The multi-dimensional time-domain computational fluid dynamics(CFD) approach is extended to calculate the acoustic attenuation performance of water-filled piping silencers. Transmission loss predictions from the time-...The multi-dimensional time-domain computational fluid dynamics(CFD) approach is extended to calculate the acoustic attenuation performance of water-filled piping silencers. Transmission loss predictions from the time-domain CFD approach and the frequency-domain finite element method(FEM) agree well with each other for the dual expansion chamber silencer, straight-through and cross-flow perforated tube silencers without flow. Then, the time-domain CFD approach is used to investigate the effect of flow on the acoustic attenuation characteristics of perforated tube silencers. The numerical predictions demonstrate that the mean flow increases the transmission loss, especially at higher frequencies, and shifts the transmission loss curve to lower frequencies.展开更多
Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic disp...Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.展开更多
Rice sheath blight, caused by Rhizoctonia solani AG1-IA, is a major disease in rice-growing areas worldwide. Effectors of phytopathogenic fungi play important roles during the infection process of fungal pathogens ont...Rice sheath blight, caused by Rhizoctonia solani AG1-IA, is a major disease in rice-growing areas worldwide. Effectors of phytopathogenic fungi play important roles during the infection process of fungal pathogens onto their host plants. However, the molecular mechanisms by which R. solani effectors regulate rice immunity are not well understood. Through prediction, 78 candidate effector molecules were identified. Using the tobacco rattle virus-host induced gene silencing(TRV-HIGS) system, 45 RNAi constructs of effector genes were infiltrated into Nicotiana benthamiana leaves. The results revealed that eight of these constructs resulted in a significant reduction in necrosis caused by infection with the AG1-IA strain GD-118. Additionally, stable rice transformants carrying the double-stranded RNA construct for one of the effector genes, AGLIP1, were generated to further verify the function of this gene. The suppression of the AGLIP1 gene increased the resistance of both N. benthamiana and rice against GD-118, and also affected the growth rate of GD-118, indicating that AGLIP1 is a key pathogenic factor. Small RNA sequencing showed that the HIGS vectors were processed into si RNAs within the plants and then translocated to the fungi, leading to the silencing of the target genes. As a result, AGLIP1 might be an excellent candidate for HIGS, thereby enhancing crop resistance against the pathogen and contributing to the control of R. solani infection.展开更多
Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant species.Employing molecular breeding technology for the development of cotton vari...Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant species.Employing molecular breeding technology for the development of cotton varieties with heightened resistance to VW stands out as one of the most efficacious protective measures.In this study,we successfully generated two stable transgenic lines of cotton(Gossypium hirsutum L.),VdThitRNAi-1 and VdThit-RNAi-2,using host-induced gene silencing(HIGS)technology to introduce double-stranded RNA(dsRNA)targeting the thiamine transporter protein gene(VdThit).Southern blot analysis confirmed the presence of a single-copy insertion in each line.Microscopic examination showed marked reductions in the colonization and spread of Vd-mCherry in the roots of VdThit-RNAi cotton compared to wild type(WT).The corresponding disease index and fungal biomass of VdThit-RNAi-1/2 also exhibited significant reductions.Real-time quantitative PCR(qRT-PCR)analysis demonstrated a substantial inhibition of VdThit expression following prolonged inoculation of VdThit-RNAi cotton.Small RNA sequencing(sRNA-Seq)analysis revealed the generation of a substantial number of VdThit-specific siRNAs in the VdThit-RNAi transgenic lines.Additionally,the silencing of VdThit by the siVdThit produced by VdThit-RNAi-1/2 resulted in the elevated expression of multiple genes involved in the thiamine biosynthesis pathway in Vd.Under field conditions,VdThit-RNAi transgenic cotton exhibited significantly enhanced disease resistance and yield compared with WT.In summary,our findings underscore the efficacy of HIGS targeting VdThit in restraining the infection and spread of Vd in cotton,thereby potentially enabling the development of cotton breeding as a promising strategy for managing VW.展开更多
David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges ...David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges the grand narratives of national history by emphasizing the indispensable role of women’s experiences.Through characters like Dulcie and Rachael,Wicomb portrays the female body as a site of resistance and resilience,highlighting the need for more nuanced and inclusive ways of documenting history.Underscoring the inexpressibility of trauma and the limitations of language and representation,the novel self-reflexively acknowledges its own aporia of completing the narrative,embodying the ongoing struggle to capture the full breadth of human experience.展开更多
Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis,yet their prolonged activation induces apoptosis and disrupts organismal health1-3.How stress responses are tur...Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis,yet their prolonged activation induces apoptosis and disrupts organismal health1-3.How stress responses are turned off at the right time and place remains poorly understood.Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress.展开更多
The high pressure waves generated due to muzzle blast flow of tank gun during firing is a critical issue to examine. The impulsive noise from the gun has various negative effects such as damage of human bodies, damage...The high pressure waves generated due to muzzle blast flow of tank gun during firing is a critical issue to examine. The impulsive noise from the gun has various negative effects such as damage of human bodies, damage of structures, creating an environmental, social problem and also military problems such as exposure of location of troops. This high pressure impulsive sound, generated during the blast flow, was studied and attenuated. An axisymmetric computational domain was constructed by employing Spalart Allmaras turbulence model. Approximately 90% of pressure and 20 dB of sound level are reduced due to the use of the three baffle silencer at the muzzle end of the gun barrel, in comparison with the tank gun without silencer. Also, the sound pressure level at different points in the ambient region shows the same attenuation in results. This study will be helpful to understand the blast wave characteristics and also to get a good idea to design silencer for large caliber weapon system.展开更多
The developmental stage-specific silencing of the human ε-globin gene during embryonic life is controlled, inpart, by the silencer (-392bp~-177bp) upstream of thisgene. In order to elucidate its role, the nuclear ex...The developmental stage-specific silencing of the human ε-globin gene during embryonic life is controlled, inpart, by the silencer (-392bp~-177bp) upstream of thisgene. In order to elucidate its role, the nuclear extractfrom the human fetal liver has been prepared and the interactions between trans-acting factors and this silencerelement have been examined. By using DNasel footprinting assay, a major protected region from -278bp to -235bpwithin this silencer element was identified. Furthermore,we found in gel mobility shift assay and Southwestern blotting assay that there were at least four trans-acting factors (MW ≈ 32, 28, 26 and 22kD) in the nuclear extractisolated from the human fetal liver, which could specifically bind to this region. Our results suggested that thesetrans-acting factors might play an important role in silencing the human embryonic ε-globin gene expression at thefetal stage through the interactions with this silencer.展开更多
In marine engine exhaust silencing systems, the presence of exhaust gas flow influences the sound propagation inside the systems and the acoustic attenuation performance of silencers. In order to investigate the effec...In marine engine exhaust silencing systems, the presence of exhaust gas flow influences the sound propagation inside the systems and the acoustic attenuation performance of silencers. In order to investigate the effects of three-dimensional gas flow and acoustic damping on the acoustic attenuation characteristics of marine engine exhaust silencers, a dual reciprocity boundary element method (DRBEM) was developed. The acoustic governing equation in three-dimensional potential flow was derived first, and then the DRBEM numerical procedure is given. Compared to the conventional boundary element method (CBEM), the DRBEM considers the second order terms of flow Mach number in the acoustic governing equation, so it is suitable for the cases with higher Mach number subsonic flow. For complex exhaust silencers, it is difficult to apply the single-domain boundary element method, so a substructure approach based on the dual reciprocity boundary element method is presented. The experiments for measuring transmission loss of silencers are conducted, and the experimental setup and measurements are explained. The transmission loss of a single expansion chamber silencer with extended inlet and outlet were predicted by DRBEM and compared with the measurements. The good agreements between predictions and measurements are observed, which demonstrated that the derived acoustic governing equation and the DRBEM numerical procedure in the present study are correct.展开更多
Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM),a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused b...Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM),a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused by the rotor slot permeance harmonics.By analyzing the research status of electromagnetic vibration of the WSIM and the composition of the air-gap magnetic field of the motor,the idea that the auxiliary slots mainly affect the air-gap field harmonics by changing the air-gap permeance of the motor is put forward.The mathematical model of air-gap permeance of WSIM is established to simulate the influence of auxiliary slots on the air-gap permeance.Through the parametric analysis of the mathematical model,the change of auxiliary slot size is simulated.The air-gap permeance waveform is decomposed by the two-dimensional Fourier transform,and then the variation of the air-gap permeance harmonics with the size of the auxiliary slot is analyzed.Finally,the finite element simulation model of the WSIM with the auxiliary slots is established,and the waveform of the air-gap flux density of the motor is analyzed to verify the effectiveness of the mathematical model.Meanwhile,the results show that after opening the auxiliary slot,the radial electromagnetic force of the motor was reduced by 28.4%.展开更多
Based on existing low-frequency water-filled impedance tube testing facilities, which is a part of the Low Frequency Facility of the Naval Undersea Warfare Center in Beijing, an improved water-filled pulse tube method...Based on existing low-frequency water-filled impedance tube testing facilities, which is a part of the Low Frequency Facility of the Naval Undersea Warfare Center in Beijing, an improved water-filled pulse tube method is presented in this short paper. This proposed study is significantly different from the conventional pulse tube method because of the capability for a single plane damped sine pulse wave to generate in the water-filled pulse tube with a regular waveform and short duration time of about 1ms. During the generation process of the pulse, an inverse filter principle was adopted to compensate the transducer response. The effect of the characteristics of tube termination can be eliminated through the generation process of the pulse. Reflection coefficient from a water/air interface was measured to verify the proposed method. When compared with the expected theoretical values, a relatively good agreement can be obtained in the low frequency range of 500-2 000 Hz.展开更多
Some experimental data recorded from impact tests on empty and water-filled pressurized mild steel pipes are presented. The pipes were supported as a three-span continuous beam and impacted laterally by a rigid indent...Some experimental data recorded from impact tests on empty and water-filled pressurized mild steel pipes are presented. The pipes were supported as a three-span continuous beam and impacted laterally by a rigid indenter at the mid-span of middle span. Three kinds of indenter nose shapes were used: blunt-nose, hemisphere-nose and 90?conical-nose. The internal pressure ranged up to 20 MPa. The perforation failure modes and corresponding critical impact energies were obtained under different test conditions. The time-history curves of the internal pressure and impact force were given. The experiments show that the media filled in the tube greatly decreased the ballistic limit energy.展开更多
The optimization of the acoustic silencer volume is very important to develop it and to get high-performance,the importance of the silencer was appeared in industrial field to eliminate the noise of the duct by effici...The optimization of the acoustic silencer volume is very important to develop it and to get high-performance,the importance of the silencer was appeared in industrial field to eliminate the noise of the duct by efficient and economical method.The main goal of this research is to optimize the transmission loss(TL)by analytical method of the Double-Chamber Silencer(DCS),the TL has been selected as the main parameter in silencer because it does not based on the source or the termination impedances.First we calculated the power transmission coefficient(PTC)and the TL of an acoustic silencer,then used the Lagrange method to optimize the silencer length.All calculation of silencer data is obtained by solving the governing equations in commercial software Matlab®.A several calculations for different silencer length at many frequency ranges were performed simultaneously.Finally,this research supports the efficient and rapid techniques for DCS optimal design under narrow space.The results show that the acoustic TL is maximized at the desired frequency.展开更多
Acoustic performance of dissipative silencer was evaluated to determine the effectiveness of perforated duct porosity and absorbent material density in reducing occupational noise exposure propagated from centrifugal...Acoustic performance of dissipative silencer was evaluated to determine the effectiveness of perforated duct porosity and absorbent material density in reducing occupational noise exposure propagated from centrifugal fan.Design charts were applied to predict noise reduction and length of a dissipative silencer.Dissipative silencers with various punched duct porosity(14%,30%and 40%)and sound absorbent density(80 Kg/m^(3),120 Kg/m^(3),and 140 Kg/m^(3))were designed and fabricated.According to ISO9612 and ISO11820,noise level was measured before and after installing all nine test silencers at fixed workstations around the discharge side of a centrifugal fan in a manufacturing plant.On average,the noise level at the discharge side of a fan without silencer was measured to be 93.6 dBA,whereas it was significantly mitigated by 67.4 dBA to 70.1 dBA after installing all silencers.Dynamic insertion loss for a dissipative silencer with 100 cm length was predicted to be 27.9 dB,which was in agreement with experimental ones.Although,there was no significant differences between insertion loss of silencers,the one with 30%porosity and 120 Kg/m^(3)rock wool density had the highest insertion loss of 26.2 dBA.Dissipative silencers noticeably reduced centrifugal fan noise exposures.Increasing sound absorbent density and duct porosity up to a certain limit could probably be effective in noise reduction of dissipative silencers.展开更多
The contribution moves from highlighting how,in the context of Michel Serres’and posthumanism’s proposal of rethinking the human and the world in a perspective of inter-implication and universal co-belonging,silence...The contribution moves from highlighting how,in the context of Michel Serres’and posthumanism’s proposal of rethinking the human and the world in a perspective of inter-implication and universal co-belonging,silence(of the human word)assumes the function of a catalyst for the recognition/re-aestheticization of the human body in its sensory-aesthetic-cognitive-relational-hybrid dimensionality,and,with and for it,of the world in its agency(including artistic).Within the framework of this perspective,the investigation thus proposes a reading of art as a relation/catalyzer of relations,that is,as a(re)activation of positive relations of the human with and for a world that reveals itself to be increasingly hyper-complex,that is,more-than-human,in the continuity/inseparability of nature and culture.Taking Serresian ideas on artistic practices as non(only)human forms of expression and posthumanist“isomorphic”positions on non-human agency as tools,the research then highlights the“more-than-human”scope of art and the fact that artistic practices are responsive actions.So much so that,the human being emerges as co-agent and,of course,co-owner.展开更多
目的了解3所三级甲等综合医院护士组织沉默现状,探讨其影响因素。方法采用便利抽样法,2023年4月—8月采用一般资料调查表、护士组织沉默问卷、医院磁性要素量表(the essential of magnetism scale,EMO)对西安市3所三级甲等综合医院的87...目的了解3所三级甲等综合医院护士组织沉默现状,探讨其影响因素。方法采用便利抽样法,2023年4月—8月采用一般资料调查表、护士组织沉默问卷、医院磁性要素量表(the essential of magnetism scale,EMO)对西安市3所三级甲等综合医院的874临床护士进行调查,并采用多重线性回归分析其组织沉默的影响因素。结果共855名护士完成研究。护士组织沉默总分(56.33±8.55)分;医院磁性水平总分(107.63±12.85)分。护士组织沉默与医院磁性水平呈负相关(r=-0.318,P<0.010)。医院磁性水平、年龄、职称、护龄是护士组织沉默的影响因素(均P<0.001),共同解释其62.60%的变异。结论护士组织沉默与医院磁性水平处于中等偏低水平。护士年龄小、职称低、护龄短、医院磁性水平低,其组织沉默水平较高,护理管理者可通过提高医院磁性水平来减少护士的组织沉默。展开更多
基金Project(11174065)supported by the National Natural Science Foundation of China
文摘The multi-dimensional time-domain computational fluid dynamics(CFD) approach is extended to calculate the acoustic attenuation performance of water-filled piping silencers. Transmission loss predictions from the time-domain CFD approach and the frequency-domain finite element method(FEM) agree well with each other for the dual expansion chamber silencer, straight-through and cross-flow perforated tube silencers without flow. Then, the time-domain CFD approach is used to investigate the effect of flow on the acoustic attenuation characteristics of perforated tube silencers. The numerical predictions demonstrate that the mean flow increases the transmission loss, especially at higher frequencies, and shifts the transmission loss curve to lower frequencies.
文摘Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.
基金supported by the Henan Province Science and Technology Research Project, China (Grant No. 242102110232)the National Natural Science Foundation of China (Grant No. 31801677)the Major Program of Guangdong Basic and Applied Basic Research, China (Grant No. 2019B030302006)。
文摘Rice sheath blight, caused by Rhizoctonia solani AG1-IA, is a major disease in rice-growing areas worldwide. Effectors of phytopathogenic fungi play important roles during the infection process of fungal pathogens onto their host plants. However, the molecular mechanisms by which R. solani effectors regulate rice immunity are not well understood. Through prediction, 78 candidate effector molecules were identified. Using the tobacco rattle virus-host induced gene silencing(TRV-HIGS) system, 45 RNAi constructs of effector genes were infiltrated into Nicotiana benthamiana leaves. The results revealed that eight of these constructs resulted in a significant reduction in necrosis caused by infection with the AG1-IA strain GD-118. Additionally, stable rice transformants carrying the double-stranded RNA construct for one of the effector genes, AGLIP1, were generated to further verify the function of this gene. The suppression of the AGLIP1 gene increased the resistance of both N. benthamiana and rice against GD-118, and also affected the growth rate of GD-118, indicating that AGLIP1 is a key pathogenic factor. Small RNA sequencing showed that the HIGS vectors were processed into si RNAs within the plants and then translocated to the fungi, leading to the silencing of the target genes. As a result, AGLIP1 might be an excellent candidate for HIGS, thereby enhancing crop resistance against the pathogen and contributing to the control of R. solani infection.
基金supported by the National Key Research and Development Program of China(2022YFD1200300)the National Natural Science Foundation of China(32072376 and 32372515)+3 种基金Winall Hi-tech Seed Co.,Ltd.,China(GMLM2023)the Nanfan Special Project of Chinese Academy of Agricultural Sciences(CAAS)(ZDXM2303 and YBXM2415)the Natural Science Foundation of Hebei Province,China(C2022204205)the Agricultural Science and Technology Innovation Program of CAAS。
文摘Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant species.Employing molecular breeding technology for the development of cotton varieties with heightened resistance to VW stands out as one of the most efficacious protective measures.In this study,we successfully generated two stable transgenic lines of cotton(Gossypium hirsutum L.),VdThitRNAi-1 and VdThit-RNAi-2,using host-induced gene silencing(HIGS)technology to introduce double-stranded RNA(dsRNA)targeting the thiamine transporter protein gene(VdThit).Southern blot analysis confirmed the presence of a single-copy insertion in each line.Microscopic examination showed marked reductions in the colonization and spread of Vd-mCherry in the roots of VdThit-RNAi cotton compared to wild type(WT).The corresponding disease index and fungal biomass of VdThit-RNAi-1/2 also exhibited significant reductions.Real-time quantitative PCR(qRT-PCR)analysis demonstrated a substantial inhibition of VdThit expression following prolonged inoculation of VdThit-RNAi cotton.Small RNA sequencing(sRNA-Seq)analysis revealed the generation of a substantial number of VdThit-specific siRNAs in the VdThit-RNAi transgenic lines.Additionally,the silencing of VdThit by the siVdThit produced by VdThit-RNAi-1/2 resulted in the elevated expression of multiple genes involved in the thiamine biosynthesis pathway in Vd.Under field conditions,VdThit-RNAi transgenic cotton exhibited significantly enhanced disease resistance and yield compared with WT.In summary,our findings underscore the efficacy of HIGS targeting VdThit in restraining the infection and spread of Vd in cotton,thereby potentially enabling the development of cotton breeding as a promising strategy for managing VW.
基金This work was supported by Humanities and Social Sciences Fund of Ministry of Education of China(No.19XJA7520012020)by National Social Science Fund of China(No.20BWW069).
文摘David’s Story by Zoë Wicomb addresses the complexities of representing female suffering and the limitations of traditional historical narratives in capturing the experiences of marginalized bodies.It challenges the grand narratives of national history by emphasizing the indispensable role of women’s experiences.Through characters like Dulcie and Rachael,Wicomb portrays the female body as a site of resistance and resilience,highlighting the need for more nuanced and inclusive ways of documenting history.Underscoring the inexpressibility of trauma and the limitations of language and representation,the novel self-reflexively acknowledges its own aporia of completing the narrative,embodying the ongoing struggle to capture the full breadth of human experience.
文摘Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis,yet their prolonged activation induces apoptosis and disrupts organismal health1-3.How stress responses are turned off at the right time and place remains poorly understood.Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress.
基金Project(NRF-2010-013-D00007) supported by the National Research Foundation of KoreaProject supported by 2010 Year Research Professor Fund of Gyeongsang National University, Korea and NIIED Korea
文摘The high pressure waves generated due to muzzle blast flow of tank gun during firing is a critical issue to examine. The impulsive noise from the gun has various negative effects such as damage of human bodies, damage of structures, creating an environmental, social problem and also military problems such as exposure of location of troops. This high pressure impulsive sound, generated during the blast flow, was studied and attenuated. An axisymmetric computational domain was constructed by employing Spalart Allmaras turbulence model. Approximately 90% of pressure and 20 dB of sound level are reduced due to the use of the three baffle silencer at the muzzle end of the gun barrel, in comparison with the tank gun without silencer. Also, the sound pressure level at different points in the ambient region shows the same attenuation in results. This study will be helpful to understand the blast wave characteristics and also to get a good idea to design silencer for large caliber weapon system.
文摘The developmental stage-specific silencing of the human ε-globin gene during embryonic life is controlled, inpart, by the silencer (-392bp~-177bp) upstream of thisgene. In order to elucidate its role, the nuclear extractfrom the human fetal liver has been prepared and the interactions between trans-acting factors and this silencerelement have been examined. By using DNasel footprinting assay, a major protected region from -278bp to -235bpwithin this silencer element was identified. Furthermore,we found in gel mobility shift assay and Southwestern blotting assay that there were at least four trans-acting factors (MW ≈ 32, 28, 26 and 22kD) in the nuclear extractisolated from the human fetal liver, which could specifically bind to this region. Our results suggested that thesetrans-acting factors might play an important role in silencing the human embryonic ε-globin gene expression at thefetal stage through the interactions with this silencer.
基金the National Natural Science Foundation of China under Grant No.10474016.
文摘In marine engine exhaust silencing systems, the presence of exhaust gas flow influences the sound propagation inside the systems and the acoustic attenuation performance of silencers. In order to investigate the effects of three-dimensional gas flow and acoustic damping on the acoustic attenuation characteristics of marine engine exhaust silencers, a dual reciprocity boundary element method (DRBEM) was developed. The acoustic governing equation in three-dimensional potential flow was derived first, and then the DRBEM numerical procedure is given. Compared to the conventional boundary element method (CBEM), the DRBEM considers the second order terms of flow Mach number in the acoustic governing equation, so it is suitable for the cases with higher Mach number subsonic flow. For complex exhaust silencers, it is difficult to apply the single-domain boundary element method, so a substructure approach based on the dual reciprocity boundary element method is presented. The experiments for measuring transmission loss of silencers are conducted, and the experimental setup and measurements are explained. The transmission loss of a single expansion chamber silencer with extended inlet and outlet were predicted by DRBEM and compared with the measurements. The good agreements between predictions and measurements are observed, which demonstrated that the derived acoustic governing equation and the DRBEM numerical procedure in the present study are correct.
基金supported by the National Natural Science Funds of China No.51977055Major Science and Technology program of Anhui province No.201903a05020042Anhui Province key laboratory of Large-scale Submersible Electric Pump and Accoutrements。
文摘Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM),a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused by the rotor slot permeance harmonics.By analyzing the research status of electromagnetic vibration of the WSIM and the composition of the air-gap magnetic field of the motor,the idea that the auxiliary slots mainly affect the air-gap field harmonics by changing the air-gap permeance of the motor is put forward.The mathematical model of air-gap permeance of WSIM is established to simulate the influence of auxiliary slots on the air-gap permeance.Through the parametric analysis of the mathematical model,the change of auxiliary slot size is simulated.The air-gap permeance waveform is decomposed by the two-dimensional Fourier transform,and then the variation of the air-gap permeance harmonics with the size of the auxiliary slot is analyzed.Finally,the finite element simulation model of the WSIM with the auxiliary slots is established,and the waveform of the air-gap flux density of the motor is analyzed to verify the effectiveness of the mathematical model.Meanwhile,the results show that after opening the auxiliary slot,the radial electromagnetic force of the motor was reduced by 28.4%.
基金Supported by the National Natural Science Foundation of China under Grant No. 11204242 China Postdoctoral Foundation under Grant No. 2011M501477
文摘Based on existing low-frequency water-filled impedance tube testing facilities, which is a part of the Low Frequency Facility of the Naval Undersea Warfare Center in Beijing, an improved water-filled pulse tube method is presented in this short paper. This proposed study is significantly different from the conventional pulse tube method because of the capability for a single plane damped sine pulse wave to generate in the water-filled pulse tube with a regular waveform and short duration time of about 1ms. During the generation process of the pulse, an inverse filter principle was adopted to compensate the transducer response. The effect of the characteristics of tube termination can be eliminated through the generation process of the pulse. Reflection coefficient from a water/air interface was measured to verify the proposed method. When compared with the expected theoretical values, a relatively good agreement can be obtained in the low frequency range of 500-2 000 Hz.
基金Project supported by the National Natural Science Foundation of China (No. 10072036) the Foundation for Returned Scholars from Abroad of Shanxi Province (No. 2000-26).
文摘Some experimental data recorded from impact tests on empty and water-filled pressurized mild steel pipes are presented. The pipes were supported as a three-span continuous beam and impacted laterally by a rigid indenter at the mid-span of middle span. Three kinds of indenter nose shapes were used: blunt-nose, hemisphere-nose and 90?conical-nose. The internal pressure ranged up to 20 MPa. The perforation failure modes and corresponding critical impact energies were obtained under different test conditions. The time-history curves of the internal pressure and impact force were given. The experiments show that the media filled in the tube greatly decreased the ballistic limit energy.
文摘The optimization of the acoustic silencer volume is very important to develop it and to get high-performance,the importance of the silencer was appeared in industrial field to eliminate the noise of the duct by efficient and economical method.The main goal of this research is to optimize the transmission loss(TL)by analytical method of the Double-Chamber Silencer(DCS),the TL has been selected as the main parameter in silencer because it does not based on the source or the termination impedances.First we calculated the power transmission coefficient(PTC)and the TL of an acoustic silencer,then used the Lagrange method to optimize the silencer length.All calculation of silencer data is obtained by solving the governing equations in commercial software Matlab®.A several calculations for different silencer length at many frequency ranges were performed simultaneously.Finally,this research supports the efficient and rapid techniques for DCS optimal design under narrow space.The results show that the acoustic TL is maximized at the desired frequency.
基金the framework of a faculty research project under the code of Ethics Committee of IR.QUMS.REC.1396.163.We also thank Mehrdad Keshavarz Siahposh and Mohammad Soleiman Abady for their technical assistance in all our experimental work.
文摘Acoustic performance of dissipative silencer was evaluated to determine the effectiveness of perforated duct porosity and absorbent material density in reducing occupational noise exposure propagated from centrifugal fan.Design charts were applied to predict noise reduction and length of a dissipative silencer.Dissipative silencers with various punched duct porosity(14%,30%and 40%)and sound absorbent density(80 Kg/m^(3),120 Kg/m^(3),and 140 Kg/m^(3))were designed and fabricated.According to ISO9612 and ISO11820,noise level was measured before and after installing all nine test silencers at fixed workstations around the discharge side of a centrifugal fan in a manufacturing plant.On average,the noise level at the discharge side of a fan without silencer was measured to be 93.6 dBA,whereas it was significantly mitigated by 67.4 dBA to 70.1 dBA after installing all silencers.Dynamic insertion loss for a dissipative silencer with 100 cm length was predicted to be 27.9 dB,which was in agreement with experimental ones.Although,there was no significant differences between insertion loss of silencers,the one with 30%porosity and 120 Kg/m^(3)rock wool density had the highest insertion loss of 26.2 dBA.Dissipative silencers noticeably reduced centrifugal fan noise exposures.Increasing sound absorbent density and duct porosity up to a certain limit could probably be effective in noise reduction of dissipative silencers.
文摘The contribution moves from highlighting how,in the context of Michel Serres’and posthumanism’s proposal of rethinking the human and the world in a perspective of inter-implication and universal co-belonging,silence(of the human word)assumes the function of a catalyst for the recognition/re-aestheticization of the human body in its sensory-aesthetic-cognitive-relational-hybrid dimensionality,and,with and for it,of the world in its agency(including artistic).Within the framework of this perspective,the investigation thus proposes a reading of art as a relation/catalyzer of relations,that is,as a(re)activation of positive relations of the human with and for a world that reveals itself to be increasingly hyper-complex,that is,more-than-human,in the continuity/inseparability of nature and culture.Taking Serresian ideas on artistic practices as non(only)human forms of expression and posthumanist“isomorphic”positions on non-human agency as tools,the research then highlights the“more-than-human”scope of art and the fact that artistic practices are responsive actions.So much so that,the human being emerges as co-agent and,of course,co-owner.
文摘目的了解3所三级甲等综合医院护士组织沉默现状,探讨其影响因素。方法采用便利抽样法,2023年4月—8月采用一般资料调查表、护士组织沉默问卷、医院磁性要素量表(the essential of magnetism scale,EMO)对西安市3所三级甲等综合医院的874临床护士进行调查,并采用多重线性回归分析其组织沉默的影响因素。结果共855名护士完成研究。护士组织沉默总分(56.33±8.55)分;医院磁性水平总分(107.63±12.85)分。护士组织沉默与医院磁性水平呈负相关(r=-0.318,P<0.010)。医院磁性水平、年龄、职称、护龄是护士组织沉默的影响因素(均P<0.001),共同解释其62.60%的变异。结论护士组织沉默与医院磁性水平处于中等偏低水平。护士年龄小、职称低、护龄短、医院磁性水平低,其组织沉默水平较高,护理管理者可通过提高医院磁性水平来减少护士的组织沉默。