Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be ...Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are展开更多
Background:The impact of the coronavirus disease 2019(COVID-19)pandemic on the etiology of non-COVID-19 viral pneumonia remains to be identified.We investigated the evolution of non-COVID-19 viral pneumonia in hospita...Background:The impact of the coronavirus disease 2019(COVID-19)pandemic on the etiology of non-COVID-19 viral pneumonia remains to be identified.We investigated the evolution of non-COVID-19 viral pneumonia in hospitalized patients before and after the COVID-19 pandemic.Methods:This is a single-center retrospective study.Patients who came to West China Hospital of Sichuan Univer-sity diagnosed with non-COVID-19 viral pneumonia from January 1,2016 to December 31,2021,were included and divided into pre-and post-COVID-19 groups according to the date of the COVID-19 outbreak in China.The results of 13 viral nucleic acid tests were compared between the two groups.Results:A total of 5937 patients(3954 in the pre-COVID-19 group and 1983 in the post-COVID-19 group)were analyzed.Compared with the pre-COVID-19 group,the proportion of patients tested for respiratory non-COVID-19 viral nucleic acid was significantly increased in the post-COVID-19 group(14.78%vs.22.79%,P<0.05).However,the non-COVID-19 virus-positive rates decreased from 37.9% to 14.6% after the COVID-19 outbreak(P<0.001).Notably,non-COVID-19 viral pneumonia caused by the influenza A virus H1N1(InfAH1N1)(2009)dropped to 0%after the pandemic.The top three viruses were InfAH1N1(2009)(13.9%),human rhinovirus(7.4%),and human adenovirus(3.4%)in the pre-COVID-19 group,and human rhinovirus(3.8%),human respiratory syncytial virus(2.0%),human parainfluenza virus(1.1%)and InfAH3N2(1.1%)in the post-COVID-19 group.Conclusions:The proportion of non-COVID-19 viral pneumonia decreased significantly after the COVID-19 out-break,among which InfAH1N1(2009)pneumonia decreased the most dramatically.展开更多
目的了解深圳市男男同性性行为人群(men who have sex with men,MSM)八种疱疹病毒(her‐pes viruses,HHV)携带率,分析深圳市MSM人群HHV感染的危险因素。方法采用非概率抽样法收集2021年4月―12月在深圳市咨询检测的男性口腔拭子及调查问...目的了解深圳市男男同性性行为人群(men who have sex with men,MSM)八种疱疹病毒(her‐pes viruses,HHV)携带率,分析深圳市MSM人群HHV感染的危险因素。方法采用非概率抽样法收集2021年4月―12月在深圳市咨询检测的男性口腔拭子及调查问卷,分为MSM组及对照组,用实时荧光定量核酸扩增技术,对8种HHV DNA进行检测,用Epidata双份录入问卷。对调查对象的人口学信息进行描述性分析,采用χ^(2)检验分析其性行为情况和HIV、梅毒、疱疹病毒感染情况,采用logistic回归进行HIV、疱疹病毒感染危险因素分析。结果共调查250人,其中MSM组126人,对照组124人。MSM组HHV人群中,HSV-1携带率为9.52%(12/126)、HSV-2携带率为2.38%(3/126)、VZV携带率为0、EBV携带率为37.30%(47/126)、HCMV携带率为0.79%(1/126)、HHV-6携带率为19.05%(24/126)、HHV-7携带率为94.44%(119/126)、HHV-8携带率为0.79%(1/126);对照组人群HSV-1携带率为2.42%(3/124)、HSV-2携带率为4.03%(5/124)、VZV携带率为0、EB病毒携带率为20.16%(25/124)、HCMV携带率为0、HHV-6携带率为14.52%(18/124)、HHV-7携带率为95.57%(119/124)、HHV-8携带率为0。MSM组的HSV-1、EB病毒携带率显著高于对照组(χ^(2)分别为5.593、8.954;P均<0.05);灌肠行为(a OR=6.549,95%CI:1.773~24.184)是HSV-1感染的危险因素,吸烟(a OR=3.277,95%CI:1.219~8.807)是EB病毒感染的危险因素;未发现其他HHV感染相关危险因素。结论减少灌肠行为有助于减少HSV-1感染的发生,减少吸烟有助于减少EBV感染的发生。由于MSM人群具有较高的HIV感染风险,会引发较重的HHV疾病负担,虽然MSM组与对照组的6种HHV感染谱总体相近,但有必要加强MSM人群HHV感染的监测和干预。展开更多
目的:了解宁夏2011年-2012年度流行性感冒流行情况和病毒流行株及其构成。方法:每周统计监测点流感样病例(ILI),采集ILI咽拭子标本,采用real time RT-PCR检测方法进行核酸检测;对核酸检测阳性标本进行病毒分离。结果:全区流感哨点医院...目的:了解宁夏2011年-2012年度流行性感冒流行情况和病毒流行株及其构成。方法:每周统计监测点流感样病例(ILI),采集ILI咽拭子标本,采用real time RT-PCR检测方法进行核酸检测;对核酸检测阳性标本进行病毒分离。结果:全区流感哨点医院共采集ILI标本2515份,核酸检测阳性标本535份,阳性率为21.27%,其中B型流感病毒阳性率88.79%,季节H3N2亚型阳性率7.10%,新甲型H1N1阳性率4.11%;对核酸检测阳性标本进行病毒分离,分离出流感毒株为165株;各年龄组核酸检测阳性率差别有统计学意义(P<0.001)。结论:2011年-2012年度宁夏流感监测地区的流行情况相对较为平静,主要发病群体是学龄前儿童和中小学生,流感病毒的优势毒株为B型。展开更多
文摘Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are
基金supported by the National Key Research and Development Program(grant number:2022YFC2009804)Sichuan Science and Technology Program(grant number:2021YFS0003).
文摘Background:The impact of the coronavirus disease 2019(COVID-19)pandemic on the etiology of non-COVID-19 viral pneumonia remains to be identified.We investigated the evolution of non-COVID-19 viral pneumonia in hospitalized patients before and after the COVID-19 pandemic.Methods:This is a single-center retrospective study.Patients who came to West China Hospital of Sichuan Univer-sity diagnosed with non-COVID-19 viral pneumonia from January 1,2016 to December 31,2021,were included and divided into pre-and post-COVID-19 groups according to the date of the COVID-19 outbreak in China.The results of 13 viral nucleic acid tests were compared between the two groups.Results:A total of 5937 patients(3954 in the pre-COVID-19 group and 1983 in the post-COVID-19 group)were analyzed.Compared with the pre-COVID-19 group,the proportion of patients tested for respiratory non-COVID-19 viral nucleic acid was significantly increased in the post-COVID-19 group(14.78%vs.22.79%,P<0.05).However,the non-COVID-19 virus-positive rates decreased from 37.9% to 14.6% after the COVID-19 outbreak(P<0.001).Notably,non-COVID-19 viral pneumonia caused by the influenza A virus H1N1(InfAH1N1)(2009)dropped to 0%after the pandemic.The top three viruses were InfAH1N1(2009)(13.9%),human rhinovirus(7.4%),and human adenovirus(3.4%)in the pre-COVID-19 group,and human rhinovirus(3.8%),human respiratory syncytial virus(2.0%),human parainfluenza virus(1.1%)and InfAH3N2(1.1%)in the post-COVID-19 group.Conclusions:The proportion of non-COVID-19 viral pneumonia decreased significantly after the COVID-19 out-break,among which InfAH1N1(2009)pneumonia decreased the most dramatically.
文摘目的了解深圳市男男同性性行为人群(men who have sex with men,MSM)八种疱疹病毒(her‐pes viruses,HHV)携带率,分析深圳市MSM人群HHV感染的危险因素。方法采用非概率抽样法收集2021年4月―12月在深圳市咨询检测的男性口腔拭子及调查问卷,分为MSM组及对照组,用实时荧光定量核酸扩增技术,对8种HHV DNA进行检测,用Epidata双份录入问卷。对调查对象的人口学信息进行描述性分析,采用χ^(2)检验分析其性行为情况和HIV、梅毒、疱疹病毒感染情况,采用logistic回归进行HIV、疱疹病毒感染危险因素分析。结果共调查250人,其中MSM组126人,对照组124人。MSM组HHV人群中,HSV-1携带率为9.52%(12/126)、HSV-2携带率为2.38%(3/126)、VZV携带率为0、EBV携带率为37.30%(47/126)、HCMV携带率为0.79%(1/126)、HHV-6携带率为19.05%(24/126)、HHV-7携带率为94.44%(119/126)、HHV-8携带率为0.79%(1/126);对照组人群HSV-1携带率为2.42%(3/124)、HSV-2携带率为4.03%(5/124)、VZV携带率为0、EB病毒携带率为20.16%(25/124)、HCMV携带率为0、HHV-6携带率为14.52%(18/124)、HHV-7携带率为95.57%(119/124)、HHV-8携带率为0。MSM组的HSV-1、EB病毒携带率显著高于对照组(χ^(2)分别为5.593、8.954;P均<0.05);灌肠行为(a OR=6.549,95%CI:1.773~24.184)是HSV-1感染的危险因素,吸烟(a OR=3.277,95%CI:1.219~8.807)是EB病毒感染的危险因素;未发现其他HHV感染相关危险因素。结论减少灌肠行为有助于减少HSV-1感染的发生,减少吸烟有助于减少EBV感染的发生。由于MSM人群具有较高的HIV感染风险,会引发较重的HHV疾病负担,虽然MSM组与对照组的6种HHV感染谱总体相近,但有必要加强MSM人群HHV感染的监测和干预。
文摘目的:了解宁夏2011年-2012年度流行性感冒流行情况和病毒流行株及其构成。方法:每周统计监测点流感样病例(ILI),采集ILI咽拭子标本,采用real time RT-PCR检测方法进行核酸检测;对核酸检测阳性标本进行病毒分离。结果:全区流感哨点医院共采集ILI标本2515份,核酸检测阳性标本535份,阳性率为21.27%,其中B型流感病毒阳性率88.79%,季节H3N2亚型阳性率7.10%,新甲型H1N1阳性率4.11%;对核酸检测阳性标本进行病毒分离,分离出流感毒株为165株;各年龄组核酸检测阳性率差别有统计学意义(P<0.001)。结论:2011年-2012年度宁夏流感监测地区的流行情况相对较为平静,主要发病群体是学龄前儿童和中小学生,流感病毒的优势毒株为B型。
