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Prostate-specific antigen half-life: a new predictor of progression- free survival and overall survival in Chinese prostate cancer patients 被引量:6
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作者 Guo-Wen Lin Xu-Dong Yao +9 位作者 Shi-Lin Zhang Bo Dai Chun-Guang Ma Hai-Liang Zhang Yi-Jun Shen Yao Zhu Yi-Ping Zhu Guo-Hai Shi Xiao-Jian Qin Ding-Wei Ye 《Asian Journal of Andrology》 SCIE CAS CSCD 2009年第4期443-450,共8页
We investigated the potential value of prostate-specific antigen half-life (PSAHL) and decreasing velocity (PSAVd) to predict progression-free survival (PFS) and overall survival (OS) in Chinese patients with ... We investigated the potential value of prostate-specific antigen half-life (PSAHL) and decreasing velocity (PSAVd) to predict progression-free survival (PFS) and overall survival (OS) in Chinese patients with prostate cancer. A total of 153 patients treated with hormonal therapy were included in the study. Of these, 78 patients progressed to hormone- refractory prostate cancer (HRPC) and 24 patients died by the end of follow-up. PSAHL was defined as the time during which prostate-specific antigen (PSA) concentration became half of the initial value during the first hormonal therapy. PSAVd reflected the decreasing velocity of PSA during the first hormonal therapy. PFS was defined as the interval from the beginning of hormonal therapy to HRPC. Cox proportional hazards regression analysis was used to evaluate whether PSAHL and PSAVd were significantly associated with PFS and OS. The median PSAHL and PSAVd were 0.50 months and 33.8 ng mL^-1 per month. The median PFS and OS were 22.7 months (95% confidence interval [CI], 22.0-29.6 months) and 43.5 months (95% CI, 37.9-48.4 months), respectively. On univariate and multivariate analysis, long PSAHL (〉 0.5 months), metastatic disease, high biopsy Gleason scores (〉 8) and high nadir PSA (〉 0.4 ng mL^-1) were all found to be significantly associated with short PFS. Long PSAHL, high nadir PSA and short PSA doubling time (PSADT 〈 2.0 months) were significantly associated with short OS. There were no significant relationships between PSAVd and either PFS or OS. Thus, PSAHL is a promising new independent predictor of survival. Patients with long PSAHL were identified as those at high risk for a relatively short PFS and OS. 展开更多
关键词 PREDICTOR prognosis prostate cancer prostate-specific antigen decreasing velocity prostate-specific antigen half-life
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