Mesenchymal stem cell therapy in atherosclerosis:A bibliometric and visual analysis

BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis of studies on the use of MSC therapy for AS over the past two decades,assess key trends and provide insights for future research directions.METHODS We systematically searched the Web of Science Core Collection database for articles published between 1999 and 2023,yielding a total of 556 articles.Visual representation and bibliometric analysis of information and trends were facilitated using CiteSpace,the R package‘bibliometrix’and VOSviewer.RESULTS The analyzed articles were predominantly from 52 countries/regions,with prominent contributions from China and the United States.A cohort of 3057 authors contributed to these publications,with the works of Libby P distinguished by their influence and citation count.Int J Mol Sci has emerged as the journal with the highest publication volume,prominently disseminating influential papers and identifying citation outbreaks.Furthermore,our analysis identified current research hotspots within the field,focusing on vascular progenitor cells,inflammatory mechanisms,and extracellular vesicles.Emerging research frontiers,such as extracellular vesicles and oxidative stress,have been highlighted as areas of burgeoning interest.Finally,we offer perspectives on the status of research and future directions of MSC therapy in AS.CONCLUSION This comprehensive analysis provides valuable insights for advancing scientific research on MSC therapy for AS.By elucidating pivotal trends and research directions,this study aimed to foster innovation and promote the progress of disciplines in this field,thereby contributing to advancing scientific knowledge and clinical practice.

Bibliometric analysis of research in epilepsy and comorbid depression from 2014 to 2023

BACKGROUND Epilepsy and depression have complicated bidirectional relationships.Our study aimed to explore the field of epilepsy comorbid with depression in a bibliometric perspective from 2014-2023.AIM To improve our understanding of epilepsy and depression by evaluating the relationship between epilepsy and depression,bibliometric analyses were performed.METHODS Epilepsy and depression-related publications from the last decade were retrieved from the Web of Science Core Collection.We conducted bibliometric and visual analysis using VOSviewer and CiteSpace,examining authorships,countries,institutions,journals of publication,co-citations of references,connections between keywords,clusters of keywords,and keywords with citation bursts.RESULTS Over the past ten years,we collected 1045 research papers focusing on the field of epilepsy and comorbid depression.Publications on epilepsy and depression have shown a general upward trend over time,though with some fluctuations.The United States,with 287 articles,and the University of Melbourne,contributing 34 articles,were the top countries and institutions,respectively.In addition,in the field of epilepsy and depression,Professor Lee,who has published 30 articles,was the most contributing author.The hot topics pay attention to the quality of life in patients with epilepsy and depression.CONCLUSION We reported that quality of life and stigma in patients with epilepsy comorbid with depression are possible future hot topics and directions in the field of epilepsy and depression research.

Visual Analysis of Application and Development Trend of Agarwood Based on CiteSpace

The Chinese traditional medicine,agarwood,is a commonly used medicine for regulating qi,which has many clinical applications because of its unique curative effect.In this study,CiteSpace software was used to visually analyze the application and development trend of agarwood in the literature from CNKI website in the period of 2007-2022.The analysis results showed that the research on agarwood has basically formed core groups of authors,and universities and their affiliated hospitals are main publishing institutions.Moreover,in this study,several research directions of agarwood were also summarized,including clinical research,chemical composition,structural identification and quality standards,showing that agarwood has rich and flexible application prospects in many aspects.On this basis,several suggestions were put forward:strengthening the cooperation between universities and research institutes and building a scientific research cooperation community,and promoting the combination of clinical research and laboratory research.

Development,hotspots and trend directions of groundwater numerical simulation:A bibliometric and visualization analysis

Groundwater is a vital component of the hydrological cycle and essential for the sustainable development of ecosystems.Numerical simulation methods are key tools for addressing scientific challenges in groundwater research.This study uses bibliometric visualization analysis to examine the progress and trends in groundwater numerical simulation methods.By analyzing literature indexed in the Web of Science database from January 1990 to February 2023,and employing tools such as Citespace and VOSviewer,we assessed publication volume,research institutions and their collaborations,prolific scholars,keyword clustering,and emerging trends.The findings indicate an overall upward trend in both the number of publications and citations concerning groundwater numerical simulations.Since 2010,the number of publications has tripled compared to the total before 2010,underscoring the increasing significance and potential of numerical simulation methods in groundwater science.China,in particular,has shown remarkable growth in this field over the past decade,surpassing the United States,Canada,and Germany.This progress is closely linked to strong national support and active participation from research institutions,especially the contributions from teams at Hohai University,China University of Geosciences,and the University of Science and Technology of China.Collaboration between research teams is primarily seen between China and the United States,with less noticeable cooperation among other countries,resulting in a diverse and dispersed development pattern.Keyword analysis highlights that international research hotspots include groundwater recharge,karst water,geothermal water migration,seawater intrusion,variable density flow,contaminant and solute transport,pollution remediation,and land subsidence.Looking ahead,groundwater numerical simulations are expected to play a more prominent role in areas such as climate change,surface water-groundwater interactions,the impact of groundwater nitrates on the environment and health,submarine groundwater discharge,ecological water use,groundwater management,and risk prevention.

Research Characteristics of Thermal Comfort of Urban Block Landscape Based on Knowledge Graph Analysis

The landscape environment of urban blocks plays a significant role in improving the comfort of urban thermal environment and promoting green and high-quality development.The 342 papers related to the research on the impact of urban block landscape environment on thermal comfort in China,collected by CNKI(China National Knowledge Infrastructure)from 2002 to 2022,are used as the research object.Through bibliometric statistical analysis,LLR algorithm,and cluster analysis,the current research status of the impact of urban block landscape environment on thermal comfort in China is analyzed and processed,and its external characteristics are identified.Using the information visualization software CiteSpace,the research topics in the field of the impact of urban block landscape environment on thermal comfort are presented in the form of knowledge graphs.Through co-occurrence analysis of keywords and trend of word frequency changes,the development trends of research hotspots and cutting-edge fields of the impact of urban block landscape environment on thermal comfort are determined,hoping to provide reference for future research in this field.

Bibliometric and visual analysis of post-stroke hemiplegia in the past 20 years

Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 years.Methods:Articles about post-stroke hemiplegia from January 2005 to December 2024 were analyzed in the Web of Science database.CiteSpace software was used to conduct co-citation analysis of the articles about post-stroke hemiplegia as well as cooperative network analyses of authors,countries,and institutions,as well as keyword co-occurrence,clustering,emergence,and time line analyses.The results were displayed in a visual atlas.Result:A total of 2625 papers were obtained,and there were more publications overall.China and the United States had the most number of articles,while Chae,John was the author with the most number of articles.Capital Med University and Ohio State University had the most articles among their agencies.The keywords"stroke"and"rehabilitation"were used the most.The key word analysis indicates that the present study focus is on exercise rehabilitation measures and post-stroke treatment.Conclusion:Using CiteSpace software to analyze the literature on post-stroke hemiplegia,it is discovered that the use of new technologies in the field of mechanical thrombectomy and the effectiveness of rehabilitation techniques like mirror treatment are the key areas of study attention.This study has positive significance for finding safer and more effective treatments for post-stroke hemiplegia.

Research hotspots andfrontiersanalysisoftraditional Chinese medicine constitution identification:Avisual analysis of literature based on CiteSpaceand vosviewer

Objective:To explore the development and hotspots in the field of traditional Chinese medicine(TCM)constitution identification since the year 2000.Methods:Using CiteSpace and VOSviewer software,literature from five prominent databases including VIP,WanFang,China National Knowledge Infrastructure(CNKI),PubMed,and Web ofScience was analyzed.Visual methods were used to examine the annual publications,keywords,authors,and collaborative networks.Results:After deduplication with EndNotes,a total of 5,747 articles meeting the criteria were included.Since 2000,the publications of TCM constitution identification shown three major stages:a significant increasing trend with the year before 2016,a fluctuating trend from 2016 to 2021,and a decreasing trend with the year after 2021.The co-occurrence analysis ofkeywords revealed health management,hypertension,and constitution as hot directions in this field of research.CiteSpace was used for keyword clustering and burst analysis,health management,medical life,and constitution emerged as the latest hotspots in the past three years,which will be the main development directions in the future.Clusters such as hypertension,preventive treatment,and health management were identified,representing the main research themes at present.VOSviewer and CiteSpace were used for co-occurrence and clustering analysis of authors,revealing collaborative research networks,with prominent groups represented by WANG Qi,WANG Ji,LI Lingru,HOU Shujuan,ZHU Yanbo,etc.Conclusion:Research related to TCM constitution identification is developing rapidly,involving various aspects of medical care and daily life.However,there is still a need to build an extensive academic platform,strengthen the dissemination of Chinese medicine culture,standardize,intellectualize and universalize the identification of TCM constitution assessments,and construct a health service system with Chinese characteristics.

Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

Measurement Analysis and Evaluation of Twenty-Five Years of Mathematics Education Research in China:Visual Econometric Analysis Based on CiteSpace Knowledge Mapping(1999-2024)

Since the new century,China’s mathematics curriculum reform in basic education has continued to move forward in attempts and explorations,presenting many new changes,trends,movements,and developments.Sorting out,analyzing,and summarizing the achievements,experiences,problems,and challenges in this journey are conducive to providing insights for the reform and development of the Chinese basic education mathematics curriculum in the new era.This paper analyses the research on mathematics education in China(1999-2024)using the visual measurement of CiteSpace knowledge mapping,hoping to provide directions for the future of mathematics education in China.

Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis

Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain unclear.In this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core Collection.We found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 clusters.In cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–2013.For example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic prospects.Some researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular disease.All of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was observed.The contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current authoritative studies have focused on basic research towards the stem cell treatment of diabetic retinopathy.Existing clinical studies are of low quality and have insufficient evidence levels,and their findings have not yet been widely accepted in clinical practice.Major challenges during stem cell transplantation remain,including stem cell heterogeneity,cell delivery,and the effective homing of stem cells to damaged tissue.However,clinical trials examining potential stem cell-based treatments of diabetic retinopathy,including the use of pluripotent stem cells,retinal pigment epithelial cells,bone marrow mesenchymal stem cells,and endothelial progenitor cells,are currently ongoing,and high-quality clinical evidence is likely to appear in the future,to promote clinical transformation.

Bibliometric profile of neurogenic bladder in the literature:a 20-year bibliometric analysis

Neurogenic bladder is a dysfunction of the lower urinary tract caused by nervous system disor- der. We investigated the trends in publication of articles under the topic ＂neurogenic bladder＂ using bibliometric analysis. Articles on neurogenic bladder, published between 1995 and 2014, were retrieved from the ISI Web of Science citation database. We analyzed the search results for authors, countries, institutions, journals, and top-cited papers. A total of 1,904 articles were re- trieved. There was a small increase in the number of articles on neurogenic bladder from 1995 （n = 43） to 2014 （n = 117）. The USA was the leading country in the total number of articles （n = 598）. However, the number of publications from China has rapidly increased, and China was ranked second in 2014. Emmanuel Chartier-Kastler （n = 65） was the most productive author, and University of Paris VI （Paris 6） （n = 61） was the most productive institution. The Journal of Urology published the greatest number of artides on this topic （n = 285）. Articles on neurogenic bladder were often published in a professional journal under the category Urology ＆ Nephrology, Neurosciences ＆ Neurology, or Rehabilitation. Visualization analysis based on co-citation networks was conducted using CiteSpace III. Visualization analysis revealed that the hot spots in neurogenic bladder were botulinum toxin-A, prazosin, bethanechol, and afferent pathways. These findings provide new insight into the publication trends and hot spots in neurogenic bladder.

Bibliometrics and visual analysis for clinical research on intervention of traditional Chinese medicine nursing technology on rheumatoid arthritis

Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.

Visualization analysis of lecithin in drugs based on electrochemiluminescent single gold microbeads

Fast and high-throughput determination of drugs is a key trend in clinical medicine.Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications,and microscopic analysis has been a hot topic in recent years,especially for electrochemiluminescence(ECL).This paper describes a simple ECL method based on single gold microbeads to image lecithin.Lecithin reacts to produce hydrogen peroxide under the successive enzymatic reaction of phospholipase D and choline oxidase.ECL was generated by the electrochemical reaction between a luminol analog and hydrogen peroxide,and ECL signals were imaged by a camera.Despite the heterogeneity of single gold microbeads,their luminescence obeyed statistical regularity.The average luminescence of 30 gold microbeads is correlated with the lecithin concentration,and thus,a visualization method for analyzing lecithin was established.Calibration curves were constructed for ECL intensity and lecithin concentration,achieving detection limits of 0.05 m M lecithin.This ECL imaging platform based on single gold microbeads exhibits outstanding advantages,such as high throughput,versatility and low cost,and holds great potential in disease diagnostics,environmental monitoring and food safety.

Visualization analysis of the research status of FU Qingzhu’s Obstetrics and Gynecology based on bibliometrics

Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.Methods Retrieved all related literature in the research field of FQZNK from the domestic and foreign databases:China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,and Web of Science(WOS)core database,including Science Citation Index Expanded(SCIE),Social Sciences Citation Index(SSCI),and Arts&Humanities Citation Index(A&HCI).The search range was from January 1,1980 to March 10,2021.In addition,bibliometrics and CiteSpace 5.7.R2 software were used to analyze literature types,published journals,cited literature,the number of author publica-tions,co-author networks,co-institution networks,keyword co-occurrence networks,keyword clusters,and keyword bursts.Results A total of 678 valid records were included in the final dataset.Literature types,high publication journals,highly cited literature,high-yield institutions,high-yield research teams,and high-productivity scholars in this research field were found through bibliometrics.Liter-ature types can be divided into four categories,among which 451 are theoretical studies on academic thoughts of FQZNK,accounting for 66.5%of the included journals.The Journal of Shanxi Traditional Chinese Medicine had the largest volume of published articles(61),ac-counting for 9.0%of the total number of the included journals.The most cited literature was ZHOU Mingxin’s article“Using the quantitative method to discuss author’s authenticity and formula characteristics of FU Qingzhu’s Obstetrics and Gynecology”,which was cited 94 times.Hunan University of Chinese Medicine,the institution with the most publications,published 45 articles,and YOU Zhaoling,the most published author,published 33 articles.Moreover,it was found that most high-yield researchers came from high-yield institutions and that Hun-an University of Chinese Medicine had the most research on FQZNK.Keyword co-occur-rence analysis revealed that the keyword“FQZNK”had the highest frequency(597 times)and the highest centrality(1.00).Keyword cluster analysis used the Log-Likelihood Ratio(LLR)al-gorithm to form eleven important clusters:#0 treatment aiming at its root causes,#1 gynecopathy,#2 Siwu Decoction(四物汤),#3 FU Qingzhu,#4 post-partum,#5 infertility,#6 dysmenorrhea,#7 sterility,#8 coordinate the heart and kidney,#9 Danggui Buxue Decoction(当归补血汤),and#10 treatment.It was found that the prescriptions of FQZNK were studied mainly before 2000,the theoretical studies were mainly conducted before 2010,and its clinic-al application was mainly explored from 2010 until now.Diseases such as dysmenorrhea,morbid vaginal discharge,infertility,metrorrhagia,and polycystic ovarian syndrome(PCOS)have recently become popular topics in this field.Conclusion The current study provides more scientific,accurate,and comprehensive sci-entific support for further research and development of traditional Chinese medicine(TCM)in FQZNK.With this foundation,people can use burst detection to ascertain the current hot-spots in research,get their development trends,and forecast future research directions.In ad-dition,infertility,morbid vaginal discharge,flooding,and PCOS treatments based on TCM syndrome differentiation are currently popular research topics for FQZNK.

Intravitreal triamcinolone acetonide： a ＂real world＂ analysis of visual acuity, pressure and outcomes

Dear Sir,Triamcinolone acetonide（TA）is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhibitors[1-2].

Visual analysis of research hotspots and trends in the treatment of immune thrombocytopenia with traditional Chinese medicine

Objective Through bibliometrics and visual analysis of the related studies on traditional Chinese medicine(TCM)treatment of immune thrombocytopenia(ITP),this study aims to sort out the overall research progress,hotspots,and trends in this field,and provide reference for further research in ITP.Methods The articles on ITP treated by TCM were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang Database,China Science and Technology Journal Database(VIP),Web of Science Core Collection(WOSCC),and PubMed.The retrieval time was from the establishment of the databases to July 31,2022.VOSviewer,CiteSpace,Carrot2,and Note-Express were used for data analysis of the articles in terms of their quantities,types,and journals,and for visualization of research hotspots,authors,institutions,and keywords.Results 1493 Chinese articles and 40 English articles were included.The articles in Chinese mainly focus on clinical trial research and clinical experience summary,while the English articles mainly focus on clinical trial research and animal research.The Chinese articles were published in 317 Chinese journals,while English articles were published in 29 English journals.Research hotspots include the clinical syndrome differentiation of ITP,the therapeutic effect of TCM compounds on ITP,and the mechanism of ITP treatment.Keyword analysis shows that there are many research achievements in integrated traditional Chinese and western medicine treatment,clinical research,famous doctors’experience,TCM treatment,cellular immunity,and humoral immunity.The authors with the most articles in Chinese and English are Professor CHEN Xinyi and Professor MA Rou,respectively,and the research institutions with the most articles are Dongzhimen Hospital of Beijing University of Chinese Medicine and Xiyuan Hospital of China Academy of Chinese Medical Sciences.Chinese herbs often used to treat ITP clinically include Xianhecao(Agrimoniae Herba),Nvzhenzi(Ligustri Lucidi Fructus),Mohanlian(Ecliptae Herba),Zhongjiefeng(Sarcandrae Herba),etc.,and the prescription usually used to treat ITP include Guipi Decoction(归脾汤),Xijiao Dihuang Decoction(犀角地黄汤),Bazhen Decoction(八珍汤),Erzhi Pill(二至丸),and Xiaochaihu De-coction(小柴胡汤).The main development trends toward retrospective study,TCM treatment mechanism,and data mining.

A knowledge discovery method based on analysis of multiple co-occurrence relationships in collections of journal papers

Purpose: This paper explores a method of knowledge discovery by visualizing and analyzing co-occurrence relations among three or more entities in collections of journal articles.Design/methodology/approach: A variety of methods such as the model construction,system analysis and experiments are used. The author has improved Morris' crossmapping technique and developed a technique for directly describing,visualizing and analyzing co-occurrence relations among three or more entities in collections of journal articles.Findings: The visualization tools and the knowledge discovery method can efficiently reveal the multiple co-occurrence relations among three entities in collections of journal papers. It can reveal more and in-depth information than analyzing co-occurrence relations between two entities. Therefore,this method can be used for mapping knowledge domain that is manifested in association with the entities from multi-dimensional perspectives and in an all-round way.Research limitations: The technique could only be used to analyze co-occurrence relations of less than three entities at present.Practical implications: This research has expanded the study scope of co-occurrence analysis.The research result has provided a theoretical support for co-occurrence analysis.Originality/value: There has not been a systematic study on co-occurrence relations among multiple entities in collections of journal articles. This research defines multiple co-occurrence and the research scope,develops the visualization analysis tool and designs the analysis model of the knowledge discovery method.

Information visualization analysis on Advances in Psychological Science:1983-2014

Objective： To describe the revolution and research status of Advances in Psychological Science. Methods： A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with the information visualization method using Citespace software from the aspects of pub- lications, cited frequency and downloads, funding, organizations, authors and keywords. Results： The results showed that the amount of literature published annually had an upward tendency, and 49.4% of the papers were supported by national or provincial projects. Institutions such as the Chinese Academy of Sciences （CAS） and the normal universities were rated in the forefront of the sci- entific research output. Xiting Huang, Hong Li and Yuejia Luo were at the top of the list of prolific authors. Conclusions： A new pattern of cooperative development of the theory and application in the field of psychological research is forming.

Cumulative sum analysis score and phacoemulsification competency learning curve

AIM： To use the cumulative sum analysis score（CUSUM） to construct objectively the learning curve of phacoemulsification competency.METHODS： Three second-year residents and an experienced consultant were monitored for a series of 70 phacoemulsification cases each and had their series analysed by CUSUM regarding posterior capsule rupture（PCR） and best-corrected visual acuity. The acceptable rate for PCR was 〈5%（lower limit h） and the unacceptable rate was 〉10%（upper limit h）. The acceptable rate for bestcorrected visual acuity worse than 20/40 was 〈10%（lower limit h） and the unacceptable rate was 〉20%（upper limit h）. The area between lower limit h and upper limit h is called the decision interval. RESULTS： There was no statistically significant difference in the mean age, sex or cataract grades between groups. The first trainee achieved PCR CUSUM competency at his 22 nd case. His best-corrected visual acuity CUSUM was in the decision interval from his third case and stayed there until the end, never reaching competency. The second trainee achieved PCR CUSUM competency at his 39^ th case. He could reach best-corrected visual acuity CUSUM competency at his 22 ^nd case. The third trainee achieved PCR CUSUM competency at his 41 st case. He reached bestcorrected visual acuity CUSUM competency at his 14 ^th case.CONCLUSION： The learning curve of competency in phacoemulsification is constructed by CUSUM and in average took 38 cases for each trainee to achieve it.

Seismic hazard analysis for central-western Argentina

In this study, we present a PSHA（Probabilistic Seismic Hazard Analysis） for the city of San Juan, which is located in the central-western region of Argentina（30°S-35.5°S; 66.5°W-71°W）. In addition to crustal earthquakes provided by catalogues, recent paleoseismological and neotectonic investigations have permitted to consider events which occurred during the last 400 years.Four seismogenic sources that could cause damages to the studied site corresponding to Precordillera,Western Sierras Pampeanas, Basement of the Cuyana Basin and Cordillera Principal were identified.Based on the evaluation of the contribution of these sources,maximum moment magnitudes above 7.5（Mw） are expected.High values of SA（spectral acceleration）（0.2 and 1 s periods） and PGA（peak ground acceleration） were found in the city of San Juan, which suggests that it is located in a zone of high seismic hazard.Finally, the obtained SA spectra were compared with the seismic-resistant construction standards of Argentina INPRES-CIRSOC 103 [1]. Results suggest that for the city of San Juan and for a return period of475 years, it covers the seismic requirements of the structures.