[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly int...[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly into the control group (62 cases) and the treatment group (64 cases). The control group was treated with routine western medicine, and the treatment group was treated with routine western medicine combined with Huangku Qingxin Mixture, both for one month. Then, observed the changes of Myerburg score, SAS score, symptom score and dynamic electrocardiogram in the two groups before and after treatment.[Results] The total effective rate of clinical symptoms was 82.81% in the treatment group and 64.52% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). The total effective rate of dynamic electrocardiogram was 84.38% in the treatment group and 58.06% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). Before treatment, there was no significant difference being found in the comparison of the scores of Myerburg and SAS in the two groups ( P >0.05). After treatment, Myerburg score and SAS score in the two groups were lower than those before treatment ( P <0.05);Myerburg score and SAS score in the treatment group were both better than those in the control group ( P <0.05). Before treatment, there was no significant difference in the comparison of the QT interval dispersion (QTd) and the corrected QT interval dispersion (QTcd) by Bazette formula ( P >0.05). After treatment, the results of QTd and QTcd in the two groups were lower than those before treatment ( P <0.05);the results of QTd and QTcd in the treatment group were better than those in the control group ( P <0.05).[Conclusions] The application of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets can effectively reduce Myerburg scores and SAS scores in patients with ventricular premature beat, shorten QTd and QTcd, and improve the life quality of patients. It has no adverse clinical reaction.展开更多
Objective:To explore the clinical efficacy of Ningxin Tongluo Decoction(宁心通络汤)combined with Dapagliflozin in the treatment of type 2 diabetes mellitus complicated with ventricular premature beats.Methods:Ninety-t...Objective:To explore the clinical efficacy of Ningxin Tongluo Decoction(宁心通络汤)combined with Dapagliflozin in the treatment of type 2 diabetes mellitus complicated with ventricular premature beats.Methods:Ninety-two patients with type 2 diabetes mellitus complicated with ventricular premature beats in our hospital were randomly divided into control group(n=46)and observation group(n=46).The control group was treated with routine Western medicine,and the observation group was treated with Ningxin Tongluo Decoction on the basis of the control group.The clinical efficacy of the two groups before and after treatment,TCM syndrome score,blood glucose levels[fasting blood glucose(GLU),glycosylated hemoglobin(Hb A1c)],glucose metabolism levels[fasting insulin(FINS),insulin resistance index(HOMA-IR)],the number of ventricular premature beats detected by 24-hour ambulatory electrocardiogram,heart rate turbulence(HRT)[initial oscillation(TO),oscillation slope(TS)],and heart rate variability(HRV)standard deviation of two normal R-R intervals(SDNN),standard deviation of average normal R-R intervals every 5 minutes(SDANN)and root mean square of adjacent normal R-R intervals(RMSSD)were observed.Results:After treatment,the total effective rate of the observation group was 89.13%,significantly higher than that of the control group(73.91%),and the difference was statistically significant(P<0.05).Both groups could reduce TCM syndrome score,blood glucose level,glucose metabolism level,reduce the number of ventricular premature beats,improve HRT and HRV levels,and the observation group was superior to the control group,and the difference was statistically significant(P<0.05).Conclusion:Ningxin Tongluo Decoction combined with Dapagliflozin is effective in treating type 2 diabetes mellitus patients with ventricular premature beats.It can reduce blood glucose level,improve HRV and HRT,improve autonomic nerve function and exert antiarrhythmic effect.展开更多
Ventricular premature beat,a kind of arrhythmia,is one of common diseases which not only decreases the quality of life but also has the danger of death.The pathogenesis in Traditional Chinese Medicine is that the inju...Ventricular premature beat,a kind of arrhythmia,is one of common diseases which not only decreases the quality of life but also has the danger of death.The pathogenesis in Traditional Chinese Medicine is that the injury of heart and kidney is the essence and the block of solid evil such as phlegm and blood stasis is the manifestation.The teacher,Li Yuan,has worked in clinic for decades and considered that the important pathogenesis of the VP beat is“heat transformed from Yang”,which cannot be ignored as it is on the influence of diverse factors and can be observed in different symptoms and different treatment states of the disease.展开更多
Objective To investigate the mechanism of ventricular dilation-induced arrhythmias by dilating isolated rat hearts. Methods Isolated rat hearts were perfused by Langerdorff method. After equilibration,80 hearts were r...Objective To investigate the mechanism of ventricular dilation-induced arrhythmias by dilating isolated rat hearts. Methods Isolated rat hearts were perfused by Langerdorff method. After equilibration,80 hearts were randomly divided into four groups as follows:(1) control group(n=20) ,(2) Ca2+ preconditioning(CPC) group(n=20) ,(3) streptomycin group(n=20) ,and(4) CPC + streptomycin group(n=20) . A latex balloon which can be filled with fluid was anchored in the left ventricle through the left atrium and mitral valve. Epicardial ECG of the left ventricle,left ventricular pressure,coronary flow and heart rate were recorded before and during ventricular dilation by injecting fluid into the latex balloon. The rate and duration of ventricular dilation-induced arrhythmias were recorded. Results Under the same increase in ventricular end-diastolic pressure made by inflation of the balloon,the rate of arrhythmias was 100% and duration of arrhythmias was 2. 56±0.46s in the control group. Both the rates of premature ventricular beat(90%) and ventricular tachycardia 70%) were high. Compared with the control group,the total rate(60%) of arrhythmias was lower,and duration(1.67±0.61s) of arrhythmias was shorter in the CPC group. Both the rates of premature ventricular beat(60%) and ventricular tachycardia(40%) were low comparatively. The rate of arrhythmias(45%) was lower and duration(1.64±0.42s) of arrhythmias was shorter,and the rates of premature ventricular beat(30%) or ventricular tachycardia(35%) were lower in the streptomycin group than in the control one. The least ventricular dilation-induced arrhythmias occurred in the CPC + streptomycin group. The rate of arrhythmias(10%) was the lowest and duration(1.01±0.37s) of arrhythmias was the shortest;both the rates of premature ventricular beat(5%) and ventricular tachycardia(10%) were the lowest. Conclusions Ventricular dilation may induce arrhythmias in isolated rat hearts. Stretch-activated ion channel and the increase in [Ca2+]i are supposed to play important roles in the pathological mechanism.展开更多
文摘[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly into the control group (62 cases) and the treatment group (64 cases). The control group was treated with routine western medicine, and the treatment group was treated with routine western medicine combined with Huangku Qingxin Mixture, both for one month. Then, observed the changes of Myerburg score, SAS score, symptom score and dynamic electrocardiogram in the two groups before and after treatment.[Results] The total effective rate of clinical symptoms was 82.81% in the treatment group and 64.52% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). The total effective rate of dynamic electrocardiogram was 84.38% in the treatment group and 58.06% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). Before treatment, there was no significant difference being found in the comparison of the scores of Myerburg and SAS in the two groups ( P >0.05). After treatment, Myerburg score and SAS score in the two groups were lower than those before treatment ( P <0.05);Myerburg score and SAS score in the treatment group were both better than those in the control group ( P <0.05). Before treatment, there was no significant difference in the comparison of the QT interval dispersion (QTd) and the corrected QT interval dispersion (QTcd) by Bazette formula ( P >0.05). After treatment, the results of QTd and QTcd in the two groups were lower than those before treatment ( P <0.05);the results of QTd and QTcd in the treatment group were better than those in the control group ( P <0.05).[Conclusions] The application of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets can effectively reduce Myerburg scores and SAS scores in patients with ventricular premature beat, shorten QTd and QTcd, and improve the life quality of patients. It has no adverse clinical reaction.
文摘Objective:To explore the clinical efficacy of Ningxin Tongluo Decoction(宁心通络汤)combined with Dapagliflozin in the treatment of type 2 diabetes mellitus complicated with ventricular premature beats.Methods:Ninety-two patients with type 2 diabetes mellitus complicated with ventricular premature beats in our hospital were randomly divided into control group(n=46)and observation group(n=46).The control group was treated with routine Western medicine,and the observation group was treated with Ningxin Tongluo Decoction on the basis of the control group.The clinical efficacy of the two groups before and after treatment,TCM syndrome score,blood glucose levels[fasting blood glucose(GLU),glycosylated hemoglobin(Hb A1c)],glucose metabolism levels[fasting insulin(FINS),insulin resistance index(HOMA-IR)],the number of ventricular premature beats detected by 24-hour ambulatory electrocardiogram,heart rate turbulence(HRT)[initial oscillation(TO),oscillation slope(TS)],and heart rate variability(HRV)standard deviation of two normal R-R intervals(SDNN),standard deviation of average normal R-R intervals every 5 minutes(SDANN)and root mean square of adjacent normal R-R intervals(RMSSD)were observed.Results:After treatment,the total effective rate of the observation group was 89.13%,significantly higher than that of the control group(73.91%),and the difference was statistically significant(P<0.05).Both groups could reduce TCM syndrome score,blood glucose level,glucose metabolism level,reduce the number of ventricular premature beats,improve HRT and HRV levels,and the observation group was superior to the control group,and the difference was statistically significant(P<0.05).Conclusion:Ningxin Tongluo Decoction combined with Dapagliflozin is effective in treating type 2 diabetes mellitus patients with ventricular premature beats.It can reduce blood glucose level,improve HRV and HRT,improve autonomic nerve function and exert antiarrhythmic effect.
文摘Ventricular premature beat,a kind of arrhythmia,is one of common diseases which not only decreases the quality of life but also has the danger of death.The pathogenesis in Traditional Chinese Medicine is that the injury of heart and kidney is the essence and the block of solid evil such as phlegm and blood stasis is the manifestation.The teacher,Li Yuan,has worked in clinic for decades and considered that the important pathogenesis of the VP beat is“heat transformed from Yang”,which cannot be ignored as it is on the influence of diverse factors and can be observed in different symptoms and different treatment states of the disease.
基金grants from the National Natural Science Foundation of China (No.30270559)
文摘Objective To investigate the mechanism of ventricular dilation-induced arrhythmias by dilating isolated rat hearts. Methods Isolated rat hearts were perfused by Langerdorff method. After equilibration,80 hearts were randomly divided into four groups as follows:(1) control group(n=20) ,(2) Ca2+ preconditioning(CPC) group(n=20) ,(3) streptomycin group(n=20) ,and(4) CPC + streptomycin group(n=20) . A latex balloon which can be filled with fluid was anchored in the left ventricle through the left atrium and mitral valve. Epicardial ECG of the left ventricle,left ventricular pressure,coronary flow and heart rate were recorded before and during ventricular dilation by injecting fluid into the latex balloon. The rate and duration of ventricular dilation-induced arrhythmias were recorded. Results Under the same increase in ventricular end-diastolic pressure made by inflation of the balloon,the rate of arrhythmias was 100% and duration of arrhythmias was 2. 56±0.46s in the control group. Both the rates of premature ventricular beat(90%) and ventricular tachycardia 70%) were high. Compared with the control group,the total rate(60%) of arrhythmias was lower,and duration(1.67±0.61s) of arrhythmias was shorter in the CPC group. Both the rates of premature ventricular beat(60%) and ventricular tachycardia(40%) were low comparatively. The rate of arrhythmias(45%) was lower and duration(1.64±0.42s) of arrhythmias was shorter,and the rates of premature ventricular beat(30%) or ventricular tachycardia(35%) were lower in the streptomycin group than in the control one. The least ventricular dilation-induced arrhythmias occurred in the CPC + streptomycin group. The rate of arrhythmias(10%) was the lowest and duration(1.01±0.37s) of arrhythmias was the shortest;both the rates of premature ventricular beat(5%) and ventricular tachycardia(10%) were the lowest. Conclusions Ventricular dilation may induce arrhythmias in isolated rat hearts. Stretch-activated ion channel and the increase in [Ca2+]i are supposed to play important roles in the pathological mechanism.
