Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 pat...Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR.展开更多
The incidence and prevalence of hypertension are increasing as a consequence of the obesity epidemic.Adipocytes and their variety of factors make contributions to the long-term regulation of blood pressure.The pathoph...The incidence and prevalence of hypertension are increasing as a consequence of the obesity epidemic.Adipocytes and their variety of factors make contributions to the long-term regulation of blood pressure.The pathophysiologic states of hypertension,including obesity,are regulated by the production of adipocytederived factors.Increased body mass index was closely linked to elevated blood pressure.Mostly the hypertensive subjects were obese as well as overweight.There are numerous adipokines,however,this review article only focuses on the major adipokines including chemerin,visfatin,retinol-binding protein 4,plasminogen activator inhibitor-1,monocyte chemotactic protein-1,omentin-1,lipocalin-2,vaspin,progranulin,complement c1q tumor necrosis factor-related protein,and nesfatin-1 role in the pathogenesis of hypertension.This review article concludes the significant association of major adipokines in the pathogenesis of hypertensives.New research should be focused on other newly reported adipokine roles in hypertensive subjects and the management of these adipokines in hypertensive subjects.The discovery of this information could result in the creation of antihypertensive medications,particularly those that focus on obesity-related hypertension.展开更多
目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法...目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法测定血清VF水平。结果 GDM组BMI、脐血血清VF水平均高于对照组(P均<0.05)。相关分析发现,VF水平与BMI及血清Fins水平均呈正相关(r分别为0.468、0.524,P均<0.05)。结论 GDM患者脐血血清VF水平升高,在GDM发病中发挥重要作用。展开更多
V isfatin是腹部内脏脂肪组织高表达的一种生物活性小分子,能够调控腹部脂肪细胞的分化和成脂作用,并能与胰岛素受体结合,调节胰岛素敏感性。V isfatin的发现及其类胰岛素生物活性,引发人们对体内糖脂代谢平衡、脂肪细胞分化与增殖的重...V isfatin是腹部内脏脂肪组织高表达的一种生物活性小分子,能够调控腹部脂肪细胞的分化和成脂作用,并能与胰岛素受体结合,调节胰岛素敏感性。V isfatin的发现及其类胰岛素生物活性,引发人们对体内糖脂代谢平衡、脂肪细胞分化与增殖的重新认识。展开更多
基金Xi’an Science and Technology Bureau Fund(23YXYJ0103)Shaanxi Provincial Science and Technology Department Fund(S2022-YF-YBSF-0939).
文摘Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR.
文摘The incidence and prevalence of hypertension are increasing as a consequence of the obesity epidemic.Adipocytes and their variety of factors make contributions to the long-term regulation of blood pressure.The pathophysiologic states of hypertension,including obesity,are regulated by the production of adipocytederived factors.Increased body mass index was closely linked to elevated blood pressure.Mostly the hypertensive subjects were obese as well as overweight.There are numerous adipokines,however,this review article only focuses on the major adipokines including chemerin,visfatin,retinol-binding protein 4,plasminogen activator inhibitor-1,monocyte chemotactic protein-1,omentin-1,lipocalin-2,vaspin,progranulin,complement c1q tumor necrosis factor-related protein,and nesfatin-1 role in the pathogenesis of hypertension.This review article concludes the significant association of major adipokines in the pathogenesis of hypertensives.New research should be focused on other newly reported adipokine roles in hypertensive subjects and the management of these adipokines in hypertensive subjects.The discovery of this information could result in the creation of antihypertensive medications,particularly those that focus on obesity-related hypertension.
文摘目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法测定血清VF水平。结果 GDM组BMI、脐血血清VF水平均高于对照组(P均<0.05)。相关分析发现,VF水平与BMI及血清Fins水平均呈正相关(r分别为0.468、0.524,P均<0.05)。结论 GDM患者脐血血清VF水平升高,在GDM发病中发挥重要作用。
