The Lhasa River Basin forms an essential human settlement area in the southern part of the Qinghai-Tibet Plateau.This study employed ecosystem service value(ESV)evaluation model,terrain gradient grading,and Geodetecto...The Lhasa River Basin forms an essential human settlement area in the southern part of the Qinghai-Tibet Plateau.This study employed ecosystem service value(ESV)evaluation model,terrain gradient grading,and Geodetector to analyze land use and ESV in the Lhasa River Basin from 1985 to 2020.The findings reveal that:(1)From 1985 to 2020,grassland was the dominant land use.There was a trend of grassland reduction and the expansion of other land types.(2)ESV has increased over the research period(with a total increase of 0.84%),with higher values in the southeast and lower values in the northwest.Grassland contributed the most to ESV,and climate regulation and hydrological regulation were the ecosystem services that contribute the most to ESV.(3)Natural factors like NDVI and altitude,as well as economic factors like population density and distance from roads,influenced the spatial differentiation of ESV,the explanatory power of NDVI reached up to 0.47.The interaction between factors had a greater impact than individual factors.These research results can provide theoretical support for national spatial planning and ecological environment protection in the Lhasa River Basin and other similar areas.展开更多
As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem ...As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem service value(ESV).Based on the patterns of land use change and the ESV change in Su-Xi-Chang metropolitan area from 2000 to 2020,we set up four scenarios:natural development scenario,urban development scenario,arable land protection scenario and ecological protection scenario,and simulated the impact of land use changes on the ESV in these scenarios.The results showed that:1) the area of built-up land in the Su-XiChang metropolitan area increased significantly from 2000 to 2020,and the area of other types of land decreased.Arable land underwent the highest transfer-out area,and was primarily converted into built-up land.The total ESV of Su-Xi-Chang metropolitan area increased initially then declined from 2000–2020,and the value of almost all individual ecosystem services decreased.2) Population density,GDP per area,night lighting intensity,and road network density can negatively impact the ESV.3) The total ESV loss under the natural development and urban development scenarios was high,and the expansion of the built-up land and the drastic shrinkage of the arable land contributed to the ESV decline under both scenarios.The total ESV under arable land protection and ecological protection scenarios increases,and therefore these scenarios are suitable for future land use optimization in Su-Xi-Chang.This study could provide a certain reference for land use planning and allocation,and offer guidance for the rational allocation of land resources.展开更多
Yellow mealworm larvae(YML;Tenebrio molitor) are considered as a valuable insect species for animal feed due to their high nutritional values and ability to grow under different substrates and rearing conditions. Adva...Yellow mealworm larvae(YML;Tenebrio molitor) are considered as a valuable insect species for animal feed due to their high nutritional values and ability to grow under different substrates and rearing conditions. Advances in the understanding of entomophagy and animal nutrition over the past decades have propelled research areas toward testing multiple aspects of YML to exploit them better as animal feed sources. This review aims to summarize various approaches that could be exploited to maximize the nutritional values of YML as an animal feed ingredient. In addition, YML has the potential to be used as an antimicrobial or bioactive agent to improve animal health and immune function in production animals. The dynamics of the nutritional profile of YML can be influenced by multiple factors and should be taken into account when attempting to optimize the nutrient contents of YML as an animal feed ingredient. Specifically, the use of novel land-based and aquatic feeding resources, probiotics, and the exploitation of larval gut microbiomes as novel strategies can assist to maximize the nutritional potential of YML. Selection of relevant feed supplies, optimization of ambient conditions, the introduction of novel genetic selection procedures, and implementation of effective post-harvest processing may be required in the future to commercialize mealworm production. Furthermore, the use of appropriate agricultural practices and technological improvements within the mealworm production sector should be aimed at achieving both economic and environmental sustainability. The issues highlighted in this review could pave the way for future approaches to improve the nutritional value of YML.展开更多
BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human well-being.AIM To detecting serum changes in carcinoembryonic antigen(CEA),carbohydrate antigens(CA)724,CA242,and CA19-9 ex...BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human well-being.AIM To detecting serum changes in carcinoembryonic antigen(CEA),carbohydrate antigens(CA)724,CA242,and CA19-9 expression among patients with gastric cancer.METHODS Eighty patients diagnosed with gastric cancer between January 2020 and January 2023 were included in the observation group,while 80 patients with benign gastric diseases were included in the control group.Both groups were tested for tumor markers(CA724,CEA,CA242,and CA19-9].Tumor marker indicators(CA724,CEA,CA242,and CA19-9)were compared between the two groups,assessing positive rates of tumor markers across various stages in the observation group.Additionally,single and combined detection of various tumor markers were examined.RESULTS The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value observed for the combined detection of CA724,CEA,CA242,and CA19-9 were higher than those of CA724,CEA,CA242,and CA19-9 individually.Therefore,the combined detection of CA724,CEA,CA242,and CA19-9 has a high diagnostic accuracy and could reduce the occurrence of missed or misdiagnosed cases,facilitating the early diagnosis and treatment of patients.CONCLUSION CA724,CEA,CA242,and CA19-9 serum levels in gastric cancer patients significantly surpassed those in non-gastric cancer patients(P<0.05).Their combined detection can improve the diagnostic accuracy for gastric cancer,warranting clinical promotion.展开更多
BACKGROUND Despite significant advancements in the medical treatment of primary hepato-cellular carcinoma(PHC)in recent years,enhancing therapeutic effects and im-proving prognosis remain substantial challenges worldw...BACKGROUND Despite significant advancements in the medical treatment of primary hepato-cellular carcinoma(PHC)in recent years,enhancing therapeutic effects and im-proving prognosis remain substantial challenges worldwide.AIM To investigate the expression levels of serum vascular endothelial growth factor(VEGF)and interleukin(IL)-17 in patients with PHC and evaluate their diagnostic value while exploring their relationship with patients’clinical characteristics.METHODS The study included 50 patients with confirmed PHC who visited Wuhan Han-yang Hospital from January 2021 to January 2022,and 50 healthy individuals from the same period served as the control group.Serum VEGF and IL-17 levels in both groups were measured by Enzyme-Linked Immunosorbent Assay,and their diagnostic value was assessed using receiver operating characteristic(ROC)curves.Pearson correlation analysis was performed to examine the relationship between serum VEGF and IL-17 levels.Pathological data of the PHC patients were analyzed to determine the relationship between serum VEGF and IL-17 levels and pathological characteristics.RESULTS Serum VEGF and IL-17 levels were significantly higher in the study group com-pared to the control group(P<0.05).No significant association was observed between serum VEGF and IL-17 levels and gender,age,combined cirrhosis,tumor diameter,or degree of differentiation(P>0.05).However,there was a significant relationship between clinical TNM stage,tumor metastasis,and serum VEGF and IL-17 levels(P<0.05).Correlation analysis revealed a positive correlation between serum VEGF and IL-17(P<0.05).ROC analysis demonstrated that both serum VEGF and IL-17 had good diagnostic efficacy for PHC.CONCLUSION Serum VEGF and IL-17 levels were significantly higher in PHC patients compared to healthy individuals.Their levels were closely related to pathological features such as tumor metastasis and clinical TNM stage,and there was a significant positive correlation between VEGF and IL-17.These biomarkers may serve as valuable reference in-dicators for the early diagnosis and treatment guidance of PHC.展开更多
Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of...Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ecosystems.Here,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental factors.Moreover,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing seasons.The results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial patterns.NDVI was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global warming.Note that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing season.These findings are conducive to improving our understanding of alpine grassland ecosystem carbon-climate feedbacks under warming climates.展开更多
Thermal analysis plays a key role in the online inspection of molten iron quality.Different solidification process of molten iron can be reflected by thermal analysis curves,and silicon is one of important elements af...Thermal analysis plays a key role in the online inspection of molten iron quality.Different solidification process of molten iron can be reflected by thermal analysis curves,and silicon is one of important elements affecting the solidification of molten iron.In this study,FeSi75 was added in one chamber of the dual-chamber sample cup,and the influences of FeSi75 additive on the characteristic values of thermal analysis curves and vermiculating rate were investigated.The results show that with the increase of FeSi75,the start temperature of austenite formation TALfirstly decreases and then increases,but the start temperature of eutectic growth TSEF,the lowest eutectic temperature TEU,temperature at maximum eutectic reaction rate TEM,and highest eutectic temperature TERkeep always an increase.The temperature at final solidification point TEShas little change.The FeSi75 additive has different influences on the vermiculating rate of molten iron with different vermiculation,and the vermiculating rate increases for lower vermiculation molten iron while decreases for higher one.According to the thermal analysis curves obtained by a dual-chamber sample cup with 0.30wt.%FeSi75 additive in one chamber,the vermiculating rate of molten iron can be evaluated by comparing the characteristic values of these curves.The time differenceΔtERcorresponding to the highest eutectic temperature TERhas a closer relationship with the vermiculating rate,and a parabolic regression curve between the time differenceΔtERand vermiculating rateηhas been obtained within the range of 65%to 95%,which is suitable for the qualified melt.展开更多
Urban agglomerations,serving as pivotal centers of human activity,undergo swift alterations in ecosystem services prompted by shifts in land utilization.Strengthening the monitoring of ecosystem services in present an...Urban agglomerations,serving as pivotal centers of human activity,undergo swift alterations in ecosystem services prompted by shifts in land utilization.Strengthening the monitoring of ecosystem services in present and future urban agglomerations contributes to the rational planning of these areas and enhances the well-being of their inhabitants.Here,we analyzed land use conversion in the Yangtze River Delta(YRD)urban agglomeration during 1990-2020 and discussed the spatiotemporal response and main drivers of changes in ecosystem service value(ESV).By considering the different development strategic directions described in land use planning policies,we predicted land use conversion and its impact on ESV using the Future Land Use Simulation(FLUS)model in three scenari-os in 2025 and 2030.Results show that:1)from 1990 to 2020,land use change is mainly manifested as the continuous expansion of con-struction land to cultivated land.Among the reduced cultivated land,82.2%were occupied by construction land.2)The land use types conversion caused a loss of 21.85 billion yuan(RMB)in ESV during 1990-2020.Moreover,the large reduction of cultivated land area led to the continuous decline of food production value,accounting for 13%of the total ESV loss.3)From 2020 to 2030,land use change will mainly focus on Yangzhou and Zhenjiang in central Jiangsu Province and Taizhou in southern Zhejiang Province.Under the BAU(natural development)and ED(cultivated land protection)scenarios,construction land expansion remains dominant.In contrast,under the EP(ecological protection)scenario,the areas of water bodies and forest land increase significantly.Among the different scenarios,ESV is highest in the EP scenario,making it the optimal solution for sustainable land use.It can be seen that the space use conflict among urban,agriculture and ecology is a key factor leading to ESV change in the urban agglomeration of Yangtze River Delta.There-fore,it is crucial to maintain spatial land use coordination.Our findings provide suggestions for scientific and rational land use planning for the urban agglomeration.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is limited.AIM To analyze the impacts of stress granule(SG)genes on overall survival(OS)...BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is limited.AIM To analyze the impacts of stress granule(SG)genes on overall survival(OS),survival time,and prognosis in HCC.METHODS The combined The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC),GSE25097,and GSE36376 datasets were utilized to obtain genetic and clinical information.Optimal hub gene numbers and corresponding coefficients were determined using the Least absolute shrinkage and selection operator model approach,and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate Cox regression,respectively.The prognostic model’s receiver operating characteristic(ROC)curve was produced and plotted utilizing the time ROC software package.Nomogram models were constructed to predict the outcomes at 1,3,and 5-year OS prognostications with good prediction accuracy.RESULTS We identified seven SG genes(DDX1,DKC1,BICC1,HNRNPUL1,CNOT6,DYRK3,CCDC124)having a prognostic significance and developed a risk score model.The findings of Kaplan-Meier analysis indicated that the group with a high risk exhibited significantly reduced OS in comparison with those of the low-risk group(P<0.001).The nomogram model’s findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC cohort.Gene Ontology and Gene Set Enrichment Analysis suggested that these SGs might be involved in the cell cycle,RNA editing,and other biological processes.CONCLUSION Based on the impact of SG genes on HCC prognosis,in the future,it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.展开更多
With the continuous expansion of the scale of renewable energy installation,the demand for energy storage has increased significantly.However,there are significant differences in the value of energy storage in differe...With the continuous expansion of the scale of renewable energy installation,the demand for energy storage has increased significantly.However,there are significant differences in the value of energy storage in different scenarios,and the phenomenon of diminishing marginal benefits of energy storage is becoming more apparent.Therefore,themulti-dimensional value evolution trend of energy storage has become a key issue.This study selects indicators from three dimensions of energy storage:low-carbon emission reduction,smoothing wind and solar power fluctuations,and saving generation costs,quantifying the economic,environmental,and technical values of energy storage.This forms a quantitative evaluation system for energy storage value.By comparing the calculated system values under different energy storage capacities,the marginal value evolution trend of energy storage is obtained.Meanwhile,considering factors such as the utilization rate of renewable energy,the change in energy storage value under different scenarios is analyzed.The results show that the value of long-duration energy storage is significantly affected by the energy storage capacity.Specifically,when the charge-discharge efficiency of longduration energy storage reaches 0.6 or above,the system value increases significantly.Additionally,appropriately reducing the cost of energy storage capacity also helps to improve its system value.展开更多
Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor aff...Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor affecting LF prognosis.Interleukins(Ils)are a type of cytokine that act and interact with multiple cells,including immune cells.These signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory response.To date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of LF.This article reviews the potential use of Ils as the prognostic biomarkers of LF.Particularly,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to LF.Harnessing biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient survival.Thus,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.展开更多
BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and convenience.However,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean...BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and convenience.However,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in Jilin,China,remains inconclusive.AIM To determine the best cut-off of HbA1c for diagnosing DR among the Chinese.METHODS This cross-sectional study included 1933 participants from the Yanbian area of Jilin Province,China.Trained investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the investigation.The best cut-off value for HbA1c was established via the receiver operating characteristic curve.The factors associated with HbA1c-associated risk factors were determined via linear regression.RESULTS The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation set.The prevalence of DR was 3.27% in the total population.HbA1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation set.In both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off value.The optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,respectively.Age,body mass index,and FBG were determined as the risk factors impacting HbA1c levels.CONCLUSION HbA1c may serve as a useful diagnostic indicator for DR.An HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.展开更多
Reservoirs provide a variety of services with economic values across multiple sectors. As demands for reservoir services continue to grow and precipitation patterns evolve, it becomes ever more important to consider t...Reservoirs provide a variety of services with economic values across multiple sectors. As demands for reservoir services continue to grow and precipitation patterns evolve, it becomes ever more important to consider the integrated suite of values and tradeoffs that attend changes in water uses and availability. Section 316 (b) of the Clean Water Act requires that owners of certain water cooled power plants evaluate technologies and operational measures that can reduce their impacts to aquatic organisms. The studies must discuss the social costs and benefits of alternative technologies including cooling towers (79 Fed. Reg. 158, 48300 - 48439). Cooling towers achieve their effect through evaporation. This manuscript estimates the property value, recreation, and hydroelectric generation impacts that could result from the evaporative water loss associated with installing cooling towers at the McGuire Nuclear Generating Station (McGuire) located on Lake Norman, North Carolina. Although this study specifically evaluates the effects of evaporative water loss from cooling towers, its methods are applicable to estimating the economic benefits and costs of a new water user or reduced water input in any complex reservoir system that supports steam electric generation, hydroelectric generation, residential properties, recreation, irrigation, and municipal water use.展开更多
This review article examines the relationship between health and economic development,highlighting the economic benefits of investing in health.The rise of non-communicable diseases(NCDs)and the COVID-19 pandemic have...This review article examines the relationship between health and economic development,highlighting the economic benefits of investing in health.The rise of non-communicable diseases(NCDs)and the COVID-19 pandemic have exposed high demand for increased investment in health as well as critical gaps in the global health system,particularly in low-and middle-income countries,where investments in primary healthcare and innovations in health technologies are lacking.The article emphasizes the importance of examining the economic impact of health,providing a summary of the different pathways through which health impacts the economy and reviewing various economic analyses,including a novel methodology called the health-augmented macroeconomic model(HMM)for evaluating the macroeconomic value of investing in health.The article suggests that reducing disease burdens can effectively generate sizable economic returns,and it is vital to integrate the concept of economic value in health policies and interventions.展开更多
Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic str...Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic stresses, which leads to the use of synthetic fertilizers and pesticides, which cause significant damage to the environment and human health due to the presence of synthetics residues in the seeds, pods and in the leaves that are eaten. Promoting the use of natural products is becoming a necessity for organic and eco-responsible agriculture that limits contamination problems and improves people’s purchasing power. This study aims to assess the effect of biostimulants based on natural products on the growth and nutritional value of common bean (Phaseolus vulgaris L.). Bean seedlings from white variety (MEX-142) and red variety (DOR-701) were treated every seven days in the field from their pre-emergence, emergence and growth to their maturation under a randomized block experimental design. Six treatments and three repetitions with the biostimulants based on natural products and controls were thus performed and the agromorphological parameters were measured. After 120 days, the contents of growth biomarkers and defense-related enzymes were evaluated in leaves, while the contents of macromolecules, minerals and antinutrients were evaluated in seeds. These biostimulants significantly increased (P P < 0.0001) of antinutrients including oxalates, phytates, tannins and saponins in seeds compared to controls (T+ and T−). Treatment with biostimulants, in particular BS4, improves the performance of bean plants in the field as well as the biofortification of seeds regardless of the variety.展开更多
In the era of advanced machine learning techniques,the development of accurate predictive models for complex medical conditions,such as thyroid cancer,has shown remarkable progress.Accurate predictivemodels for thyroi...In the era of advanced machine learning techniques,the development of accurate predictive models for complex medical conditions,such as thyroid cancer,has shown remarkable progress.Accurate predictivemodels for thyroid cancer enhance early detection,improve resource allocation,and reduce overtreatment.However,the widespread adoption of these models in clinical practice demands predictive performance along with interpretability and transparency.This paper proposes a novel association-rule based feature-integratedmachine learning model which shows better classification and prediction accuracy than present state-of-the-artmodels.Our study also focuses on the application of SHapley Additive exPlanations(SHAP)values as a powerful tool for explaining thyroid cancer prediction models.In the proposed method,the association-rule based feature integration framework identifies frequently occurring attribute combinations in the dataset.The original dataset is used in trainingmachine learning models,and further used in generating SHAP values fromthesemodels.In the next phase,the dataset is integrated with the dominant feature sets identified through association-rule based analysis.This new integrated dataset is used in re-training the machine learning models.The new SHAP values generated from these models help in validating the contributions of feature sets in predicting malignancy.The conventional machine learning models lack interpretability,which can hinder their integration into clinical decision-making systems.In this study,the SHAP values are introduced along with association-rule based feature integration as a comprehensive framework for understanding the contributions of feature sets inmodelling the predictions.The study discusses the importance of reliable predictive models for early diagnosis of thyroid cancer,and a validation framework of explainability.The proposed model shows an accuracy of 93.48%.Performance metrics such as precision,recall,F1-score,and the area under the receiver operating characteristic(AUROC)are also higher than the baseline models.The results of the proposed model help us identify the dominant feature sets that impact thyroid cancer classification and prediction.The features{calcification}and{shape}consistently emerged as the top-ranked features associated with thyroid malignancy,in both association-rule based interestingnessmetric values and SHAPmethods.The paper highlights the potential of the rule-based integrated models with SHAP in bridging the gap between the machine learning predictions and the interpretability of this prediction which is required for real-world medical applications.展开更多
The green innovation value chain is a key step in transforming green,innovative scientific,and technological achievements into productive forces.The establishment of green innovation value chains based on value distri...The green innovation value chain is a key step in transforming green,innovative scientific,and technological achievements into productive forces.The establishment of green innovation value chains based on value distribution rather than technical conditions can effectively overcome the common bottleneck faced by different nations during their green innovation endeavors,namely,the substitution of conventional products with green alternatives.This study investigates the impeded diffusion of green products and their underlying causes,analyzes the internal structure and mechanism of the green innovation value chain,and explores the establishment of regional green innovation value chains and the models available for value chain upgrading.展开更多
This paper explores the data theory of value along the line of reasoning epochal characteristics of data-theoretical innovation-paradigmatic transformation and,through a comparison of hard and soft factors and observa...This paper explores the data theory of value along the line of reasoning epochal characteristics of data-theoretical innovation-paradigmatic transformation and,through a comparison of hard and soft factors and observation of data peculiar features,it draws the conclusion that data have the epochal characteristics of non-competitiveness and non-exclusivity,decreasing marginal cost and increasing marginal return,non-physical and intangible form,and non-finiteness and non-scarcity.It is the epochal characteristics of data that undermine the traditional theory of value and innovate the“production-exchange”theory,including data value generation,data value realization,data value rights determination and data value pricing.From the perspective of data value generation,the levels of data quality,processing,use and connectivity,data application scenarios and data openness will influence data value.From the perspective of data value realization,data,as independent factors of production,show value creation effect,create a value multiplier effect by empowering other factors of production,and substitute other factors of production to create a zero-price effect.From the perspective of data value rights determination,based on the theory of property,the tragedy of the private outweighs the comedy of the private with respect to data,and based on the theory of sharing economy,the comedy of the commons outweighs the tragedy of the commons with respect to data.From the perspective of data pricing,standardized data products can be priced according to the physical product attributes,and non-standardized data products can be priced according to the virtual product attributes.Based on the epochal characteristics of data and theoretical innovation,the“production-exchange”paradigm has undergone a transformation from“using tangible factors to produce tangible products and exchanging tangible products for tangible products”to“using intangible factors to produce tangible products and exchanging intangible products for tangible products”and ultimately to“using intangible factors to produce intangible products and exchanging intangible products for intangible products”.展开更多
Establishing a sense of ritual within tourism consumption scenarios offers tourists the opportunity for interactive engagement.Drawing upon the value co-creation theory,this study constructed an influence mechanism mo...Establishing a sense of ritual within tourism consumption scenarios offers tourists the opportunity for interactive engagement.Drawing upon the value co-creation theory,this study constructed an influence mechanism model to examine tourists'active engagement in the process of co-creating tourism experience values.It employed Partial Least Squares Structural Equation Modeling(PLS-SEM)to empirically test the proposed hypotheses.The findings demonstrate that the model constructed in the present study exhibits robust reliability,validity,and explanatory power.The perception of the sense of ritual in tourism exerts a significant positive influence on tourists’co-creation of tourism experience values,thereby significantly enhancing both the communitas and flow experienced by tourists during their travels.Moreover,such communitas and flow can mediate the influence of the sense of ritual in tourism on tourists’co-creation of tourism experience values.This study contributes to advancing the current research on tourists’co-creation of tourism experience values and the sense of ritual in tourism,thereby providing theoretical foundations for cultivating a sense of ritual within tourism consumption scenarios.展开更多
Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from M...Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from March 2020 to November 2021 and randomly divided into an observation group and an ACBT (Active Cycle of Breathing Technique) training group. Accelerated recovery care and routine care were respectively used in the perioperative period to compare the nursing effects of the two groups. Results: All perioperative indicators in the observation group were shorter than those in the ACBT training group. The pain scores at different time periods after surgery were lower in the observation group than in the ACBT training group (P 0.05). The improvement in the above indicators was higher in the observation group than in the ACBT training group after nursing care (P Conclusion: Accelerated recovery care during the perioperative period for lung cancer surgery patients showed significant effectiveness.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.U20A20112)Construction of Talent Innovation Team and Laboratory Platform of Tibet University-Construction of Plateau Geothermal New Energy Innovation Team and Laboratory Platform(Grant No.2022ZDTD10)Central Support for Local Ministry and Regional Joint Construction/First-class Everest Construction Project-Construction of Geological Resources and Geological Engineering Characteristics(Grant No.Tibetan Finance Pre-indication[2022]No.1).
文摘The Lhasa River Basin forms an essential human settlement area in the southern part of the Qinghai-Tibet Plateau.This study employed ecosystem service value(ESV)evaluation model,terrain gradient grading,and Geodetector to analyze land use and ESV in the Lhasa River Basin from 1985 to 2020.The findings reveal that:(1)From 1985 to 2020,grassland was the dominant land use.There was a trend of grassland reduction and the expansion of other land types.(2)ESV has increased over the research period(with a total increase of 0.84%),with higher values in the southeast and lower values in the northwest.Grassland contributed the most to ESV,and climate regulation and hydrological regulation were the ecosystem services that contribute the most to ESV.(3)Natural factors like NDVI and altitude,as well as economic factors like population density and distance from roads,influenced the spatial differentiation of ESV,the explanatory power of NDVI reached up to 0.47.The interaction between factors had a greater impact than individual factors.These research results can provide theoretical support for national spatial planning and ecological environment protection in the Lhasa River Basin and other similar areas.
基金Under the auspices of Humanities and Social Sciences Foundation of Soochow University(No.22XM2008)National Social Science Foundation of China(No.23BGL168)。
文摘As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem service value(ESV).Based on the patterns of land use change and the ESV change in Su-Xi-Chang metropolitan area from 2000 to 2020,we set up four scenarios:natural development scenario,urban development scenario,arable land protection scenario and ecological protection scenario,and simulated the impact of land use changes on the ESV in these scenarios.The results showed that:1) the area of built-up land in the Su-XiChang metropolitan area increased significantly from 2000 to 2020,and the area of other types of land decreased.Arable land underwent the highest transfer-out area,and was primarily converted into built-up land.The total ESV of Su-Xi-Chang metropolitan area increased initially then declined from 2000–2020,and the value of almost all individual ecosystem services decreased.2) Population density,GDP per area,night lighting intensity,and road network density can negatively impact the ESV.3) The total ESV loss under the natural development and urban development scenarios was high,and the expansion of the built-up land and the drastic shrinkage of the arable land contributed to the ESV decline under both scenarios.The total ESV under arable land protection and ecological protection scenarios increases,and therefore these scenarios are suitable for future land use optimization in Su-Xi-Chang.This study could provide a certain reference for land use planning and allocation,and offer guidance for the rational allocation of land resources.
基金supported by research grants from Regionalt Forskningsfond (RFF) Trondelag (In FeedProject number: 309859),where Nord University is the project leading institution,and Gullimunn AS and Mære Landbruksskole are project partnerssupported by the CEER project (Project number: 2021/10345) funded by the Norwegian Agency for International Cooperation and Quality Enhancement in Higher Education (HK-dir) under the Norwegian Partnership Program for Global Academic Cooperation (NORPART ) with support from the Norwegian Ministry of Education and Research (MER)。
文摘Yellow mealworm larvae(YML;Tenebrio molitor) are considered as a valuable insect species for animal feed due to their high nutritional values and ability to grow under different substrates and rearing conditions. Advances in the understanding of entomophagy and animal nutrition over the past decades have propelled research areas toward testing multiple aspects of YML to exploit them better as animal feed sources. This review aims to summarize various approaches that could be exploited to maximize the nutritional values of YML as an animal feed ingredient. In addition, YML has the potential to be used as an antimicrobial or bioactive agent to improve animal health and immune function in production animals. The dynamics of the nutritional profile of YML can be influenced by multiple factors and should be taken into account when attempting to optimize the nutrient contents of YML as an animal feed ingredient. Specifically, the use of novel land-based and aquatic feeding resources, probiotics, and the exploitation of larval gut microbiomes as novel strategies can assist to maximize the nutritional potential of YML. Selection of relevant feed supplies, optimization of ambient conditions, the introduction of novel genetic selection procedures, and implementation of effective post-harvest processing may be required in the future to commercialize mealworm production. Furthermore, the use of appropriate agricultural practices and technological improvements within the mealworm production sector should be aimed at achieving both economic and environmental sustainability. The issues highlighted in this review could pave the way for future approaches to improve the nutritional value of YML.
文摘BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human well-being.AIM To detecting serum changes in carcinoembryonic antigen(CEA),carbohydrate antigens(CA)724,CA242,and CA19-9 expression among patients with gastric cancer.METHODS Eighty patients diagnosed with gastric cancer between January 2020 and January 2023 were included in the observation group,while 80 patients with benign gastric diseases were included in the control group.Both groups were tested for tumor markers(CA724,CEA,CA242,and CA19-9].Tumor marker indicators(CA724,CEA,CA242,and CA19-9)were compared between the two groups,assessing positive rates of tumor markers across various stages in the observation group.Additionally,single and combined detection of various tumor markers were examined.RESULTS The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value observed for the combined detection of CA724,CEA,CA242,and CA19-9 were higher than those of CA724,CEA,CA242,and CA19-9 individually.Therefore,the combined detection of CA724,CEA,CA242,and CA19-9 has a high diagnostic accuracy and could reduce the occurrence of missed or misdiagnosed cases,facilitating the early diagnosis and treatment of patients.CONCLUSION CA724,CEA,CA242,and CA19-9 serum levels in gastric cancer patients significantly surpassed those in non-gastric cancer patients(P<0.05).Their combined detection can improve the diagnostic accuracy for gastric cancer,warranting clinical promotion.
文摘BACKGROUND Despite significant advancements in the medical treatment of primary hepato-cellular carcinoma(PHC)in recent years,enhancing therapeutic effects and im-proving prognosis remain substantial challenges worldwide.AIM To investigate the expression levels of serum vascular endothelial growth factor(VEGF)and interleukin(IL)-17 in patients with PHC and evaluate their diagnostic value while exploring their relationship with patients’clinical characteristics.METHODS The study included 50 patients with confirmed PHC who visited Wuhan Han-yang Hospital from January 2021 to January 2022,and 50 healthy individuals from the same period served as the control group.Serum VEGF and IL-17 levels in both groups were measured by Enzyme-Linked Immunosorbent Assay,and their diagnostic value was assessed using receiver operating characteristic(ROC)curves.Pearson correlation analysis was performed to examine the relationship between serum VEGF and IL-17 levels.Pathological data of the PHC patients were analyzed to determine the relationship between serum VEGF and IL-17 levels and pathological characteristics.RESULTS Serum VEGF and IL-17 levels were significantly higher in the study group com-pared to the control group(P<0.05).No significant association was observed between serum VEGF and IL-17 levels and gender,age,combined cirrhosis,tumor diameter,or degree of differentiation(P>0.05).However,there was a significant relationship between clinical TNM stage,tumor metastasis,and serum VEGF and IL-17 levels(P<0.05).Correlation analysis revealed a positive correlation between serum VEGF and IL-17(P<0.05).ROC analysis demonstrated that both serum VEGF and IL-17 had good diagnostic efficacy for PHC.CONCLUSION Serum VEGF and IL-17 levels were significantly higher in PHC patients compared to healthy individuals.Their levels were closely related to pathological features such as tumor metastasis and clinical TNM stage,and there was a significant positive correlation between VEGF and IL-17.These biomarkers may serve as valuable reference in-dicators for the early diagnosis and treatment guidance of PHC.
基金supported by the National Science Foundation of China(Grant No.41930759)the Gansu Provincial Science and Technology Program(Grant No.22ZD6FA005)+4 种基金the National Science Foundation of China(Grant Nos.41875018 and 41875016)the Science and Technology Research Plan of Gansu Province(Grant Nos.20JR10RA070 and 22JR5RA048)the Chinese Academy of Sciences(CAS)“Light of West China”Program(Grant No.E2290302)the Gansu Provincial Science and Technology Program(Grant No.23JRRA609)the integrated Land Ecosystem-Atmosphere Processes Study(iLEAPS).
文摘Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ecosystems.Here,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental factors.Moreover,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing seasons.The results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial patterns.NDVI was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global warming.Note that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing season.These findings are conducive to improving our understanding of alpine grassland ecosystem carbon-climate feedbacks under warming climates.
基金the financial support of the State Key Laboratory of Engine Reliability(skler-202105)。
文摘Thermal analysis plays a key role in the online inspection of molten iron quality.Different solidification process of molten iron can be reflected by thermal analysis curves,and silicon is one of important elements affecting the solidification of molten iron.In this study,FeSi75 was added in one chamber of the dual-chamber sample cup,and the influences of FeSi75 additive on the characteristic values of thermal analysis curves and vermiculating rate were investigated.The results show that with the increase of FeSi75,the start temperature of austenite formation TALfirstly decreases and then increases,but the start temperature of eutectic growth TSEF,the lowest eutectic temperature TEU,temperature at maximum eutectic reaction rate TEM,and highest eutectic temperature TERkeep always an increase.The temperature at final solidification point TEShas little change.The FeSi75 additive has different influences on the vermiculating rate of molten iron with different vermiculation,and the vermiculating rate increases for lower vermiculation molten iron while decreases for higher one.According to the thermal analysis curves obtained by a dual-chamber sample cup with 0.30wt.%FeSi75 additive in one chamber,the vermiculating rate of molten iron can be evaluated by comparing the characteristic values of these curves.The time differenceΔtERcorresponding to the highest eutectic temperature TERhas a closer relationship with the vermiculating rate,and a parabolic regression curve between the time differenceΔtERand vermiculating rateηhas been obtained within the range of 65%to 95%,which is suitable for the qualified melt.
基金Under the auspices of National Natural Science Foundation of China(No.42276234)National Social Science Foundation Major Project of China(No.23&ZD105)+1 种基金the Open Fund of the Key Laboratory of Coastal Zone Exploitation and Protection,Ministry of Natural Resources of China(No.2023CZEPK04)the Science and Technology Major Project of Ningbo(No.2021Z181)。
文摘Urban agglomerations,serving as pivotal centers of human activity,undergo swift alterations in ecosystem services prompted by shifts in land utilization.Strengthening the monitoring of ecosystem services in present and future urban agglomerations contributes to the rational planning of these areas and enhances the well-being of their inhabitants.Here,we analyzed land use conversion in the Yangtze River Delta(YRD)urban agglomeration during 1990-2020 and discussed the spatiotemporal response and main drivers of changes in ecosystem service value(ESV).By considering the different development strategic directions described in land use planning policies,we predicted land use conversion and its impact on ESV using the Future Land Use Simulation(FLUS)model in three scenari-os in 2025 and 2030.Results show that:1)from 1990 to 2020,land use change is mainly manifested as the continuous expansion of con-struction land to cultivated land.Among the reduced cultivated land,82.2%were occupied by construction land.2)The land use types conversion caused a loss of 21.85 billion yuan(RMB)in ESV during 1990-2020.Moreover,the large reduction of cultivated land area led to the continuous decline of food production value,accounting for 13%of the total ESV loss.3)From 2020 to 2030,land use change will mainly focus on Yangzhou and Zhenjiang in central Jiangsu Province and Taizhou in southern Zhejiang Province.Under the BAU(natural development)and ED(cultivated land protection)scenarios,construction land expansion remains dominant.In contrast,under the EP(ecological protection)scenario,the areas of water bodies and forest land increase significantly.Among the different scenarios,ESV is highest in the EP scenario,making it the optimal solution for sustainable land use.It can be seen that the space use conflict among urban,agriculture and ecology is a key factor leading to ESV change in the urban agglomeration of Yangtze River Delta.There-fore,it is crucial to maintain spatial land use coordination.Our findings provide suggestions for scientific and rational land use planning for the urban agglomeration.
基金Supported by Hebei Traditional Chinese Medicine Scientific Research Project,No.2023223.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is limited.AIM To analyze the impacts of stress granule(SG)genes on overall survival(OS),survival time,and prognosis in HCC.METHODS The combined The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC),GSE25097,and GSE36376 datasets were utilized to obtain genetic and clinical information.Optimal hub gene numbers and corresponding coefficients were determined using the Least absolute shrinkage and selection operator model approach,and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate Cox regression,respectively.The prognostic model’s receiver operating characteristic(ROC)curve was produced and plotted utilizing the time ROC software package.Nomogram models were constructed to predict the outcomes at 1,3,and 5-year OS prognostications with good prediction accuracy.RESULTS We identified seven SG genes(DDX1,DKC1,BICC1,HNRNPUL1,CNOT6,DYRK3,CCDC124)having a prognostic significance and developed a risk score model.The findings of Kaplan-Meier analysis indicated that the group with a high risk exhibited significantly reduced OS in comparison with those of the low-risk group(P<0.001).The nomogram model’s findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC cohort.Gene Ontology and Gene Set Enrichment Analysis suggested that these SGs might be involved in the cell cycle,RNA editing,and other biological processes.CONCLUSION Based on the impact of SG genes on HCC prognosis,in the future,it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.
基金supported financially by Thematic Project of the State Grid Liaoning Electric Power Company Limited Economic Research Institute under Grant SGLNJY00GHJS2310109.
文摘With the continuous expansion of the scale of renewable energy installation,the demand for energy storage has increased significantly.However,there are significant differences in the value of energy storage in different scenarios,and the phenomenon of diminishing marginal benefits of energy storage is becoming more apparent.Therefore,themulti-dimensional value evolution trend of energy storage has become a key issue.This study selects indicators from three dimensions of energy storage:low-carbon emission reduction,smoothing wind and solar power fluctuations,and saving generation costs,quantifying the economic,environmental,and technical values of energy storage.This forms a quantitative evaluation system for energy storage value.By comparing the calculated system values under different energy storage capacities,the marginal value evolution trend of energy storage is obtained.Meanwhile,considering factors such as the utilization rate of renewable energy,the change in energy storage value under different scenarios is analyzed.The results show that the value of long-duration energy storage is significantly affected by the energy storage capacity.Specifically,when the charge-discharge efficiency of longduration energy storage reaches 0.6 or above,the system value increases significantly.Additionally,appropriately reducing the cost of energy storage capacity also helps to improve its system value.
基金The National Natural Science Foundation of China,No.82260907,No.82260899,and No.82274434.
文摘Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor affecting LF prognosis.Interleukins(Ils)are a type of cytokine that act and interact with multiple cells,including immune cells.These signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory response.To date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of LF.This article reviews the potential use of Ils as the prognostic biomarkers of LF.Particularly,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to LF.Harnessing biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient survival.Thus,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.
基金Supported by National Key R&D Program of China,No.2016YFC1305700.
文摘BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and convenience.However,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in Jilin,China,remains inconclusive.AIM To determine the best cut-off of HbA1c for diagnosing DR among the Chinese.METHODS This cross-sectional study included 1933 participants from the Yanbian area of Jilin Province,China.Trained investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the investigation.The best cut-off value for HbA1c was established via the receiver operating characteristic curve.The factors associated with HbA1c-associated risk factors were determined via linear regression.RESULTS The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation set.The prevalence of DR was 3.27% in the total population.HbA1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation set.In both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off value.The optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,respectively.Age,body mass index,and FBG were determined as the risk factors impacting HbA1c levels.CONCLUSION HbA1c may serve as a useful diagnostic indicator for DR.An HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.
文摘Reservoirs provide a variety of services with economic values across multiple sectors. As demands for reservoir services continue to grow and precipitation patterns evolve, it becomes ever more important to consider the integrated suite of values and tradeoffs that attend changes in water uses and availability. Section 316 (b) of the Clean Water Act requires that owners of certain water cooled power plants evaluate technologies and operational measures that can reduce their impacts to aquatic organisms. The studies must discuss the social costs and benefits of alternative technologies including cooling towers (79 Fed. Reg. 158, 48300 - 48439). Cooling towers achieve their effect through evaporation. This manuscript estimates the property value, recreation, and hydroelectric generation impacts that could result from the evaporative water loss associated with installing cooling towers at the McGuire Nuclear Generating Station (McGuire) located on Lake Norman, North Carolina. Although this study specifically evaluates the effects of evaporative water loss from cooling towers, its methods are applicable to estimating the economic benefits and costs of a new water user or reduced water input in any complex reservoir system that supports steam electric generation, hydroelectric generation, residential properties, recreation, irrigation, and municipal water use.
文摘This review article examines the relationship between health and economic development,highlighting the economic benefits of investing in health.The rise of non-communicable diseases(NCDs)and the COVID-19 pandemic have exposed high demand for increased investment in health as well as critical gaps in the global health system,particularly in low-and middle-income countries,where investments in primary healthcare and innovations in health technologies are lacking.The article emphasizes the importance of examining the economic impact of health,providing a summary of the different pathways through which health impacts the economy and reviewing various economic analyses,including a novel methodology called the health-augmented macroeconomic model(HMM)for evaluating the macroeconomic value of investing in health.The article suggests that reducing disease burdens can effectively generate sizable economic returns,and it is vital to integrate the concept of economic value in health policies and interventions.
文摘Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic stresses, which leads to the use of synthetic fertilizers and pesticides, which cause significant damage to the environment and human health due to the presence of synthetics residues in the seeds, pods and in the leaves that are eaten. Promoting the use of natural products is becoming a necessity for organic and eco-responsible agriculture that limits contamination problems and improves people’s purchasing power. This study aims to assess the effect of biostimulants based on natural products on the growth and nutritional value of common bean (Phaseolus vulgaris L.). Bean seedlings from white variety (MEX-142) and red variety (DOR-701) were treated every seven days in the field from their pre-emergence, emergence and growth to their maturation under a randomized block experimental design. Six treatments and three repetitions with the biostimulants based on natural products and controls were thus performed and the agromorphological parameters were measured. After 120 days, the contents of growth biomarkers and defense-related enzymes were evaluated in leaves, while the contents of macromolecules, minerals and antinutrients were evaluated in seeds. These biostimulants significantly increased (P P < 0.0001) of antinutrients including oxalates, phytates, tannins and saponins in seeds compared to controls (T+ and T−). Treatment with biostimulants, in particular BS4, improves the performance of bean plants in the field as well as the biofortification of seeds regardless of the variety.
文摘In the era of advanced machine learning techniques,the development of accurate predictive models for complex medical conditions,such as thyroid cancer,has shown remarkable progress.Accurate predictivemodels for thyroid cancer enhance early detection,improve resource allocation,and reduce overtreatment.However,the widespread adoption of these models in clinical practice demands predictive performance along with interpretability and transparency.This paper proposes a novel association-rule based feature-integratedmachine learning model which shows better classification and prediction accuracy than present state-of-the-artmodels.Our study also focuses on the application of SHapley Additive exPlanations(SHAP)values as a powerful tool for explaining thyroid cancer prediction models.In the proposed method,the association-rule based feature integration framework identifies frequently occurring attribute combinations in the dataset.The original dataset is used in trainingmachine learning models,and further used in generating SHAP values fromthesemodels.In the next phase,the dataset is integrated with the dominant feature sets identified through association-rule based analysis.This new integrated dataset is used in re-training the machine learning models.The new SHAP values generated from these models help in validating the contributions of feature sets in predicting malignancy.The conventional machine learning models lack interpretability,which can hinder their integration into clinical decision-making systems.In this study,the SHAP values are introduced along with association-rule based feature integration as a comprehensive framework for understanding the contributions of feature sets inmodelling the predictions.The study discusses the importance of reliable predictive models for early diagnosis of thyroid cancer,and a validation framework of explainability.The proposed model shows an accuracy of 93.48%.Performance metrics such as precision,recall,F1-score,and the area under the receiver operating characteristic(AUROC)are also higher than the baseline models.The results of the proposed model help us identify the dominant feature sets that impact thyroid cancer classification and prediction.The features{calcification}and{shape}consistently emerged as the top-ranked features associated with thyroid malignancy,in both association-rule based interestingnessmetric values and SHAPmethods.The paper highlights the potential of the rule-based integrated models with SHAP in bridging the gap between the machine learning predictions and the interpretability of this prediction which is required for real-world medical applications.
基金the part of the“Research on Paths to High-quality Development in Agriculture Against the Backdrop of Rural Revitalization,”a project of the Publicity Department of the CPC Central Committee for Young Talents in Publicity,Socialist Thought and Cultural Promotionthe National Social Science Fund of China-supported project,“Research on Theoretical Logic and Realization Path of Urban-Rural Integration Based on Industrial Internet”(21XJL001)+1 种基金the major project of Sichuan province in philosophy and social science planning,“Research on the Innovation and Policy Adaptation of Sichuan’s Agricultural Green Development System under the‘Dual Carbon’Goal”(SC22ZDYC44)the key project of Sichuan province in soft science research and planning,“Research on the Path to Peak Carbon and Carbon Neutrality of the Agricultural Sector in Rural Areas of Sichuan Province”(2022JDR0157).
文摘The green innovation value chain is a key step in transforming green,innovative scientific,and technological achievements into productive forces.The establishment of green innovation value chains based on value distribution rather than technical conditions can effectively overcome the common bottleneck faced by different nations during their green innovation endeavors,namely,the substitution of conventional products with green alternatives.This study investigates the impeded diffusion of green products and their underlying causes,analyzes the internal structure and mechanism of the green innovation value chain,and explores the establishment of regional green innovation value chains and the models available for value chain upgrading.
基金funded by“Management Model Innovation of Chinese Enterprises”Research Project,Institute of Industrial Economics,CASS(Grant No.2019-gjs-06)Project under the Graduate Student Scientific and Research Innovation Support Program,University of Chinese Academy of Social Sciences(Graduate School)(Grant No.2022-KY-118).
文摘This paper explores the data theory of value along the line of reasoning epochal characteristics of data-theoretical innovation-paradigmatic transformation and,through a comparison of hard and soft factors and observation of data peculiar features,it draws the conclusion that data have the epochal characteristics of non-competitiveness and non-exclusivity,decreasing marginal cost and increasing marginal return,non-physical and intangible form,and non-finiteness and non-scarcity.It is the epochal characteristics of data that undermine the traditional theory of value and innovate the“production-exchange”theory,including data value generation,data value realization,data value rights determination and data value pricing.From the perspective of data value generation,the levels of data quality,processing,use and connectivity,data application scenarios and data openness will influence data value.From the perspective of data value realization,data,as independent factors of production,show value creation effect,create a value multiplier effect by empowering other factors of production,and substitute other factors of production to create a zero-price effect.From the perspective of data value rights determination,based on the theory of property,the tragedy of the private outweighs the comedy of the private with respect to data,and based on the theory of sharing economy,the comedy of the commons outweighs the tragedy of the commons with respect to data.From the perspective of data pricing,standardized data products can be priced according to the physical product attributes,and non-standardized data products can be priced according to the virtual product attributes.Based on the epochal characteristics of data and theoretical innovation,the“production-exchange”paradigm has undergone a transformation from“using tangible factors to produce tangible products and exchanging tangible products for tangible products”to“using intangible factors to produce tangible products and exchanging intangible products for tangible products”and ultimately to“using intangible factors to produce intangible products and exchanging intangible products for intangible products”.
基金This study was supported by the Humanities and Social Sciences Project of the Ministry of Education(No.23YJA790070)the Graduate Innovation Research Project of Southwest Minzu University(No.YB2022621)the Research Project of BCIMY(No.BCIMY1910).
文摘Establishing a sense of ritual within tourism consumption scenarios offers tourists the opportunity for interactive engagement.Drawing upon the value co-creation theory,this study constructed an influence mechanism model to examine tourists'active engagement in the process of co-creating tourism experience values.It employed Partial Least Squares Structural Equation Modeling(PLS-SEM)to empirically test the proposed hypotheses.The findings demonstrate that the model constructed in the present study exhibits robust reliability,validity,and explanatory power.The perception of the sense of ritual in tourism exerts a significant positive influence on tourists’co-creation of tourism experience values,thereby significantly enhancing both the communitas and flow experienced by tourists during their travels.Moreover,such communitas and flow can mediate the influence of the sense of ritual in tourism on tourists’co-creation of tourism experience values.This study contributes to advancing the current research on tourists’co-creation of tourism experience values and the sense of ritual in tourism,thereby providing theoretical foundations for cultivating a sense of ritual within tourism consumption scenarios.
文摘Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from March 2020 to November 2021 and randomly divided into an observation group and an ACBT (Active Cycle of Breathing Technique) training group. Accelerated recovery care and routine care were respectively used in the perioperative period to compare the nursing effects of the two groups. Results: All perioperative indicators in the observation group were shorter than those in the ACBT training group. The pain scores at different time periods after surgery were lower in the observation group than in the ACBT training group (P 0.05). The improvement in the above indicators was higher in the observation group than in the ACBT training group after nursing care (P Conclusion: Accelerated recovery care during the perioperative period for lung cancer surgery patients showed significant effectiveness.