OPTIMIZATION METHOD FOR VIRTUAL PRODUCT DEVELOPMENT BASED ON SIMULATION METAMODEL AND ITS APPLICATION

Virtual product development (VPD) is essentially based on simulation. Due tocomputational inefficiency, traditional engineering simulation software and optimization methods areinadequate to analyze optimization problems in VPD. Optimization method based on simulationmetamodel for virtual product development is proposed to satisfy the needs of complex optimaldesigns driven by VPD. This method extends the current design of experiments (DOE) by variousmetamodeling technologies. Simulation metamodels are built to approximate detailed simulation codes,so as to provide link between optimization and simulation, or serve as a bridge for simulationsoftware integration among different domains. An example of optimal design for composite materialstructure is used to demonstrate the newly introduced method.

A Worsted Yarn Virtual Production System Based on BP Neural Network

Back-Propagation (BP) neural network and its modified algorithm are introduced. Two series of BP neural network models have been established to predict yarn properties and to deduce wool fiber qualities. The results from these two series of models have been compared with the measured values respectively, proving that the accuracy in both the prediction model and the deduction model is high. The experimental results and the corresponding analysis show that the BP neural network is an efficient technique for the quality prediction and has wide prospect in the application of worsted yarn production system.

Constructing the Virtual Production Line

In order to study the constructing technology of virtual production line, the structure model of virtual production line was presented, and the object oriented technique was used to establish its basic classes and relevant models, including solid model, behavior model and object oriented Petri net based control model, and based on this, the constructing of virtual production line was realized. The application proved that the virtual production line had many good characteristics, such as visualization, interaction, multi layer and reusability, and it's an efficient tool of analyzing and modeling for layout planning and rapidly reconfiguring of production line.

RESEARCH ON PRODUCT INNOVATION DESIGN IN VIRTUAL PRODUCT DEVELOPMENT

An integrated template of virtual product development alters primarilysequential tradition mode of product life cycle. The template integrates all processes of productdevelopment using digital modem. An environment of virtual product development provides productdevelopment environment of integration, communion, network, concurrent and collaboration. Combiningdevelopment of new rapier loom, an innovated design process is researched in virtual productdevelopment, which consists three portions: constructing an integration development environment,innovation design and manufacturing simulation. The innovated design process realizes reversedesign, mechanism concept design, structural design and analysis, performance analysis andmanufacturing process simulation of virtual product, which can enhance greatly product performanceand reduce cost and development cycle of new product.

Research on Design Optimization Strategy in Virtual Product Development

Simulation and optimization are the key points of virtual product development (VPD). Traditional engineering simulation software and optimization methods are inadequate to analyze the optimization problems because of its computational inefficiency. A systematic design optimization strategy by using statistical methods and mathematical optimization technologies is proposed. This method extends the design of experiments (DOE) and the simulation metamodel technologies. Metamodels are built to in place of detailed simulation codes based on effectively DOE, and then be linked to optimization routines for fast analysis, or serve as a bridge for integrating simulation software across different domains. A design optimization of composite material structure is used to demonstrate the newly introduced methodology.

Virtual Product Development Integrated with KBE

This paper analyses the integration modes of the virtual product development with KBE. The system architecture of virtual product development with KBE has been built and the key technique has been studied to support the system. Knowledge driven method has been put forward based on the traditional theory as a new method of virtual product development. An applied case is presented by taking moving cone assembly as an example to illustrate the process of knowledge driven method in detail. This concludes virtual product development integrated with KBE is feasible to raise the design efficiency and promote the sharing of information and knowledge.

Virtual screening and optimization of typeⅡ inhibitors of JAK2 from a natural product library

OBJECTIVE To utilize a structure-based lead optimization approach to generate novel natural product-like typeⅡ inhibitors of JAK2 using the DOLPHIN protocol.METHODS Initially,the DOLHPIN computational protocol was employed to convert an active(DFG-in)conformation of JAK2 into a typeⅡ-compatible conformation,which was used as a model for the structure-based virtual screening of 150 000 natural product-like compounds in silico.The novel biflavonoid analogues were designed and synthesized based on the structure of lead compound and then tested for JAK2 and STAT3 inhibitory activity,cytotoxicity and HCV antiviral activity.RESULTS The top eleven highest-scoring compounds were generated from the initial high-throughput virtual screening.Amentoflavone 1a,a biflavonoid from the Chinese plant Gingko biloba,emerged as a promising candidate for further biological evaluation.In dose-response experiments,amentoflavone 1ainhibited JAK2 activity in a concentration dependent fashion with an IC50 value of 5μmol·L-1.As a proof-of-concept,we designed nine analogues 1b-1j with the addition of one or more aliphatic side chains to the biflavonoid scaffold of 1a.The octyl(C8)analogue 1bdisplayed superior potency against JAK2 activity and HCV activity compared to the parent compound 1a,validating the structure-based lead optimization approach used in this study.Moreover,kinetic analysis indicated that analogue 1bexhibited a non-competitive mode of inhibition,suggesting that this compound may be a putative typeⅡ inhibitor of JAK2.CONCLUSION Amentoflavone 1ahas been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library.In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo.Molecular modeling and kinetic experiments suggested that the analogues may function as typeⅡ inhibitors of JAK2.

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

OBJECTIVE To apply molecular docking techniques to identify STAT3 inhibitors from a database of over 90 000 natural product and natural product-like compounds.METHODS Molecular docking was used for the virtual screening campaign and hit validation of STAT3 inhibitor.To further evaluate the potency of candidates at inhibiting STAT3-DNA binding activity,a STAT3 and STAT1transcription factor ELISA was performed.A dual-luciferase reporter assay,co-immunoprecipitation assay and Western blotting were carried out for the investigation of effect of compound 1 on STAT3-driven transcription,STAT3 dimerization and STAT3 phosphorylation.Finally,the cell toxicity of compound 1 was assessed by using MTT assay on different cell lines.RESULTS The virtual screening campaign furnished fourteen hit compounds,from which compound 1 emerged as a top candidate.Compound 1inhibited STAT3DNA-binding activity in vitro and attenuated STAT3-directed transcription in cellulo with selectivity over STAT1 and comparable potency to the wellknown STAT3 inhibitor S3I-201.Furthermore,compound 1 inhibited STAT3 dimerization and decreased STAT3 phosphorylation in cells without affecting STAT1 dimerization and phosphorylation.Compound 1 also exhibited selective anti-proliferative activity against cancer cells over normal cells in vitro.CONCLUSION The benzofuran derivative 1 was identified as a potential inhibitor of STAT3 dimerization using in silico screening.Molecular docking analysis suggested that compound 1 might putatively function as an inhibitor of STAT3 dimerization by binding to the SH2 domain.To the best of our knowledge,compound 1 has not been reported as a STAT3 inhibitor and no biological activity of compound 1 has been presented in the literature.

PRODUCT MODELLING TO SUPPORT PRODUCT DEVELOPMENT IN A VIRTUAL ENTERPRISE

The concept of Virtual Enterprise (VE) is closely related to the Global Manufacturing (GM) paradigm. How to develop a computer system which supports the product development in VE is an issue to be discussed in this paper. The emphasis is placed on the product modelling in the VE context. In the paper, a new concept of information modelling called ’heterogeneous data’ situation is clarified, which is further related to the ’Instance As Type’ (TAT) phenomenon. Modelling for IAT is discussed. Modelling for the partner company behaviour is presented as well.

创新升级背景下全球电影科技发展与思考启示——记2023年度SMPTE媒体技术峰会

本文结合对2023年度SMPTE媒体技术峰会国内外影视科技创新成果的研究分析,总结提炼出全球电影科技发展与应用的新进展新特点新趋势,在此基础上,统筹我国电影科技发展特点与应用需求,提出推进电影行业提质升级和高质量发展的思考与启示。

多感官体验下三维虚拟交互式水墨动画的设计与制作

水墨画是纯用水墨进行艺术创作的绘画种类,具有独特的审美意蕴、丰富的动作艺术语言和不拘一格的表现形式。三维虚拟交互技术对水墨画形式创新提供了支持,借助三维制作软件、虚拟交互制作软件、平面及后期制作软件,三维虚拟交互式水墨动画的艺术特质更为凸显。三维虚拟交互式水墨动画设计实践包括基于内容题材及视觉元素的设计实践、基于角色模型及分镜构图的设计实践两大类,在制作过程中应按照基础模型的设定及动画制作、水墨渲染效果的制作、虚拟三维环境下动态交互效果的制作的流程加以实施。

Exploiting Virtual Elasticity of Production Systems to Respect OTD—Part 3: Basic Considerations for Modelling CPPS Characterized by Non-Ergodic Order Entry and Non-Deterministic Product-Mix for Fully Flexible Addressable Workstations

The recently experienced hype concerning the so-called “4th Industrial Revolution” of production systems has prompted several papers of various subtopics regarding Cyber-Phdysical Production Systems (CPPS). However, important aspects such as the modelling of CPPS to understand the theory regarding the performance of highly non-ergodic and non-deterministic flexible manufacturing systems in terms of Exit Rate (ER), Manufacturing Lead Time (MLT), and On-Time Delivery (OTD) have not yet been examined systematically and even less modeled analytically. To develop the topic, in this paper, the prerequisites for modelling such systems are defined in order to be able to derive an explicit and dedicated production mathematics-based understanding of CPPS and its dynamics: switching from explorative simulation to rational modelling of the manufacturing “physics” led to an own and specific manufacturing theory. The findings have led to enouncing, among others, the Theorem of Non-Ergodicity as well as the Batch Cycle Time Deviation Function giving important insights to model digital twin-based CPPS for complying with the mandatory OTD.

人工智能技术的电影美学应用场景及其前景

人工智能技术正在深入走进各个行业,应用场景日益丰富,电影美学是其中一个极其重要的领域。探索人工智能技术的电影美学应用场景有两条路径:间断式有限应用实践,是当下主流的“现实主义”路径;全流程无限应用实验,是一条长期处在艺术畅想、理论憧憬中并属于近期先锋探索的理想主义路径。前者采用虚拟拍摄方式,后者采用自动生成方式。使用文字和笔画的概念可能有助于理解这方面的理想主义先驱的一致性,甚至可能有助于理解上述两条探索路径的一致性。两者在某个点上汇合在一起,是完全有可能的。

非遗虚拟空间生产体验对文化自信的影响

随着沉浸式体验技术的广泛运用,如何通过虚拟空间提升传统非遗文化的传播效用成为社会各界关注的问题。本研究基于列斐伏尔的“空间三元论”对非遗虚拟空间生产问题进行探讨,关注其中各空间生产要素对于非遗文化认同、文化自信的影响。本研究通过2×2×2组间实验(N=209)发现:非遗虚拟情境下空间生产体验具有具身性,空间真实度和参与度有助于提升非遗虚拟空间生产体验的传播效用;非遗虚拟场域下空间表征的效用是有条件的,非遗虚拟空间真实度和文化度的叠加才能对非遗文化认同产生影响;虚拟空间生产体验中VR信息素养具有部分效用:体验者的VR信息素养影响非遗虚拟空间真实度体验的效用,但不影响非遗虚拟空间参与度的效用。

基于虚拟技术的复合型人才培养体系建设——以化工单元及流程仿真实习为例

针对现有化学化工人才培养体系的不足,基于虚拟仿真技术,本着“虚实结合、相互补充、能实不虚”原则,构建“开放式”和“一站式”的“专业教学–科学研究–就业实践”三层次实验实习实践平台,打造理论知识与实践相结合的虚拟资源,提升仿真实习教学效果,提高综合实践能力,培养化学化工复合型应用人才。

基于虚拟现实的三维动漫制作相关技术研究

文章探讨了基于虚拟现实的三维动漫制作相关技术,包括虚拟现实技术、动画技术、渲染技术和建模技术。首先,对虚拟现实技术的特征与优势进行分析总结;其次,重点探讨虚拟现实技术在三维动漫制作中的具体技术与应用方式;最后,提出应用中的注意事项。通过该研究,可以了解基于虚拟现实的三维动漫制作相关技术的应用和优化方法,为未来的动漫制作提供参考和借鉴。

虚拟仿真技术在动物生产学实验教学中的应用

虚拟仿真技术是利用计算机和多媒体平台,模拟真实的实验条件和环境,实现情景和操作条件再现的一项新型信息技术,其不受场地、时空、设备和危险性等因素影响,是新农科和现代畜牧业教学发展的趋势。本文以动物生产学实验教学为例,介绍了实验教学的现状和虚拟仿真技术在学科中的优势,分析了虚拟仿真教学系统的构建、应用情况和存在的问题,并对未来的发展提出了建议,以期提高学生的实践操作能力。

基于数字孪生的套筒智能检测生产线虚拟调试技术

针对套筒智能检测生产线调试过程中存在调试周期长、试错成本高等问题,设计了基于数字孪生(DT)和虚拟调试(VC)技术,构建了套筒智能检测生产线VC系统。基于DT五维模型的套筒智能检测生产线和VC系统结构模型,明确套筒智能检测生产线的工作原理;阐述VC系统中智能检测生产线的数字空间搭建、控制系统设计、数据同步和交互、实时状态监测、故障模拟与恢复等关键技术。通过实验,证明了该方法的可行性与有效性,并为智能检测生产线的设计提供了参考。

基于虚拟现实技术的杯盖装配智能生产线设计

为解决传统机械自动化设计周期长、效率低、成本高等困境,将虚拟现实技术与传统设计相结合,提高传统设计的效率和数字化。以某企业的保温杯的杯盖装配自动化生产线设计为案例,分析虚拟现实技术与机械自动化设计的融合方法和路径。首先将虚拟现实技术应用到机械设计的模型构建上,并对机械零件装配的仿真模拟,模拟其在虚拟环境中的运动,明确机械零件的运动轨迹,记录机械零件运动时的坐标,保障虚拟装配的准确性;其次利用虚拟现实技术实现虚拟装配,实现机械零件在虚拟环境中的拆装展示,支持设计人员与虚拟环境的交互。利用虚拟现实技术,实现了对杯盖装配自动生产线的设计,使设计真能够更清楚地了解到产品设计的效果,不仅降低了开发生产线所需的成本,而且减少了复杂的生产线物理模型,测试生产线所需的场地维护费用也随之降低。同时大幅缩短了生产线设计时间,使产品快速、高效地投向市场。

基于数字孪生的模块化生产系统实践教学平台设计与实现

该文将数字孪生技术应用于模块化生产系统(modular production system,MPS)的智能化改造中,构建了基于数字孪生的MPS实践教学平台。依托监控系统和虚实交互等关键技术,增加了MPS数字孪生体的虚拟建模、虚实联调和PLC程序软件在环/硬件在环调试等实训环节;验证了MPS实践教学平台设计方案的可行性;制定了新的教学框架及详细的实训内容和考核方案。最后,将实训内容与大学生竞赛相结合,提高了学生对智能制造、工业生产的认知能力和实践动手能力。