Diabetic wounds are a difficult medical challenge.Excessive secretion of matrix metalloproteinase-9(MMP-9)in diabetic wounds further degrades the extracellular matrix and growth factors and causes severe vascular dama...Diabetic wounds are a difficult medical challenge.Excessive secretion of matrix metalloproteinase-9(MMP-9)in diabetic wounds further degrades the extracellular matrix and growth factors and causes severe vascular damage,which seriously hinders diabetic wound healing.To solve these issues,a double-network porous hydrogel composed of poly(methyl methacrylate-co-acrylamide)(p(MMA-co-AM))and polyvinyl alcohol(PVA)was constructed by the high internal phase emulsion(HIPE)technique for the delivery of potassium sucrose octasulfate(PSO),a drug that can inhibit MMPs,increase angiogenesis and improve microcirculation.The hydrogel possessed a typical polyHIPE hierarchical microstructure with interconnected porous morphologies,high porosity,high specific surface area,excellent mechanical properties and suitable swelling properties.Meanwhile,the p(MMA-co-AM)/PVA@PSO hydrogel showed high drug-loading performance and effective PSO release.In addition,both in vitro and in vivo studies showed that the p(MMA-co-AM)/PVA@PSO hydrogel had good biocompatibility and significantly accelerated diabetic wound healing by inhibiting excessive MMP-9 in diabetic wounds,increasing growth factor secretion,improving vascularization,increasing collagen deposition and promoting re-epithelialization.Therefore,this study provided a reliable therapeutic strategy for diabetic wound healing,some theoretical basis and new insights for the rational design and preparation of wound hydrogel dressings with high porosity,high drug-loading performance and excellent mechanical properties.展开更多
As promising engineering materials for green and sustainable processes, porous metalorganic framework(MOF)-polymer composites show great potential in applications, including adsorption, separation, catalysis, and bioe...As promising engineering materials for green and sustainable processes, porous metalorganic framework(MOF)-polymer composites show great potential in applications, including adsorption, separation, catalysis, and bioengineering. Owing to the mild and scalable operation, porous polymeric materials derived from high internal phase emulsion templates(polyHIPE) have received great interests in recent decades. In this contribution, research progress of the preparation of porous MOF@polyHIPE composites and their applications are reviewed, highlighting how can MOF particles be shaped by HIPE templates, in particular the polymerizable ones. Four different emulsion templates stabilized by MOFs and the applications of corresponding MOF@polyHIPE are included. Hopefully,both the state-of-art and future directions present herein can give rise to the development of highperformance porous MOF@polyHIPEs.展开更多
High internal phase emulsions (HIPEs) stabilized by nanoparticles based on biomacromolecules are challenging issues in recent decade.Herein,a newly developed HIPE was investigated by using heat-denatured porcine plasm...High internal phase emulsions (HIPEs) stabilized by nanoparticles based on biomacromolecules are challenging issues in recent decade.Herein,a newly developed HIPE was investigated by using heat-denatured porcine plasma protein (PPP) nanoparticles at pH 6.5 as emulsifier,and its emulsifying stability could be significantly enhanced by compounding carrageenan (CG).In the miscible system,PPP and CG formed hybrid particles through non-covalent interaction,and the sizes and zeta-potentials of the particles increased significantly along with addition of CG (from 0 to 0.7%,w/v),reached up to about 3.6 μm and −53 mV at 0.5% (w/v),respectively.CG weakened the ability of PPP to lower interfacial tension of oil/water (O/W),but increased the apparent viscosity of the system.The results from CLSM,rheology and stability experiments indicated a significant increasing trend of the HIPEs stability and solid-like characteristics along with addition of CG.Compared with the controls including bovine serum albumin (BSA),BSA-CG and CG alone,PPP-CG hybrid particles had good performance in fabricating and stabilizing the HIPEs.The work revealed the novel function of PPP as emulsifier of HIPEs and so offered the theoretical direction for application of PPP as a mass by-product,as well as an excellent HIPEs system for food,medicine and cosmetics fields.展开更多
Interfacial solar steam generation holds great promise in water desalination thanks to its high energy efficiency by heating only the top layer of water for evaporation.While three‐dimensional(3D)evaporators have bee...Interfacial solar steam generation holds great promise in water desalination thanks to its high energy efficiency by heating only the top layer of water for evaporation.While three‐dimensional(3D)evaporators have been proven to increase the evaporation rate by harnessing the energy from the surroundings,further development is still required in terms of convenient fabrication with potential scalability.Herein,we propose to overcome this challenge by using a high internal phase emulsion(HIPE)to template the synthesis of 3D hierarchically porous evaporators.The HIPE‐templated synthesis combined with a molding process can efficiently fabricate the desired 3D shape without wasting any materials and generate a hierarchically porous internal structure for continuous water supply.Engineering the overall shape and internal pores produces a 3D evaporator that can suppress conduction heat loss and efficiently collect thermal energy from its surroundings,boosting the evaporation rate to 2.82 kg/(m2 h)under 1‐sun illumination,which is significantly higher than conventional 2D evaporators.HIPE‐templating synthesis is an easy but effective way to produce various porous polymers,promising for a wide range of applications where easy production,excellent shape control,and potential scalability are critical.展开更多
Flexible shape-memory polymers were synthesized by Pickering high internal phase emulsion(HIPE)polymerization and used to adsorb and separate tetrodotoxin(TTX)from an aqueous solution.SiO_(2)nanoparticles were used to...Flexible shape-memory polymers were synthesized by Pickering high internal phase emulsion(HIPE)polymerization and used to adsorb and separate tetrodotoxin(TTX)from an aqueous solution.SiO_(2)nanoparticles were used to stabilize the Pickering oil-in-water(O/W)HIPEs.We introduced imidazolium-modified bromobutyl rubber(IBR)with excellent mechanical properties and high viscosity into the emulsion system as the shape-memory monomer.The properties,such as shape memory and morphology,were characterized by various methods,and batches of static adsorption experiments were conducted to analyze the adsorption performance of SiO_(2)@IBR on TTX.The characterization revealed that the SiO_(2)@IBR had a porous structure and good shape memory.Thus,the combination of SiO_(2)particles and IBR prevented shedding of SiO_(2)and enhanced the mechanical and adsorption properties of SiO_(2)@IBR.The results of the adsorption experiments indicated that the SiO_(2)@IBR had good adsorption of TTX.Both the Langmuir and Freundlich models fitted the isothermal adsorption experiment process.The TTX adsorption capacity of SiO_(2)@IBR was about 290.44 mg/g at 308 K.The fitting results of the pseudo-first-order and pseudosecond-order kinetic models showed that the adsorption process involved both chemical bonding and physical adsorption.After 10 adsorption and desorption experiments,the adsorption capacity of SiO_(2)@IBR decreased less than 0.03%,indicating that it had good adsorption and regeneration performance.展开更多
Polymerized high internal phase emulsion(polyHIPE)monoliths were prepared and applied as adsorbent materials for solid-phase extraction(SPE)of malachite green(MG)and leucomalachite green(LMG)from water samples.The pol...Polymerized high internal phase emulsion(polyHIPE)monoliths were prepared and applied as adsorbent materials for solid-phase extraction(SPE)of malachite green(MG)and leucomalachite green(LMG)from water samples.The polyHIPE monoliths were prepared by post-functionalization of monolithic surface with 6-aminocaproic acid(ACA)via ring opening reaction of epoxy groups in glycidyl methacrylate(GMA)-based polyHIPEs,and then applied to the preconcentration and determination of trace MG and LMG in environmental water samples by combing with high-performance liquid chromatog-raphy(HPLC).Taking MG and LMG as targets,main factors affecting SPE performance of the polyHIPE monoliths were investigated.Under the optimized conditions,the ACA-functionalized polyHIPE monoliths could effectively preconcentrate MG and LMG from 150 mL of water samples,and the recoveries of MG and LMG at three spiked levels were ranged from 84.8 to 97.4%with the relative standard deviations(RSDs)lower than 6%.The proposed method exhibited good linearity in the range of 2-200 ng mL^(-1),with low limits of detection of 17.0 and 8.7 pg mL^(-1)for MG and LMG,respectively.In addi-tion,the prepared ACA-modified polyHIPE monolith showed good durability and stability,and it could be reused for 200 cycles without obvious losing the extraction performance.展开更多
基金supported by the National Key Research and Development Program of China(2022YFB4601402)the National Natural Science Foundation of China(32201109,51772233,82072446)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(2022B1515120052,2021A1515110557)the Key Basic Research Program of Shenzhen(JCYJ20200109150218836)the Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory(HJL202202A002)the Trauma Microsurgery Clinical Medical Research Center of Hubei Province and the Health Commission of Hubei Province Medical Leading Talent Project(LJ20200405).
文摘Diabetic wounds are a difficult medical challenge.Excessive secretion of matrix metalloproteinase-9(MMP-9)in diabetic wounds further degrades the extracellular matrix and growth factors and causes severe vascular damage,which seriously hinders diabetic wound healing.To solve these issues,a double-network porous hydrogel composed of poly(methyl methacrylate-co-acrylamide)(p(MMA-co-AM))and polyvinyl alcohol(PVA)was constructed by the high internal phase emulsion(HIPE)technique for the delivery of potassium sucrose octasulfate(PSO),a drug that can inhibit MMPs,increase angiogenesis and improve microcirculation.The hydrogel possessed a typical polyHIPE hierarchical microstructure with interconnected porous morphologies,high porosity,high specific surface area,excellent mechanical properties and suitable swelling properties.Meanwhile,the p(MMA-co-AM)/PVA@PSO hydrogel showed high drug-loading performance and effective PSO release.In addition,both in vitro and in vivo studies showed that the p(MMA-co-AM)/PVA@PSO hydrogel had good biocompatibility and significantly accelerated diabetic wound healing by inhibiting excessive MMP-9 in diabetic wounds,increasing growth factor secretion,improving vascularization,increasing collagen deposition and promoting re-epithelialization.Therefore,this study provided a reliable therapeutic strategy for diabetic wound healing,some theoretical basis and new insights for the rational design and preparation of wound hydrogel dressings with high porosity,high drug-loading performance and excellent mechanical properties.
基金supported by the National Natural Science Foundation of China (21808140, 21978089)Shanghai Rising-Star Program (22QA1402800)the Fundamental Research Funds for the Central Universities
文摘As promising engineering materials for green and sustainable processes, porous metalorganic framework(MOF)-polymer composites show great potential in applications, including adsorption, separation, catalysis, and bioengineering. Owing to the mild and scalable operation, porous polymeric materials derived from high internal phase emulsion templates(polyHIPE) have received great interests in recent decades. In this contribution, research progress of the preparation of porous MOF@polyHIPE composites and their applications are reviewed, highlighting how can MOF particles be shaped by HIPE templates, in particular the polymerizable ones. Four different emulsion templates stabilized by MOFs and the applications of corresponding MOF@polyHIPE are included. Hopefully,both the state-of-art and future directions present herein can give rise to the development of highperformance porous MOF@polyHIPEs.
基金supported by the National Natural Science Foundation of China(31371741).
文摘High internal phase emulsions (HIPEs) stabilized by nanoparticles based on biomacromolecules are challenging issues in recent decade.Herein,a newly developed HIPE was investigated by using heat-denatured porcine plasma protein (PPP) nanoparticles at pH 6.5 as emulsifier,and its emulsifying stability could be significantly enhanced by compounding carrageenan (CG).In the miscible system,PPP and CG formed hybrid particles through non-covalent interaction,and the sizes and zeta-potentials of the particles increased significantly along with addition of CG (from 0 to 0.7%,w/v),reached up to about 3.6 μm and −53 mV at 0.5% (w/v),respectively.CG weakened the ability of PPP to lower interfacial tension of oil/water (O/W),but increased the apparent viscosity of the system.The results from CLSM,rheology and stability experiments indicated a significant increasing trend of the HIPEs stability and solid-like characteristics along with addition of CG.Compared with the controls including bovine serum albumin (BSA),BSA-CG and CG alone,PPP-CG hybrid particles had good performance in fabricating and stabilizing the HIPEs.The work revealed the novel function of PPP as emulsifier of HIPEs and so offered the theoretical direction for application of PPP as a mass by-product,as well as an excellent HIPEs system for food,medicine and cosmetics fields.
基金supported by the University of California Riverside and the Korea Institute of Materials Science through the UC‐KIMS Center for Innovation Materials for Energy and EnvironmentJinxing Chen acknowledges the support of the National Natural Science Foundation of China(Grant No.51901147)the Su‐Zhou Key Laboratory of Functional Nano and Soft Materials,Collaborative Innovation Center of Suzhou Nano Science and Technology,and the 111 Project.The authors also thank Ms.Jessica Lujia Yin and Mr.Zirui Zhou for their kind assistance.
文摘Interfacial solar steam generation holds great promise in water desalination thanks to its high energy efficiency by heating only the top layer of water for evaporation.While three‐dimensional(3D)evaporators have been proven to increase the evaporation rate by harnessing the energy from the surroundings,further development is still required in terms of convenient fabrication with potential scalability.Herein,we propose to overcome this challenge by using a high internal phase emulsion(HIPE)to template the synthesis of 3D hierarchically porous evaporators.The HIPE‐templated synthesis combined with a molding process can efficiently fabricate the desired 3D shape without wasting any materials and generate a hierarchically porous internal structure for continuous water supply.Engineering the overall shape and internal pores produces a 3D evaporator that can suppress conduction heat loss and efficiently collect thermal energy from its surroundings,boosting the evaporation rate to 2.82 kg/(m2 h)under 1‐sun illumination,which is significantly higher than conventional 2D evaporators.HIPE‐templating synthesis is an easy but effective way to produce various porous polymers,promising for a wide range of applications where easy production,excellent shape control,and potential scalability are critical.
基金Project supported by the National Natural Science Foundation of China(No.21878026)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX19_1798)+1 种基金the Jiangsu Province University Blue Projectthe Project of Higher Education Reform in Jiangsu Province(No.2019JSJG022),China。
文摘Flexible shape-memory polymers were synthesized by Pickering high internal phase emulsion(HIPE)polymerization and used to adsorb and separate tetrodotoxin(TTX)from an aqueous solution.SiO_(2)nanoparticles were used to stabilize the Pickering oil-in-water(O/W)HIPEs.We introduced imidazolium-modified bromobutyl rubber(IBR)with excellent mechanical properties and high viscosity into the emulsion system as the shape-memory monomer.The properties,such as shape memory and morphology,were characterized by various methods,and batches of static adsorption experiments were conducted to analyze the adsorption performance of SiO_(2)@IBR on TTX.The characterization revealed that the SiO_(2)@IBR had a porous structure and good shape memory.Thus,the combination of SiO_(2)particles and IBR prevented shedding of SiO_(2)and enhanced the mechanical and adsorption properties of SiO_(2)@IBR.The results of the adsorption experiments indicated that the SiO_(2)@IBR had good adsorption of TTX.Both the Langmuir and Freundlich models fitted the isothermal adsorption experiment process.The TTX adsorption capacity of SiO_(2)@IBR was about 290.44 mg/g at 308 K.The fitting results of the pseudo-first-order and pseudosecond-order kinetic models showed that the adsorption process involved both chemical bonding and physical adsorption.After 10 adsorption and desorption experiments,the adsorption capacity of SiO_(2)@IBR decreased less than 0.03%,indicating that it had good adsorption and regeneration performance.
基金supported by the National Natural Science Foundation of China(Grant No.21964006,and 21665006)the Natural Science Foundation from Hunan Province(No.2020JJ4640 and 2017JJ3342)+1 种基金the Natural Science Foundation from Guangxi Zhuang Autonomous Region(No.2018GXNSFAA138134)the Scientific Research Found of Changsha University(SF1934),respectively.
文摘Polymerized high internal phase emulsion(polyHIPE)monoliths were prepared and applied as adsorbent materials for solid-phase extraction(SPE)of malachite green(MG)and leucomalachite green(LMG)from water samples.The polyHIPE monoliths were prepared by post-functionalization of monolithic surface with 6-aminocaproic acid(ACA)via ring opening reaction of epoxy groups in glycidyl methacrylate(GMA)-based polyHIPEs,and then applied to the preconcentration and determination of trace MG and LMG in environmental water samples by combing with high-performance liquid chromatog-raphy(HPLC).Taking MG and LMG as targets,main factors affecting SPE performance of the polyHIPE monoliths were investigated.Under the optimized conditions,the ACA-functionalized polyHIPE monoliths could effectively preconcentrate MG and LMG from 150 mL of water samples,and the recoveries of MG and LMG at three spiked levels were ranged from 84.8 to 97.4%with the relative standard deviations(RSDs)lower than 6%.The proposed method exhibited good linearity in the range of 2-200 ng mL^(-1),with low limits of detection of 17.0 and 8.7 pg mL^(-1)for MG and LMG,respectively.In addi-tion,the prepared ACA-modified polyHIPE monolith showed good durability and stability,and it could be reused for 200 cycles without obvious losing the extraction performance.
