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Comparison of isolated-check visual evoked potential and standard automated perimetry in early glaucoma and high-risk ocular hypertension 被引量:5
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作者 Xiang-Wu Chen Ying-Xi Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第4期599-604,共6页
AIM:To compare the diagnostic performance of isolatedcheck visual evoked potential(ic VEP) and standard automated perimetry(SAP),for evaluating the application values of ic VEP in the detection of early glaucoma.... AIM:To compare the diagnostic performance of isolatedcheck visual evoked potential(ic VEP) and standard automated perimetry(SAP),for evaluating the application values of ic VEP in the detection of early glaucoma.METHODS:Totally 144 subjects(288 eyes) were enrolled in this study.ic VEP testing was performed with the Neucodia visual electrophysiological diagnostic system.A 15% positive-contrast(bright) condition pattern was used in this device to differentiate between glaucoma patients and healthy control subjects.Signal-to-noise ratios(SNR) were derived based on a multivariate statistic.The eyes were judged as abnormal if the test yielded an SNR≤1.SAP testing was performed with the Humphrey Field Analyzer II.The visual fields were deemed as abnormality if the glaucoma hemifield test results outside normal limits;or the pattern standard deviation with P〈0.05;or the cluster of three or more non-edge points on the pattern deviation plot in a single hemifield with P〈0.05,one of which must have a P〈0.01.Disc photographs were graded as either glaucomatous optic neuropathy or normal by two experts who were masked to all other patient information.Moorfields regression analysis(MRA) used as a separate diagnostic classification was performed by Heidelberg retina tomograph(HRT).RESULTS:When the disc photograph grader was used as diagnostic standard,the sensitivity for SAP and ic VEP was 32.3% and 38.5% respectively and specificity was 82.3% and 77.8% respectively.When the MRA Classifier was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 48.6% and 51.4% respectively and specificity was 84.1% and 78.0% respectively.When the combined structural assessment was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 59.2%and 53.1% respectively and specificity was 84.2% and 84.6% respectivlely.There was no statistical significance between the sensitivity or specificity of SAP and ic VEP,regardless of which diagnostic standard was based on.CONCLUSION:The diagnostic performance of ic VEP is not better than that of SAP in the detection of early glaucoma. 展开更多
关键词 isolated-check visual evoked potential standard automated perimetry signal-to-noise ratios early glaucoma
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Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects
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作者 Qi N.Cui Priyanka Gogt +5 位作者 Jonathan M.Lam Safa Siraj Lisa A.Hark Jonathan S.Myers L.Jay Katz Michael Waisbourd 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第4期577-581,共5页
AIM: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability o... AIM: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability of both modalities.METHODS: This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA. Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP) Ⅲ 30-2 Adaptive Staircase Thresholding Algorithm(ASTA) FAST protocol and OVF G-TOP white-on-white strategy. Testing order was randomized. Pearson's correlation coefficient was calculated for both mean deviation(MD) and pattern standard deviation/square root of loss of variance(PSD/s LV). Receiver operating characteristic(ROC) curves were used to determine the diagnostic abilities of both modalities. Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs) were calculated to assess test-retest repeatability. RESULTS: Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled. HEP and OVF were significantly correlated for both MD(r=-0.84; P<0.01) and PSD/s LV(r=0.79; P<0.01). Areas under the ROC curves(AUCs) were also comparable between HEP and OVF for both MD(0.74 and 0.79, respectively; P=0.26) and PSD/sL V(0.74 and 0.82; P=0.08). ICC was high for both HEP (0.96 for MD, 0.95 for PSD/s LV) and OVF(0.82 and 0.88, respectively). Mean test duration(min) was significantly shorter for OVF(2.63) compared to HEP(5.15; P<0.01). CONCLUSION: HEP and OVF show strong correlation for both MD and PSD/s LV, and have similar validity for detecting glaucoma. The test-retest repeatability is high for both HEP and OVF, however the average testing duration of HEP is significantly longer than that of OVF. 展开更多
关键词 glaucoma HEIDELBERG EDGE PERIMETER standard automated perimetry Octopus visual FIELD Analyzer visual FIELD
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Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma 被引量:2
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作者 Lukas Reznicek Sophie Burzer +5 位作者 Andrea Laubichler Ali Nasseri Chris P Lohmann Nikolaus Feucht Michael Ulbig Mathias Maier 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第10期1534-1538,共5页
AIM:To evaluate and compare structural optical coherence tomography(OCT)-based parameters,such as Bruch’s membrane opening-minimum rim width(BMO-MRW),and retinal nerve fiber layer(RNFL)thickness in glaucoma pa... AIM:To evaluate and compare structural optical coherence tomography(OCT)-based parameters,such as Bruch’s membrane opening-minimum rim width(BMO-MRW),and retinal nerve fiber layer(RNFL)thickness in glaucoma patients with visual field(VF)defects,and to correlate both to mean deviation(MD)values of obtained standard achromatic perimetry(SAP)examinations.METHODS:Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals.All study participants underwent a full ophthalmic examination and VF testing with SAP.Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT.Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.RESULTS:A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36healthy right eyes of 36 individuals in the control group.Global MD of values correlated significantly with global RNFL(Pearson corr.coeff:0.632,P=0.001)and global BMO-MRW(Pearson corr.coeff:0.746,P〈0.001)values in the glaucoma group.Global MD and sectorial RNFL or BMO-MRW values correlated less significantly.In the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients(〉4 diopters)within the glaucoma group(n=6)revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.CONCLUSION:In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients. 展开更多
关键词 glaucoma optical coherence tomography Bruch's membrane opening-minimum rim width retinal nerve fibre layer myopia standard automated perimetry visual field defects
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Central visual function and inner retinal structure in primary open-angle glaucoma 被引量:3
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作者 Li-juan XU Sha-ling LI +2 位作者 Vance ZEMON Yan-qian XIE Yuan-bo LIANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2020年第4期305-314,共10页
To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma(POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into earl... To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma(POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential(ic VEP) testing, 24-2 standard automated perimetry(SAP), and Cirrus optical coherence tomography(OCT) examinations. Signal-to-noise ratio(SNR) measures obtained from ic VEP responses to isolated checks presented at four depths of modulation(DOMs;8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity(mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness(GCL+IPLT) and peripapillary retinal nerve fiber layer thickness(pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls(P<0.001). A significant positive association was found between SNR at 14% DOM and GCL+IPLT at the inferior sector in early glaucoma(r=0.465, P=0.004). In moderate to advanced glaucoma, significant correlations were found between SNR at 32% DOM and mean GCL+IPLT(r=0.364, P=0.023), superior GCL+IPLT(r=0.358, P=0.025), and mean p RNFLT(r=0.396, P=0.025). In addition, in moderate to advanced glaucoma, there were significant correlations between mMS and all relevant measures of retinal thickness(r=0.330–0.663, P< 0.010). In early glaucoma, significant correlations were found between mean mMS and minimum GCL+IPLT(r=0.373, P=0.023), and between inferior mMS and superior GCL+IPLT(r=0.470, P=0.003). Linear models provided a good explanation for the relationship between SNR and inner retinal thickness(IRT), whereas nonlinear models better explained the relationship between mMS and IRT. In early glaucoma, both SNR and mMS were related moderately and significantly to IRT, whereas in moderate to advanced glaucoma, mMS was more strongly correlated with IRT than SNR. 展开更多
关键词 Isolated-check visual evoked potential(icVEP) Primary open-angle glaucoma(POAG) Optical coherence tomography(OCT) Standard automated perimetry(SAP)
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联合多种视功能检查对原发性开角型青光眼早期诊断的意义 被引量:6
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作者 蓝育青 刘嫣芬 葛坚 《眼科学报》 1998年第4期199-203,235,共6页
目的:了解原发性开角型青光眼视觉电生理和计算机自动视野检查结果的变化特点并对其视功能状况进行综合分析,以寻找比较敏感和特异的参数,为原发性开角型青光眼较早期(视野改变出现前)和早期诊断提供依据。方法:对36例(70眼)原发性开角... 目的:了解原发性开角型青光眼视觉电生理和计算机自动视野检查结果的变化特点并对其视功能状况进行综合分析,以寻找比较敏感和特异的参数,为原发性开角型青光眼较早期(视野改变出现前)和早期诊断提供依据。方法:对36例(70眼)原发性开角型青光眼患者、8例(12眼)可疑性青光眼患者、30例(60眼)正常对照者分别进行视网膜振荡电位(OPs)、视网膜电图(PERG)、视诱发电位(PVEP)和Humphery计算机自动视野检查。结果:在原发性开角型青光眼视野改变出现前,PERG的异常率较高,而于疾病的早期、中期和晚期,则表现为自动视野和PERG的异常率较高。原发性开角型青光眼患者OPs与C/D负相关,与视野指数、眼压和视力无相关性;PERG振幅与视野指数和眼压负相关,与C/D和视力无相关性;PVEP潜伏期与视野指数和C/D正相关,而与眼压无相关性。结论:统计学结果提示,对原发性开角型青光眼不同的表现形式,可选用不同的视功能检查指标。在视野改变出现前,如眼底未见明显改变,仅表现为眼压升高,PERG可能为比较敏感的参考指标;而一旦眼底发生改变,尽管眼压不高,可考虑选用OPs或PVEP作为观察指标。对早期、中期和晚期青光眼,PERG和自动视野的诊断和监测价值较好。联合多种视功能检查对原发性开角型青光眼早期或较早期(视野改变出现前)诊断具? 展开更多
关键词 视觉 电生理 自动视野检查 开角型青光眼 诊断
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单侧青光眼视野缺损患者假阴性反应的眼间差异 被引量:2
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作者 吴劲松 王竫华 +1 位作者 王大博 康菊 《眼科研究》 CSCD 北大核心 2004年第4期412-414,共3页
目的 探讨单侧青光眼视野缺损患者电脑视野检查假阴性反应率的眼间差异及相关因素。方法 选取2 0 0 0年 1月~ 2 0 0 2年 10月在青岛大学医学院附属医院眼科视野检查室行Octopus 10 1自动静态视野检查的单侧青光眼视野缺损患者 66例... 目的 探讨单侧青光眼视野缺损患者电脑视野检查假阴性反应率的眼间差异及相关因素。方法 选取2 0 0 0年 1月~ 2 0 0 2年 10月在青岛大学医学院附属医院眼科视野检查室行Octopus 10 1自动静态视野检查的单侧青光眼视野缺损患者 66例进行研究 ;比较患者眼间视力、眼压、杯盘比、检查时间及假阴性反应率、假阳性反应率、平均偏差、平均光敏感度的差异 ,并分析假阴性反应率的相关因素。结果 视野缺损眼与视野正常眼的假阴性反应率 (FN)差异显著 ,且与检查的先后顺序无关 ,而两眼在视力、眼压、瞳孔直径等方面无明显差异 ;视野缺损眼平均偏差 (MD)与FN相关 ,在MD越高的眼 ,FN越高 ;而正常眼MD与FN无关。结论 假阴性反应率可能与视野缺损有关 ;用假阴性反应率作为可靠性指数来监测受检者的专心程度、注意力集中程度 ,是不合适的。 展开更多
关键词 电脑视野检查 假阴性反应 视野缺损 青光眼
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一种评价青光眼视野损害的新方法——上下方Bjerrum区静态光阈值不对称 被引量:3
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作者 陈晓明 吴振中 蒋幼芹 《眼科研究》 CSCD 1993年第1期42-44,共3页
鉴于早期青光眼视野缺损具有上下方视野不对称特点,根据不对称视野计分可能发现早期青光眼视野损害。通过比较同一跟上下Bjerrum区相对应点群的平均光敏感度,分析54只已有早期或中期视野缺损的青光眼和105只正常眼的自动视野计资料。94.... 鉴于早期青光眼视野缺损具有上下方视野不对称特点,根据不对称视野计分可能发现早期青光眼视野损害。通过比较同一跟上下Bjerrum区相对应点群的平均光敏感度,分析54只已有早期或中期视野缺损的青光眼和105只正常眼的自动视野计资料。94.44%(51/54)的青光眼和92.38%(97/105)的正常眼被正确鉴定。此分析方法简单,对于检测青光眼视野缺损有较高的敏感性和特异性。 展开更多
关键词 青光眼 视野缺损 视野检查
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蓝-黄视野结合视觉电生理检查在原发性开角型青光眼早期诊断中的意义 被引量:1
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作者 李昂 李婵 段国平 《中国现代医学杂志》 CAS CSCD 北大核心 2012年第16期84-88,共5页
目的探讨蓝—黄视野结合视觉电生理检查对原发性开角型青光眼早期诊断的临床应用价值,为临床青光眼早期诊断提供较为客观敏感的检测方法。方法选择53例53眼标准自动视野检查正常的可疑开角型青光眼患者及30例60眼正常人进行蓝—黄视野... 目的探讨蓝—黄视野结合视觉电生理检查对原发性开角型青光眼早期诊断的临床应用价值,为临床青光眼早期诊断提供较为客观敏感的检测方法。方法选择53例53眼标准自动视野检查正常的可疑开角型青光眼患者及30例60眼正常人进行蓝—黄视野检查结合图形视网膜电图及多焦视网膜电图,并对其结果进行对比研究。结果在可疑青光眼患者中,B/Y视野检查31眼视野出现异常,与正常人比较差异有显著性。P-ERG检查眼的N95波潜伏期延长有明显差异,mf-ERG检查眼的N1P1N2波潜伏期有明显差异。结论对于原发性青光眼早期发生,在眼底及普通视野未出现明显异常的患者,B/Y视野检查联合P-ERG,mf-ERG检查无疑是一种敏感性较高的检查手段。 展开更多
关键词 原发性开角型青光眼 视觉电生理 蓝黄视野
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青光眼静态阈值不对称 被引量:1
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作者 陈晓明 吴振中 蒋幼芹 《眼科研究》 CSCD 1994年第1期43-45,共3页
通过比较双眼Bjerrum区平均光敏感度(MS),分析36名至少1眼有早或中期视野缺损的青光眼和42名正常人自动视野检查资料,应用自定的标准,获得80.6%(29/36)的敏感性和88.1%(37/42)的特异性。在... 通过比较双眼Bjerrum区平均光敏感度(MS),分析36名至少1眼有早或中期视野缺损的青光眼和42名正常人自动视野检查资料,应用自定的标准,获得80.6%(29/36)的敏感性和88.1%(37/42)的特异性。在青光眼组,较低MS眼多为较高眼压眼,在有不对称C/D值或相对性传入性瞳孔障碍者,较大青光眼杯或传入性瞳孔障碍眼MS恒低于对侧眼。 展开更多
关键词 青光眼 视野缺损 不对称性损害
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蓝黄视野联合图形视觉电生理检查在原发性开角型青光眼早期诊断中应用 被引量:6
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作者 海鸥 安洁 《临床军医杂志》 CAS 2016年第1期38-40,43,共4页
目的探讨蓝黄视野和图形视觉电生理检查在原发性开角型青光眼早期诊断中的敏感性,为临床早期诊断提供依据。方法选择36例(52眼)可疑青光眼患者和32例(54眼)正常对照者进行蓝黄视野(B/YP)、图形视网膜点图(P-ERG)和图形视网膜诱发电位(P-... 目的探讨蓝黄视野和图形视觉电生理检查在原发性开角型青光眼早期诊断中的敏感性,为临床早期诊断提供依据。方法选择36例(52眼)可疑青光眼患者和32例(54眼)正常对照者进行蓝黄视野(B/YP)、图形视网膜点图(P-ERG)和图形视网膜诱发电位(P-VEP)检查。B/YP采用Humphrey-750型全自动电脑视野计进行检查,P-ERG和P-VEP采用RETIscan和RETI-port视觉电生理检查系统进行检测。结果 (1)可疑青光眼组中全视网膜光敏度均值为(16.39±3.26)d B,正常对照组的全视网膜光敏度均值为(21.65±2.14)d B,两组比较,差异有显著统计学意义(t=3.62,P<0.01)。可疑青光眼组的平均缺损值为(4.32±2.18)d B,正常组的平均缺损值为(2.85±1.83)d B,两组比较,差异有显著统计学意义(t=2.45,P<0.05)。(2)可疑青光眼组的N95振幅值为(8.16±2.53)μV,峰时值为(96.75±11.29)ms,正常对照组的N95振幅值为(9.82±2.25)μV,峰时值为(91.43±9.63)ms。振幅值与峰时值两组间比较,差异均有显著统计学意义(t=4.69,t=3.15,P<0.01)。(3)可疑青光眼组P100振幅为(8.73±2.54)μV,正常组的振幅为(10.58±2.26)μV。两组比较,差异有显著统计学意义(t=3.48,P<0.01)。可疑青光眼组P100的潜伏期为(102.36±3.29)ms,正常对照组的潜伏期为(98.28±2.75)ms,两组比较,差异有显著统计学意义(t=2.24,P<0.05)。结论 B/YP检查能发现白/白视野(W/WP)尚不能检出的视野缺损,PERG和PVEP对青光眼的早期变化有较高的敏感性,蓝黄视野检查联合图形视觉电生理对原发性开角型青光眼的早期诊断有较高的应用价值。 展开更多
关键词 蓝黄视野 视觉电生理 原发性开角型青光眼内容
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