024年第4期317-323,共7页
The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occu... The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occupation and school,physical health,mental health,spirituality,and social support systems.The Mental Health Recovery Checklist(MHRC)was developed at The Dorm,an intensive outpatient mental health treatment program for young adults in New York,NY,and Washington DC that services individuals between the ages of 18 and 35 years old.The present study is cross-sectional,as data were pulled from clients’records who were discharged between January 2018 and May 2023.Pearson Correlations and Cronbach’s alpha were used to determine scale reliability.To establish validity,an Exploratory Factor Analysis(EFA)was conducted to assess a single-factor model using Principal Axis Factoring.Cronbach’s alpha was high(α=0.88),indicating good reliability.In the EFA,all items loaded strongly on a single factor.The unidimensional structure revealed in the EFA highlights the interconnected nature of various life domains as they pertain to mental health recovery in young adults.Future research is warranted to explore whether there are additional dimensions of mental health recovery that have not been assessed in the present scale. 展开更多
关键词 Mental health recovery young adult validation study mental health checklist
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Validation of the Trail Making Test B for the Cognitive Assessment of Patients with Cancer in Palliative Care
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作者 Juliano dos Santos Cibele Andrucioli de Mattos Pimenta +2 位作者 Geana Paula Kurita Patricia Emilia Braga Per Sjogren 《Open Journal of Statistics》 2014年第6期435-445,共11页
Introduction: Cognitive impairment is common in patients with cancer;however, studies examining the adaptation and validation of instruments for use in patients with cancer are scarce. Purpose: The purpose of this stu... Introduction: Cognitive impairment is common in patients with cancer;however, studies examining the adaptation and validation of instruments for use in patients with cancer are scarce. Purpose: The purpose of this study was to validate the Trail Making Test B (TMT-B) for use in patients with cancer. Methods: Ninety-four outpatients receiving palliative treatment and 39 healthy companions were assessed. Patients were tested with the TMT-B and answered questions regarding the presence and intensity of pain, fatigue, quality of sleep, anxiety, and depression, at two time points with a 7-day inter-assessment interval. Results: The instrument discriminated between patients, who were slower, and healthy companions with respect to the time required to complete the test, but not in terms of the number of errors. The test was stable for the healthy companions across the two assessments in terms of time to complete the TMT-B and the number of errors;for patients, the instrument was stable only for the number of errors. Performance on the TMT-B did not correlate with pain, fatigue, depression, anxiety, or sensation of rest. Conclusions: TMT-B cannot be considered fully validated. Further studies incorporating and comparing other instruments evaluating executive function and mental flexibility are needed. 展开更多
关键词 COGNITION Executive Function Hospice Care NEOPLASMS Neuropsychological Tests validation studies
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Validation of Peek Acuity application in pediatric screening programs in Paraguay 被引量:2
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作者 Bryce de Venecia Yasmin Bradfield +2 位作者 Ralph Moiler Trane Alicia Bareiro Miguel Scalamogna 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第8期1384-1389,共6页
AIM: To validate the Peek Acuity mobile phone application in pediatric populations and compare its utility, both economic and diagnostic, against conventional screening methods using a pediatric ophthalmologist exami... AIM: To validate the Peek Acuity mobile phone application in pediatric populations and compare its utility, both economic and diagnostic, against conventional screening methods using a pediatric ophthalmologist examination as the gold standard.METHODS: A cohort of 393 subjects from Fernando de la Mora, Paraguay(ages 6-16 y) were enrolled in the study. Subjects were randomly assigned a starting screening modality among: Peek Acuity, a single line of tumbling E optotypes set at 20/40, and Spot Vision Screener. Once completing the first screening modality, the subjects completed the two remaining techniques. Referral criteria were established based on the most current American Association of Pediatric Ophthalmology and Strabismus(AAPOS) recommendations: 20/40 for Peek Acuity and the tumbling E, and refractive error detection for the Spot Vision Screener. Subjects that failed to achieve the cutoff for any of the three screening techniques or subjects that passed the screening but were randomly selected to perform a comprehensive eye exam to determine the false negative rate, were evaluated by a pediatric ophthalmologist. This evaluation was considered the gold standard, and included vision assessment by a Snellen chart, strabismus evaluation, and cycloplegic refraction with dilated fundoscopy.RESULTS: We obtained 48% sensitivity, 83% specificity, 43% positive predictive value, and 86% negative predictive value for Peek Acuity's ability to refer compared to evaluation by a pediatric ophthalmologist, failing to achieve a desired sensitivity for implementation. Peek Acuity trended to overestimate the subject's visual acuity, providing a higher visual acuity that would not indicate referral for a comprehensive eye examination. However, its high specificity accurately predicted a significant number of children who did not need further evaluation. When comparing the three screening methods, no single screening modality outperformed the others. Peek Acuity represented a technology that was economically feasible compared to other screening modalities in low income settings, due to the prevalence of cell phone use.CONCLUSION: Peek Acuity represents an efficient tool that has potential for implementation in school screenings with different strategies aimed at pediatric populations due to its low cost and high specificity. An increase in sensitivity would improve detection of children with refractive errors. 展开更多
关键词 pediatric ophthalmology validation study SCREENING mobile phone application
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Snow and sea ice thermodynamics in the Arctic:Model validation and sensitivity study against SHEBA data 被引量:6
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作者 Cheng Bin Timo Vihma +2 位作者 Zhang Zhanhai Li Zhijun Wu Huiding 《Chinese Journal of Polar Science》 2008年第2期108-122,共15页
Evolution of the Arctic sea ice and its snow cover during the SHEBA year were simulated by applying a high-resolution thermodynamic snow/ice model (HIGHTSI). Attention was paid to the impact of albedo on snow and se... Evolution of the Arctic sea ice and its snow cover during the SHEBA year were simulated by applying a high-resolution thermodynamic snow/ice model (HIGHTSI). Attention was paid to the impact of albedo on snow and sea ice mass balance, effect of snow on total ice mass balance, and the model vertical resolution. The SHEBA annual simulation was made applying the best possible external forcing data set created by the Sea Ice Model Intercomparison Project. The HIGHTSI control run reasonably reproduced the observed snow and ice thickness. A number of albedo schemes were incorporated into HIGHTSI to study the feedback processes between the albedo and snow and ice thickness. The snow thickness turned out to be an essential variable in the albedo parameterization. Albedo schemes dependent on the surface temperature were liable to excessive positive feedback effects generated by errors in the modelled surface temperature. The superimposed ice formation should be taken into account for the annual Arctic sea ice mass balance. 展开更多
关键词 ARCTIC sea ice Model validation and sensitivity study SHEBA data.
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Evaluation of joint awareness after acetabular fracture:Validation of the Forgotten Joint Score according to the COSMIN checklist protocol
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作者 Viola Freigang Johannes Weber +4 位作者 Karolina Mueller Christian Pfeifer Michael Worlicek Volker Alt Florian Michael Baumann 《World Journal of Orthopedics》 2021年第2期69-81,共13页
BACKGROUND A fracture of the acetabulum is an uncommon,but serious injury.Established outcome tools do not reflect the patient’s perspective after fracture of the hip joint.Originally designed for post-arthroplasty p... BACKGROUND A fracture of the acetabulum is an uncommon,but serious injury.Established outcome tools do not reflect the patient’s perspective after fracture of the hip joint.Originally designed for post-arthroplasty patients,the Forgotten Joint Score(FJS)is a patient-reported outcome measurement(PROM)tool evaluating the diseasespecific health-related quality of life(HR-QoL).AIM To validate the FJS in patients after acetabular fracture.METHODS In a prospective mono-centric cohort study,we evaluated 100 patients at mean 5.2±3.6 years after a fracture of the acetabulum.The validation study followed the complete COSMIN checklist protocol.For calculation of convergent validity,we used the Tegner-Activity Scale,the Western Ontario and McMaster Universities Osteoarthritis Index,the EuroQol-5D,and a subjective rating of change as an anchor variable.RESULTS We confirmed good internal consistency with a Cronbach‘s alpha of 0.95.With an intraclass correlation coefficient of 0.99(95%CI:0.97,0.99),test-retest reliability of the FJS was excellent.Correlation coefficients between the questionnaires were moderate to high ranging from|0.56|to|0.83|(absolute value).No relevant floor or ceiling effects occurred.Standard error of measurement was 3.2 and smallest detectable change(SDC)was 8.8.Thus,changes greater than 8.8 points between two assessments denote a real change in FJS.CONCLUSION The FJS is a valid and reliable tool for evaluation of patient-reported outcome in posttraumatic condition after acetabular fracture.The SDC indicating a real clinical improvement was 8.8 points in the FJS.We could confirm responsiveness of the FJS and found no relevant floor-or ceiling effects. 展开更多
关键词 Patient reported outcome measurement validation study Hip joint Forgotten Joint Score Acetabulum fracture COSMIN checklist
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Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes 被引量:21
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作者 Samuel Quan Alexandra Frolkis +9 位作者 Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan 《World Journal of Gastroenterology》 SCIE CAS 2014年第46期17568-17577,共10页
AIM: To evaluate the incidence, surgery, mortality, and readmission of upper gastrointestinal bleeding (UGIB) secondary to peptic ulcer disease (PUD).
关键词 EPIDEMIOLOGY Peptic ulcer hemorrhage Digestive system surgical procedures MORTALITY ENDOSCOPY validation studies INCIDENCE
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Accuracy of ultrasound elastography for predicting breast cancer response to neoadjuvant chemotherapy: A systematic review and meta-analysis 被引量:3
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作者 Wei Chen Li-Xiang Fang +1 位作者 Hai-Lan Chen Jian-Hua Zheng 《World Journal of Clinical Cases》 SCIE 2022年第11期3436-3448,共13页
BACKGROUND Several studies have reported the prognostic value of ultrasound elastography(UE)in patients receiving neoadjuvant chemotherapy(NACT)for breast cancer.However,the assessment of parameters differed between s... BACKGROUND Several studies have reported the prognostic value of ultrasound elastography(UE)in patients receiving neoadjuvant chemotherapy(NACT)for breast cancer.However,the assessment of parameters differed between shear-wave elastography and strain elastography in terms of measured elasticity parameter and mode of imaging.It is important,therefore,to assess the accuracy of the two modes of elastography.AIM To assess the accuracy of UE for predicting the pathologic complete response(pCR)in breast cancer patients following NACT.METHODS A comprehensive and systematic search was performed in the databases of MEDLINE,EMBASE,SCOPUS,PubMed Central,CINAHL,Web of Science and Cochrane library from inception until December 2020.Meta-analysis was performed using STATA software“Midas”package.RESULTS A total of 14 studies with 989 patients were included.The pooled sensitivities were 86%[95%confidence interval(CI):76%-92%]for UE,77%(95%CI:68%-84%)for shear-wave elasto-graphy,and 92%(95%CI:73%-98%)for strain-wave elastography.The pooled score specificities were 86%(95%CI:80%-90%)for UE,84%(95%CI:72%-91%)for shear-wave elasticity,and 87%(95%CI:81%-92%)for strain-wave elastography.A significant heterogeneity was found among studies based on the chi-square test results and an I2 statistic>75%.CONCLUSION Strain-wave type of UE can accurately predict the pCR following NACT amongst breast cancer patients.Studies exploring its accuracy in different ethnic populations are required to strengthen the evidence. 展开更多
关键词 Breast cancer CHEMOTHERAPY META-ANALYSIS Ultrasonography validation studies
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The effectiveness of the TAX 327 nomogram in predicting overall survival in Chinese patients with metastatic castration-resistant prostate cancer
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作者 Xiao-Jie Bian Yao Zhu +7 位作者 Yi-Jun Shen Jin-You Wang Chun-Guang Ma Hai-Liang Zhan Bo Dai Shi-Lin Zhang Xu-Dong Yao Ding-Wei Ye 《Asian Journal of Andrology》 SCIE CAS CSCD 2013年第5期679-684,共6页
Based on the results of TAX 327, a nomogram was developed to predict the overall survival of metastatic castration-resistant prostate cancer (mCRPC) after first-line chemotherapy. The nomogram, however, has not been... Based on the results of TAX 327, a nomogram was developed to predict the overall survival of metastatic castration-resistant prostate cancer (mCRPC) after first-line chemotherapy. The nomogram, however, has not been validated in an independent dataset, especially in a series out of clinical trials. Thus, the objective of the current study was to validate the TAX 327 nomogram in a community setting in China. A total of 146 patients with mCRPC who received first-line chemotherapy (docetaxel or mitoxantrone) were identified. Because clinical trials are limited in China's Mainland, those patients did not receive investigational treatment after the failure of first-line chemotherapy. The predicted overall survival rate was calculated from the TAX 327 nomogram. The validity of the model was assessed with discrimination, calibration and decision curve analysis. The median survival of the cohort was 21 months (docetaxel) and 19 months (mitoxantrone) at last follow-up. The predictive c-index of the TAX 327 nomogram was 0.66 (95% CI: 0.54-0.70). The calibration plot demonstrated that the 2-year survival rate was underestimated by the nomogram. Decision curve analysis showed a net benefit of the nomogram at a threshold probability greater than 30%. In conclusion, the present validation study did not confirm the predictive value of the TAX 327 nomogram in a contemporary community series of men in China, and further studies with a large sample size to develop or validate nomograms for predicting survival and selecting therapies in advanced prostate cancer are necessary. 展开更多
关键词 CASTRATION-RESISTANT CHEMOTHERAPY NOMOGRAM prostate cancer validation studies
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Disordered eating behaviour and eating disorder among adolescents with type 1 diabetes:An integrative review
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作者 Maria Conceição Santos Oliveira Cunha Francisco Clécio Silva Dutra +5 位作者 Laura Martins Mendes Cavaleiro Brito Rejane Ferreira Costa Maria Wendiane Gueiros Gaspar Danilo Ferreira Sousa Márcio Flávio Moura deAraújo Maria Veraci Oliveira Queiroz 《World Journal of Meta-Analysis》 2022年第5期244-254,共11页
BACKGROUND Type 1 diabetes(DT1)in adolescents brings behavioural changes,altered nutritional habits,and eating disorders.AIM To identify and analyze the validated instruments that examine the disordered eating behavio... BACKGROUND Type 1 diabetes(DT1)in adolescents brings behavioural changes,altered nutritional habits,and eating disorders.AIM To identify and analyze the validated instruments that examine the disordered eating behaviour and eating disorders among adolescents with DT1.METHODS An integrative review was accomplished based on the following databases:PubMed,LILACS,CINAHL,Scopus,Web of Science,and Reference Citation Analysis(RCA),including publications in Portuguese,English,or Spanish,without time limit and time published.RESULTS The main instruments to evaluate disordered eating behaviour were The Diabetes Eating Problem Survey-Revised,The Diabetes Eating Problem Survey,and the eating attitudes test-26,and for eating disorders the main instruments used were The Bulimic Investigation Test of Edinburgh,The Binge Eating Scale,The Child Eating Disorder Examination,The five questions of the(Sick,Control,One,Fat and Food),and The Mind Youth Questionnaire.These instruments showed an effect in evaluating risks regarding nutritional habits or feeding grievances,with outcomes related to weight control,inadequate use of insulin,and glycaemia unmanageability.We did not identify publication bias.CONCLUSION Around the world,the most used scale to study the risk of disordered eating behaviour or eating disorder is The Diabetes Eating Problem Survey-Revised.International researchers use this scale to identify high scores in adolescents with DT1 and a relationship with poorer glycemic control and psychological problems related to body image. 展开更多
关键词 ADOLESCENT Type 1 diabetes mellitus validation studies Nutritional behaviour Eating disorder REVIEW
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Multidimensional Pain Inventory(MPI):Adaptation to Orthodontic Patients and Its Psychometric Properties
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作者 Lucas Arrais Campos Jose Aparecido da Silva +2 位作者 Ary Santos-Pinto Joao Maroco Juliana Alvares Duarte Bonini Campos 《Pain Studies and Treatment》 2019年第1期1-20,共20页
Background: Pain perception may result from orthodontic treatment and should be considered in clinical management. Its assessment should not be limited to the intensity of perceived pain but should also consider the p... Background: Pain perception may result from orthodontic treatment and should be considered in clinical management. Its assessment should not be limited to the intensity of perceived pain but should also consider the psychosocial and behavioral aspects involved. Objective: The aims of this study were to adapt and validate the Multidimensional Pain Inventory (MPI) for orthodontic patients, and present a proposal to calculate an overall score of the pain-related aspects and compare these scores with the usual methodology used. Methods: Face validity of the MPI was estimated and orthodontic version (MPI-Orthodontic) was developed. Factorial validity was evaluated by confirmatory analysis. Convergent and discriminant validity and reliability were estimated. The fit of Second-Order Hierarchical Models was estimated. Concurrent validity of MPI-Orthodontic was evaluated against the Visual Analogue Scale. Invariance of the factorial models was evaluated for independent samples and according to sex and age. Overall score was calculated using the matrix of regression weights and compared to simple arithmetic mean. Results: 507 individuals (63.3% women;age: 26.32 (SD = 11.70) years) participated. For the fit of Part I (psychosocial aspects) of the MPI-Orthodontic, it added correlation between two items and excluded one item;for Part II (behavioral aspects) two items were excluded. The models presented adequate fit to the sample. Reliability was adequate. MPI-Orthodontic presented invariance for independent samples and adequate concurrent and divergent validity. Score obtained with the simple arithmetic mean was overestimated for Part I and underestimated for Part II. Conclusion: MPI-Orthodontic was valid, reliable and invariant for the evaluation of the orthodontic pain. It is recommended to calculate overall weighted scores for pain assessment. 展开更多
关键词 Pain Measurement ORTHODONTICS PSYCHOMETRICS validation studies Multidimensional Pain Inventory
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DPM dissipation experiment at MST's experimental mine and comparison with CFD simulation 被引量:9
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作者 ZHENG Yi LAN Hai THIRUVENGADAM Magesh TIEN Jerry C 《Journal of Coal Science & Engineering(China)》 2011年第3期285-289,共5页
Diesel Particulate Matter (DPM) is regulated in the U.S. for both underground coal and metal/nonmetal mines. Today, many underground mines still face difficulty in compliance with DPM regulations. The DPM research c... Diesel Particulate Matter (DPM) is regulated in the U.S. for both underground coal and metal/nonmetal mines. Today, many underground mines still face difficulty in compliance with DPM regulations. The DPM research carried out in Missouri University of Science and Technology (MST) is to use computational fluid dynamics (CFD) to study the DPM distribution in commonly used face areas. The result is expected to be used for selection of DPM reduction strategies and better working practices, which can help the underground mines to meet regulation limits and improve the working environment for the miners. An experiment was conducted at MST's Experimental Mine to validate CFD simulation. DPM was collected at four locations downstream of a stationary diesel engine. The experiment data were then compared with the CFD simulation results. The comparison shows that CFD simulation can forecast the location of DPM concentration with practical accuracy (less than 0.15 m). CFD can be used to further study DPM distribution in commonly used working faces and give guidance to DPM reduction. 展开更多
关键词 DPM DPM dissipation CFD validation study
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Development of a Training Textbook for Countermeasures to “Verbal Abuse, Physical Assault, and Harassment in Pediatric Medical Settings”
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作者 Rie Wakimizu Hinako Kuwahara +1 位作者 Yumiko Saito Makoto Saito 《Health》 2022年第1期63-69,共7页
<strong>Background: </strong>Recently, abuse, assault, and harassment in pediatric medical settings have become more serious. We extracted typical problems from a nationwide simultaneous survey on abuse in... <strong>Background: </strong>Recently, abuse, assault, and harassment in pediatric medical settings have become more serious. We extracted typical problems from a nationwide simultaneous survey on abuse in the pediatric medical field and developed a training textbook to simulate or discuss these issues with colleagues. This study aimed to confirm the validity and usability of the contents of this training textbook. <strong>Methods:</strong> The textbook was mailed to the heads of 51 medical institutions affiliated with the Society of Ambulatory and General Pediatrics of Japan (SAGPJ) and the participants of the SAGPJ online workshop, who were asked to evaluate the textbook using a three-point scale to answer the following questions and provide opinions and impressions about the textbook. Q1. Do you think the whole content and structure of this textbook are useful? Q2. Would you use this textbook as a training textbook for all staff at your facility? A simple tabulation was performed on the evaluation using a three-point scale, while content analysis was performed on the opinions and impressions of the participants. <strong>Results:</strong> In response to Q1 and Q2, all 63 staff members from 55 facilities answered “3: Yes.” Opinions and impressions on the training textbook included “I think it can be used for workplace training” and “it is useful for exchanging various opinions among staff members and gaining a common opinion.” <strong>Conclusion:</strong> We developed a training textbook on abuse, assault, and harassment in pediatric medical settings based on a nationwide survey and confirmed the validity and usability of its contents. 展开更多
关键词 PEDIATRIC Safety Management TEXTBOOK validation Study Workplace Violence
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Ten Rules of Foot Care—The Development of a Short Questionnaire for Patients with Diabetes
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作者 Ileana Antohe Alina Delia Popa 《Journal of Diabetes Mellitus》 2021年第3期83-96,共14页
<strong>Objective:</strong> The aim of this study was to develop and validate a questionnaire for patients with diabetes to assess the foot self-care. <strong>Methods:</strong> A validation stu... <strong>Objective:</strong> The aim of this study was to develop and validate a questionnaire for patients with diabetes to assess the foot self-care. <strong>Methods:</strong> A validation study was carried out in a sample of 200 patients with diabetes. Item analyses included the assessment of difficulty index, discrimination capacity and the correlation of items with the total score of the questionnaire. Factor analysis was used to test construct validity. Test-retest reliability was assessed with a sample of 31 patients. Criterion validity was determined by comparing the scores of patients with a history of foot ulcers with the scores of patients without this complication. <strong>Results:</strong> The internal consistency assessed by the Cronbach’s alpha (0.731) and test-retest reliability (r = 0.714, p = 0.001) for all sections were acceptable. Factor analysis revealed three factors: foot care, footwear and foot-damaging behavior, which explained 54.34% of the variance. All items had factor loading of greater than 0.4. Patients with diabetic neuropathy had a lower score after completing the foot care education questionnaire (Mann-Whitney U, p < 0.001). <strong>Conclusion:</strong> This questionnaire meets the reliability and validity conditions necessary for its application in our patients with diabetes. 展开更多
关键词 Diabetes Mellitus Foot Care validation Study Diabetic Foot Ulcers
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Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma 被引量:5
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作者 Takehiro Noji Satoko Uemura +10 位作者 Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano 《Hepatobiliary Surgery and Nutrition》 SCIE 2022年第3期375-385,共11页
Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed ... Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. 展开更多
关键词 Perihilar cholangiocarcinoma(PHCC) post operative mortality score post-hepatectomy liver failure score(PHLFS) validation study
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Method study and uncertainty analysis of calibration coefficients validation based on the Inner Mongolia test site 被引量:1
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作者 GAO HaiLiang GU XingFa +3 位作者 YU Tao GONG Hui LI JiaGuo LI XiaoYing 《Science China Earth Sciences》 SCIE EI CAS 2013年第9期1540-1547,共8页
Calibration coefficients validation is the foundation for ascertaining the sensor performance and carrying out the quantitative application.Based on the analysis of the differences between the calibration and validati... Calibration coefficients validation is the foundation for ascertaining the sensor performance and carrying out the quantitative application.Based on the analysis of the differences between the calibration and validation,two calibration coefficients validation methods were introduced in this paper.Taking the HJ-1A satellite CCD1 camera as an example,the uncertainties of calibration coefficients validation were analyzed.The calibration coefficients validation errors were simulated based on the measured data at an Inner Mongolia test site.The result showed that in the large view angle,the ground directional reflectance variation and the atmospheric path variation were the main error sources in calibration coefficients validation.The ground directional reflectance correction and atmospheric observation angle normalization should be carried out to improve the validation accuracy of calibration coefficients. 展开更多
关键词 Method study and uncertainty analysis of calibration coefficients validation based on the Inner Mongolia test site
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Validation of the Investigator 24plex QS Kit:a 6-dye multiplex PCR assay for forensic application in the Chinese Han population
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作者 Ruiyang Tao Chong Chen +6 位作者 Xiang Sheng Ruocheng Xia Xiaochun Zhang Jingyi Zhang Zihao Yang Suhua Zhang Chengtao Li 《Forensic Sciences Research》 CSCD 2022年第2期172-180,共9页
The Investigator 24plex QS Kit(QIAGEN,Hilden,Germany)is a 6-dye fluorescent chemistry short tandem repeat(STR)polymerase chain reaction(PCR)amplification system that simultaneously amplifies 20 of the expanded Combine... The Investigator 24plex QS Kit(QIAGEN,Hilden,Germany)is a 6-dye fluorescent chemistry short tandem repeat(STR)polymerase chain reaction(PCR)amplification system that simultaneously amplifies 20 of the expanded Combined DNA Index System(CODIS)core STR loci,SE33,DYS391,and the standard sex-determining locus,amelogenin,as well as two special internal performance quality sensor controls(QS1 and QS2),which are included in the primer mix to check the PCR performance.This study was designed to be a pilot evaluation of this STR-PCR kit in a Chinese Han population regarding the PCR conditions,sensitivity,precision,accuracy,repeatability,reproducibility,and concordance;tolerance to PCR inhibitors;applicability to real“forensic-type”samples;species specificity;mixture,balance and stutter analyses,and utility in a population investigation.The exhaustive validation studies demonstrated that the Investigator 24plex QS system is accurate,sensitive and robust for STR genotyping.In addition,these genetic markers in the population data in our study indicated that they can also be useful for forensic identification and paternity testing in the Chinese Han population. 展开更多
关键词 Forensic sciences forensic genetics short tandem repeat(STR)typing Investigator 24plex QS Kit validation study
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The effects of Park sham needles: a pilot study 被引量:2
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作者 May To Caroline Alexander 《Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第1期20-24,共5页
BACKGROUND: When performing clinical trials involving acupuncture, it can be difficult to choose a placebo control. OBJECTIVE: To validate the Park sham needle for use as a double-blind control intervention. DESIGN,... BACKGROUND: When performing clinical trials involving acupuncture, it can be difficult to choose a placebo control. OBJECTIVE: To validate the Park sham needle for use as a double-blind control intervention. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: Two different methods were employed. First, a researcher blinded to needle type administered the Park sham or a real needle, chosen at random, on the arms of 16 healthy volunteers. The researcher and the volunteers independently recorded which needle type they thought had been applied at each acupuncture point. Second, 19 patients with shoulder impingement syndrome were randomly assigned to receive acupuncture applied with the real needle or the Park sham needle, once a week for 6 weeks alongside a course of physiotherapy. At the end of the 6 sessions the patients recorded which needle type they thought was being used. The results were analyzed with a Fisher's exact test. This study was carried out in the Outpatient Department of Physiotherapy in Chafing Cross Hospital, London, UK, on healthy volunteers and patients with shoulder impingement pain. The age range was 23 to 54 and 22 to 74 years respectively. RESULTS: Of the healthy volunteers, there was no difference (P=0.23) between the number of needles that were correctly (n=43) or incorrectly identified (n=53). All patients thought that they had received the real needles. The researcher correctly identified all needles that were applied. CONCLUSION: The researcher delivering the acupuncture recognized the needle type. However, both healthy and patient volunteers were blind to the needle type. This demonstrates that the Park sham needle is an effective single-blind control. It should be noted that the number of patients recruited was small and the study was underpowered to detect an effect of treatment. 展开更多
关键词 ACUPUNCTURE PLACEBOS shoulder impingement syndrome validation studies as topic pilot projects
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Clinical and radiographic predictors in diagnosing sputum smear- negative pulmonary tuberculosis in HIV-negative patients: a cross- sectional study in China 被引量:2
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作者 LI Xin-xu JIANG Shi-wen +6 位作者 ZHANG Hui JING Kuan-he WANG Li LI Wei-bin LIU Xiao-qiu YAO Hong-yan WANG Li-xia 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第19期3662-3667,共6页
Background In county-level tuberculosis (TB) dispensaries in China,the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radio... Background In county-level tuberculosis (TB) dispensaries in China,the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors.Methods The study was conducted simultaneously in three counties per province in Chongqing Municipality and Liaoning Province in China between May 2005 and May 2006.A total of 432 new SNPT patients who are HIV-negative and more than 15 years old diagnosed by expert panels in county-level TB dispensaries were recruited.Their sputum samples were collected for culture before anti-TB treatment,and the treatment outcomes (changes of X-rays) were followed up at the end of the 6th month.Results Of the 432 SNPT patients,sputum culture positive (9.7%) or culture negative with good changes of X-rays at the end of the 6th month (73.6%) was validated as SNPT.Four predictive variables were associated with validated SNPT in the multivariate logistic regression model:age ≤55 years old (odds ratio (OR) 5.66; 95% CI 2.69-11.91),〉60 days of cough (OR 3.73; 95% CI 1.10-12.65),≥10% of pulmonary consolidation in the lungs (OR 5.40; 95% CI 2.90-10.06),and pulmonary consolidation in the upper lobe anterior segment (OR 3.00; 95% CI 1.57-5.72).The area under the receiver operating characteristic curve of the model was 0.77 (95% CI 0.71-0.83).Conclusion Four predictors of clinical and radiological characteristics that had a good diagnostic performance of SNPT deserve to be recommended as index indicators of SNPT diagnosis in county-level TB dispensaries in China. 展开更多
关键词 validation study TUBERCULOSIS smear negative pulmonary/radiography
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