A network-based Virtual Private Network (VPN) architecture by using fundamental routing mechanism is proposed. This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modu...A network-based Virtual Private Network (VPN) architecture by using fundamental routing mechanism is proposed. This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modules. The packet format employs the encapsulation of IPSec ESP(Encapsulating Security Payload), an impact path code and an extended DS(Differentiated Services) code to support multi-path routing and QoS. Comparing with other models of VPN, this network system can be deployed in the current network with little investment, and it is easy to implement. The simulation result shows its performance is better than the traditional VPN system of black box mode.展开更多
The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patient...The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex.展开更多
In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significa...In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significantly improve the utilization efficiency of computing resources. In this paper,we study the computing resource allocation strategy for one VBS by considering the non-negligible effect of delay introduced by switches. Specifically,we formulate the VBS's sum computing rate maximization as a set optimization problem. To address this problem,we firstly propose a computing resource schedule algorithm,namely,weight before one-step-greedy(WBOSG),which has linear computation complexity and considerable performance. Then,OSG retreat(OSG-R) algorithm is developed to further improve the system performance at the expense of computational complexity. Simulation results under practical setting are provided to validate the proposed two algorithms.展开更多
The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dis...The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments.展开更多
A novel robot navigation algorithm with global path generation capability is presented. Local minimum is a most intractable but is an encountered frequently problem in potential field based robot navigation.Through ap...A novel robot navigation algorithm with global path generation capability is presented. Local minimum is a most intractable but is an encountered frequently problem in potential field based robot navigation.Through appointing appropriately some virtual local targets on the journey, it can be solved effectively. The key concept employed in this algorithm are the rules that govern when and how to appoint these virtual local targets. When the robot finds itself in danger of local minimum, a virtual local target is appointed to replace the global goal temporarily according to the rules. After the virtual target is reached, the robot continues on its journey by heading towards the global goal. The algorithm prevents the robot from running into local minima anymore. Simulation results showed that it is very effective in complex obstacle environments.展开更多
A novel three-dimensional(3D) imaging lidar system which is based on a virtual instrument technique is introduced in this paper. The main characteristics of the system include: the capability of modeling a 3D objec...A novel three-dimensional(3D) imaging lidar system which is based on a virtual instrument technique is introduced in this paper. The main characteristics of the system include: the capability of modeling a 3D object in accordance with the actual one by connecting to a geographic information system(GIS), and building the scene for the lidar experiment including the simulation environment. The simulation environment consists of four parts: laser pulse, atmospheric transport,target interaction, and receiving unit. Besides, the system provides an interface for the on-site experiment. In order to process the full waveform, we adopt the combination of pulse accumulation and wavelet denoising for signal enhancement.We also propose an optimized algorithm for data decomposition: the V-L decomposition method, which combines Vondrak smoothing and laser-template based fitting. Compared with conventional Gaussian decomposition, the new method brings an improvement in both precision and resolution of data decomposition. After applying V-L decomposition to the lidar system, we present the 3D reconstructed model to demonstrate the decomposition method.展开更多
文摘A network-based Virtual Private Network (VPN) architecture by using fundamental routing mechanism is proposed. This network is a virtual overlay network based on the relay of IP-in-IP tunneling of virtual routing modules. The packet format employs the encapsulation of IPSec ESP(Encapsulating Security Payload), an impact path code and an extended DS(Differentiated Services) code to support multi-path routing and QoS. Comparing with other models of VPN, this network system can be deployed in the current network with little investment, and it is easy to implement. The simulation result shows its performance is better than the traditional VPN system of black box mode.
基金supported by the National Natural Science Foundationof China,No.30973165
文摘The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex.
基金funded by the key project of the National Natural Science Foundation of China (No.61431001)the National High-Tech R&D Program (863 Program 2015AA01A705)New Technology Star Plan of Beijing (No.xx2013052)
文摘In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significantly improve the utilization efficiency of computing resources. In this paper,we study the computing resource allocation strategy for one VBS by considering the non-negligible effect of delay introduced by switches. Specifically,we formulate the VBS's sum computing rate maximization as a set optimization problem. To address this problem,we firstly propose a computing resource schedule algorithm,namely,weight before one-step-greedy(WBOSG),which has linear computation complexity and considerable performance. Then,OSG retreat(OSG-R) algorithm is developed to further improve the system performance at the expense of computational complexity. Simulation results under practical setting are provided to validate the proposed two algorithms.
基金the National Natural Science Foundation of China (No. 81173009)the Technology Bureau in Shenyang (No. ZCJJ2013402)the Project for New Century Excellent Talents of Ministry of Education (No. NCET-12-1015)
文摘The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments.
文摘A novel robot navigation algorithm with global path generation capability is presented. Local minimum is a most intractable but is an encountered frequently problem in potential field based robot navigation.Through appointing appropriately some virtual local targets on the journey, it can be solved effectively. The key concept employed in this algorithm are the rules that govern when and how to appoint these virtual local targets. When the robot finds itself in danger of local minimum, a virtual local target is appointed to replace the global goal temporarily according to the rules. After the virtual target is reached, the robot continues on its journey by heading towards the global goal. The algorithm prevents the robot from running into local minima anymore. Simulation results showed that it is very effective in complex obstacle environments.
基金Project supported by the National Natural Science Foundation of China(Grant No.608320036)
文摘A novel three-dimensional(3D) imaging lidar system which is based on a virtual instrument technique is introduced in this paper. The main characteristics of the system include: the capability of modeling a 3D object in accordance with the actual one by connecting to a geographic information system(GIS), and building the scene for the lidar experiment including the simulation environment. The simulation environment consists of four parts: laser pulse, atmospheric transport,target interaction, and receiving unit. Besides, the system provides an interface for the on-site experiment. In order to process the full waveform, we adopt the combination of pulse accumulation and wavelet denoising for signal enhancement.We also propose an optimized algorithm for data decomposition: the V-L decomposition method, which combines Vondrak smoothing and laser-template based fitting. Compared with conventional Gaussian decomposition, the new method brings an improvement in both precision and resolution of data decomposition. After applying V-L decomposition to the lidar system, we present the 3D reconstructed model to demonstrate the decomposition method.
基金Supported by the High Technology Research and Development Programme of China (No. 2003AA1Z2070 ) and the National Natural Science Foundation of China (No. 90412013).