The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by c...The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ioni-zable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard par-tition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The ob-tained results have been summarized in ionic partition dia-grams, which are a useful tool for predicting and interpret-ing the transfer mechanisms of ionizable drugs at the liq-uid/liquid interfaces and biological membranes.展开更多
2020年超长梅雨期内的持续强降雨,导致安徽省发生全域性洪涝灾害,为了快速、准确地提取洪涝淹没范围,为防汛救灾提供科学支撑,选取安徽境内巢湖流域和淮河流域的灾前和灾中Sentinel-1A数据,首先,在快速预处理基础上,采用双极化水体指数(...2020年超长梅雨期内的持续强降雨,导致安徽省发生全域性洪涝灾害,为了快速、准确地提取洪涝淹没范围,为防汛救灾提供科学支撑,选取安徽境内巢湖流域和淮河流域的灾前和灾中Sentinel-1A数据,首先,在快速预处理基础上,采用双极化水体指数(Sentinel-1A dual-polarized water index,SDWI)法,并结合地形因子对平原和山区分别提取水体信息,建立一套洪水淹没区监测流程;然后通过该流程利用灾前、灾中两期合成孔径雷达数据提取2020年7月27日巢湖流域、淮河流域行蓄洪区洪水淹没范围。结果显示:SDWI比直接用后向散射系数提取水体具有优势;7月27日巢湖流域洪水淹没区面积为524.8 km^(2),其中受洪灾较重的是白石天河子流域,西河子流域次之;淮河流域安徽境内行蓄洪区,沿淮的4个地市淹没面积从大到小依次为淮南市、阜阳市、六安市、蚌埠市。研究表明,基于Sentinel-1A数据,采用SDWI和地形因子建立的洪水淹没区监测流程对平原和山区都具有较好的准确性、适用性,且具有较高的时效性,便于及时开展洪水灾害监测。展开更多
明确不同水氮互作对强筋优质小麦师栾02-1产量和加工品质的影响,为强筋小麦生产中如何通过合理灌溉和优化氮肥施用量来实现协同提高籽粒产量和加工品质的目标提供理论依据。2017-2020年,大田条件下设置浇水次数和施氮量二因子裂区试验,...明确不同水氮互作对强筋优质小麦师栾02-1产量和加工品质的影响,为强筋小麦生产中如何通过合理灌溉和优化氮肥施用量来实现协同提高籽粒产量和加工品质的目标提供理论依据。2017-2020年,大田条件下设置浇水次数和施氮量二因子裂区试验,主区为浇水次数,设春浇一水(W1,拔节水)和春浇两水(W2,拔节水+开花水);副区为氮肥施用量,设N0、N1、N2、N3、N4和N5(0、60、120、180、240和300 kg hm^(-2))6个水平。结果表明,施氮量0~300 kg hm^(-2)时,不同降水年型春浇一水、春浇两水小麦产量随施氮量的增加均先增加后减少,产量最高值对应的施氮量均为240 kg hm^(-2)。施氮量120~300 kg hm^(-2)时,春浇两水处理产量显著高于春浇一水处理。水氮互作对小麦单位面积收获穗数的影响最大,其次是千粒重,对穗粒数的影响最小。施氮量0~300 kg hm^(-2)时,2017-2018年度(丰水年型),春浇两水小麦湿面筋含量、沉降值、吸水率、面团稳定时间、拉伸能量、最大拉伸阻力平均值均高于春浇一水,而2018-2019、2019-2020年度(干旱年型)则相反:春浇一水高于春浇两水。不同降水年型春浇一水、春浇两水小麦湿面筋含量和沉降值随施氮量的增加先增加后减少或逐渐增加,二者最大值对应的施氮量为240 kg hm^(-2)或300 kg hm^(-2);稳定时间、拉伸能量和最大拉伸阻力随施氮量的增加均先增加后减少,施氮量240 kg hm^(-2)时达到最大值。不同降水年型强筋优质小麦师栾02-1生育期春浇两水、施氮量240 kg hm^(-2)时,籽粒产量和加工品质表现最佳。展开更多
KF or K2CO3 was added into the 1-butanol-water system and two phases were formed： water-rich phase （water phase） and 1-butanol-rich phase （1-butanol phase）. The liquid liquid equilibrium （LLE） data for 1-butano...KF or K2CO3 was added into the 1-butanol-water system and two phases were formed： water-rich phase （water phase） and 1-butanol-rich phase （1-butanol phase）. The liquid liquid equilibrium （LLE） data for 1-butanol-water-KF and 1-butanol-water-K2CO3 systems were measured at 25℃ and showed that 1-butanol phase contained negligible salt and water phase contained negligible 1-butanol when the concentrations of KF and K2CO3 in the water phase were equal to or higher than 27.11% and 31.68% , respectively. Thus water could be separated efficiently from 1-butanol-water by adding KF or K2CO3 into the system. A theoretical calculation of LLE data was calculated by using the Pitzer theory to get water activity in the water phase, and by the models, such as the Wilson, NRTL or the UNIQUAC for the 1-butanol phase. For 1-hutanol-water-KF system, the experimental data were found in good agreement with the calculated results by using Pitzer theory and Wilson equa tion, while for 1-butanol-water-K2CO3 system, the experimental data were found in good agreement with the calculated results by using Pitzer theory and UNIQUAC eauation.展开更多
TO THE EDITOR Sir,I read with great interest the recently pubiished article in rhe World Journal of Gastroenterology by JIn and co-workers on the cloning and characterization of Porcine aquaporin 1 water channel from ...TO THE EDITOR Sir,I read with great interest the recently pubiished article in rhe World Journal of Gastroenterology by JIn and co-workers on the cloning and characterization of Porcine aquaporin 1 water channel from the pig liver and studies on its expression in展开更多
Consuming a high-fructose diet induces metabolic syndrome （MS）-Iike features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular diseas...Consuming a high-fructose diet induces metabolic syndrome （MS）-Iike features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular disease. Because mineral deficiency intensifies the deleterious effects of fructose consumption and mineral ingestion is protective against MS, we aimed to characterize the effects of 8weeks of natural mineral-rich water consumption on the structural organization and expression of vascular growth factors and receptors on the corpus cavernosum （CC） in 10% fructose-fed Sprague-Dawley rats （FRUCT）. Differences were not observed in the organization of the CC either on the expression of vascular endothelial growth factor （VEGF） or the components of the angiopoietins/Tie2 system. However, opposing expression patterns were observed for VEGF receptors （an increase and a decrease for VEGFR1 and VEGFR2, respectively） in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion. Mineral-rich water ingestion （FRUCTMIN） increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin I expression compared with the control and FRUCT groups. Western blot results were consistent with the dual immunofluorescence evaluation. Plasma oxidized low-density lipoprotein and plasma testosterone levels were similar among the experimental groups, although a tendency for an increase in the former was observed in the FRUCTMIN group. The mineral-rich water-treated rats presented changes similar to those observed in rats treated with MS-protective polyphenol-rich beverages or subjected to energy restriction, which led us to hypothesize that the effects of mineral-rich water consumption may be more vast than those directly observed in this study.展开更多
An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple meth...An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple method for synthesis.The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.展开更多
文摘The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ioni-zable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard par-tition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The ob-tained results have been summarized in ionic partition dia-grams, which are a useful tool for predicting and interpret-ing the transfer mechanisms of ionizable drugs at the liq-uid/liquid interfaces and biological membranes.
文摘2020年超长梅雨期内的持续强降雨,导致安徽省发生全域性洪涝灾害,为了快速、准确地提取洪涝淹没范围,为防汛救灾提供科学支撑,选取安徽境内巢湖流域和淮河流域的灾前和灾中Sentinel-1A数据,首先,在快速预处理基础上,采用双极化水体指数(Sentinel-1A dual-polarized water index,SDWI)法,并结合地形因子对平原和山区分别提取水体信息,建立一套洪水淹没区监测流程;然后通过该流程利用灾前、灾中两期合成孔径雷达数据提取2020年7月27日巢湖流域、淮河流域行蓄洪区洪水淹没范围。结果显示:SDWI比直接用后向散射系数提取水体具有优势;7月27日巢湖流域洪水淹没区面积为524.8 km^(2),其中受洪灾较重的是白石天河子流域,西河子流域次之;淮河流域安徽境内行蓄洪区,沿淮的4个地市淹没面积从大到小依次为淮南市、阜阳市、六安市、蚌埠市。研究表明,基于Sentinel-1A数据,采用SDWI和地形因子建立的洪水淹没区监测流程对平原和山区都具有较好的准确性、适用性,且具有较高的时效性,便于及时开展洪水灾害监测。
文摘明确不同水氮互作对强筋优质小麦师栾02-1产量和加工品质的影响,为强筋小麦生产中如何通过合理灌溉和优化氮肥施用量来实现协同提高籽粒产量和加工品质的目标提供理论依据。2017-2020年,大田条件下设置浇水次数和施氮量二因子裂区试验,主区为浇水次数,设春浇一水(W1,拔节水)和春浇两水(W2,拔节水+开花水);副区为氮肥施用量,设N0、N1、N2、N3、N4和N5(0、60、120、180、240和300 kg hm^(-2))6个水平。结果表明,施氮量0~300 kg hm^(-2)时,不同降水年型春浇一水、春浇两水小麦产量随施氮量的增加均先增加后减少,产量最高值对应的施氮量均为240 kg hm^(-2)。施氮量120~300 kg hm^(-2)时,春浇两水处理产量显著高于春浇一水处理。水氮互作对小麦单位面积收获穗数的影响最大,其次是千粒重,对穗粒数的影响最小。施氮量0~300 kg hm^(-2)时,2017-2018年度(丰水年型),春浇两水小麦湿面筋含量、沉降值、吸水率、面团稳定时间、拉伸能量、最大拉伸阻力平均值均高于春浇一水,而2018-2019、2019-2020年度(干旱年型)则相反:春浇一水高于春浇两水。不同降水年型春浇一水、春浇两水小麦湿面筋含量和沉降值随施氮量的增加先增加后减少或逐渐增加,二者最大值对应的施氮量为240 kg hm^(-2)或300 kg hm^(-2);稳定时间、拉伸能量和最大拉伸阻力随施氮量的增加均先增加后减少,施氮量240 kg hm^(-2)时达到最大值。不同降水年型强筋优质小麦师栾02-1生育期春浇两水、施氮量240 kg hm^(-2)时,籽粒产量和加工品质表现最佳。
文摘KF or K2CO3 was added into the 1-butanol-water system and two phases were formed： water-rich phase （water phase） and 1-butanol-rich phase （1-butanol phase）. The liquid liquid equilibrium （LLE） data for 1-butanol-water-KF and 1-butanol-water-K2CO3 systems were measured at 25℃ and showed that 1-butanol phase contained negligible salt and water phase contained negligible 1-butanol when the concentrations of KF and K2CO3 in the water phase were equal to or higher than 27.11% and 31.68% , respectively. Thus water could be separated efficiently from 1-butanol-water by adding KF or K2CO3 into the system. A theoretical calculation of LLE data was calculated by using the Pitzer theory to get water activity in the water phase, and by the models, such as the Wilson, NRTL or the UNIQUAC for the 1-butanol phase. For 1-hutanol-water-KF system, the experimental data were found in good agreement with the calculated results by using Pitzer theory and Wilson equa tion, while for 1-butanol-water-K2CO3 system, the experimental data were found in good agreement with the calculated results by using Pitzer theory and UNIQUAC eauation.
文摘TO THE EDITOR Sir,I read with great interest the recently pubiished article in rhe World Journal of Gastroenterology by JIn and co-workers on the cloning and characterization of Porcine aquaporin 1 water channel from the pig liver and studies on its expression in
文摘Consuming a high-fructose diet induces metabolic syndrome （MS）-Iike features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular disease. Because mineral deficiency intensifies the deleterious effects of fructose consumption and mineral ingestion is protective against MS, we aimed to characterize the effects of 8weeks of natural mineral-rich water consumption on the structural organization and expression of vascular growth factors and receptors on the corpus cavernosum （CC） in 10% fructose-fed Sprague-Dawley rats （FRUCT）. Differences were not observed in the organization of the CC either on the expression of vascular endothelial growth factor （VEGF） or the components of the angiopoietins/Tie2 system. However, opposing expression patterns were observed for VEGF receptors （an increase and a decrease for VEGFR1 and VEGFR2, respectively） in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion. Mineral-rich water ingestion （FRUCTMIN） increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin I expression compared with the control and FRUCT groups. Western blot results were consistent with the dual immunofluorescence evaluation. Plasma oxidized low-density lipoprotein and plasma testosterone levels were similar among the experimental groups, although a tendency for an increase in the former was observed in the FRUCTMIN group. The mineral-rich water-treated rats presented changes similar to those observed in rats treated with MS-protective polyphenol-rich beverages or subjected to energy restriction, which led us to hypothesize that the effects of mineral-rich water consumption may be more vast than those directly observed in this study.
文摘An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple method for synthesis.The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.
