OPTIMIZATION METHOD FOR VIRTUAL PRODUCT DEVELOPMENT BASED ON SIMULATION METAMODEL AND ITS APPLICATION

Virtual product development (VPD) is essentially based on simulation. Due tocomputational inefficiency, traditional engineering simulation software and optimization methods areinadequate to analyze optimization problems in VPD. Optimization method based on simulationmetamodel for virtual product development is proposed to satisfy the needs of complex optimaldesigns driven by VPD. This method extends the current design of experiments (DOE) by variousmetamodeling technologies. Simulation metamodels are built to approximate detailed simulation codes,so as to provide link between optimization and simulation, or serve as a bridge for simulationsoftware integration among different domains. An example of optimal design for composite materialstructure is used to demonstrate the newly introduced method.

A Worsted Yarn Virtual Production System Based on BP Neural Network

Back-Propagation (BP) neural network and its modified algorithm are introduced. Two series of BP neural network models have been established to predict yarn properties and to deduce wool fiber qualities. The results from these two series of models have been compared with the measured values respectively, proving that the accuracy in both the prediction model and the deduction model is high. The experimental results and the corresponding analysis show that the BP neural network is an efficient technique for the quality prediction and has wide prospect in the application of worsted yarn production system.

Constructing the Virtual Production Line

In order to study the constructing technology of virtual production line, the structure model of virtual production line was presented, and the object oriented technique was used to establish its basic classes and relevant models, including solid model, behavior model and object oriented Petri net based control model, and based on this, the constructing of virtual production line was realized. The application proved that the virtual production line had many good characteristics, such as visualization, interaction, multi layer and reusability, and it's an efficient tool of analyzing and modeling for layout planning and rapidly reconfiguring of production line.

RESEARCH ON PRODUCT INNOVATION DESIGN IN VIRTUAL PRODUCT DEVELOPMENT

An integrated template of virtual product development alters primarilysequential tradition mode of product life cycle. The template integrates all processes of productdevelopment using digital modem. An environment of virtual product development provides productdevelopment environment of integration, communion, network, concurrent and collaboration. Combiningdevelopment of new rapier loom, an innovated design process is researched in virtual productdevelopment, which consists three portions: constructing an integration development environment,innovation design and manufacturing simulation. The innovated design process realizes reversedesign, mechanism concept design, structural design and analysis, performance analysis andmanufacturing process simulation of virtual product, which can enhance greatly product performanceand reduce cost and development cycle of new product.

Research on Design Optimization Strategy in Virtual Product Development

Simulation and optimization are the key points of virtual product development (VPD). Traditional engineering simulation software and optimization methods are inadequate to analyze the optimization problems because of its computational inefficiency. A systematic design optimization strategy by using statistical methods and mathematical optimization technologies is proposed. This method extends the design of experiments (DOE) and the simulation metamodel technologies. Metamodels are built to in place of detailed simulation codes based on effectively DOE, and then be linked to optimization routines for fast analysis, or serve as a bridge for integrating simulation software across different domains. A design optimization of composite material structure is used to demonstrate the newly introduced methodology.

Virtual Product Development Integrated with KBE

This paper analyses the integration modes of the virtual product development with KBE. The system architecture of virtual product development with KBE has been built and the key technique has been studied to support the system. Knowledge driven method has been put forward based on the traditional theory as a new method of virtual product development. An applied case is presented by taking moving cone assembly as an example to illustrate the process of knowledge driven method in detail. This concludes virtual product development integrated with KBE is feasible to raise the design efficiency and promote the sharing of information and knowledge.

Virtual screening and optimization of typeⅡ inhibitors of JAK2 from a natural product library

OBJECTIVE To utilize a structure-based lead optimization approach to generate novel natural product-like typeⅡ inhibitors of JAK2 using the DOLPHIN protocol.METHODS Initially,the DOLHPIN computational protocol was employed to convert an active(DFG-in)conformation of JAK2 into a typeⅡ-compatible conformation,which was used as a model for the structure-based virtual screening of 150 000 natural product-like compounds in silico.The novel biflavonoid analogues were designed and synthesized based on the structure of lead compound and then tested for JAK2 and STAT3 inhibitory activity,cytotoxicity and HCV antiviral activity.RESULTS The top eleven highest-scoring compounds were generated from the initial high-throughput virtual screening.Amentoflavone 1a,a biflavonoid from the Chinese plant Gingko biloba,emerged as a promising candidate for further biological evaluation.In dose-response experiments,amentoflavone 1ainhibited JAK2 activity in a concentration dependent fashion with an IC50 value of 5μmol·L-1.As a proof-of-concept,we designed nine analogues 1b-1j with the addition of one or more aliphatic side chains to the biflavonoid scaffold of 1a.The octyl(C8)analogue 1bdisplayed superior potency against JAK2 activity and HCV activity compared to the parent compound 1a,validating the structure-based lead optimization approach used in this study.Moreover,kinetic analysis indicated that analogue 1bexhibited a non-competitive mode of inhibition,suggesting that this compound may be a putative typeⅡ inhibitor of JAK2.CONCLUSION Amentoflavone 1ahas been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library.In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo.Molecular modeling and kinetic experiments suggested that the analogues may function as typeⅡ inhibitors of JAK2.

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

OBJECTIVE To apply molecular docking techniques to identify STAT3 inhibitors from a database of over 90 000 natural product and natural product-like compounds.METHODS Molecular docking was used for the virtual screening campaign and hit validation of STAT3 inhibitor.To further evaluate the potency of candidates at inhibiting STAT3-DNA binding activity,a STAT3 and STAT1transcription factor ELISA was performed.A dual-luciferase reporter assay,co-immunoprecipitation assay and Western blotting were carried out for the investigation of effect of compound 1 on STAT3-driven transcription,STAT3 dimerization and STAT3 phosphorylation.Finally,the cell toxicity of compound 1 was assessed by using MTT assay on different cell lines.RESULTS The virtual screening campaign furnished fourteen hit compounds,from which compound 1 emerged as a top candidate.Compound 1inhibited STAT3DNA-binding activity in vitro and attenuated STAT3-directed transcription in cellulo with selectivity over STAT1 and comparable potency to the wellknown STAT3 inhibitor S3I-201.Furthermore,compound 1 inhibited STAT3 dimerization and decreased STAT3 phosphorylation in cells without affecting STAT1 dimerization and phosphorylation.Compound 1 also exhibited selective anti-proliferative activity against cancer cells over normal cells in vitro.CONCLUSION The benzofuran derivative 1 was identified as a potential inhibitor of STAT3 dimerization using in silico screening.Molecular docking analysis suggested that compound 1 might putatively function as an inhibitor of STAT3 dimerization by binding to the SH2 domain.To the best of our knowledge,compound 1 has not been reported as a STAT3 inhibitor and no biological activity of compound 1 has been presented in the literature.

PRODUCT MODELLING TO SUPPORT PRODUCT DEVELOPMENT IN A VIRTUAL ENTERPRISE

The concept of Virtual Enterprise (VE) is closely related to the Global Manufacturing (GM) paradigm. How to develop a computer system which supports the product development in VE is an issue to be discussed in this paper. The emphasis is placed on the product modelling in the VE context. In the paper, a new concept of information modelling called ’heterogeneous data’ situation is clarified, which is further related to the ’Instance As Type’ (TAT) phenomenon. Modelling for IAT is discussed. Modelling for the partner company behaviour is presented as well.

创新升级背景下全球电影科技发展与思考启示——记2023年度SMPTE媒体技术峰会

本文结合对2023年度SMPTE媒体技术峰会国内外影视科技创新成果的研究分析,总结提炼出全球电影科技发展与应用的新进展新特点新趋势,在此基础上,统筹我国电影科技发展特点与应用需求,提出推进电影行业提质升级和高质量发展的思考与启示。

Exploiting Virtual Elasticity of Production Systems to Respect OTD—Part 3: Basic Considerations for Modelling CPPS Characterized by Non-Ergodic Order Entry and Non-Deterministic Product-Mix for Fully Flexible Addressable Workstations

The recently experienced hype concerning the so-called “4th Industrial Revolution” of production systems has prompted several papers of various subtopics regarding Cyber-Phdysical Production Systems (CPPS). However, important aspects such as the modelling of CPPS to understand the theory regarding the performance of highly non-ergodic and non-deterministic flexible manufacturing systems in terms of Exit Rate (ER), Manufacturing Lead Time (MLT), and On-Time Delivery (OTD) have not yet been examined systematically and even less modeled analytically. To develop the topic, in this paper, the prerequisites for modelling such systems are defined in order to be able to derive an explicit and dedicated production mathematics-based understanding of CPPS and its dynamics: switching from explorative simulation to rational modelling of the manufacturing “physics” led to an own and specific manufacturing theory. The findings have led to enouncing, among others, the Theorem of Non-Ergodicity as well as the Batch Cycle Time Deviation Function giving important insights to model digital twin-based CPPS for complying with the mandatory OTD.

人工智能技术的电影美学应用场景及其前景

人工智能技术正在深入走进各个行业,应用场景日益丰富,电影美学是其中一个极其重要的领域。探索人工智能技术的电影美学应用场景有两条路径:间断式有限应用实践,是当下主流的“现实主义”路径;全流程无限应用实验,是一条长期处在艺术畅想、理论憧憬中并属于近期先锋探索的理想主义路径。前者采用虚拟拍摄方式,后者采用自动生成方式。使用文字和笔画的概念可能有助于理解这方面的理想主义先驱的一致性,甚至可能有助于理解上述两条探索路径的一致性。两者在某个点上汇合在一起,是完全有可能的。

非遗虚拟空间生产体验对文化自信的影响

随着沉浸式体验技术的广泛运用,如何通过虚拟空间提升传统非遗文化的传播效用成为社会各界关注的问题。本研究基于列斐伏尔的“空间三元论”对非遗虚拟空间生产问题进行探讨,关注其中各空间生产要素对于非遗文化认同、文化自信的影响。本研究通过2×2×2组间实验(N=209)发现:非遗虚拟情境下空间生产体验具有具身性,空间真实度和参与度有助于提升非遗虚拟空间生产体验的传播效用;非遗虚拟场域下空间表征的效用是有条件的,非遗虚拟空间真实度和文化度的叠加才能对非遗文化认同产生影响;虚拟空间生产体验中VR信息素养具有部分效用:体验者的VR信息素养影响非遗虚拟空间真实度体验的效用,但不影响非遗虚拟空间参与度的效用。

基于虚拟现实的三维动漫制作相关技术研究

文章探讨了基于虚拟现实的三维动漫制作相关技术,包括虚拟现实技术、动画技术、渲染技术和建模技术。首先,对虚拟现实技术的特征与优势进行分析总结;其次,重点探讨虚拟现实技术在三维动漫制作中的具体技术与应用方式;最后,提出应用中的注意事项。通过该研究,可以了解基于虚拟现实的三维动漫制作相关技术的应用和优化方法,为未来的动漫制作提供参考和借鉴。

虚拟仿真技术在动物生产学实验教学中的应用

虚拟仿真技术是利用计算机和多媒体平台,模拟真实的实验条件和环境,实现情景和操作条件再现的一项新型信息技术,其不受场地、时空、设备和危险性等因素影响,是新农科和现代畜牧业教学发展的趋势。本文以动物生产学实验教学为例,介绍了实验教学的现状和虚拟仿真技术在学科中的优势,分析了虚拟仿真教学系统的构建、应用情况和存在的问题,并对未来的发展提出了建议,以期提高学生的实践操作能力。

以“四个统筹”为核心的农业水管理策略研究

近年来,我国粮食生产重心不断向以东北、黄淮海等为代表的北方地区转移,粮食生产呈现出与水资源分布错位的格局。粮食生产用水特征分析显示,北方地区的粮食生产水足迹低,但粮食水足迹占比大,与区域水资源可利用量的空间分布相悖,大规模粮食生产导致北方地区水资源压力不断增加。面对保障粮食安全面临的水资源禀赋不足、水土资源空间分布不均、国际突发事件影响等挑战,提出统筹蓝水与绿水利用,统筹实体水和虚拟水耦合调控,统筹国内和国际粮食虚拟水贸易,统筹农艺、工程、生物和管理节水措施等“四个统筹”,构建农业高效用水新理论与新方法,提升农业新质生产力在农业节水方面的效能,实现粮食生产和消费全过程用水安全。

基于虚拟现实的测井作业过程模拟仿真系统的开发

测井作业是油气田勘探开发过程中的重要环节,熟悉测井作业过程是相关工科专业学生的必备教学环节。但由于各种原因,导致目前学生很难有机会去油田现场进行测井作业过程的生产实习。本研究首先利用3D MAX软件建立了井场设备和井场环境的模型;依据常规测井流程,运用虚化引擎软件制作了测井仪器工作原理及测井作业操作流程的3D动画;利用虚拟现实技术还原了井场环境,模拟了测井人员的工作过程。最后利用现场的测井数据,调用测井解释软件,绘制了测井解释曲线,实现了对储层的评价。该系统为生产实习提供了一种沉浸式模拟教学手段。

面向钣金混流生产线的仿真优化研究

文章以某电梯钣金加工公司的钣金混流生产线为背景,通过虚拟仿真方法对钣金生产环节中的投产序列和瓶颈问题进行优化。首先,根据某电梯门板生产线的实际生产状况,建立生产线的仿真模型,以工件完工时间、设备空闲时间和设备总切换时间为目标,基于遗传算法,优化钣金混流生产线的投产序列;其次,通过分析缓存区添加位置和容量对钣金生产线产量的影响,解决生产线堵塞、利用率不平衡等问题。结果表明,对生产线的优化有效,经优化后的投产序列相比原始投产序列整体时间缩短约15%,通过适宜的缓存区设置,各工位设备平均利用率提高了9.6%,产量提高了14.15%。

基于递进式培养的电气节能虚仿平台开发

以抽油机的电气节能改造、注水泵的变频调速、海上钻井平台电力系统的无功补偿为主体,结合现场实际工况,设计开发了典型石油钻采设备电气节能技术虚拟仿真平台。实验过程施行“知识—能力—素质”的递进式培养,在掌握石油石化行业典型的电气节能技术的基础上,通过该平台进行电机选型、设计控制电路、分析设备耗能等各种实验模拟操作与分析,并能准确评价节能方案的可行性与经济性。

基于数字孪生的模块化生产系统实践教学平台设计与实现

该文将数字孪生技术应用于模块化生产系统(modular production system,MPS)的智能化改造中,构建了基于数字孪生的MPS实践教学平台。依托监控系统和虚实交互等关键技术,增加了MPS数字孪生体的虚拟建模、虚实联调和PLC程序软件在环/硬件在环调试等实训环节;验证了MPS实践教学平台设计方案的可行性;制定了新的教学框架及详细的实训内容和考核方案。最后,将实训内容与大学生竞赛相结合,提高了学生对智能制造、工业生产的认知能力和实践动手能力。