Refinement modeling and verification of secure operating systems for communication in digital twins

In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the digital twin communication system implementation is completely correct.Formal verification is currently recognized as a method to ensure the correctness of software system for communication in digital twins because it uses rigorous mathematical methods to verify the correctness of systems for communication in digital twins and can effectively help system designers determine whether the system is designed and implemented correctly.In this paper,we use the interactive theorem proving tool Isabelle/HOL to construct the formal model of the X86 architecture,and to model the related assembly instructions.The verification result shows that the system states obtained after the operations of relevant assembly instructions is consistent with the expected states,indicating that the system meets the design expectations.

Anti-Jamming Null Space Projection Beamforming Based on Symbiotic Radio

With the development of information technology,more and more devices are connected to the Internet through wireless communication to complete data interconnection.Due to the broadcast characteristics ofwireless channels,wireless networks have suffered more and more malicious attacks.Physical layer security has received extensive attention from industry and academia.MIMO is considered to be one of the most important technologies related to physical layer security.Through beamforming technology,messages can be transmitted to legitimate users in an offset direction that is as orthogonal as possible to the interference channel to ensure the reception SINR by legitimate users.Combining the symbiotic radio(SR)technology,this paper considers a symbiotic radio antijamming MIMO system equipped with a multi-antenna system at the main base station.In order to avoid the interference signal and improve the SINR of the signal received by the user.The base station is equipped with a uniform rectangular antenna array,and using Null Space Projection(NSP)Beamforming,Intelligent Reflecting Surface(IRS)can assist in changing the beam’s angle.The simulation results show that NSP Beamforming could make a better use of the null space of interference,which can effectively improve the received SINR of users under directional interference,and improve the utilization efficiency of signal energy.

Semantic Consistency and Correctness Verification of Digital Traffic Rules

The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human drivers.Using formal or digital methods,natural language traffic rules can be translated into machine language and used by autonomous vehicles.In this paper,a translation flow is designed.Beyond the translation,a deeper examination is required,because the semantics of natural languages are rich and complex,and frequently contain hidden assumptions.The issue of how to ensure that digital rules are accurate and consistent with the original intent of the traffic rules they represent is both significant and unresolved.In response,we propose a method of formal verification that combines equivalence verification with model checking.Reasonable and reassuring digital traffic rules can be obtained by utilizing the proposed traffic rule digitization flow and verification method.In addition,we offer a number of simulation applications that employ digital traffic rules to assess vehicle violations.The experimental findings indicate that our digital rules utilizing metric temporal logic(MTL)can be easily incorporated into simulation platforms and autonomous driving systems(ADS).

The First Verification Test of Space-Ground Collaborative Intelligence via Cloud-Native Satellites

Recent advancements in satellite technologies and the declining cost of access to space have led to the emergence of large satellite constellations in Low Earth Orbit(LEO).However,these constellations often rely on bent-pipe architecture,resulting in high communication costs.Existing onboard inference architectures suffer from limitations in terms of low accuracy and inflexibility in the deployment and management of in-orbit applications.To address these challenges,we propose a cloud-native-based satellite design specifically tailored for Earth Observation tasks,enabling diverse computing paradigms.In this work,we present a case study of a satellite-ground collaborative inference system deployed in the Tiansuan constellation,demonstrating a remarkable 50%accuracy improvement and a substantial 90%data reduction.Our work sheds light on in-orbit energy,where in-orbit computing accounts for 17%of the total onboard energy consumption.Our approach represents a significant advancement of cloud-native satellite,aiming to enhance the accuracy of in-orbit computing while simultaneously reducing communication cost.

Dynamic Signature Verification Using Pattern Recognition

Dynamic signature is a biometric modality that recognizes an individual’s anatomic and behavioural characteristics when signing their name. The rampant case of signature falsification (Identity Theft) was the key motivating factor for embarking on this study. This study was necessitated by the damages and dangers posed by signature forgery coupled with the intractable nature of the problem. The aim and objectives of this study is to design a proactive and responsive system that could compare two signature samples and detect the correct signature against the forged one. Dynamic Signature verification is an important biometric technique that aims to detect whether a given signature is genuine or forged. In this research work, Convolutional Neural Networks (CNNsor ConvNet) which is a class of deep, feed forward artificial neural networks that has successfully been applied to analysing visual imagery was used to train the model. The signature images are stored in a file directory structure which the Keras Python library can work with. Then the CNN was implemented in python using the Keras with the TensorFlow backend to learn the patterns associated with the signature. The result showed that for the same CNNs-based network experimental result of average accuracy, the larger the training dataset, the higher the test accuracy. However, when the training dataset are insufficient, better results can be obtained. The paper concluded that by training datasets using CNNs network, 98% accuracy in the result was recorded, in the experimental part, the model achieved a high degree of accuracy in the classification of the biometric parameters used.

A Novel High-Efficiency Transaction Verification Scheme for Blockchain Systems

Blockchain can realize the reliable storage of a large amount of data that is chronologically related and verifiable within the system.This technology has been widely used and has developed rapidly in big data systems across various fields.An increasing number of users are participating in application systems that use blockchain as their underlying architecture.As the number of transactions and the capital involved in blockchain grow,ensuring information security becomes imperative.Addressing the verification of transactional information security and privacy has emerged as a critical challenge.Blockchain-based verification methods can effectively eliminate the need for centralized third-party organizations.However,the efficiency of nodes in storing and verifying blockchain data faces unprecedented challenges.To address this issue,this paper introduces an efficient verification scheme for transaction security.Initially,it presents a node evaluation module to estimate the activity level of user nodes participating in transactions,accompanied by a probabilistic analysis for all transactions.Subsequently,this paper optimizes the conventional transaction organization form,introduces a heterogeneous Merkle tree storage structure,and designs algorithms for constructing these heterogeneous trees.Theoretical analyses and simulation experiments conclusively demonstrate the superior performance of this scheme.When verifying the same number of transactions,the heterogeneous Merkle tree transmits less data and is more efficient than traditional methods.The findings indicate that the heterogeneous Merkle tree structure is suitable for various blockchain applications,including the Internet of Things.This scheme can markedly enhance the efficiency of information verification and bolster the security of distributed systems.

Ghost Module Based Residual Mixture of Self-Attention and Convolution for Online Signature Verification

Online Signature Verification (OSV), as a personal identification technology, is widely used in various industries.However, it faces challenges, such as incomplete feature extraction, low accuracy, and computational heaviness. Toaddress these issues, we propose a novel approach for online signature verification, using a one-dimensionalGhost-ACmix Residual Network (1D-ACGRNet), which is a Ghost-ACmix Residual Network that combines convolutionwith a self-attention mechanism and performs improvement by using Ghost method. The Ghost-ACmix Residualstructure is introduced to leverage both self-attention and convolution mechanisms for capturing global featureinformation and extracting local information, effectively complementing whole and local signature features andmitigating the problem of insufficient feature extraction. Then, the Ghost-based Convolution and Self-Attention(ACG) block is proposed to simplify the common parts between convolution and self-attention using the Ghostmodule and employ feature transformation to obtain intermediate features, thus reducing computational costs.Additionally, feature selection is performed using the random forestmethod, and the data is dimensionally reducedusing Principal Component Analysis (PCA). Finally, tests are implemented on the MCYT-100 datasets and theSVC-2004 Task2 datasets, and the equal error rates (EERs) for small-sample training using five genuine andforged signatures are 3.07% and 4.17%, respectively. The EERs for training with ten genuine and forged signaturesare 0.91% and 2.12% on the respective datasets. The experimental results illustrate that the proposed approacheffectively enhances the accuracy of online signature verification.

Efficacy of Juanbi capsule on ameliorating knee osteoarthritis:a network pharmacology and experimental verification-based study

Background:The purpose of the study was to investigate the active ingredients and potential biochemical mechanisms of Juanbi capsule in knee osteoarthritis based on network pharmacology,molecular docking and animal experiments.Methods:Chemical components for each drug in the Juanbi capsule were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,while the target proteins for knee osteoarthritis were retrieved from the Drugbank,GeneCards,and OMIM databases.The study compared information on knee osteoarthritis and the targets of drugs to identify common elements.The data was imported into the STRING platform to generate a protein-protein interaction network diagram.Subsequently,a“component-target”network diagram was created using the screened drug components and target information with Cytoscape software.Common targets were imported into Metascape for GO function and KEGG pathway enrichment analysis.AutoDockTools was utilized to predict the molecular docking of the primary chemical components and core targets.Ultimately,the key targets were validated through animal experiments.Results:Juanbi capsule ameliorated Knee osteoarthritis mainly by affecting tumor necrosis factor,interleukin1β,MMP9,PTGS2,VEGFA,TP53,and other cytokines through quercetin,kaempferol,andβ-sitosterol.The drug also influenced the AGE-RAGE,interleukin-17,tumor necrosis factor,Relaxin,and NF-κB signaling pathways.The network pharmacology analysis results were further validated in animal experiments.The results indicated that Juanbi capsule could decrease the levels of tumor necrosis factor-αand interleukin-1βin the serum and synovial fluid of knee osteoarthritis rats and also down-regulate the expression levels of MMP9 and PTGS2 proteins in the articular cartilage.Conclusion:Juanbi capsule may improve the knee bone microstructure and reduce the expression of inflammatory factors of knee osteoarthritis via multiple targets and multiple signaling pathways.

Verification and Application Evaluation of Intelligent Audit Rules for The UN9000 Urine Analysis System

Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to November 2021 were randomly selected,and all samples were manually microscopic examined after the detection of the UN9000 urine analysis line.The intelligent audit rules(including the microscopic review rules and manual verification rules)were validated based on the manual microscopic examination and manual audit,and the rules were adjusted to apply to our laboratory.The laboratory turnaround time(TAT)before and after the application of intelligent audit rules was compared.Result:The microscopic review rate of intelligent rules was 25.63%(292/1139),the true positive rate,false positive rate,true negative rate,and false negative rate were 27.66%(315/1139),6.49%(74/1139),62.34%(710/1139)and 3.51%(40/1139),respectively.The approval consistency rate of manual verification rules was 84.92%(727/856),the approval inconsistency rate was 0%(0/856),the interception consistency rate was 12.61%(108/856),and the interception inconsistency rate was 0%(0/856).Conclusion:The intelligence audit rules for urine analysis by Cui et al.have good clinical applicability in our laboratory.

GNSS array receiver faced with overloaded interferences:anti-jamming performance and the incident directions of interferences

Anti-jamming solutions based on antenna arrays enhance the anti-jamming ability and the robustness of global navigation satellite system(GNSS)receiver remarkably.However,the performance of the receiver will deteriorate significantly in the overloaded interferences scenario.We define the overloaded interferences scenario as where the number of interferences is more than or equal to the number of antenna arrays elements.In this paper,the effect mechanism of interferences with different incident directions is found by studying the anti-jamming performance of the adaptive space filter.The theoretical analysis and conclusions,which are first validated through numerical examples,reveal the relationships between the optimal weight vector and the eigenvectors of the input signal autocorrelation matrix,the relationships between the interference cancellation ratio(ICR),the signal to interference and noise power ratio(SINR)of the adaptive space filter output and the number of interferences,the eigenvalues of the input signal autocorrelation matrix.In addition,two simulation experiments are utilized to further corroborate the theoretical findings through soft anti-jamming receiver.The simulation results match well with the theoretical analysis results,thus validating the effect mechanism of overloaded interferences.The simulation results show that,for a four elements circular array,the performance difference is up to 19 dB with different incident directions of interferences.Anti-jamming performance evaluation and jamming deployment optimization can obtain more accurate and efficient results by using the conclusions.

A measurable refinement method of design and verification for micro-kernel operating systems in communication network

A secure operating system in the communication network can provide the stable working environment,which ensures that the user information is not stolen.The micro-kernel operating system in the communication network retains the core functions in the kernel,and unnecessary tasks are implemented by calling external processes.Due to the small amount of code,the micro-kernel architecture has high reliability and scalability.Taking the microkernel operating system in the communication network prototype VSOS as an example,we employ the objdump tool to disassemble the system source code and get the assembly layer code.On this basis,we apply the Isabelle/HOL,a formal verification tool,to model the system prototype.By referring to the mathematical model of finite automata and taking the process scheduling module as an example,the security verification based on the assembly language layer is developed.Based on the Hoare logic theory,each assembly statement of the module is verified in turn.The verification results show that the scheduling module of VSOS has good functional security,and also show the feasibility of the refinement framework.

Numerical simulation and experimental verification of plasma jet development in gas gap switch

Plasma jet triggered gas gap switch has obvious advantages in fast control switch.The development of the plasma in the ambient medium is the key factor affecting the triggering conduction of the gas switch.However,the plasma jet process and its characteristic parameters are complicated and the existing test methods cannot fully characterize its development laws.In this work,a two-dimensional transient fluid calculation model of the plasma jet process of the gas gap switch is established based on the renormalization-group k-εturbulence equation.The results show that the characteristic parameters and morphological evolution of the plasma jet are basically consistent with the experimental results,which verifies the accuracy of the simulation model calculation.The plasma jet is a long strip with an initial velocity of 1.0 km·s-1and develops in both axial and radial directions.The jet velocity fluctuates significantly with axial height.As the plasma jet enters the main gap,the pressure inside the trigger cavity drops by80%,resulting in a rapid drop in the jet velocity.When the plasma jet head interacts with the atmosphere,the two-phase fluid compresses each other,generating a forward-propelled pressure wave.The plasma jet heads flow at high velocity,a negative pressure zone is formed in the middle part of the jet,and the pressure peak decreases gradually with height.As the value of the inlet pressure increases,the characteristic parameters of the plasma jet increase.The entrainment phenomenon is evident,which leads to an increase in the pressure imbalance of the atmospheric gas medium,leading to a significant Coanda effect.Compared with air,the characteristic parameters of a plasma jet in SF6are lower,and the morphological evolution is significantly suppressed.The results of this study can provide some insight into the mechanism of action of the switch jet plasma development process.

Hyper-Tuned Convolutional Neural Networks for Authorship Verification in Digital Forensic Investigations

Authorship verification is a crucial task in digital forensic investigations,where it is often necessary to determine whether a specific individual wrote a particular piece of text.Convolutional Neural Networks(CNNs)have shown promise in solving this problem,but their performance highly depends on the choice of hyperparameters.In this paper,we explore the effectiveness of hyperparameter tuning in improving the performance of CNNs for authorship verification.We conduct experiments using a Hyper Tuned CNN model with three popular optimization algorithms:Adaptive Moment Estimation(ADAM),StochasticGradientDescent(SGD),andRoot Mean Squared Propagation(RMSPROP).The model is trained and tested on a dataset of text samples collected from various authors,and the performance is evaluated using accuracy,precision,recall,and F1 score.We compare the performance of the three optimization algorithms and demonstrate the effectiveness of hyperparameter tuning in improving the accuracy of the CNN model.Our results show that the Hyper Tuned CNN model with ADAM Optimizer achieves the highest accuracy of up to 90%.Furthermore,we demonstrate that hyperparameter tuning can help achieve significant performance improvements,even using a relatively simple model architecture like CNNs.Our findings suggest that the choice of the optimization algorithm is a crucial factor in the performance of CNNs for authorship verification and that hyperparameter tuning can be an effective way to optimize this choice.Overall,this paper demonstrates the effectiveness of hyperparameter tuning in improving the performance of CNNs for authorship verification in digital forensic investigations.Our findings have important implications for developing accurate and reliable authorship verification systems,which are crucial for various applications in digital forensics,such as identifying the author of anonymous threatening messages or detecting cases of plagiarism.

OffSig-SinGAN: A Deep Learning-Based Image Augmentation Model for Offline Signature Verification

Offline signature verification(OfSV)is essential in preventing the falsification of documents.Deep learning(DL)based OfSVs require a high number of signature images to attain acceptable performance.However,a limited number of signature samples are available to train these models in a real-world scenario.Several researchers have proposed models to augment new signature images by applying various transformations.Others,on the other hand,have used human neuromotor and cognitive-inspired augmentation models to address the demand for more signature samples.Hence,augmenting a sufficient number of signatures with variations is still a challenging task.This study proposed OffSig-SinGAN:a deep learning-based image augmentation model to address the limited number of signatures problem on offline signature verification.The proposed model is capable of augmenting better quality signatures with diversity from a single signature image only.It is empirically evaluated on widely used public datasets;GPDSsyntheticSignature.The quality of augmented signature images is assessed using four metrics like pixel-by-pixel difference,peak signal-to-noise ratio(PSNR),structural similarity index measure(SSIM),and frechet inception distance(FID).Furthermore,various experiments were organised to evaluate the proposed image augmentation model’s performance on selected DL-based OfSV systems and to prove whether it helped to improve the verification accuracy rate.Experiment results showed that the proposed augmentation model performed better on the GPDSsyntheticSignature dataset than other augmentation methods.The improved verification accuracy rate of the selected DL-based OfSV system proved the effectiveness of the proposed augmentation model.

Detailed analysis and simulation verification for reconstruction of plasma optical boundary with spectrometric technique on HL-2M tokamak

The plasma optical boundary reconstruction technique based on Hommen's theory is promising for future tokamaks with high parameters. In this work, we conduct detailed analysis and simulation verification to estimate the ‘logic loophole' of this technique. The finite-width effect and unpredictable errors reduce the technique's reliability, which leads to this loophole. Based on imaging theory, the photos of a virtual camera are simulated by integrating the assumed luminous intensity of plasma. Based on Hommen's theory, the plasma optical boundary is reconstructed from the photos. Comparing the reconstructed boundary with the one assumed, the logic loophole and its two effects are quantitatively estimated. The finite-width effect is related to the equivalent thickness of the luminous layer, which is generally about 2-4 cm but sometimes larger. The level of unpredictable errors is around 0.65 cm. The technique based on Hommen's theory is generally reliable, but finite-width effect and unpredictable errors have to be taken into consideration in some scenarios. The parameters of HL-2M are applied in this work.

Dynamic Spectrum Anti-Jamming with Distributed Learning and Transfer Learning

Physical-layer security issues in wireless systems have attracted great attention.In this paper,we investigate the spectrum anti-jamming(AJ)problem for data transmissions between devices.Considering fast-changing physical-layer jamming attacks in the time/frequency domain,frequency resources have to be configured for devices in advance with unknown jamming patterns(i.e.the time-frequency distribution of the jamming signals)to avoid jamming signals emitted by malicious devices.This process can be formulated as a Markov decision process and solved by reinforcement learning(RL).Unfortunately,stateof-the-art RL methods may put pressure on the system which has limited computing resources.As a result,we propose a novel RL,by integrating the asynchronous advantage actor-critic(A3C)approach with the kernel method to learn a flexible frequency pre-configuration policy.Moreover,in the presence of time-varying jamming patterns,the traditional AJ strategy can not adapt to the dynamic interference strategy.To handle this issue,we design a kernelbased feature transfer learning method to adjust the structure of the policy function online.Simulation results reveal that our proposed approach can significantly outperform various baselines,in terms of the average normalized throughput and the convergence speed of policy learning.

Anti-jamming channel access in 5G ultra-dense networks: a game-theoretic learning approach

This paper investigates the Quality of Experience(QoE)oriented channel access anti-jamming problem in 5th Generation Mobile Communication(5G)ultra-dense networks.Firstly,considering that the 5G base station adopts beamforming technology,an anti-jamming model under Space Division Multiple Access(SDMA)conditions is proposed.Secondly,the confrontational relationship between users and the jammer is formulated as a Stackelberg game.Besides,to achieve global optimization,we design a local cooperation mechanism for users and formulate the cooperation and competition among users as a local altruistic game.By proving that the local altruistic game is an Exact Potential Game(EPG),we further prove the existence of pure strategy Nash Equilibrium(NE)among users and Stackelberg Equilibrium(SE)between users and jammer.Thirdly,to obtain the equilibrium solutions of the proposed games,we propose an anti-jamming channel selection algorithm and improve its convergence speed through heterogeneous learning parameters.The simulation results validate the convergence and effectiveness of the proposed algorithm.Compared with the throughput optimization scheme,our proposed scheme obtain a greater network satisfaction rate.Finally,we also analyze user fairness changes during the algorithm convergence process and get some interesting conclusions.

Formal Verification Platform as a Service:WebAssembly Vulnerability Detection Application

In order to realize a general-purpose automatic formal verification platform based on WebAssembly technology as a web service(FVPS),which aims to provide an automated report of vulnerability detections,this work builds a Hyperledger Fabric blockchain runtime model.It proposes an optimized methodology of the functional equivalent translation from source program languages to formal languages.This methodology utilizes an external application programming interface(API)table to replace the source codes in compilation,thereby pruning the part of housekeeping codes to ease code inflation.Code inflation is a significant metric in formal language translation.Namely,minor code inflation enhances verification scale and performance efficiency.It determines the efficiency of formal verification,involving launching,running,and memory usage.For instance,path explosion increases exponentially,resulting in out-of-memory.The experimental results conclude that program languages like golang severely impact code inflation.FVPS reduces the wasm code size by over 90%,achieving two orders of optimization magnitude,from 2000 kilobyte(KB)to 90 KB.That means we can cope with golang applications up to 20 times larger than the original in scale.This work eliminates the gap between Hyperledger Fabric smart contracts and WebAssembly.Our approach is pragmatic,adaptable,extendable,and flexible.Nowadays,FVPS is successfully applied in a Railway-Port-Aviation blockchain transportation system.

One-Class Arabic Signature Verification: A Progressive Fusion of Optimal Features

Signature verification is regarded as the most beneficial behavioral characteristic-based biometric feature in security and fraud protection.It is also a popular biometric authentication technology in forensic and commercial transactions due to its various advantages,including noninvasiveness,user-friendliness,and social and legal acceptability.According to the literature,extensive research has been conducted on signature verification systems in a variety of languages,including English,Hindi,Bangla,and Chinese.However,the Arabic Offline Signature Verification(OSV)system is still a challenging issue that has not been investigated as much by researchers due to the Arabic script being distinguished by changing letter shapes,diacritics,ligatures,and overlapping,making verification more difficult.Recently,signature verification systems have shown promising results for recognizing signatures that are genuine or forgeries;however,performance on skilled forgery detection is still unsatisfactory.Most existing methods require many learning samples to improve verification accuracy,which is a major drawback because the number of available signature samples is often limited in the practical application of signature verification systems.This study addresses these issues by presenting an OSV system based on multifeature fusion and discriminant feature selection using a genetic algorithm(GA).In contrast to existing methods,which use multiclass learning approaches,this study uses a oneclass learning strategy to address imbalanced signature data in the practical application of a signature verification system.The proposed approach is tested on three signature databases(SID)-Arabic handwriting signatures,CEDAR(Center of Excellence for Document Analysis and Recognition),and UTSIG(University of Tehran Persian Signature),and experimental results show that the proposed system outperforms existing systems in terms of reducing the False Acceptance Rate(FAR),False Rejection Rate(FRR),and Equal Error Rate(ERR).The proposed system achieved 5%improvement.

Active components of Bupleuri Radix in the treatment of schizophrenia analyzed by network pharmacology and clinical verification

Background:Bupleuri Radix is a common Chinese medicinal material in traditional Chinese medicine.Currently,the therapeutic effect of treating schizophrenia is relatively well understood.However,there are fewer studies examining the underlying mechanisms of its treatment.The objective of the study was to investigate the primary mechanisms of Bupleuri Radix in treating schizophrenia through network pharmacology and clinical validation.Method:Network pharmacology revealed possible molecular mechanisms,followed by clinical verification.Sixty-seven schizophrenia patients undergoing treatment at the Hunan Brain Hospital between October and November 2022 were recruited and randomly divided into the olanzapine group and the olanzapine+Bupleuri Radix group.Additionally,32 healthy people undergoing physical examinations during the same period were included as the control group.The patient’s positive and negative symptom scale scores were compared.qPCR was used to detect the mRNA expression levels of ESR1,mTOR,EIF4E,and SMAD4 in peripheral blood.Results:Through network pharmacological analysis,it was concluded in this study that Bupleuri Radix might regulate the mTOR,PI3K-Akt,and HIF-1 signaling pathways.Clinical experiments indicated that compared with before treatment,the positive and negative symptom scale scores and total scores of the two treatment groups were significantly decreased after treatment(P<0.01).In addition,the positive and negative symptom scale scores and total scores in the olanzapine+Bupleuri Radix group were significantly decreased(P<0.01)compared to the olanzapine group after treatment.Before treatment,ESR1 mRNA expression levels in peripheral blood were significantly higher in the two treatment groups than in the control group,whereas the mRNA expression levels of mTOR,EIF4E,and SMAD4 in peripheral blood were significantly lower(P<0.01).The mRNA expression levels of mTOR,EIF4E,and SMAD4 in peripheral blood were significantly higher after therapy than before treatment,whereas the mRNA expression levels of ESR1 in peripheral blood were significantly lower(P<0.01).After therapy,the olanzapine+Bupleuri Radix group’s mRNA expression levels of mTOR,EIF4E,and SMAD4 were significantly higher than those of the olanzapine group,whereas the mRNA expression levels of ESR1 were significantly lower(P<0.01).Conclusion:The mechanism of Bupleuri Radix’s therapeutic efficacy in schizophrenia may involve the up-regulation of mTOR,EIF4E,and SMAD4 mRNA expression and the down-regulation of ESR1 mRNA expression in peripheral blood.