Carbon fiber reinforced plastics provide many excellent properties and are widely used in the aerospace industry.However,the existing composites autoclave process still faces difficulties such as high-energy consumpti...Carbon fiber reinforced plastics provide many excellent properties and are widely used in the aerospace industry.However,the existing composites autoclave process still faces difficulties such as high-energy consumption,uneven distribution of temperature field,complications of pressure transmission,and high cost,which limit their application in manufacturing of large complex composites components.In this study,the vibration treatment was introduced into the composites microwave curing process innovatively.On the basis of giving full play to the uniform heating characteristics of the microwave,the problems of a large number of internal defects and poor molding quality caused by the insufficient curing pressure have been solved.The results showed that the samples cured by the improved microwave process without external pressure had a few internal voids,excellent interface bonding conditions,and lower residual stress.Their properties were almost consistent with the samples prepared by the standard autoclave process,which provided a new method for the high-performance,efficient,safe,and low-cost manufacturing of large complex composites components.展开更多
Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and internatio...Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.展开更多
Alzheimer’s disease (AD) is progressively being recognized amongst the most vital medical and social issues in older individuals in industrialized and non-industrialized countries. To date, just symptomatic medicatio...Alzheimer’s disease (AD) is progressively being recognized amongst the most vital medical and social issues in older individuals in industrialized and non-industrialized countries. To date, just symptomatic medications exist for this disease, all attempting to offset the neurotransmitter disturbance.?Recently, cholinesterase inhibitors (CIs) are now accessible and have been authorized for the treatment of mild to moderate AD. Further remedial alternative available for moderate to severe AD is memantine, an N-methyl-D-aspartate receptor noncompetitive antagonist. Treatments equipped for halting or slightly adjusting the course of AD are known as “ailment changing” medications, and are still under extensive examination. To obstruct the movement of the ailment, they need to interfere with the pathogenic steps in charge of the clinical symptoms, including the disposition of extracellular amyloid?β?plaques and intracellular neurofibrillary tangle formation, irritation, oxidative damage, iron deregulation and cholesterol metabolism. This paper discusses the cure for Alzheimer’s disease, the current symptomatic treatments and the treatment of mild and moderate Alzheimer’s disease and the functions of its drugs.展开更多
基金Project(2018YFA0702800)supported by the National Key R&D Program of China。
文摘Carbon fiber reinforced plastics provide many excellent properties and are widely used in the aerospace industry.However,the existing composites autoclave process still faces difficulties such as high-energy consumption,uneven distribution of temperature field,complications of pressure transmission,and high cost,which limit their application in manufacturing of large complex composites components.In this study,the vibration treatment was introduced into the composites microwave curing process innovatively.On the basis of giving full play to the uniform heating characteristics of the microwave,the problems of a large number of internal defects and poor molding quality caused by the insufficient curing pressure have been solved.The results showed that the samples cured by the improved microwave process without external pressure had a few internal voids,excellent interface bonding conditions,and lower residual stress.Their properties were almost consistent with the samples prepared by the standard autoclave process,which provided a new method for the high-performance,efficient,safe,and low-cost manufacturing of large complex composites components.
基金Supported by National Key Research and Development Program of China 2023,No:2023YFC2308100.
文摘Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.
文摘Alzheimer’s disease (AD) is progressively being recognized amongst the most vital medical and social issues in older individuals in industrialized and non-industrialized countries. To date, just symptomatic medications exist for this disease, all attempting to offset the neurotransmitter disturbance.?Recently, cholinesterase inhibitors (CIs) are now accessible and have been authorized for the treatment of mild to moderate AD. Further remedial alternative available for moderate to severe AD is memantine, an N-methyl-D-aspartate receptor noncompetitive antagonist. Treatments equipped for halting or slightly adjusting the course of AD are known as “ailment changing” medications, and are still under extensive examination. To obstruct the movement of the ailment, they need to interfere with the pathogenic steps in charge of the clinical symptoms, including the disposition of extracellular amyloid?β?plaques and intracellular neurofibrillary tangle formation, irritation, oxidative damage, iron deregulation and cholesterol metabolism. This paper discusses the cure for Alzheimer’s disease, the current symptomatic treatments and the treatment of mild and moderate Alzheimer’s disease and the functions of its drugs.
