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Wind-Thermal Environmental Characteristic of Multi-Variable Passive Enhanced Natural Ventilation System for High and Large Space Building
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作者 Lin Liu Haoran Huang +2 位作者 Chenghe Wu Liru Liu Jing Tian 《Journal of Harbin Institute of Technology(New Series)》 CAS 2023年第5期34-51,共18页
Natural ventilation effects in high and large space buildings of tropical areas greatlya ffect the air conditioning energy consumption.Aiming at nearly zero energy building design,thisp aper mainly contributes to prov... Natural ventilation effects in high and large space buildings of tropical areas greatlya ffect the air conditioning energy consumption.Aiming at nearly zero energy building design,thisp aper mainly contributes to provide theoretical basis and reference for thermal comfortable air conditioning system design of high and large space buildings.Taking a theatre in Hainan as study object,a newly composite enhanced natural ventilation system is proposed by integrating theu nderground tunnel-based earth to air heat exchange system and the solar chimney.Ventilationq uantity,air velocity and air temperature field,human vertical temperature gradient differenceu nder24simulation working conditions are considered and analyzed by using ANSYS Fluent.Fort he underground tunnel,results show that Group Two with double underground tunnels and side airs upply location shows its advantages in cooling effects and air supply uniformity.Then for the solar chimney,results show that the solar radiation intensity contributes to larger difference int ransmission power and leads to different cooling effects.On the whole,the system under workingc ondition No.7with120m long,side air supply,double underground tunnel and20m high,1mw ide,0.6°absorber plate angle solar chimney shows its priority in better comprehensive performance. 展开更多
关键词 natural ventilation solar chimney earth to air heat exchange system energyc onservation thermal environment
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Driving pressure in mechanical ventilation:A review 被引量:1
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作者 Syeda Farheen Zaidi Asim Shaikh +2 位作者 Daniyal Aziz Khan Salim Surani Iqbal Ratnani 《World Journal of Critical Care Medicine》 2024年第1期15-27,共13页
Driving pressure(ΔP)is a core therapeutic component of mechanical ventilation(MV).Varying levels ofΔP have been employed during MV depending on the type of underlying pathology and severity of injury.However,ΔP lev... Driving pressure(ΔP)is a core therapeutic component of mechanical ventilation(MV).Varying levels ofΔP have been employed during MV depending on the type of underlying pathology and severity of injury.However,ΔP levels have also been shown to closely impact hard endpoints such as mortality.Considering this,conducting an in-depth review ofΔP as a unique,outcome-impacting therapeutic modality is extremely important.There is a need to understand the subtleties involved in making sureΔP levels are optimized to enhance outcomes and minimize harm.We performed this narrative review to further explore the various uses ofΔP,the different parameters that can affect its use,and how outcomes vary in different patient populations at different pressure levels.To better utilizeΔP in MV-requiring patients,additional large-scale clinical studies are needed. 展开更多
关键词 Driving pressure Acute respiratory distress syndrome MORTALITY Positive end-expiratory pressure Ventilator induced lung injury Mechanical ventilation
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Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface
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作者 Haotian Zheng Bingyou Jiang +1 位作者 Haoyu Wang Yuannan Zheng 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第1期204-220,共17页
In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface,an experimental platform for forced ventilation and dust removal was built based on the similar princ... In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface,an experimental platform for forced ventilation and dust removal was built based on the similar principles.Through the similar experiment and numerical simulation,the distribution of airflow field in the roadway and the spatial and temporal evolution of dust pollution under the conditions of forced ventilation were determined.The airflow field in the roadway can be divided into three zones:jet zone,vortex zone and reflux zone.The dust concentration gradually decreases from the head to the rear of the roadway.Under the forced ventilation conditions,there is a unilateral accumulation of dust,with higher dust concentrations away from the ducts.The position of the equipment has an interception effect on the dust.The maximum error between the test value and the simulation result is 12.9%,which verifies the accuracy of the experimental results.The research results can provide theoretical guidance for the application of dust removal technology in coal mine. 展开更多
关键词 Heading surface Forced ventilation Airflow field Dust pollution
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Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation
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作者 Li-Yuan Huang Bin Huang +1 位作者 Zheng Lv Xiao-Dan Lu 《World Journal of Clinical Cases》 SCIE 2024年第18期3482-3490,共9页
BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and mortality.In traditional ... BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and mortality.In traditional Chinese medicine,AECOPD is linked to phlegm-heat and blood-stasis,presenting symptoms like thick sputum,fever,and chest pain.It has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD,suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type AECOPD.AIM To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type AECOPD.METHODS One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two groups.The treatment group received acetylcysteine inhalation(10%solution,5 mL,twice daily)along with conventional therapy,whereas the control group received only conventional therapy.The treatment duration was 14 d.Inflammatory markers(C-reactive protein,interleukin-6,and tumor necrosis factor-alpha)in the serum and sputum as well as lung function parameters(forced expiratory volume in one second,forced vital capacity,and peak expiratory flow)were assessed pre-and post-treatment.Acetylcysteine inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group(P<0.05).This suggests that acetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type AECOPD.RESULTS Acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control group.These differences were statistically significant(P<0.05).The study concluded that acetylcysteine inhalation had a positive effect on microinflammation and lung ventilation function in patients with this type of AECOPD,suggesting its potential as an adjuvant therapy for such cases.CONCLUSION Acetylcysteine inhalation demonstrated significant improvements in reducing inflammatory markers in the serum and sputum,as well as enhancing lung ventilation function parameters in patients with phlegm-heat and bloodstasis type AECOPD.These findings suggest that acetylcysteine could serve as a valuable adjuvant therapy for individuals with this specific type of AECOPD,offering benefits for managing microinflammation and optimizing lung function. 展开更多
关键词 Acute exacerbation Chronic obstructive pulmonary disease Traditional Chinese medicine ACETYLCYSTEINE Phlegm-heat and blood-stasis Lung ventilation function
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Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients
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作者 Hong-Xun Yuan Li-Na Zhang +1 位作者 Gang Li Li Qiao 《World Journal of Psychiatry》 SCIE 2024年第3期370-379,共10页
BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term sedation.It remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical venti... BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term sedation.It remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical ventilation.AIM To compare the neuroprotective effects of dexmedetomidine and propofol for sedation during prolonged mechanical ventilation in patients without brain injury.METHODS Patients who underwent mechanical ventilation for>72 h were randomly assigned to receive sedation with dexmedetomidine or propofol.The Richmond Agitation and Sedation Scale(RASS)was used to evaluate sedation effects,with a target range of-3 to 0.The primary outcomes were serum levels of S100-βand neuron-specific enolase(NSE)every 24 h.The secondary outcomes were remifentanil dosage,the proportion of patients requiring rescue sedation,and the time and frequency of RASS scores within the target range.RESULTS A total of 52 and 63 patients were allocated to the dexmedetomidine group and propofol group,respectively.Baseline data were comparable between groups.No significant differences were identified between groups within the median duration of study drug infusion[52.0(IQR:36.0-73.5)h vs 53.0(IQR:37.0-72.0)h,P=0.958],the median dose of remifentanil[4.5(IQR:4.0-5.0)μg/kg/h vs 4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the median percentage of time in the target RASS range without rescue sedation[85.6%(IQR:65.8%-96.6%)vs 86.7%(IQR:72.3%-95.3),P=0.592],and the median frequency within the target RASS range without rescue sedation[72.2%(60.8%-91.7%)vs 73.3%(60.0%-100.0%),P=0.880].The proportion of patients in the dexmedetomidine group who required rescue sedation was higher than in the propofol group with statistical significance(69.2%vs 50.8%,P=0.045).Serum S100-βand NSE levels in the propofol group were higher than in the dexmedetomidine group with statistical significance during the first six and five days of mechanical ventilation,respectively(all P<0.05).CONCLUSION Dexmedetomidine demonstrated stronger protective effects on the brain compared to propofol for long-term mechanical ventilation in patients without brain injury. 展开更多
关键词 DEXMEDETOMIDINE PROPOFOL SEDATION Prolonged mechanical ventilation Brain protective
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Effects of unilateral superimposed high-frequency jet ventilation on porcine hemodynamics and gas exchange during one-lung flooding
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作者 Thomas Lesser Frank Wolfram +1 位作者 Conny Braun Reiner Gottschall 《World Journal of Experimental Medicine》 2024年第1期88-99,共12页
BACKGROUND Superimposed high-frequency jet ventilation(SHFJV)is suitable for respiratory motion reduction and essential for effective lung tumor ablation.Fluid filling of the target lung wing one-lung flooding(OLF)is ... BACKGROUND Superimposed high-frequency jet ventilation(SHFJV)is suitable for respiratory motion reduction and essential for effective lung tumor ablation.Fluid filling of the target lung wing one-lung flooding(OLF)is necessary for therapeutic ultrasound applications.However,whether unilateral SHFJV allows adequate hemodynamics and gas exchange is unclear.AIM To compared SHFJV with pressure-controlled ventilation(PCV)during OLF by assessing hemodynamics and gas exchange in different animal positions.METHODS SHFJV or PCV was used alternatingly to ventilate the non-flooded lungs of the 12 anesthetized pigs during OLF.The animal positions were changed from left lateral position to supine position(SP)to right lateral position(RLP)every 30 min.In each position,ventilation was maintained for 15 min in both modalities.Hemodynamic variables and arterial blood gas levels were repeatedly measured.RESULTS Unilateral SHFJV led to lower carbon dioxide removal than PCV without abnormally elevated carbon dioxide levels.SHFJV slightly decreased oxygenation in SP and RLP compared with PCV;the lowest values of PaO_(2) and PaO_(2)/FiO_(2) ratio were found in SP[13.0;interquartile range(IQR):12.6-5.6 and 32.5(IQR:31.5-38.9)kPa].Conversely,during SHFJV,the shunt fraction was higher in all animal positions(highest in the RLP:0.30).CONCLUSION In porcine model,unilateral SHFJV may provide adequate ventilation in different animal positions during OLF.Lower oxygenation and CO_(2) removal rates compared to PCV did not lead to hypoxia or hypercapnia.SHFJV can be safely used for lung tumor ablation to minimize ventilation-induced lung motion. 展开更多
关键词 One-lung ventilation Unilateral superimposed high-frequency jet ventilation One-lung flooding
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Performance Evaluation of Solar Chimney Draft: Application to Ventilation
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作者 Boukaré Ouedraogo Adama Ouedraogo +2 位作者 Arouna Kabore Kalifa Palm Dieudonné Joseph Bahiebo 《Smart Grid and Renewable Energy》 2024年第4期107-122,共16页
Ventilation is one of the factors contributing to energy consumption in buildings and food preservation. The solar chimney proves to be an alternative for reducing conventional energy consumption. Thus, in this study,... Ventilation is one of the factors contributing to energy consumption in buildings and food preservation. The solar chimney proves to be an alternative for reducing conventional energy consumption. Thus, in this study, the performance of a solar chimney with two active faces for thermally drawing air from a chamber for preserving agri-food products was evaluated. These performances were experimentally assessed through data measurements: temperatures and velocities within the chimney, and their analysis using Excel and MATLAB. The obtained results were compared with those from literature to verify their validity. From this study, it is found that the maximum temperature at the chimney outlet reaches 49.4˚C with an average value of 43.7˚C. Additionally, the heating evolution of the chimney air presents four (04) identical phases in pairs, reflecting the chimney’s operation throughout day. The temperature difference between the outlet and inlet of the chimney reaches a maximum of 17˚C with an average of 12.6˚C. Regarding airflow, the maximum air velocity at the chimney outlet is 0.8 m/s, and the average velocities have consistently been greater than or equal to 0.46 m/s. Thus, it can be concluded that the solar chimney is capable of providing ventilation for the preservation chamber through thermal draft. 展开更多
关键词 Solar Chimney Natural ventilation Thermal Draft AIRFLOW Chimney Effect
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Respiratory Mechanics, Respiratory Muscle Strength, Control of Ventilation and Gas Exchange in Patients with Autoimmune Liver Disease
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作者 Ahmet Baydur Jacob Korula 《Open Journal of Respiratory Diseases》 2024年第2期25-38,共14页
Objectives: To assess respiratory elastance and resistive properties in patients with autoimmune liver disorders using the passive relaxation expiration technique and compare findings to a group of patients with non-a... Objectives: To assess respiratory elastance and resistive properties in patients with autoimmune liver disorders using the passive relaxation expiration technique and compare findings to a group of patients with non-autoimmune liver disease and control subjects. These findings were then related to control of ventilation and gas exchange. A secondary objective was to assess respiratory muscle strength and gas exchange and their relation to respiratory mechanics. Methods: Measurements included respiratory elastance and resistance using the passive relaxation method. Pulmonary function, gas exchange and control of ventilation were assessed using standard methods. Results: a) Compared to control subjects, Ers in patients with liver disease was on average 50% greater than in controls;b) mean respiratory resistance, expressed as the respiratory constants, K<sub>1</sub> and K<sub>2</sub> in the Rohrer relationship, Pao/V’ = K<sub>1</sub> + K<sub>2</sub>V’, was not different from control resistance;c) mean maximal inspiratory and maximal expiratory pressures averaged 36% and 55% of their respective control values;d) inspiratory occlusion pressure in 0.1 sec (P<sub>0.1</sub>) was increased and negatively associated with FVC;and e) increases in P<sub>0.1</sub>, mean inspiratory flow (Vt/Ti) and presence of respiratory alkalosis confirmed the increase in ventilatory drive. Despite inspiratory muscle weakness in patients, P<sub>0.1</sub>/Pimax averaged 5-fold higher than in control subjects. Conclusions: Despite inspiratory muscle weakness and a V’<sub>E</sub> similar to that in normal subjects, central drive is increased in patients with chronic liver disease. The increase in ventilatory drive is related to smaller lung volumes and weakly associated with increase in respiratory elastance. Findings confirm that P<sub>0.1</sub> is a reliable measure of central drive and is an approach that can be used in the evaluation of control of ventilation in patients with chronic liver disease. 展开更多
关键词 Autoimmune Liver Disease Control of ventilation Occlusion Pressure Passive Relaxation Method Primary Biliary Cirrhosis Respiratory Elastance Respiratory Resistance
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Impact of Sedation Protocols on Elderly Patients Undergoing Mechanical Ventilation and Off-Line Weaning
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作者 Yihui Li Yamin Yuan +1 位作者 Jinquan Zhou Li Ma 《Journal of Clinical and Nursing Research》 2024年第4期322-333,共12页
The proportion of elderly patients in intensive care is increasing, and a significant proportion of them require mechanical ventilation. How to implement safe and effective mechanical ventilation for elderly patients,... The proportion of elderly patients in intensive care is increasing, and a significant proportion of them require mechanical ventilation. How to implement safe and effective mechanical ventilation for elderly patients, and when appropriate off-line is an important issue in the field of critical care medicine. Appropriate sedation can improve patient outcomes, but excessive sedation may lead to prolonged mechanical ventilation and increase the risk of complications. Elderly patients should be closely monitored and evaluated on an individual basis while offline, and the sedation regimen should be dynamically adjusted. This requires the healthcare team to consider the patient’s sedation needs, disease status, and pharmacodynamics and pharmacokinetics of the drug to arrive at the best strategy. Although the current research has provided valuable insights and strategies for sedation and off-line management, there are still many problems to be further explored and solved. 展开更多
关键词 Elderly patients Mechanical ventilation Off-line strategy Sedation treatment
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Analysis of the Effect of Non-Invasive Positive Pressure Ventilation in Emergency Treatment of Severe Bronchial Asthma with Respiratory Failure
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作者 Hua Liu 《Journal of Clinical and Nursing Research》 2024年第6期58-63,共6页
Objective:This study aims to evaluate the clinical efficacy of non-invasive positive pressure ventilation(NIPPV)in patients with severe bronchial asthma combined with respiratory failure.Methods:90 patients with sever... Objective:This study aims to evaluate the clinical efficacy of non-invasive positive pressure ventilation(NIPPV)in patients with severe bronchial asthma combined with respiratory failure.Methods:90 patients with severe bronchial asthma combined with respiratory failure between September 2022 and December 2023 were selected for the study and randomly divided into the experimental group(NIPPV-assisted treatment)and the control group.The differences between the two groups were compared in terms of total effective rate of treatment,days of clinical symptom disappearance,days of hospitalization,lung function indexes,incidence of adverse reactions,and quality of life.Results:Patients in the experimental group had a significantly higher total effective rate of treatment(97.78%)than the control group(75.56%).In terms of pulmonary function indexes,patients in the experimental group showed significant improvement after treatment,especially the increase in forced expiratory volume and forced vital capacity,while these improvements were not as obvious in the control group.In addition,the incidence of adverse reactions was significantly lower in the experimental group than in the control group,suggesting that the application of NIPPV is relatively safe.Quality of life assessment also showed that patients in the experimental group had significantly better quality of life than the control group after treatment.Conclusion:This study demonstrated the effectiveness of NIPPV as an adjunctive treatment for severe bronchial asthma combined with respiratory failure.NIPPV can improve lung function,reduce the incidence of adverse effects,increase the overall effectiveness of the treatment,and contribute to the improvement of patients'quality of life.Therefore,NIPPV should be regarded as an effective and safe treatment in clinical management,especially in patients with severe bronchial asthma combined with respiratory failure,where its application has potential clinical significance. 展开更多
关键词 Non-invasive positive pressure ventilation Adjunctive therapy Respiratory failure Severe bronchial asthma combined with respiratory failure Outcome assessment
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Numerical simulation to evaluate gas diffusion of turbulent flow in mine ventilation system 被引量:11
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作者 Arif Widiatmojo Kyuro Sasaki +4 位作者 Nuhindro Priagung Widodo Yuichi Sugai Johannes Sinaga Haris Yusuf 《International Journal of Mining Science and Technology》 SCIE EI 2013年第3期349-355,共7页
Tracer gas technique is a method to analyze the airflow path, measure the airflow quantity, and detect any recirculation or leakages in underground mine. In addition, it is also possible to evaluate the axial gas diff... Tracer gas technique is a method to analyze the airflow path, measure the airflow quantity, and detect any recirculation or leakages in underground mine. In addition, it is also possible to evaluate the axial gas diffusion of gas in turbulent bulk flow by utilizing the tracer gas data. This paper discussed about the measurement using tracer gas technique in Cibaliung Underground Mine, Indonesia and the evaluation of effective axial diffusion coefficient, E, by numerical simulation. In addition, a scheme to treat network flow in mine ventilation system was also proposed. The effective axial diffusion coefficient for each airway was evaluated based on Taylor's theoretical equation. It is found that the evaluated diffusion coefficient agrees well with Taylor's equation by considering that the wall friction factor, f, is higher than those for smooth pipe flow. It also shows that the value of effective diffusion coefficient can be inherently determined and the value is constant when matching with other measurements. Furthermore, there are possibilities to utilize the tracer gas measurement data to evaluate the airway friction factors. 展开更多
关键词 Tracer gas Effective axial diffusion coefficient Mine ventilation Numerical simulation
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Effect of sequential assist-control ventilation on cardio-pulmonary function and systemic inflammatory state of chronic pulmonary heart disease complicated with respiratory failure patients 被引量:2
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作者 Jiang Wang Ya-Dong Yang +1 位作者 Qiu-Fang She Yu Tang 《Journal of Hainan Medical University》 2018年第8期10-13,共4页
Objective:To discuss the effect of sequential assist-control ventilation on cardio-pulmonary function and systemic inflammatory state of chronic pulmonary heart disease complicated with respiratory failure patients.Me... Objective:To discuss the effect of sequential assist-control ventilation on cardio-pulmonary function and systemic inflammatory state of chronic pulmonary heart disease complicated with respiratory failure patients.Method: A total of 90 cases of chronic pulmonary heart disease complicated with respiratory failure patients, who were treated in our hospital between May, 2012 and Feb., 2016, were selected, and were divided into study group (n=45) and control group (n=45) based on random number table. Patients in control group were given auxiliary - control ventilation. (A/C) treatment during the whole course, while patients in study group were given A/C+BiPAP treatment. Cardio-pulmonary function and serum inflammatory factor content difference was compared inboth groups before and after operation.Results: Before treatment, difference ofcardiac function indicator, ABG level and inflammatory factor content in both groups had no statistical significance. After treatment, cardiac function indicator (PASP, RVd) levels in both groups were lower than before treatment, and EFRV levels were higher than before treatment, and changes in study group were more obvious than that in control group;ABG indicator (PaO2) levels in both groups were higher than before treatment, and PaCO2 levels werelower than before treatment, and changes in study group were more obvious than that in control group;serum inflammatory factor (hs-CRP, IL-6, TNF-α) content in both groups was lower than before treatment, and changes in study group were more obvious than that in control group.Conclusion: sequential assist-control ventilation could optimize the cardio-pulmonary function of chronic pulmonary heart disease complicated with respiratory failure patients and reduce the systemic inflammatory response. 展开更多
关键词 Chronic PULMONARY heart disease Respiratory failure SEQUENTIAL assist-control ventilation Cardio-pulmonary function Inflammatory response
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Study of the Temperature Distribution in a Road Tunnel Under the Effect of Two Ventilation Systems 被引量:1
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作者 Kalech Brahim Bouterra Mourad +1 位作者 El Cafsi Afif Belghith Ali 《Journal of Environmental Protection》 2011年第3期231-242,共12页
This paper proposes numerical investigations carried out on a small scale tunnel model airing to study the fire-induced smoke control by longitudinal and longitudinal-natural ventilation systems. We studied the effect... This paper proposes numerical investigations carried out on a small scale tunnel model airing to study the fire-induced smoke control by longitudinal and longitudinal-natural ventilation systems. We studied the effect of two ventilation systems on the temperature distribution and stratification of the pollutant to estimate the efficiency of ventilation systems. The flow is characterized by the temperature fields, temperature profiles and the Froude number. The numerical tool used is FDS (version 4.0). This numerical study requires validation with an experience of literature. Good agreement with experimental results confirms the possibility of using this code in the problem. 展开更多
关键词 TUNNEL FIRE ventilation FDS STRATIFIED FLOW TEMPERATURE
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Effect of different ventilation methods combined with pulmonary surfactant on neonatal acute respiratory distress syndrome 被引量:3
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作者 Qing Qing Ping Zha +1 位作者 Li-Ying Dai Yang Wang 《World Journal of Clinical Cases》 SCIE 2023年第25期5878-5886,共9页
BACKGROUND Acute respiratory distress syndrome precipitates is widespread pulmonary injury in impacted individuals,the neonatal respiratory distress syndrome(NRDS),primarily observed in preterm infants,represents a pr... BACKGROUND Acute respiratory distress syndrome precipitates is widespread pulmonary injury in impacted individuals,the neonatal respiratory distress syndrome(NRDS),primarily observed in preterm infants,represents a prevalent critical condition in neonatal clinical settings.AIM To investigate the clinical efficacy of various ventilation strategies combined with pulmonary surfactant(PS)therapy in the treatment of NRDS.METHODS A total of 20 neonates diagnosed with respiratory distress syndrome,admitted between May 2021 and June 2022,were randomly assigned to either a research group or a control group.Neonates in the research group received treatment involving high-frequency oscillatory ventilation(HFOV)in conjunction with PS.In contrast,neonates in the control group were administered either controlled mechanical ventilation or synchronous intermittent mandatory ventilation,combined with PS.Arterial blood samples from the neonates in both groups were collected before treatment,as well as 6 h,12 h,24 h,and 48 h post-treatment.These samples underwent blood gas analysis,with measurements taken for pH value,partial pressures of oxygen(O_(2))and carbon dioxide.Concurrently,data was collected on the duration of ventilator use,length of hospitalization time,O_(2) treatment time,treatment outcomes,and complications of the ventilator.RESULTS From 6-48 h post-treatment,both groups demonstrated significant improvements in arterial blood pH and oxygen partial pressure,along with a significant decrease in carbon dioxide partial pressure compared to pre-treatment values(P<0.05).Although these changes progressed over time,there were no significant differences between the two groups(P>0.05).However,the research group had significantly lower X-ray scores,shorter hospitalization time,and less time on O_(2) therapy compared to the control group(P<0.05).Mortality rates were similar between the two groups(P>0.05),but the research group had a significantly lower incidence of complications(P<0.05).CONCLUSION The integration of HFOV combine with PS has proven to effectively expedite the treatment duration,decrease the occurrence of complications,and secure the therapeutic efficacy in managing NRDS. 展开更多
关键词 Neonatal respiratory distress syndrome Pulmonary surfactant Mechanical ventilation Respiratory distress syndrome Acute respiratory distress syndrome
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Effect of lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation on the blood gas results and systemic state of patients with COPD complicated by severe pneumonia 被引量:1
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作者 Chang-Hao Yao Zhao-Hua Dai Rui-Li Chai 《Journal of Hainan Medical University》 2017年第22期87-90,共4页
Objective: To discuss the effect of lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation on the blood gas results and systemic state of patients with COPD complicated by severe p... Objective: To discuss the effect of lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation on the blood gas results and systemic state of patients with COPD complicated by severe pneumonia. Methods: A total of 68 patients with COPD complicated by severe pneumonia who were treated in the hospital between November 2015 and April 2017 were collected, retrospectively analyzed and then divided into the group A (n=35) who received noninvasive positive pressure ventilation and the group B (n=33) who received lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation. The differences in arterial blood gas and serum index levels were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in arterial blood gas index levels as well as serum contents of inflammatory mediators, stress hormones and myocardial enzyme spectrum indexes between the two groups. After treatment, arterial blood gas indexes PH and PaO2 levels of group B were higher than those of group A;serum inflammatory mediators HMGB1, PCT and hs-CRP contents were lower than those of group A;serum stress hormones Cor, AngⅠ and AngⅡcontents were lower than those of group A;serum myocardial enzyme spectrum indexesα-HBDH and cTn-Ⅰ contents were lower than those of group A. Conclusion: Lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation can effectively optimize the arterial blood gas levels, reduce systemic inflammatory stress state and protect the myocardial function of patients with COPD complicated by severe pneumonia. 展开更多
关键词 COPD Severe PNEUMONIA Non-invasive positive pressure ventilation Lung LAVAGE VIA FIBER BRONCHOSCOPE
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Dimensionless Study on Secretion Clearance of a Pressure Controlled Mechanical Ventilation System with Double Lungs
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作者 Dongkai Shen Qian Zhang +2 位作者 Yixuan Wang Huiqing Ge Zujin Luo 《Computer Modeling in Engineering & Sciences》 SCIE EI 2018年第2期117-139,共23页
A pressure controlled mechanical ventilator with an automatic secretion clearance function can improve secretion clearance safely and efficiently.Studies on secretion clearance by pressure controlled systems show that... A pressure controlled mechanical ventilator with an automatic secretion clearance function can improve secretion clearance safely and efficiently.Studies on secretion clearance by pressure controlled systems show that these are suited for clinical applications.However,these studies are based on a single lung electric model and neglect the coupling between the two lungs.The research methods applied are too complex for the analysis of a multi-parameter system.In order to understand the functioning of the human respiratory system,this paper develops a dimensionless mathematical model of doublelung mechanical ventilation system with a secretion clearance function.An experiment is designed to verify the mathematical model through comparison of dimensionless experimental data and dimensionless simulation data.Finally,the coupling between the two lungs is studied,and an orthogonal experiment designed to identify the impact of each parameter on the system. 展开更多
关键词 DIMENSIONLESS system MECHANICAL ventilation SECRETION CLEARANCE DOUBLE lungs PRESSURE control
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Clinical evaluation of ventilation mode on acute exacerbation of chronic obstructive pulmonary disease with respiratory failure 被引量:1
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作者 Jun-Jun Wang Zhong Zhou Li-Ying Zhang 《World Journal of Clinical Cases》 SCIE 2023年第26期6040-6050,共11页
BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains rela... BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains relatively limited.This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.AIM To determine whether pressure-controlled ventilation(PCV)can lower peak airway pressures(PAPs)and reduce the incidence of barotrauma compared to volume-controlled ventilation(VCV),without compromising clinical outcomes and oxygenation parameters.METHODS We have evaluated 600 patients who were hospitalized due to a severe COPD exacerbation,with 400 receiving mechanical ventilation for the respiratory failure.The participants were divided into two different groups,who were administered either VCV or PCV,along with appropriate management.We thereafter observed patients'attributes,clinical factors,and laboratory,radiographic,and arterial blood gas evaluations at the start and during their stay in the intensive care unit(ICU).We have also employed appropriate statistical methods for the data analysis.RESULTS Both the VCV and PCV groups experienced significant enhancements in the respiratory rate,tidal volume,and arterial blood gas values during their time in the ICU.However,no significant distinctions were detected between the groups in terms of oxygenation indices(partial pressures of oxygen/raction of inspired oxygen ratio)and partial pressures of carbon dioxide improvements.There was no considerable disparity observed between the VCV and PCV groups in the hospital mortality(32%vs 28%,P=0.53),the number of days of ICU stay[median interquartile range(IQR):9(6-14)d vs 8(5-13)d,P=0.41],or the duration of the mechanical ventilation[median(IQR):6(4-10)d vs 5(3-9)d,P=0.47].The PCV group displayed lower PAPs compared to the VCV group(P<0.05)from the beginning of mechanical ventilation until extubation or ICU departure.The occurrence of barotrauma was considerably lower in the PCV group in comparison to the VCV group(6%vs 16%,P=0.03).CONCLUSION Both VCV and PCV were found to be effective in treating patients with acute COPD exacerbation.However,PCV was associated with lower PAPs and a significant decrease in barotrauma,thus indicating that it might be a safer ventilation method for this group of patients.However,further large-scale study is necessary to confirm these findings and to identify the best ventilation approach for patients experiencing an acute COPD exacerbation. 展开更多
关键词 Chronic obstructive pulmonary disease Mechanical ventilation Volume-controlled ventilation Pressurecontrolled ventilation BAROTRAUMA Respiratory failure
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Effectiveness of daily interruption of sedation in sedated patients with mechanical ventilation in ICU: A systematic review
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作者 Hong-Bo Chen Jun Liu +1 位作者 Li-Qin Chen Gong-Chao Wang 《International Journal of Nursing Sciences》 2014年第4期346-351,共6页
Purpose:To evaluate the effectiveness of daily sedation interruption in patients with mechanical ventilation in intensive care unit(ICU).Methods:The randomized controlled trials(RCTs)on the application of daily interr... Purpose:To evaluate the effectiveness of daily sedation interruption in patients with mechanical ventilation in intensive care unit(ICU).Methods:The randomized controlled trials(RCTs)on the application of daily interruption of sedation in sedated patients with mechanical ventilation in ICU were collected through databases including Cochrane library,MEDLINE,Web of Knowledge,Embase,CNKI,CBM and VIP Data.Two reviewers independently assessed the quality of studies and extracted the data.Meta-analysis was conducted on the included studies.Results:Eight RCTs involving 757 patients were included.The daily sedation interruptions could shorten the duration of mechanical ventilation(Z=5.36,p<0.0001),length of stay(Z=2.93,p=0.003<0.05)and reduce the rate of tracheotomy(Z=3.97,p<0.00001)in these patients.Additionally,daily sedation interruption was not associated with increased rate of unplanned extubation by the patients(Z=0.53,p=0.6<0.05).Conclusion:The application of daily interruption of sedation in patients with mechanical ventilation in ICU is safe and effective. 展开更多
关键词 Daily interruption of sedation Mechanical ventilation META-ANALYSIS SEDATION
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Prediction Analysis on the Transport Distance of Supply Air in Warm Air Heating Room with Impinging Jet Ventilation Systems
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作者 陈新秋 钟珂 +1 位作者 卢思亮 亢燕铭 《Journal of Donghua University(English Edition)》 EI CAS 2015年第5期725-730,共6页
To overcome the disadvantages of displacement ventilation( DV) and traditional mixing ventilation( MV) system,a new ventilation system known as impinging jet ventilation system( IJVS)has been developing. The warm air ... To overcome the disadvantages of displacement ventilation( DV) and traditional mixing ventilation( MV) system,a new ventilation system known as impinging jet ventilation system( IJVS)has been developing. The warm air can be supplied with impinging jet ventilation( IJV), while the DV is only used for cooling.However,the flow and temperature field of IJV under heating scenario has had few references. The paper is mainly focused on computational fluid dynamics( CFD) and developing an adequate correlation between the distance L that warm air can reach and different parameters in the warm IJVS by using response surface methodology( RSM). The results indicate that L decreases as the supply velocity υ decreases but increases as the supply temperature difference ΔT or the discharge height h decreases. In the variable air volume( VAV) system, it is necessary to determine supply parameters both under the maximum-heat-load condition and the small-heat-load condition. Unlike the VAV system,the constant air volume( CAV) system has no need to study the small-heat-load condition. Draught discomfort near the nozzle becomes the issue of concern in IJVS, thus the suitable discharge height is of great importance in design and can be calculated based on the predictive model. 展开更多
关键词 warm air heating impinging jet ventilation systems(IJVSs) transport distance of supply air response surface methodology(RSM)
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The Research of Performance Comparison of Displacement and Mixing Ventilation System in Catering Kitchen
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作者 Jianping Yuan Longyan Wang +1 位作者 Xiaofan Liu Zhixia He 《Open Journal of Fluid Dynamics》 2013年第2期61-68,共8页
A commercial kitchen is a complicated environment where multiple components of a ventilation system including hood exhaust, conditioned air supply, and makeup air systems work together but not always in unison. And th... A commercial kitchen is a complicated environment where multiple components of a ventilation system including hood exhaust, conditioned air supply, and makeup air systems work together but not always in unison. And the application of an appropriate ventilation system is extremely vital to keep the catering kitchen comfortable, which consequently promotes the productivity and gains. Application of two systems (traditional mixing ventilation system and thermal displacement ventilation system) is compared in a typical kitchen environment using computational fluid dynamics modeling which was used to investigate the difference between mixing and displacement ventilation (DV). It was reported in two parts, one on thermal comfort and the other one on indoor air quality. The results show that DV can maintain a thermally comfortable environment that has a low air velocity, a small temperature difference between the head and ankle level, and a low percentage of dissatisfied people, and may provide better IAQ in the occupied zone. So it was persuasive that using thermal displacement ventilation in kitchen environment allows for a reduction in space temperature without increasing the air-conditioning system capacity. 展开更多
关键词 KITCHEN DISPLACEMENT ventilation MIXING ventilation NUMERICAL SIMULATION
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