The Vinaya School is a school of Buddhism in China, of which the main object was the study, the propagation and the observance of the Vinaya rules. Its basic scripture was the Four-division-vinaya(or the Dharmaguptaka...The Vinaya School is a school of Buddhism in China, of which the main object was the study, the propagation and the observance of the Vinaya rules. Its basic scripture was the Four-division-vinaya(or the Dharmaguptaka-vinaya Sifenlü 四分律), one of the five classes of the Vinaya works, and so it was also known as the School of the Four-division-vinaya.展开更多
先导化合物发现是创新药物研发的最重要环节之一。针对目前海量功能不明确的小分子化合物,本文构建了一个用来实现快速发现先导化合物,有效降低药物研发成本的计算机辅助药物筛选平台。该平台采用分布式架构思想,集成了Auto Dock Vina...先导化合物发现是创新药物研发的最重要环节之一。针对目前海量功能不明确的小分子化合物,本文构建了一个用来实现快速发现先导化合物,有效降低药物研发成本的计算机辅助药物筛选平台。该平台采用分布式架构思想,集成了Auto Dock Vina和多个小分子库,具有数据安全、计算与存储的负载均衡以及实时监控的特点。应用平台进行先导化合物筛选,在较短时间发现了有针对性的活性小分子化合物,命中率高,大大缩短先导化合物发现周期。该平台具有很好的实用性和良好的扩展性。展开更多
靶标确证是老药新用、药物毒副作用研究的关键。基于分子对接方法 Auto Dock Vina和内部构建的疾病靶标数据库,采用分布式架构,构建了反向虚拟筛选平台。应用该平台对药物吡斯的明进行靶标确证,最终成功找到其靶标乙酰胆碱酯酶,验证了...靶标确证是老药新用、药物毒副作用研究的关键。基于分子对接方法 Auto Dock Vina和内部构建的疾病靶标数据库,采用分布式架构,构建了反向虚拟筛选平台。应用该平台对药物吡斯的明进行靶标确证,最终成功找到其靶标乙酰胆碱酯酶,验证了平台的实用性和准确性。展开更多
Ulcer is one of the life threatening diseases. It is an open sore on an external or internal surface of the body caused by a break in the skin or mucous membrane which fails to heal. In this work, specific ligands tha...Ulcer is one of the life threatening diseases. It is an open sore on an external or internal surface of the body caused by a break in the skin or mucous membrane which fails to heal. In this work, specific ligands that are suitable for ulcer have been studied computationally. Docking of the triterpenoids of Lonchocarpus cyanescens with target proteins of PDB codes 1AFC, 1AXM and 2AXM were performed using AutoDock Vina and Pymol for docking and post-docking analysis, respectively. In this study, the triterpenoid ligands with binding affinity/inhibitory constants -7.2/5.21, -6.5/16.99 and -6.2/28.20 for OH, and -6.7/12.12, -6.3/23.82 and -6.1/33.40 for OCH3 were compared with the standard ligands. Our study indicates that the results corresponding to triterpenoid ligands are close to standard ligands.展开更多
Stable flies(Stomoxys spp.)are common pests of livestock in the peri-urban rangelands of Vina Division of the Adamawa Plateau.No documented information is available on their diurnal dynamics in relation to physiologic...Stable flies(Stomoxys spp.)are common pests of livestock in the peri-urban rangelands of Vina Division of the Adamawa Plateau.No documented information is available on their diurnal dynamics in relation to physiological age and landscape.The main aim of this study was to determine the trap apparent density(ADT)of Stomoxys and associate it to their diurnal activity rhythm and landscape.Vavoua traps(n=12)were used for Stomoxys collection.Trapping was carried out for seven days i.e.three days consecutively in August and four days consecutively in October,2016.Three traps were pitched in each of the three biotopes(river,cattle corral and gallery forest)of the four study sites(Galim,Mbidjoro,Velambai and Soukourwo).All female Stomoxys captured underwent ovarian dissection for the determination of their physiological ages(parous or nulliparous).A total of 218 Stomoxys were caught and identified into four species(S.niger niger,S.omega,S.calcitrans,and S.xanthomelas)with an overall ADT of 2.59 flies per trap per day and Stomoxys niger niger(1.13 s.n.n.per trap per day)recorded the highest ADT.Species richness was study site dependent.Higher catches of females 113(51.83%)were made than that of their male 105(48.17%)counterparts.Galim recorded the highest Stomoxys apparent density(4.90)as compared to other sites with a statistically significant difference(P<0.05).The proportion of parous 87(59.30%)was higher than that of their nulliparous 46(40.71%)counterparts.Parity differed with landscape and capture periods.S.n.niger was the most frequent in all biotopes and Galim recorded the highest ADT.The population of female flies was made up of adults(parous)with a bimodal diurnal activity rhythm whereas males had a unimodal activity rhythm.展开更多
文摘The Vinaya School is a school of Buddhism in China, of which the main object was the study, the propagation and the observance of the Vinaya rules. Its basic scripture was the Four-division-vinaya(or the Dharmaguptaka-vinaya Sifenlü 四分律), one of the five classes of the Vinaya works, and so it was also known as the School of the Four-division-vinaya.
文摘先导化合物发现是创新药物研发的最重要环节之一。针对目前海量功能不明确的小分子化合物,本文构建了一个用来实现快速发现先导化合物,有效降低药物研发成本的计算机辅助药物筛选平台。该平台采用分布式架构思想,集成了Auto Dock Vina和多个小分子库,具有数据安全、计算与存储的负载均衡以及实时监控的特点。应用平台进行先导化合物筛选,在较短时间发现了有针对性的活性小分子化合物,命中率高,大大缩短先导化合物发现周期。该平台具有很好的实用性和良好的扩展性。
文摘Ulcer is one of the life threatening diseases. It is an open sore on an external or internal surface of the body caused by a break in the skin or mucous membrane which fails to heal. In this work, specific ligands that are suitable for ulcer have been studied computationally. Docking of the triterpenoids of Lonchocarpus cyanescens with target proteins of PDB codes 1AFC, 1AXM and 2AXM were performed using AutoDock Vina and Pymol for docking and post-docking analysis, respectively. In this study, the triterpenoid ligands with binding affinity/inhibitory constants -7.2/5.21, -6.5/16.99 and -6.2/28.20 for OH, and -6.7/12.12, -6.3/23.82 and -6.1/33.40 for OCH3 were compared with the standard ligands. Our study indicates that the results corresponding to triterpenoid ligands are close to standard ligands.
文摘Stable flies(Stomoxys spp.)are common pests of livestock in the peri-urban rangelands of Vina Division of the Adamawa Plateau.No documented information is available on their diurnal dynamics in relation to physiological age and landscape.The main aim of this study was to determine the trap apparent density(ADT)of Stomoxys and associate it to their diurnal activity rhythm and landscape.Vavoua traps(n=12)were used for Stomoxys collection.Trapping was carried out for seven days i.e.three days consecutively in August and four days consecutively in October,2016.Three traps were pitched in each of the three biotopes(river,cattle corral and gallery forest)of the four study sites(Galim,Mbidjoro,Velambai and Soukourwo).All female Stomoxys captured underwent ovarian dissection for the determination of their physiological ages(parous or nulliparous).A total of 218 Stomoxys were caught and identified into four species(S.niger niger,S.omega,S.calcitrans,and S.xanthomelas)with an overall ADT of 2.59 flies per trap per day and Stomoxys niger niger(1.13 s.n.n.per trap per day)recorded the highest ADT.Species richness was study site dependent.Higher catches of females 113(51.83%)were made than that of their male 105(48.17%)counterparts.Galim recorded the highest Stomoxys apparent density(4.90)as compared to other sites with a statistically significant difference(P<0.05).The proportion of parous 87(59.30%)was higher than that of their nulliparous 46(40.71%)counterparts.Parity differed with landscape and capture periods.S.n.niger was the most frequent in all biotopes and Galim recorded the highest ADT.The population of female flies was made up of adults(parous)with a bimodal diurnal activity rhythm whereas males had a unimodal activity rhythm.
