Neural electrodes,the core component of neural prostheses,are usually encapsulated in polydimethylsiloxane（PDMS）.However,PDMS can generate a tissue response after implantation.Based on the physicochemical properties...Neural electrodes,the core component of neural prostheses,are usually encapsulated in polydimethylsiloxane（PDMS）.However,PDMS can generate a tissue response after implantation.Based on the physicochemical properties and excellent biocompatibility of polyurethane（PU）and poly（vinyl alcohol）（PVA）when used as coating materials,we synthesized PU/PVA hydrogel coatings and coated the surface of PDMS using plasma treatment,and the cytocompatibility to rat pheochromocytoma（PC12）cells was assessed.Protein adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92%after coating with the hydrogel.Moreover,the PC12 cells on the PU/PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated PDMS.These results indicate that the PU/PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility.展开更多
通过机械共混法将石墨烯纳米片分散至30 000 m Pa·s乙烯基封端的聚二甲基硅氧烷中,并制备了石墨烯纳米片/硅橡胶复合材料。对其微观形貌进行了表征,并考察了复合材料的性能。结果发现,随石墨烯纳米片用量的增加,复合材料的熔点逐...通过机械共混法将石墨烯纳米片分散至30 000 m Pa·s乙烯基封端的聚二甲基硅氧烷中,并制备了石墨烯纳米片/硅橡胶复合材料。对其微观形貌进行了表征,并考察了复合材料的性能。结果发现,随石墨烯纳米片用量的增加,复合材料的熔点逐渐下降,结晶度呈现先升后降的趋势。当石墨烯纳米片填充量达30份时,复合材料的导热和导电性能明显提升,当填充80份时,石墨烯纳米片/硅橡胶复合材料的热导率和体积电阻率分别达到2. 648 W/(m·K)和0. 156Ω·cm。展开更多
Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety...Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly（ethylene glycol）（PEG） and polydimethylsiloxane（PDMS） segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.展开更多
基金supported by the National Natural Science Foundation of China,No.81170768grant from the Fundamental Research Project of Shanxi Province of China,No.2015021079
文摘Neural electrodes,the core component of neural prostheses,are usually encapsulated in polydimethylsiloxane（PDMS）.However,PDMS can generate a tissue response after implantation.Based on the physicochemical properties and excellent biocompatibility of polyurethane（PU）and poly（vinyl alcohol）（PVA）when used as coating materials,we synthesized PU/PVA hydrogel coatings and coated the surface of PDMS using plasma treatment,and the cytocompatibility to rat pheochromocytoma（PC12）cells was assessed.Protein adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92%after coating with the hydrogel.Moreover,the PC12 cells on the PU/PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated PDMS.These results indicate that the PU/PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility.
基金financially supported by the National Natural Science Foundation of China (No.81671792)National Key R&D program of China (No.2016YFC0104100)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly（ethylene glycol）（PEG） and polydimethylsiloxane（PDMS） segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.
