Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the mor...Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the morphodynamic response of Dongsha beach to typhoon events,based on beach topographies and surficial sediment characteristics acquired before and after four typhoon events with varying intensities.The four typhoons had different effects on the topography and sediment characteristics of Dongsha beach.Typhoons Ampil and Danas caused the largest(-51.72 m3/m)and the smallest erosion(-8.01 m3/m),respectively.Remarkable alongshore patterns of beach profile volumetric changes were found after the four typhoon events,with more erosion in the southern and central parts of the beach and few changes in the northern part.Grain size coarsening and poor sorting were the main sediment patterns on the beach influenced by different typhoons.Typhoons that occurred in the same year after another typhoon enhanced the effect of the previous typhoon on sediment coarsening and sorting variability,but this cumulative effect was not found between typhoons that occurred during different years.A comparison of the collected data revealed that the topographic state of the beach before the typhoon,typhoon characteristics,and tidal conditions were possible reasons for the difference in the responses of Dongsha beach to typhoon events.More severe beach erosion was caused by typhoons with higher intensity levels and longer durations,and high tide levels during typhoons can determine the upper limit of the beach profile erosion site.Taken together,these results can be used to improve beach management for storm prevention.展开更多
This article analyzed the importance of information monitoring and quick response on agricultural focuses and significant events, proposed the workflow and technical framework for information monitoring and quick resp...This article analyzed the importance of information monitoring and quick response on agricultural focuses and significant events, proposed the workflow and technical framework for information monitoring and quick response based on modern information technologies, and explained key technologies during implementation and the functional structure for prototype system of the technical support platform.展开更多
-Variations of monsoon wind field in the sea area along the southeastern coast of China during the ENSO events and its influence on the sea level and sea surface temperature (SST) are explored mainly on the basis of t...-Variations of monsoon wind field in the sea area along the southeastern coast of China during the ENSO events and its influence on the sea level and sea surface temperature (SST) are explored mainly on the basis of the data of monthly mean wind at 850 hPa and five coastal stations during 1973-1987. The results from the analyses of the data and theoretical estimation show that the southwest wind anomalies appeared in the study area during the events, and northeast wind anomalies occurred in general before the events. With the coastline of the area being parallel basically to the direction of the wind, an Ekman transport will result in an accumulation of the water near the coast or a departure of the water from the coast. As a result , the sea level and SST there will be affected markedly. During the events, southwest wind will intensify in the summer, and northeast wind will weaken in the winter. Their total effect is that a large negative anomaly of the sea level and SST will occur. The estimations indicate that the monsoon wind is stronger in the summer and weaker in the winter than the normal by 1-1. 5 m/s during the events, and this anomaly will cause a decrease of the sea level by 7-11 cm . Changes of the wind field, therefore, is mainly responsible for a large negative anomalies of the sea level and SST there during the ENSO events.展开更多
This study aims to investigate whether Corporate Social Responsibility(CSR)activities reduce supply chain disruptions by examining the impact of the Suez Canal obstruction on the Ever Given container ship in March 202...This study aims to investigate whether Corporate Social Responsibility(CSR)activities reduce supply chain disruptions by examining the impact of the Suez Canal obstruction on the Ever Given container ship in March 2021.This study conclude that the more responsible companies have higher returns and are less affected by this event than the less responsible companies;the less responsible companies have lower returns.The companies with better CSR have a lower impact on their supply chains when faced with disruptions in the supply chain.展开更多
AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles pu...AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders.展开更多
In this paper,the Gutenberg-Richter model is used to generate seismic events.The events that satisfy the random distribution are also generated.With those events,the natural probability distribution of Load and Unload...In this paper,the Gutenberg-Richter model is used to generate seismic events.The events that satisfy the random distribution are also generated.With those events,the natural probability distribution of Load and Unload Response Ratio(LURR),which measures quantitatively the degree of instability of a nonlinear system,is discussed.The study is based on stress energy release,which is chosen as the response of nonlinear system F3.The comparative results from the observation catalogue and generating data are also studied.It is revealed that the natural probability of LURR is mostly stable when the sample number is sufficient.The lower the natural probability of LURR,the more the precursory is information it may contain.The influence of Y3 resulting from the sample number and the magnitude range of events is also discussed.展开更多
To exhibit or participate in the event,please contact MP Asia.For the latest updates on the World Toilet Expo & Forum 2006.please visit the event website at www.worldtolletexpo.
目的探讨全身免疫炎症反应指数(SIIRI)与冠心病患者冠状动脉狭窄严重程度及其远期主要不良心血管事件(MACE)发生风险的关系。方法回顾性连续纳入2020年12月至2021年12月因胸痛在中国人民解放军联勤保障部队第九〇四医院住院治疗并行冠...目的探讨全身免疫炎症反应指数(SIIRI)与冠心病患者冠状动脉狭窄严重程度及其远期主要不良心血管事件(MACE)发生风险的关系。方法回顾性连续纳入2020年12月至2021年12月因胸痛在中国人民解放军联勤保障部队第九〇四医院住院治疗并行冠状动脉造影检查的545例患者,根据冠状动脉造影检查结果分为冠心病组(435例)和非冠心病组(110例),根据Gensini评分将冠心病患者分为冠状动脉重度狭窄组(Gensini评分≥30分,272例)和冠状动脉轻度狭窄组(Gensini评分为1~<30分,163例)。SIIRI计算公式为SIIRI=中性粒细胞计数×单核细胞计数×血小板计数/淋巴细胞计数。冠心病患者随访1年,成功随访216例患者,根据有无终点事件分为MACE组(77例)、非MACE组(139例)。采用logistic回归模型分析冠心病和冠状动脉重度狭窄的独立预测因素,采用Cox比例风险回归模型分析冠心病患者经皮冠状动脉介入(PCI)治疗后发生MACE的独立危险因素,采用ROC曲线分析SIIRI对冠状动脉重度狭窄和MACE的预测价值。结果冠心病组的SIIRI高于非冠心病组[305.19×10^(18)(170.98×10^(18),550.76×10^(18))/L^(2) vs 121.25×10^(18)(91.17×10^(18),194.41×10^(18))/L^(2),P<0.001];当SIIRI取临界值251.02×10^(18)/L^(2)时预测冠心病的效能最高,灵敏度和特异度分别为58.9%和90.9%。冠状动脉重度狭窄组的SIIRI高于冠状动脉轻度狭窄组[420.75×10^(18)(238.76×10^(18),810.13×10^(18))/L^(2) vs 185.41×10^(18)(127.39×10^(18),294.07×10^(18))/L^(2),P<0.001];当SIIRI取临界值304.86×10^(18)/L^(2)时预测冠状动脉重度狭窄的效能最高,灵敏度和特异度分别为68.0%和79.1%。MACE组的SIIRI高于非MACE组[942.38×10^(18)(528.00×10^(18),1494.43×10^(18))/L^(2) vs 319.93×10^(18)(176.41×10^(18),498.90×10^(18))/L^(2),P<0.001];当SIIRI取临界值650.23×10^(18)/L^(2)时对冠心病患者行PCI治疗后发生MACE的预测能力最强,灵敏度和特异度分别为71.4%和84.9%。SIIRI预测冠心病和冠状动脉重度狭窄及PCI治疗后发生MACE的AUC值分别为0.809(95%CI 0.770~0.848)、0.775(95%CI 0.732~0.819)、0.798(95%CI 0.732~0.864),均高于系统性免疫炎症指数、系统性炎症反应指数、血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值和单核细胞与淋巴细胞比值。结论SIIRI是冠心病及冠状动脉重度狭窄的独立危险因素,也对冠心病患者行PCI治疗后远期发生MACE具有较好的预测价值。展开更多
基金The Zhejiang Provincial Natural Science Foundation of China under contract No.LHZ22D060001the Scientific Research Funds of the Second Institute of Oceanography,Ministry of Natural Resources under contract Nos JG2315 and XRJH2309the National Key R&D Program of China under contract No.2022YFC3106200.
文摘Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the morphodynamic response of Dongsha beach to typhoon events,based on beach topographies and surficial sediment characteristics acquired before and after four typhoon events with varying intensities.The four typhoons had different effects on the topography and sediment characteristics of Dongsha beach.Typhoons Ampil and Danas caused the largest(-51.72 m3/m)and the smallest erosion(-8.01 m3/m),respectively.Remarkable alongshore patterns of beach profile volumetric changes were found after the four typhoon events,with more erosion in the southern and central parts of the beach and few changes in the northern part.Grain size coarsening and poor sorting were the main sediment patterns on the beach influenced by different typhoons.Typhoons that occurred in the same year after another typhoon enhanced the effect of the previous typhoon on sediment coarsening and sorting variability,but this cumulative effect was not found between typhoons that occurred during different years.A comparison of the collected data revealed that the topographic state of the beach before the typhoon,typhoon characteristics,and tidal conditions were possible reasons for the difference in the responses of Dongsha beach to typhoon events.More severe beach erosion was caused by typhoons with higher intensity levels and longer durations,and high tide levels during typhoons can determine the upper limit of the beach profile erosion site.Taken together,these results can be used to improve beach management for storm prevention.
文摘This article analyzed the importance of information monitoring and quick response on agricultural focuses and significant events, proposed the workflow and technical framework for information monitoring and quick response based on modern information technologies, and explained key technologies during implementation and the functional structure for prototype system of the technical support platform.
文摘-Variations of monsoon wind field in the sea area along the southeastern coast of China during the ENSO events and its influence on the sea level and sea surface temperature (SST) are explored mainly on the basis of the data of monthly mean wind at 850 hPa and five coastal stations during 1973-1987. The results from the analyses of the data and theoretical estimation show that the southwest wind anomalies appeared in the study area during the events, and northeast wind anomalies occurred in general before the events. With the coastline of the area being parallel basically to the direction of the wind, an Ekman transport will result in an accumulation of the water near the coast or a departure of the water from the coast. As a result , the sea level and SST there will be affected markedly. During the events, southwest wind will intensify in the summer, and northeast wind will weaken in the winter. Their total effect is that a large negative anomaly of the sea level and SST will occur. The estimations indicate that the monsoon wind is stronger in the summer and weaker in the winter than the normal by 1-1. 5 m/s during the events, and this anomaly will cause a decrease of the sea level by 7-11 cm . Changes of the wind field, therefore, is mainly responsible for a large negative anomalies of the sea level and SST there during the ENSO events.
文摘This study aims to investigate whether Corporate Social Responsibility(CSR)activities reduce supply chain disruptions by examining the impact of the Suez Canal obstruction on the Ever Given container ship in March 2021.This study conclude that the more responsible companies have higher returns and are less affected by this event than the less responsible companies;the less responsible companies have lower returns.The companies with better CSR have a lower impact on their supply chains when faced with disruptions in the supply chain.
文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders.
基金This project was sponsored by the State Seismological Bureau (85-04-05-04-05)
文摘In this paper,the Gutenberg-Richter model is used to generate seismic events.The events that satisfy the random distribution are also generated.With those events,the natural probability distribution of Load and Unload Response Ratio(LURR),which measures quantitatively the degree of instability of a nonlinear system,is discussed.The study is based on stress energy release,which is chosen as the response of nonlinear system F3.The comparative results from the observation catalogue and generating data are also studied.It is revealed that the natural probability of LURR is mostly stable when the sample number is sufficient.The lower the natural probability of LURR,the more the precursory is information it may contain.The influence of Y3 resulting from the sample number and the magnitude range of events is also discussed.
文摘To exhibit or participate in the event,please contact MP Asia.For the latest updates on the World Toilet Expo & Forum 2006.please visit the event website at www.worldtolletexpo.
文摘目的探讨全身免疫炎症反应指数(SIIRI)与冠心病患者冠状动脉狭窄严重程度及其远期主要不良心血管事件(MACE)发生风险的关系。方法回顾性连续纳入2020年12月至2021年12月因胸痛在中国人民解放军联勤保障部队第九〇四医院住院治疗并行冠状动脉造影检查的545例患者,根据冠状动脉造影检查结果分为冠心病组(435例)和非冠心病组(110例),根据Gensini评分将冠心病患者分为冠状动脉重度狭窄组(Gensini评分≥30分,272例)和冠状动脉轻度狭窄组(Gensini评分为1~<30分,163例)。SIIRI计算公式为SIIRI=中性粒细胞计数×单核细胞计数×血小板计数/淋巴细胞计数。冠心病患者随访1年,成功随访216例患者,根据有无终点事件分为MACE组(77例)、非MACE组(139例)。采用logistic回归模型分析冠心病和冠状动脉重度狭窄的独立预测因素,采用Cox比例风险回归模型分析冠心病患者经皮冠状动脉介入(PCI)治疗后发生MACE的独立危险因素,采用ROC曲线分析SIIRI对冠状动脉重度狭窄和MACE的预测价值。结果冠心病组的SIIRI高于非冠心病组[305.19×10^(18)(170.98×10^(18),550.76×10^(18))/L^(2) vs 121.25×10^(18)(91.17×10^(18),194.41×10^(18))/L^(2),P<0.001];当SIIRI取临界值251.02×10^(18)/L^(2)时预测冠心病的效能最高,灵敏度和特异度分别为58.9%和90.9%。冠状动脉重度狭窄组的SIIRI高于冠状动脉轻度狭窄组[420.75×10^(18)(238.76×10^(18),810.13×10^(18))/L^(2) vs 185.41×10^(18)(127.39×10^(18),294.07×10^(18))/L^(2),P<0.001];当SIIRI取临界值304.86×10^(18)/L^(2)时预测冠状动脉重度狭窄的效能最高,灵敏度和特异度分别为68.0%和79.1%。MACE组的SIIRI高于非MACE组[942.38×10^(18)(528.00×10^(18),1494.43×10^(18))/L^(2) vs 319.93×10^(18)(176.41×10^(18),498.90×10^(18))/L^(2),P<0.001];当SIIRI取临界值650.23×10^(18)/L^(2)时对冠心病患者行PCI治疗后发生MACE的预测能力最强,灵敏度和特异度分别为71.4%和84.9%。SIIRI预测冠心病和冠状动脉重度狭窄及PCI治疗后发生MACE的AUC值分别为0.809(95%CI 0.770~0.848)、0.775(95%CI 0.732~0.819)、0.798(95%CI 0.732~0.864),均高于系统性免疫炎症指数、系统性炎症反应指数、血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值和单核细胞与淋巴细胞比值。结论SIIRI是冠心病及冠状动脉重度狭窄的独立危险因素,也对冠心病患者行PCI治疗后远期发生MACE具有较好的预测价值。