Conventional conductivity methods for measuring the void fraction in gas-liquid multiphase systems are typically affected by accuracy problems due to the presence of fluid flow and salinity.This study presents a novel...Conventional conductivity methods for measuring the void fraction in gas-liquid multiphase systems are typically affected by accuracy problems due to the presence of fluid flow and salinity.This study presents a novel approach for determining the void fraction based on a reciprocating dynamic conductivity probe used to measure the liquid film thickness under forced annular-flow conditions.The measurement system comprises a cyclone,a conductivity probe,a probe reciprocating device,and a data acquisition and processing system.This method ensures that the flow pattern is adjusted to a forced annular flow,thereby minimizing the influence of complex and variable gas-liquid flow patterns on the measurement results;Moreover,it determines the liquid film thickness solely according to circuit connectivity rather than specific conductivity values,thereby mitigating the impact of salinity.The reliability of the measurement system is demonstrated through laboratory experiments.The experimental results indicate that,in a range of gas phase superficial velocities 5–20 m/s and liquid phase superficial velocities 0.079–0.48 m/s,the maximum measurement deviation for the void fraction is 4.23%.展开更多
Aim To develop a hydrodynamic model on the void fraction in liquid slugs for gas liquid slug flow in vertical tubes. Methods Developing the model by considering the gas exchange between the Taylor bubble and the fo...Aim To develop a hydrodynamic model on the void fraction in liquid slugs for gas liquid slug flow in vertical tubes. Methods Developing the model by considering the gas exchange between the Taylor bubble and the following liquid slug. Results Some experimental data are obtained to check the model. In comparison with previous published results, the predictions from this model are better and in good agreement with the experimental data. The error is within ±20%. Conclusion The proposed model can correctly predict the void fraction in liquid slugs for gas liquid two phase slug flow in vertical tubes.展开更多
Vertical distributions of void fraction in gas-liquid and gas-liquid-solid stirred tanks have been measured in a fully baffled dished base vessel of 0.48 m diameter, using a conductivity probe. The impeller configurat...Vertical distributions of void fraction in gas-liquid and gas-liquid-solid stirred tanks have been measured in a fully baffled dished base vessel of 0.48 m diameter, using a conductivity probe. The impeller configuration (a hollow half elliptical blade dispersing turbine below two up-pumping wide blade hydrofoils, identified as HEDT+2WHu) recommended in previous work has been used in this work. The operating temperatures were 24℃ and 81℃, identified as cold and hot respectively. The effects of superficial gas velocity, agitator speed and the corresponding power input on the local void fraction in two-phase systems are .investigated and discussed. Results show thatth-e increasing of agitator speed or gas flow rate leads to an increase in local-void fraction at the majority of measurement points in both cold and hot systems. However, the unifo,rmity of gas dispersion does not always in crease as the raising of agitator speed and power input. In either cold or hot sparged conditions, the two- and three-phase systems.have similar vertical profiles for void fraction, with maxima in similar locations; however, the void fractions are significantly lower in hot sparging than with cold. In cold operation the presence of particles leads to a lower void fraction at most points, although the local void fractions increase a little with the addition of solid particles at high temperature, in good agreement with the global gas holdup results, and the possible reasons are discussed in this paper. This work can give a better understanding of the differences between cold-gassed and hot-sparged three phase'stirred tanks.展开更多
To measure the void fraction online in oil-gas pipeline, an improved electrical capacitance tomography (ECT) system has been designed. The capacitance sensor with new structure has twelve internal electrodes and overc...To measure the void fraction online in oil-gas pipeline, an improved electrical capacitance tomography (ECT) system has been designed. The capacitance sensor with new structure has twelve internal electrodes and overcomes the influence of the pipe wall. The data collection system is improved by using high performance IC (integrated circuit). Static tests of bubble flow, stratified flow and annular flow regime are carried out. Measurements are taken on bubble flow, stratified flow and slug flow. Results show that the new ECT system performs well on void fraction measurement of bubble flow and stratified flow, but the error of measurement for slug flow is more than 10%.展开更多
Oil-air two-phase flow measurement was investigated with a Venturi and void fraction meters in this work. This paper proposes a new flow rate measurement correlation in which the effect of the velocity ratio between g...Oil-air two-phase flow measurement was investigated with a Venturi and void fraction meters in this work. This paper proposes a new flow rate measurement correlation in which the effect of the velocity ratio between gas and liquid was considered. With the pressure drop across the Venturi and the void fraction that was measured by electrical capacitance tomography apparatus, both mixture flow rate and oil flow rate could be obtained by the correlation. Experiments included bubble-, slug-, wave and annular flow with the void fraction ranging from 15% to 83%, the oil flow rate ranging from 0.97 kg/s to 1.78 kg/s, the gas flow rate ranging up to 0.018 kg/s and quality ranging nearly up to 2.0%. The root-mean-square errors of mixture mass flow rate and that of oil mass flow rate were less than 5%. Furthermore, coefficients of the correlation were modified based on flow regimes, with the results showing reduced root-mean-square errors.展开更多
In order to investigate the influence of the entrance effect on the spatial distribution of phases, the experiments on gas-liquid two-phase slug flow in a vertical pipe of 0.03m ID were carried out by using optical pr...In order to investigate the influence of the entrance effect on the spatial distribution of phases, the experiments on gas-liquid two-phase slug flow in a vertical pipe of 0.03m ID were carried out by using optical probes and an EKTAPRO 1000 high speed motion analyzer. It demonstrates that the radial profile of slug flow void fraction is parabolic. Influenced by the falling liquid film, the radial profile curve of liquid slug void fraction in the wake region is also parabolic. Since fully turbulent velocity distribution is built up in the developed region,the void fraction profile in this region is the saddle type. At given superficial liquid velocity, the liquid slug void fraction increases with gas velocity. The radial profiles of liquid slug void fraction at different axial locations are all saddle curves, but void fraction is obviously high around the centerline in the entrance region. The nearer the measuring station is from the entrance, the farther the peak location is away from the wall.展开更多
The measurement of void fraction is of importance to the oil industry and chemical industry. In this article, the principle and mathematical method of determining the void fraction of horizontal gas-liquid flow by usi...The measurement of void fraction is of importance to the oil industry and chemical industry. In this article, the principle and mathematical method of determining the void fraction of horizontal gas-liquid flow by using a sin- gle-energy γ-ray system is described. The γ-ray source is the radioactive isotope of 241Am with γ-ray energy of 59.5 keV. The time-averaged value of the void fraction in a 50.0-mm i.d. transparent horizontal pipeline is measured under various combinations of the liquid flow and gas flow. It is found that increasing the gas flow rate at a fixed liquid flow rate would increase the void fraction. Test data are compared with the predictions of the correlations and a good agreement is found. The result shows that the designed γ-ray system can be used for measuring the void fraction in a horizontal gas-liquid two-phase flow with high accuracy.展开更多
The focus of this paper is on the measurement and calculation model of void fraction for the vertical upward co-current air-water slug flow in a circular tube of 15 mm inner diameter. High-speed photography and optica...The focus of this paper is on the measurement and calculation model of void fraction for the vertical upward co-current air-water slug flow in a circular tube of 15 mm inner diameter. High-speed photography and optical probes were utilized, with water superficial velocity ranging from 0.089 to 0.65 m·s^(-1)and gas superficial velocity ranging from 0.049 to 0.65 m·s^(-1). A new void fraction model based on the local parameters was proposed, disposing the slug flow as a combination of Taylor bubbles and liquid slugs. In the Taylor bubble region, correction factors of liquid film thickness Cδand nose shape CZ*were proposed to calculate aTB. In the liquid slug region, the radial void fraction distribution profiles were obtained to calculate aLS, by employing the image processing technique based on supervised machine learning. Results showed that the void fraction proportion in Taylor bubbles occupied crucial contribution to the overall void fraction. Multiple types of void fraction predictive correlations were assessed using the present data. The performance of the Schmidt model was optimal, while some models for slug flow performed not outstanding. Additionally, a predictive correlation was correlated between the central local void fraction and the cross-sectional averaged void fraction, as a straightforward form of the void fraction calculation model. The predictive correlation showed a good agreement with the present experimental data, as well as the data of Olerni et al., indicating that the new model was effective and applicable under the slug flow conditions.展开更多
In order to investigate the effect of inclination angle on the spatial distribution of phases, experiments on gas-liquid two-phase slug flow in an inclined pipe were carried out by using the optical probe and an EKTAP...In order to investigate the effect of inclination angle on the spatial distribution of phases, experiments on gas-liquid two-phase slug flow in an inclined pipe were carried out by using the optical probe and an EKTAPRO 1000 high speed motion analyzer. It has been demonstrated that the inclination angle and the mixture velocity are important parameters to influence the distribution of void fraction for upward slug flow in the inclined pipe. At high mixture velocity, the gas phase profile is axial symmetry in the cross-section of the pipe. This is similar to that for vertical slug flow. In contrast, most of the gas phase is located near the upper pipe wall at low mixture velocity. By measuring the axial variation of void fraction along the liquid slug, it can be concluded that there is a high void fraction wake region with length of 3~4D in the front of liquid slug. In the fully developed zone of liquid slug, the peak value of the void fraction is near the upper wall.展开更多
The flow patterns and the void fraction related to a gas-liquid two-phase flow in a small channel are experimentally studied.The test channel is a transparent quartz glass circular channel with an inner diameter of 6....The flow patterns and the void fraction related to a gas-liquid two-phase flow in a small channel are experimentally studied.The test channel is a transparent quartz glass circular channel with an inner diameter of 6.68 mm.The working fluids are air and water and their superficial velocities range from 0.014 to 8.127 m/s and from 0.0238 to 0.556 m/s,respectively.The void fraction is determined using the flow pattern images captured by a high-speed camera,while quick closing valves are used for verification.Four flow patterns are analyzed in experiments:slug flow,bubbly flow,annular flow and stratified flow.For intermittent flows(bubbly flow and slug flow),the cross-sectional void fraction is in a borderline condition while its probability distribution function(PDF)image displays a bimodal structure.For continuous flows(annular flow and stratified flow)the cross-sectional void fraction behaves as a fluctuating continuous curve while the(PDF)image displays a single peak structure.The volumetric void fraction data are also compared with available predictive formulas,and the results show that the agreement is very good.An effort is also provided to improve the so-called Gregory and Scott model using the available data.展开更多
A new mini-capacitance probe for measuring the local void frac-tion in gas-solid fluidized beds is developed in this paper. The measurementprincipleis analyzed. The structure of the probe , the spatial resolving power...A new mini-capacitance probe for measuring the local void frac-tion in gas-solid fluidized beds is developed in this paper. The measurementprincipleis analyzed. The structure of the probe , the spatial resolving powerand the influences of various paramete展开更多
To keep the void fraction of two-phase hydrogen in the moderator cell of the cold neutron source (CNS)of China Advanced Research Reactor (CARR) to a specified range, an annular vessel with the same size as the actual ...To keep the void fraction of two-phase hydrogen in the moderator cell of the cold neutron source (CNS)of China Advanced Research Reactor (CARR) to a specified range, an annular vessel with the same size as the actual moderator cell was used as test section. Deionized water and alcohol, sucrose, and sodium chloride solutions with different concentrations were used as working fluid to find out influences of physical properties, such as density, viscosity and surface tension, of the two-phase mixture on void fraction. The tests proved that the ratio of surface tension to density of liquid phase has great influence on void fraction: the larger the ratio, the smaller the void fraction.Since the ratio of surface tension to density of Freon 113 is lower than that of liquid hydrogen, Freon 113 can be used as a working fluid to study the void fraction in the two-phase hydrogen thermosiphon loop in the CNS of CARR and the results will be conservative.展开更多
In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, ...In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers (microphone) which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.展开更多
In regenerative medicine,the isolation of mesenchymal stromal cells(MSCs)from the adipose tissue’s stromal vascular fraction(SVF)is a critical area of study.Our review meticulously examines the isolation process of M...In regenerative medicine,the isolation of mesenchymal stromal cells(MSCs)from the adipose tissue’s stromal vascular fraction(SVF)is a critical area of study.Our review meticulously examines the isolation process of MSCs,starting with the extraction of adipose tissue.The choice of liposuction technique,anatomical site,and immediate processing are essential to maintain cell functionality.We delve into the intricacies of enzymatic digestion,emphasizing the fine-tuning of enzyme concentrations to maximize cell yield while preventing harm.The review then outlines the filtration and centrifugation techniques necessary for isolating a purified SVF,alongside cell viability assessments like flow cytometry,which are vital for confirming the efficacy of the isolated MSCs.We discuss the advantages and drawbacks of using autologous vs allogeneic SVF sources,touching upon immunocompatibility and logistical considerations,as well as the variability inherent in donor-derived cells.Anesthesia choices,the selection between hypo-dermic needles vs liposuction cannulas,and the role of adipose tissue lysers in achieving cellular dissociation are evaluated for their impact on SVF isolation.Centrifugation protocols are also analyzed for their part in ensuring the integrity of the SVF.The necessity for standardized MSC isolation protocols is highlighted,promoting reproducibility and successful clinical application.We encourage ongoing research to deepen the understanding of MSC biology and therapeutic action,aiming to further the field of regenerative medicine.The review concludes with a call for rigorous research,interdisciplinary collaboration,and strict adherence to ethical and regulatory standards to safeguard patient safety and optimize treatment outcomes with MSCs.展开更多
BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated th...BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.展开更多
Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally deter...Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as "apparent" bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.展开更多
Two-phase pipe flow occurs frequently in oil&gas industry,nuclear power plants,and CCUS.Reliable calculations of gas void fraction(or liquid holdup)play a central role in two-phase pipe flow models.In this paper w...Two-phase pipe flow occurs frequently in oil&gas industry,nuclear power plants,and CCUS.Reliable calculations of gas void fraction(or liquid holdup)play a central role in two-phase pipe flow models.In this paper we apply the fractional flow theory to multiphase flow in pipes and present a unified modeling framework for predicting the fluid phase volume fractions over a broad range of pipe flow conditions.Compared to existing methods and correlations,this new framework provides a simple,approximate,and efficient way to estimate the phase volume fraction in two-phase pipe flow without invoking flow patterns.Notably,existing correlations for estimating phase volume fraction can be transformed and expressed under this modeling framework.Different fractional flow models are applicable to different flow conditions,and they demonstrate good agreement against experimental data within 5%errors when compared with an experimental database comprising of 2754 data groups from 14literature sources,covering various pipe geometries,flow patterns,fluid properties and flow inclinations.The gas void fraction predicted by the framework developed in this work can be used as inputs to reliably model the hydraulic and thermal behaviors of two-phase pipe flows.展开更多
BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease process.In regenerative medicine,current treatments have limitations.In regenerative medicine,more rese...BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease process.In regenerative medicine,current treatments have limitations.In regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism exploration.AIM To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee OA.METHODS The study included 50 patients with Kellgren-Lawrence grades II and III OA.Patients were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)injection.Patients were followed up at 1,3,6,12,and 24 months.Visual analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all followups.The safety of SVF in terms of adverse and severe adverse events was recorded.Statistical analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United States.RESULTS Both groups had similar demographics and baseline clinical characteristics.Follow-up showed minor patient loss,resulting in 23 and 24 in groups A and B respectively.Group A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group B.This difference in pain reduction in group A was statistically significant from the third month onwards.Additionally,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to 45.16.The improvement in Group A was statistically significant from 6 months and maintained through 24 months.CONCLUSION Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in patients with primary knee OA.More adequately powered,multi-center,double-blinded,randomised clinical trials with longer follow-ups are needed to further establish safety and justify its clinical use.展开更多
Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensiona...Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing disasters.Therefore,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is proposed.True triaxial static compression and intermittent disturbance tests are carried out on monzogabbro.The effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture mechanism.Rapid increases in microseismic parameters during rock loading can be precursors for intermittent rock disturbance.Based on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental results.The sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are predicted.This study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.展开更多
Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and zebrafish.Methods:HaCa...Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and zebrafish.Methods:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and inflammation.The production of nitric oxide(NO),intracellular ROS,prostaglandin E_(2)(PGE_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT cells.Furthermore,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish model.Results:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGE_(2) in PM-induced HaCaT cells.In addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κB.Furthermore,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in zebrafish.Conclusions:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.展开更多
基金the National Natural Science Foundation of China(No.62173049)the Open Fund of the Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering(Yangtze University),YQZC202309.
文摘Conventional conductivity methods for measuring the void fraction in gas-liquid multiphase systems are typically affected by accuracy problems due to the presence of fluid flow and salinity.This study presents a novel approach for determining the void fraction based on a reciprocating dynamic conductivity probe used to measure the liquid film thickness under forced annular-flow conditions.The measurement system comprises a cyclone,a conductivity probe,a probe reciprocating device,and a data acquisition and processing system.This method ensures that the flow pattern is adjusted to a forced annular flow,thereby minimizing the influence of complex and variable gas-liquid flow patterns on the measurement results;Moreover,it determines the liquid film thickness solely according to circuit connectivity rather than specific conductivity values,thereby mitigating the impact of salinity.The reliability of the measurement system is demonstrated through laboratory experiments.The experimental results indicate that,in a range of gas phase superficial velocities 5–20 m/s and liquid phase superficial velocities 0.079–0.48 m/s,the maximum measurement deviation for the void fraction is 4.23%.
文摘Aim To develop a hydrodynamic model on the void fraction in liquid slugs for gas liquid slug flow in vertical tubes. Methods Developing the model by considering the gas exchange between the Taylor bubble and the following liquid slug. Results Some experimental data are obtained to check the model. In comparison with previous published results, the predictions from this model are better and in good agreement with the experimental data. The error is within ±20%. Conclusion The proposed model can correctly predict the void fraction in liquid slugs for gas liquid two phase slug flow in vertical tubes.
基金Supported by the National Natural Science Foundation of China (20576009, 20821004) and the National Basic Research Program of China (2007CB714300). ACKNOWLEDGEMENTS The authors sincerely acknowledge the helpful discussion with Prof John M. Smith [Fluids and Systems Research Centre, School of Engineering (J2), University of Surrey, Guildford, GU2 7XH, UK].
文摘Vertical distributions of void fraction in gas-liquid and gas-liquid-solid stirred tanks have been measured in a fully baffled dished base vessel of 0.48 m diameter, using a conductivity probe. The impeller configuration (a hollow half elliptical blade dispersing turbine below two up-pumping wide blade hydrofoils, identified as HEDT+2WHu) recommended in previous work has been used in this work. The operating temperatures were 24℃ and 81℃, identified as cold and hot respectively. The effects of superficial gas velocity, agitator speed and the corresponding power input on the local void fraction in two-phase systems are .investigated and discussed. Results show thatth-e increasing of agitator speed or gas flow rate leads to an increase in local-void fraction at the majority of measurement points in both cold and hot systems. However, the unifo,rmity of gas dispersion does not always in crease as the raising of agitator speed and power input. In either cold or hot sparged conditions, the two- and three-phase systems.have similar vertical profiles for void fraction, with maxima in similar locations; however, the void fractions are significantly lower in hot sparging than with cold. In cold operation the presence of particles leads to a lower void fraction at most points, although the local void fractions increase a little with the addition of solid particles at high temperature, in good agreement with the global gas holdup results, and the possible reasons are discussed in this paper. This work can give a better understanding of the differences between cold-gassed and hot-sparged three phase'stirred tanks.
基金the National High Technology Research and Development Program of China (863 Program) (No. 2002AA616050).
文摘To measure the void fraction online in oil-gas pipeline, an improved electrical capacitance tomography (ECT) system has been designed. The capacitance sensor with new structure has twelve internal electrodes and overcomes the influence of the pipe wall. The data collection system is improved by using high performance IC (integrated circuit). Static tests of bubble flow, stratified flow and annular flow regime are carried out. Measurements are taken on bubble flow, stratified flow and slug flow. Results show that the new ECT system performs well on void fraction measurement of bubble flow and stratified flow, but the error of measurement for slug flow is more than 10%.
基金Project (No. 2001AA413210) supported by the Hi-Tech Researchand Development Program (863) of China
文摘Oil-air two-phase flow measurement was investigated with a Venturi and void fraction meters in this work. This paper proposes a new flow rate measurement correlation in which the effect of the velocity ratio between gas and liquid was considered. With the pressure drop across the Venturi and the void fraction that was measured by electrical capacitance tomography apparatus, both mixture flow rate and oil flow rate could be obtained by the correlation. Experiments included bubble-, slug-, wave and annular flow with the void fraction ranging from 15% to 83%, the oil flow rate ranging from 0.97 kg/s to 1.78 kg/s, the gas flow rate ranging up to 0.018 kg/s and quality ranging nearly up to 2.0%. The root-mean-square errors of mixture mass flow rate and that of oil mass flow rate were less than 5%. Furthermore, coefficients of the correlation were modified based on flow regimes, with the results showing reduced root-mean-square errors.
文摘In order to investigate the influence of the entrance effect on the spatial distribution of phases, the experiments on gas-liquid two-phase slug flow in a vertical pipe of 0.03m ID were carried out by using optical probes and an EKTAPRO 1000 high speed motion analyzer. It demonstrates that the radial profile of slug flow void fraction is parabolic. Influenced by the falling liquid film, the radial profile curve of liquid slug void fraction in the wake region is also parabolic. Since fully turbulent velocity distribution is built up in the developed region,the void fraction profile in this region is the saddle type. At given superficial liquid velocity, the liquid slug void fraction increases with gas velocity. The radial profiles of liquid slug void fraction at different axial locations are all saddle curves, but void fraction is obviously high around the centerline in the entrance region. The nearer the measuring station is from the entrance, the farther the peak location is away from the wall.
基金Supported by National Natural Science Foundation of China (No. 10572143)
文摘The measurement of void fraction is of importance to the oil industry and chemical industry. In this article, the principle and mathematical method of determining the void fraction of horizontal gas-liquid flow by using a sin- gle-energy γ-ray system is described. The γ-ray source is the radioactive isotope of 241Am with γ-ray energy of 59.5 keV. The time-averaged value of the void fraction in a 50.0-mm i.d. transparent horizontal pipeline is measured under various combinations of the liquid flow and gas flow. It is found that increasing the gas flow rate at a fixed liquid flow rate would increase the void fraction. Test data are compared with the predictions of the correlations and a good agreement is found. The result shows that the designed γ-ray system can be used for measuring the void fraction in a horizontal gas-liquid two-phase flow with high accuracy.
基金supported by National Key Research and Development Program of China ( 2018YFE011061)。
文摘The focus of this paper is on the measurement and calculation model of void fraction for the vertical upward co-current air-water slug flow in a circular tube of 15 mm inner diameter. High-speed photography and optical probes were utilized, with water superficial velocity ranging from 0.089 to 0.65 m·s^(-1)and gas superficial velocity ranging from 0.049 to 0.65 m·s^(-1). A new void fraction model based on the local parameters was proposed, disposing the slug flow as a combination of Taylor bubbles and liquid slugs. In the Taylor bubble region, correction factors of liquid film thickness Cδand nose shape CZ*were proposed to calculate aTB. In the liquid slug region, the radial void fraction distribution profiles were obtained to calculate aLS, by employing the image processing technique based on supervised machine learning. Results showed that the void fraction proportion in Taylor bubbles occupied crucial contribution to the overall void fraction. Multiple types of void fraction predictive correlations were assessed using the present data. The performance of the Schmidt model was optimal, while some models for slug flow performed not outstanding. Additionally, a predictive correlation was correlated between the central local void fraction and the cross-sectional averaged void fraction, as a straightforward form of the void fraction calculation model. The predictive correlation showed a good agreement with the present experimental data, as well as the data of Olerni et al., indicating that the new model was effective and applicable under the slug flow conditions.
文摘In order to investigate the effect of inclination angle on the spatial distribution of phases, experiments on gas-liquid two-phase slug flow in an inclined pipe were carried out by using the optical probe and an EKTAPRO 1000 high speed motion analyzer. It has been demonstrated that the inclination angle and the mixture velocity are important parameters to influence the distribution of void fraction for upward slug flow in the inclined pipe. At high mixture velocity, the gas phase profile is axial symmetry in the cross-section of the pipe. This is similar to that for vertical slug flow. In contrast, most of the gas phase is located near the upper pipe wall at low mixture velocity. By measuring the axial variation of void fraction along the liquid slug, it can be concluded that there is a high void fraction wake region with length of 3~4D in the front of liquid slug. In the fully developed zone of liquid slug, the peak value of the void fraction is near the upper wall.
基金This work was supported by the Guangdong Basic and Applied Basic Research Foundation(2019A1515111116)Key R&D Program of Shandong Province(Nos.2019GSF109051,2019GGX101030)+1 种基金Shandong Provincial Postdoctoral Innovation Project(No.201902002)Foundation of Shandong University for Young Scholar’s Future Plans.
文摘The flow patterns and the void fraction related to a gas-liquid two-phase flow in a small channel are experimentally studied.The test channel is a transparent quartz glass circular channel with an inner diameter of 6.68 mm.The working fluids are air and water and their superficial velocities range from 0.014 to 8.127 m/s and from 0.0238 to 0.556 m/s,respectively.The void fraction is determined using the flow pattern images captured by a high-speed camera,while quick closing valves are used for verification.Four flow patterns are analyzed in experiments:slug flow,bubbly flow,annular flow and stratified flow.For intermittent flows(bubbly flow and slug flow),the cross-sectional void fraction is in a borderline condition while its probability distribution function(PDF)image displays a bimodal structure.For continuous flows(annular flow and stratified flow)the cross-sectional void fraction behaves as a fluctuating continuous curve while the(PDF)image displays a single peak structure.The volumetric void fraction data are also compared with available predictive formulas,and the results show that the agreement is very good.An effort is also provided to improve the so-called Gregory and Scott model using the available data.
文摘A new mini-capacitance probe for measuring the local void frac-tion in gas-solid fluidized beds is developed in this paper. The measurementprincipleis analyzed. The structure of the probe , the spatial resolving powerand the influences of various paramete
基金Supported by the National Science Foundation of China(Grant No.1 0375046)
文摘To keep the void fraction of two-phase hydrogen in the moderator cell of the cold neutron source (CNS)of China Advanced Research Reactor (CARR) to a specified range, an annular vessel with the same size as the actual moderator cell was used as test section. Deionized water and alcohol, sucrose, and sodium chloride solutions with different concentrations were used as working fluid to find out influences of physical properties, such as density, viscosity and surface tension, of the two-phase mixture on void fraction. The tests proved that the ratio of surface tension to density of liquid phase has great influence on void fraction: the larger the ratio, the smaller the void fraction.Since the ratio of surface tension to density of Freon 113 is lower than that of liquid hydrogen, Freon 113 can be used as a working fluid to study the void fraction in the two-phase hydrogen thermosiphon loop in the CNS of CARR and the results will be conservative.
文摘In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers (microphone) which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.
文摘In regenerative medicine,the isolation of mesenchymal stromal cells(MSCs)from the adipose tissue’s stromal vascular fraction(SVF)is a critical area of study.Our review meticulously examines the isolation process of MSCs,starting with the extraction of adipose tissue.The choice of liposuction technique,anatomical site,and immediate processing are essential to maintain cell functionality.We delve into the intricacies of enzymatic digestion,emphasizing the fine-tuning of enzyme concentrations to maximize cell yield while preventing harm.The review then outlines the filtration and centrifugation techniques necessary for isolating a purified SVF,alongside cell viability assessments like flow cytometry,which are vital for confirming the efficacy of the isolated MSCs.We discuss the advantages and drawbacks of using autologous vs allogeneic SVF sources,touching upon immunocompatibility and logistical considerations,as well as the variability inherent in donor-derived cells.Anesthesia choices,the selection between hypo-dermic needles vs liposuction cannulas,and the role of adipose tissue lysers in achieving cellular dissociation are evaluated for their impact on SVF isolation.Centrifugation protocols are also analyzed for their part in ensuring the integrity of the SVF.The necessity for standardized MSC isolation protocols is highlighted,promoting reproducibility and successful clinical application.We encourage ongoing research to deepen the understanding of MSC biology and therapeutic action,aiming to further the field of regenerative medicine.The review concludes with a call for rigorous research,interdisciplinary collaboration,and strict adherence to ethical and regulatory standards to safeguard patient safety and optimize treatment outcomes with MSCs.
基金funded by the Key Research and Development of the Gansu Province(No.20YF8FA 079)the Construction Project of the Gansu Clinical Medical Research Center(No.18JR2FA003).
文摘BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.
文摘Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as "apparent" bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.
基金financial support from the Energize Program between the University of Texas at Austin and Southwest Research InstituteHydraulic Fracturing and Sand Control Industrial Affiliates Program at the University of Texas at Austin for financially supporting this research。
文摘Two-phase pipe flow occurs frequently in oil&gas industry,nuclear power plants,and CCUS.Reliable calculations of gas void fraction(or liquid holdup)play a central role in two-phase pipe flow models.In this paper we apply the fractional flow theory to multiphase flow in pipes and present a unified modeling framework for predicting the fluid phase volume fractions over a broad range of pipe flow conditions.Compared to existing methods and correlations,this new framework provides a simple,approximate,and efficient way to estimate the phase volume fraction in two-phase pipe flow without invoking flow patterns.Notably,existing correlations for estimating phase volume fraction can be transformed and expressed under this modeling framework.Different fractional flow models are applicable to different flow conditions,and they demonstrate good agreement against experimental data within 5%errors when compared with an experimental database comprising of 2754 data groups from 14literature sources,covering various pipe geometries,flow patterns,fluid properties and flow inclinations.The gas void fraction predicted by the framework developed in this work can be used as inputs to reliably model the hydraulic and thermal behaviors of two-phase pipe flows.
文摘BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease process.In regenerative medicine,current treatments have limitations.In regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism exploration.AIM To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee OA.METHODS The study included 50 patients with Kellgren-Lawrence grades II and III OA.Patients were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)injection.Patients were followed up at 1,3,6,12,and 24 months.Visual analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all followups.The safety of SVF in terms of adverse and severe adverse events was recorded.Statistical analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United States.RESULTS Both groups had similar demographics and baseline clinical characteristics.Follow-up showed minor patient loss,resulting in 23 and 24 in groups A and B respectively.Group A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group B.This difference in pain reduction in group A was statistically significant from the third month onwards.Additionally,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to 45.16.The improvement in Group A was statistically significant from 6 months and maintained through 24 months.CONCLUSION Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in patients with primary knee OA.More adequately powered,multi-center,double-blinded,randomised clinical trials with longer follow-ups are needed to further establish safety and justify its clinical use.
基金the financial support from the National Natural Science Foundation of China(No.52109119)the Guangxi Natural Science Foundation(No.2021GXNSFBA075030)+2 种基金the Guangxi Science and Technology Project(No.Guike AD20325002)the Chinese Postdoctoral Science Fund Project(No.2022 M723408)the Open Research Fund of State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin(China Institute of Water Resources and Hydropower Research)(No.IWHR-SKL-202202).
文摘Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing disasters.Therefore,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is proposed.True triaxial static compression and intermittent disturbance tests are carried out on monzogabbro.The effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture mechanism.Rapid increases in microseismic parameters during rock loading can be precursors for intermittent rock disturbance.Based on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental results.The sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are predicted.This study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.
基金This work was supported financially by Korea Environment Industry&Technology Institute through Project to make multi-ministerial national biological research resources more advanced program,funded by Korea Ministry of Environment(grant number RS-2023-00230403).
文摘Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and zebrafish.Methods:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and inflammation.The production of nitric oxide(NO),intracellular ROS,prostaglandin E_(2)(PGE_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT cells.Furthermore,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish model.Results:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGE_(2) in PM-induced HaCaT cells.In addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κB.Furthermore,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in zebrafish.Conclusions:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.