Impact of asymptomatic infected individuals on epidemic transmission dynamics in multiplex networks with partial coupling

The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is common to set up a one-to-one correspondence between the nodes of a multi-layer network,ignoring the more complex situations in reality.In the present work,we explore this situation by setting up a partially coupled model of a two-layer network and investigating the impact of asymptomatic infected individuals on epidemics.We propose a self-discovery mechanism for asymptomatic infected individuals,taking into account situations such as nucleic acid testing in the community and individuals performing self-antigen testing during the epidemic.Considering these factors together,through the microscopic Markov chain approach(MMCA)and extensive Monte Carlo(MC)numerical simulations,we find that the greater the coupling between the networks,the more information dissemination is facilitated.In order to control the epidemics,more asymptomatic infected individuals should be made aware of their infection.Massive adoption of nucleic acid testing and individual adoption of antigenic self-testing can help to contain epidemic outbreaks.Meanwhile,the epidemic threshold of the proposed model is derived,and then miscellaneous factors affecting the epidemic threshold are also discussed.Current results are conducive to devising the prevention and control policies of pandemics.

Gut microbiota modulating therapy for diabetes mellitus should be individualized

In this editorial,we commented on two articles published online in August and September 2024 in the World Journal of Diabetes,which focused on modifying the gut microbiota(GM)to prevent or delay the progression of diabetes mellitus(DM)and DM-related complications.Numerous studies,many of which are animal studies,have indicated the potential role of GM in the pathogenesis of DM.However,the detailed causality and mechanisms between GM and DM have not been fully clarified.Although there have been some reports of a potential role of modifying the GM in treating DM,most lack long-term observations and are not mechanistic.Additionally,the GM and its role in DM might vary among individuals;therefore,GM-targeted interventions should be individualized to realize their therapeutic potential.

Opinion consensus incorporating higher-order interactions in individual-collective networks

In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.

Exploration of cardiac rehabilitation nursing for elderly patients with myocardial infarction based on individualized cardiac rehabilitation

BACKGROUND Myocardial infarction is a high-risk condition prevalent among the elderly population,often leading to adverse clinical manifestations such as reduced cardiopulmonary function,anxiety,and depression post-surgery.Consequently,cardiac rehabilitation holds immense importance in mitigating these complications.AIM To evaluate the effect of individualized cardiac rehabilitation on blood pressure variability(BPV)and baroreflex sensitivity(BRS)in elderly patients with myocardial infarction.METHODS A cohort of 74 elderly patients diagnosed with myocardial infarction and admitted to our hospital between January 2021 and January 2022 were subjected to random selection.Subsequently,all patients were divided into two groups,namely the research group(n=37)and the control group(n=37),utilizing the number table method.The control group received conventional drug treatment and nursing guidance intervention,while the study group underwent individualized cardiac rehabilitation in addition to the interventions received by the control group.All patients were continuously intervened for 12 wk,and the BPV of these two groups in the 1st wk(T0),the 4th wk(T1)and the 12th wk(T2)were compared,BRS,changes in cardiopulmonary function measures,and adverse cardiovascular events.RESULTS Of 24 h diastolic BPV,24 h systolic BPV,carbon dioxide ventilation equivalent slope of the research group were lower than those of the control group at T1 and T2,BRS,peak heart rate and systolic blood pressure product,1 min heart rate recovery were higher than those of the control group,and the incidence of adverse events in the research group was lower than that of the control group,the difference was statistically significant(P<0.05).CONCLUSION In this study,we found that after individualized cardiac rehabilitation in elderly patients with myocardial infarction,BPV and BRS can be effectively improved,cardiac function is significantly enhanced,and a better prognosis is obtained.

Prevalence and Individual-Level Determinants of Uptake of Three or More Doses of Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Busia County, Kenya

Background: Malaria in pregnancy causes maternal anemia, low birth weight, intrauterine growth retardation, and preterm deliveries. In malaria-endemic regions in Kenya, percentage of pregnant women hospitalized with malaria reach up to 60%. WHO recommends at least three doses of sulphadoxine pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy (IPTp) antenatally. This study sought to ascertain the prevalence and individual-level factors influencing the uptake of IPTp-SP3+. Methods: A facility-based cross-sectional study at Busia County Referral Hospital. 384 mothers were consecutively sampled at the maternity unit during delivery. Semi-structured questionnaires were used to collect data. Odds ratio (OR) and adjusted OR were used to determine statistical significance of individual factors influencing uptake of three or more IPTp-SP. Results: 43.0% of participants took IPTp-SP3+. Individual factors that affected the uptake of IPTp-SP3+ included starting ANC visits in the first trimester (adjusted odds ratio (aOR) = 2.1, 95% CI: 1.23 – 3.67, p = 0.046), having more than four ANC visits (aOR = 3.1, 95% CI: 1.49 – 6.50, p = 0.002), having a higher monthly income (aOR = 2.6, 95% CI: 1.24 – 5.36, p = 0.012), being aware of the advantages of IPTp-SP medications (aOR = 3.7, 95% CI: 1.40 – 9.74, p = 0.008), and having a positive attitude toward ANC services (aOR = 3.2, 95% CI: 1.61 – 6.31, p = 0.001). Conclusion: Less than half of the pregnant mothers are complyingIPTp-SP3+. There should be aggressive efforts by the County and National Ministries of Health promoting initiation of ANC attendance early and attendance of all the recommended eight visits together with ensuring availability of the drugs.

An Experimental Study on the Effectiveness of Individualized Online Intervention for Mental Health Literacy of Community Residents

Background:Understanding how to improve mental health literacy is conducive to maintaining and promoting individuals’mental health and well-being.However,to date,interventions for mental health literacy primarily depend on traditional education and contact interventions,which have limitations with regard to pertinence and individualization.Artificial intelligence(AI)and big data technology have influenced mental health services to be more intellectual and digital,and they also provide greater technical convenience for individualized interventions for promoting mental health literacy.However,there is relatively little research on the effectiveness of individualized online intervention for mental health literacy in the literature.This study aims to fill this void.To verify whether individualized online intervention can improve the level of mental health literacy.Methods:We conducted a pretest–post-test control experiment.The participants were recruited from a large community located in central China.A total of 152 participants completed the research.We use mixed linear model estimation and paired t-tests to analyze the data.Results:Individualized online intervention can effectively improve the mental health literacy level of participants.Specifically,we found that compared with the control group,the mental health literacy in the experimental group was significantly improved after receiving individualized online intervention.Likewise,the mental health literacy of the control group has also improved after receiving individualized online intervention.In addition,we compared the mental health literacy level of the experimental group at Time 3 to those at Time 2 and found that the mental health literacy level at Time 3 had not decreased one month later.This shows that individualized online intervention was not only momentarily effective,but also had long-term efficacy.Conclusion:This study illustrates that the individualized online intervention has both great momentary and long-term effectiveness in improving community residents’mental health literacy.

Application of patient-derived tumor models in anticancer drug development and individualized medicine

Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.

The Conflict between Individuals and Society in Seize the Day

This paper explores the existential problem in Seize the Day-the conflict between individuals and society in modern society.With a brief introduction of Saul Bellow and the novel,the paper emphasizes the analysis of the conflict and the sources of the conflict.Besides,Saul Bellow uses many rhetorical devices to intensify the conflict.The analysis of these rhetorical devices is beneficial for us to interpret and understand the true meaning of the novel.Through the study of Bellow’s vision and the novel’s metaphorical meaning,we may find an effective solution to the conflict that our human being is involved in,and realize the social values of this novel.

Research Progress on Individualized Treatment of Splenic Aneurysm

Splenic artery aneurysm has a hidden onset and atypical symptoms.There are various diagnostic methods for splenic aneurysms,among which ultrasound is the first choice for aneurysm screening.The diagnostic rate of CTA and DSA reaches 100%.In clinical practice,it is necessary to integrate medical history,symptoms and signs,and multiple imaging results to improve the diagnostic rate.In terms of treatment plans,both intervention and surgical procedures have their strengths,and the application of intervention will be more extensive.We need to adhere to the principle of individualization and choose a reasonable treatment plan for patients.At present,there are many reports on pregnant women with large splenic aneurysms both domestically and internationally.Some scholars believe that large splenic aneurysms may be related to hormonal imbalances during pregnancy,and the specific pathogenic mechanism will become a hot topic in future research.

The Impersonal Theory of Poetry in “Tradition and the Individual Talent” by TS Eliot

Eliot,an important poet,playwright,and literary critic of the nineteenth century in the United States,was the founder of Western modernism.He pioneered the modern poetic criticism.His practice of modernist poetry is the transition from traditionalist poetics to modernist poetics in the 20th century.His famous poetics theory declaration“Tradition and the Individual Talent”is an immortal classic in the field of poetics theory,in which he proposed the concept of“Traditional,”the theory of“Impersonal”poetry,“Objective Correlative,”and so on.All had a profound influence on the 20th-century poetry creation.This paper aims to analyze and discuss the important“Impersonal”theory from the three aspects of its connotation,the relationship between“Personality”and its intertextuality with New Criticism,so as to further understand Eliot’s poetic concepts.

Analysis and Innovative Strategies of Tax Preferential Policies to Promote the Sustainable Development of Small-Scale Individual Businesses

This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems.

Individualism与“个人主义”

自文艺复兴和启蒙运动以来,在西方社会一直居主导地位的价值观是individualism,但individualism并不就是国人眼里的“个人主义”,更不等同于利己主义。因为张扬个性自由、崇尚个人权利、强调民主、平等,同时也尊重他人及其权利是individualism的真正而典型的特征。但把individualism译成汉语,就成了“个人主义”,就变成了自私自利、见利忘义等极端利己主义的代名词。实际上,以个人为本位的individualism与以群体为本位的集体主义是中西文化价值观的两大基本表现。本文从individualism的传统文化探寻西方社会中individualism的历史渊源与现实状况,以期重新审视并给以公正的评价。

Individualism≠individual(个人)+ -ism(主义)

笔者通过对ｉｎｄｉｖｉｄｕａｌｉｓｍ和“个人主义”经典含义的细致比较，并根据互联网上ｉｎｄｉｖｉｄｕａｌｉｓｍ一词在现实生活中的使用情况，指出不能简单地把ｉｎｄｉｖｉｄｕａｌｉｓｍ译成“个人主义”，而应译成“个人意识”或“个人精神”为宜。

关键词的文化模筑作用:Individualism和“个人主义”分析

对关键词的翻译是中国文化史上有重要意义的大事。选取文化转型时期学人讨论颇多的关键词“个人主义”,对其源词及目的词作一些训诂的研究,讨论其翻译和应用过程,可以得出关键词的翻译对构建当时中国文化的范式所起的模筑作用。

由“individualism”一词想到的

在翻译中,"individualism"被译成"个人主义",使人们容易产生曲解,误认其为贬义词,是"自私自利"、"利己主义"的代名词。其实,英语"individualism"是个中性词,它可译成为"个体主义"或"个性主义",可与"实现自我价值"、"强化个人竞争意识"等概念联系起来,符合当今世界发展趋势,也符合语言发展的规律。换言之,也是人权思想的具体反映。实际上,以个人为本位的"individualism"与以群体为本位的集体主义是中西方文化在人生价值观上的直面撞击。

Redefine Chinese collectivism/individualism

Chinese culture, which has been regarded as a collectivistic one by such great heads as G. Hofstede and Triands for a long time, seldom receives challenge on its very nature. The authors, however, found at least three critical mistakes in Hofstede＇s work, and raised their argument that Chinese culture is not a collectivistic one, but a ＂shi＂ culture which relies heavily on context. The split of mind is the fundamental cause of this ＂shi＂ culture.

On Thoreau's Individualism

Henry David Thoreau, the most influential American writer, naturalist, philosopher in 19th century, who was also an important representative figure of the American Transcendentalism Movement, the outcast of social mainstream thoughts. For over 150 years, his thoughts have inspired people to seek a return to nature. As for his attitude towards life, he believed that human beings should live in their own way, listen to their own heart, and do what they believe is right. The purpose of this essay is to analysize Thoreau's idea of Individualism and his involvement in the crucial social issues. The analysis will first consider the nature of individualism and make distinction between Thoreau's individualism and individualism in American society. Then it will present an intensive study of Thoreau's embracing of some notions of individualism in Civil Disobedience and Walden. And the effects of his individualism have given to society not only in America but in other countries.

The Collision of Individualism in Chinese and American Talent Shows——A Case Study of American Idol and Super Girls

Recently,American talent shows with its unique glamour and huge profit have attracted many Chinese TV stations to imitate.The process of imitation is essentially a collision of American and Chinese cultures.This study focuses on American Idol and Super Girls,discusses their different manifestations of individualism and analyzes the reasons behind it.The analysis shows that the differences of the two countries'cultural background contribute to the different manifestations of individualism.In a word,during the process of imitating American talent shows,the problems of Chinese talent shows indicate that American individualism has its positive as well as negative effects.Consequently,Chinese people should hold a critical attitude toward American individualism.

A Comparison between American Individualism and Chinese Collectivism-From the View of Cherishing Life in War

There is a large discrepancy in the value concept of life.We know that the ways of cherishing life are different in war to the soldiers from different cultures.We may perceive that people's concept has been much influenced by the different cultural background and social environment.And similar cultural background and social environment may make people's value trend introject.

Individualism in Moby Dick and the Old Man and the Sea

This paper analyzes the individualism in Herman Melville's Moby Dick and Ernest Hemingway's The Old Man and the Sea to comprehend the development of individualism and the position and function in American culture.