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血清sTWEAK、Netrin-1联合APACHEⅡ评分对重型颅脑损伤患者术后预后不良的预测价值
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作者 沈晨 施巍 +2 位作者 张元杰 杨治荣 程华怡 《国际检验医学杂志》 CAS 2024年第4期404-409,415,共7页
目的探讨血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、神经轴突导向因子-1(Netrin-1)联合急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分对重型颅脑损伤患者术后预后不良的预测价值。方法选取2020年6月至2022年6月该院收治的... 目的探讨血清可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)、神经轴突导向因子-1(Netrin-1)联合急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分对重型颅脑损伤患者术后预后不良的预测价值。方法选取2020年6月至2022年6月该院收治的120例重型颅脑损伤患者,根据术后30 d预后情况分为预后良好组和预后不良组。对比两组血清sTWEAK、Netrin-1水平及APACHEⅡ评分。采用单因素和多因素Logistic回归分析重型颅脑损伤患者术后预后不良的影响因素,并据以构建血清sTWEAK、Netrin-1及APACHEⅡ评分联合应用的预测模型,受试者工作特征(ROC)曲线分析血清sTWEAK、Netrin-1水平及APACHEⅡ评分对重型颅脑损伤患者术后预后不良的预测价值。结果预后不良组的重症监护室居住时间长于预后良好组,白蛋白水平、入院时格拉斯哥昏迷评分法评分和血清Netrin-1水平低于预后良好组,多发脑挫裂伤占比、机械通气占比、入院时APACHEⅡ评分和血清sTWEAK、血清肌酐、血尿素氮水平均高于预后良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,多发脑挫裂伤、Netrin-1水平降低、入院时APACHEⅡ评分升高、sTWEAK水平升高为重型颅脑损伤患者术后预后不良的危险因素(P<0.05)。ROC曲线分析结果显示,血清sTWEAK、Netrin-1及APACHEⅡ评分3个指标单独及联合应用时曲线下面积及其95%CI分别为0.742(0.552~0.925)、0.731(0.488~0.963)、0.714(0.502~0.911)、0.882(0.795~0.947)。结论血清sTWEAK、Netrin-1联合APACHEⅡ评分对重型颅脑损伤患者术后预后不良具有较好的预测价值,可为临床治疗方案的制订提供参考。 展开更多
关键词 重型颅脑损伤 可溶性肿瘤坏死因子样凋亡弱诱导因子 神经轴突导向因子-1 急性生理学与慢性健康状况评分系统Ⅱ 预后
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自发性急性脑出血患者血浆sCD163/sTWEAK比值与预后的关系
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作者 张文超 杨雪辉 +2 位作者 尹涛 王睿健 张盟盟 《天津医药》 CAS 2024年第3期297-301,共5页
目的探究自发性急性脑出血(ACH)患者血浆可溶性CD163(sCD163)/可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)比值与预后的关系。方法纳入ACH患者90例作为病例组,根据格拉斯哥预后评分将病例组分为预后不良组(38例)和预后良好组(52例);另... 目的探究自发性急性脑出血(ACH)患者血浆可溶性CD163(sCD163)/可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)比值与预后的关系。方法纳入ACH患者90例作为病例组,根据格拉斯哥预后评分将病例组分为预后不良组(38例)和预后良好组(52例);另选取同期体检健康者45例为对照组。酶联免疫吸附试验检测血浆sCD163、sTWEAK水平并计算sCD163/sTWEAK比值。分析血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值与临床资料的相关性;Logistic回归分析ACH患者预后不良的影响因素;受试者工作特征(ROC)曲线分析sCD163/sTWEAK比值对ACH患者预后不良的预测价值。结果病例组血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值均显著高于对照组;预后良好组上述指标均低于预后不良组(P<0.05)。预后良好组血肿体积、美国国立卫生研究院卒中量表(NIHSS)评分、高血压及幕下出血比例均低于预后不良组,低密度脂蛋白胆固醇(LDL-C)高于预后不良组(P<0.05)。相关性分析表明,血浆sCD163、sTWEAK水平及sCD163/sTWEAK比值与出血部位、血肿体积、NIHSS评分、白细胞计数、血小板计数、中性粒细胞/淋巴细胞比值(NLR)呈正相关(P<0.05)。Logistic回归分析显示,sCD163/sTWEAK比值、出血部位、血肿体积、NIHSS评分为ACH患者预后不良的影响因素(P<0.05)。ROC曲线结果表明,sCD163/sTWEAK比值评估ACH患者预后不良的AUC为0.850,敏感度和特异度分别为86.84%和69.23%。结论sCD163/sTWEAK比值在ACH患者血浆中水平较高,并与预后不良有关,该值对此类患者的预后有一定预测价值。 展开更多
关键词 脑出血 细胞因子Tweak 预后 可溶性血红蛋白清道夫受体163蛋白 可溶性肿瘤坏死因子样凋亡弱诱导因子
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注意缺陷多动障碍患儿血清ACE2,TWEAK和CCL5水平检测及诊断价值研究
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作者 王立宁 史亚楠 李宝广 《现代检验医学杂志》 CAS 2024年第5期152-156,167,共6页
目的 探究血清血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2),细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)和CC趋化因子配体5(CC motif chemokine ligand 5,CC... 目的 探究血清血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2),细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)和CC趋化因子配体5(CC motif chemokine ligand 5,CCL5)水平在注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿诊断、病情严重程度评估中的价值。方法 选取2022年10月~2023年10月在河北省儿童医院就诊的125例ADHD患儿记为ADHD组,另选105例在河北省妇幼保健中心体检的健康儿童为对照组,根据临床总体印象严重程度量表(CGI-S)将患儿分为轻中度组(n=83)和重度组(n=42)。ELISA方法检测血清ACE2,TWEAK,CCL5,促黄体生成素(LH)和催乳素(PRL)水平,联合型瑞文测验(CRT)和Conners父母症状问卷(PSQ)对患儿认知和行为状况进行评分。Spearman相关性分析重度组血清ACE2,TWEAK,CCL5与CGI-S,CRT,PSQ评分的相关性;受试者工作特征(ROC)曲线分析ACE2,TWEAK,CCL5对ADHD及严重程度的诊断价值。结果 ADHD患儿血清ACE2(284.35±92.34 pg/ml),TWEAK(2.56±0.76 pg/ml)水平低于对照组(379.23±106.28 pg/ml,3.52±1.12 pg/ml),CCL5水平(7.36±2.37ng/ml)高于对照组(5.24±1.63 ng/ml),差异具有统计学意义(t=7.244,7.703,7.753,均P<0.05);重度组患儿CRT,血清ACE2,TWEAK水平低于轻中度组(t=5.318,6.686,6.490),而PSQ,CCL5水平较高于轻中度组(t=5.220,6.134),差异具有统计学意义(均P<0.05);Spearman相关性分析结果显示,重度组患儿血清ACE2,TWEAK水平与CGI-S,PSQ评分负相关(r=-0.432,-0.453;-0.421,-0.426,均P<0.001),与CRT评分呈正相关(r=0.427,0.418,均P<0.001);CCL5与CGI-S,PSQ评分呈正相关(r=0.421,0.433,均P<0.001),与CRT评分呈负相关(r=-0.446,P<0.001)。血清ACE2,TWEAK和CCL5诊断ADHD发生的AUC分别为0.814,0.803和0.807,三者联合诊断的AUC为0.945,优于各自单独诊断(Z=5.439,4.258,5.576,均P<0.001);血清ACE2,TWEAK,CCL5诊断重度ADHD的AUC分别为0.853,0.796和0.805,三者联合诊断的AUC为0.930,优于各自单独诊断(Z=2.604,3.851,3.567,均P<0.001)。结论 血清ACE2,TWEAK在ADHD患儿血清中低表达,而CCL5高表达,三者表达水平具有相关性,并且诊断ADHD发生和严重程度具有较高的价值。 展开更多
关键词 注意缺陷多动障碍 血管紧张素转换酶2 细胞因子肿瘤坏死因子样细胞凋亡弱诱导因子 CC趋化因子配体5
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Significant risk factors for intensive care unit-acquired weakness:A processing strategy based on repeated machine learning 被引量:9
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作者 Ling Wang Deng-Yan Long 《World Journal of Clinical Cases》 SCIE 2024年第7期1235-1242,共8页
BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective pr... BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective preventive measures.AIM To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment.METHODS Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission.Relevant data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were gathered.The relationships between these variables and ICU-AW were examined.Utilizing iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic curve.RESULTS Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW group.Additionally,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical significance.The most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechanical ventilation duration. 展开更多
关键词 Intensive care unit-acquired weakness Risk factors Machine learning PREVENTION Strategies
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A robust & weak-nucleophilicity electrocatalyst with an inert response for chlorine ion oxidation in large-current seawater electrolysis 被引量:1
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作者 Junting Dong Chang Yu +5 位作者 Hui Wang Lin Chen Hongling Huang Yingnan Han Qianbing Wei Jieshan Qiu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第3期486-495,I0011,共11页
Seawater splitting into hydrogen,a promising technology,is seriously limited by the durability and tolerance of electrocatalysts for chlorine ions in seawater at large current densities due to chloride oxidation and c... Seawater splitting into hydrogen,a promising technology,is seriously limited by the durability and tolerance of electrocatalysts for chlorine ions in seawater at large current densities due to chloride oxidation and corrosion.Here,we present a robust and weak-nucleophilicity nickel-iron hydroxide electrocatalyst with excellent selectivity for oxygen evolution and an inert response for chlorine ion oxidation which are key and highly desired for efficient seawater electrolysis.Such a weak-nucleophilicity electrocatalyst can well match with strong-nucleophilicity OH-compared with the weak-nucleophilicity Cl^(-),resultantly,the oxidation of OH-in electrolyte can be more easily achieved relative to chlorine ion oxidation,confirmed by ethylenediaminetetraacetic acid disodium probing test.Further,no strongly corrosive hypochlorite is produced when the operating voltage reaches about 2.1 V vs.RHE,a potential that is far beyond the thermodynamic potential of chlorine ion oxidatio n.This concept and approach to reasonably designing weaknucleophilicity electrocatalysts that can greatly avoid chlorine ion oxidation under alkaline seawater environments can push forward the seawater electrolysis technology and also accelerate the development of green hydrogen technique. 展开更多
关键词 Nickel-iron hydroxide electrocatalysts Highly selective seawater electrolysis weak nucleophilicity Oxygen evolution reaction Hydrogen
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Ultrahigh-brightness 50 MeV electron beam generation from laser wakefield acceleration in a weakly nonlinear regime
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作者 Zhongtao Xiang Changhai Yu +8 位作者 Zhiyong Qin Xuhui Jiao Jiahui Cheng Qiaoxuan Zhou Gatie Axi Jianghua Jie Ya Huang Jintan Cai Jiansheng Liu 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第3期4-10,共7页
We propose an efficient scheme to produce ultrahigh-brightness tens of MeV electron beams by designing a density-tailored plasma to induce a wakefield in the weakly nonlinear regime with a moderate laser energy of 120... We propose an efficient scheme to produce ultrahigh-brightness tens of MeV electron beams by designing a density-tailored plasma to induce a wakefield in the weakly nonlinear regime with a moderate laser energy of 120 mJ.In this scheme,the second bucket of the wakefield can have a much lower phase velocity at the steep plasma density down-ramp than the first bucket and can be exploited to implement longitudinal electron injection at a lower laser intensity,leading to the generation of bright electron beams with ultralow emittance together with low energy spread.Three-dimensional particle-in-cell simulations are carried out and demonstrate that high-quality electron beams with a peak energy of 50 MeV,ultralow emittance of28 nm rad,energy spread of 1%,charge of 4.4 pC,and short duration less than 5 fs can be obtained within a 1-mm-long tailored plasma density,resulting in an ultrahigh six-dimensional brightness B6D,n of2×1017 A/m2/0.1%.By changing the density parameters,tunable bright electron beams with peak energies ranging from 5 to 70 MeV,a small emittance of B0.1 mm mrad,and a low energy spread at a few-percent level can be obtained.These bright MeV-class electron beams have a variety of potential applications,for example,as ultrafast electron probes for diffraction and imaging,in laboratory astrophysics,in coherent radiation source generation,and as injectors for GeV particle accelerators. 展开更多
关键词 weakLY nonlinear ACCELERATION
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Measuring small longitudinal phase shifts via weak measurement amplification
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作者 徐凯 胡晓敏 +7 位作者 胡孟军 王宁宁 张超 黄运锋 柳必恒 李传锋 郭光灿 张永生 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期105-111,共7页
Weak measurement amplification,which is considered as a very promising scheme in precision measurement,has been applied to various small physical quantities estimations.Since many physical quantities can be converted ... Weak measurement amplification,which is considered as a very promising scheme in precision measurement,has been applied to various small physical quantities estimations.Since many physical quantities can be converted into phase signals,it is interesting and important to consider measuring small longitudinal phase shifts by using weak measurement.Here,we propose and experimentally demonstrate a novel weak measurement amplification-based small longitudinal phase estimation,which is suitable for polarization interferometry.We realize one order of magnitude amplification measurement of a small phase signal directly introduced by a liquid crystal variable retarder and show that it is robust to the imperfection of interference.Besides,we analyze the effect of magnification error which is never considered in the previous works,and find the constraint on the magnification.Our results may find important applications in high-precision measurements,e.g.,gravitational wave detection. 展开更多
关键词 weak measurement phase estimation quantum optics
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GLOBAL WEAK SOLUTIONS FOR AN ATTRACTION-REPULSION CHEMOTAXIS SYSTEM WITH p-LAPLACIAN DIFFUSION AND LOGISTIC SOURCE
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作者 王晓闪 王忠谦 贾哲 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期909-924,共16页
This paper is concerned with the following attraction-repulsion chemotaxis system with p-Laplacian diffusion and logistic source:■The system here is under a homogenous Neumann boundary condition in a bounded domainΩ... This paper is concerned with the following attraction-repulsion chemotaxis system with p-Laplacian diffusion and logistic source:■The system here is under a homogenous Neumann boundary condition in a bounded domainΩ ■ R^(n)(n≥2),with χ,ξ,α,β,γ,δ,k_(1),k_(2)> 0,p> 2.In addition,the function f is smooth and satisfies that f(s)≤κ-μs~l for all s≥0,with κ ∈ R,μ> 0,l> 1.It is shown that(ⅰ)if l> max{2k_(1),(2k_(1)n)/(2+n)+1/(p-1)},then system possesses a global bounded weak solution and(ⅱ)if k_(2)> max{2k_(1)-1,(2k_(1)n)/(2+n)+(2-p)/(p-1)} with l> 2,then system possesses a global bounded weak solution. 展开更多
关键词 global weak solutions attraction-repulsion P-LAPLACIAN logistic source
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Local saliency consistency-based label inference for weakly supervised salient object detection using scribble annotations
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作者 Shuo Zhao Peng Cui +1 位作者 Jing Shen Haibo Liu 《CAAI Transactions on Intelligence Technology》 SCIE EI 2024年第1期239-249,共11页
Recently,weak supervision has received growing attention in the field of salient object detection due to the convenience of labelling.However,there is a large performance gap between weakly supervised and fully superv... Recently,weak supervision has received growing attention in the field of salient object detection due to the convenience of labelling.However,there is a large performance gap between weakly supervised and fully supervised salient object detectors because the scribble annotation can only provide very limited foreground/background information.Therefore,an intuitive idea is to infer annotations that cover more complete object and background regions for training.To this end,a label inference strategy is proposed based on the assumption that pixels with similar colours and close positions should have consistent labels.Specifically,k-means clustering algorithm was first performed on both colours and coordinates of original annotations,and then assigned the same labels to points having similar colours with colour cluster centres and near coordinate cluster centres.Next,the same annotations for pixels with similar colours within each kernel neighbourhood was set further.Extensive experiments on six benchmarks demonstrate that our method can significantly improve the performance and achieve the state-of-the-art results. 展开更多
关键词 label inference salient object detection weak supervision
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ENERGY CONSERVATION FOR THE WEAK SOLUTIONS TO THE 3D COMPRESSIBLE NEMATIC LIQUID CRYSTAL FLOW
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作者 谭忠 李心亮 杨惠 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期851-864,共14页
In this paper,we establish some regularity conditions on the density and velocity fields to guarantee the energy conservation of the weak solutions for the three-dimensional compressible nematic liquid crystal flow in... In this paper,we establish some regularity conditions on the density and velocity fields to guarantee the energy conservation of the weak solutions for the three-dimensional compressible nematic liquid crystal flow in the periodic domain. 展开更多
关键词 compressible nematic liquid crystal flow weak solutions energy conservation
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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea
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作者 Shiyu Jia Cheng Wang +2 位作者 Wenlong Xu Dong Ma Fangfang Qi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期179-191,共13页
In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting conse... In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting consequences.To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual protection.Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged.The shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic characteristics.The overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness.For the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials.In this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are designed.Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance.Within the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively.The overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with higher areal density. 展开更多
关键词 Free-field explosion weak shock wave mitigation POLYUREA Polyurethane foam Multi-layered composites
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Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model
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作者 Sunny Kumar POGULURI Dongeun KIM Yoon Hyeok BAE 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期689-700,共12页
Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave conditions.These can potentia... Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave conditions.These can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow model.The model was initially validated by comparing it with published experimental and numerical computational fluid dynamics results.The current results were in good agreement with the published results.It was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular waves.Under irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately 0.8MWh.The findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions. 展开更多
关键词 asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow POWER
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IgA肾病伴新月体形成合并肾衰竭的治疗方案比较及肾组织TWEAK的表达差异
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作者 杨志英 王晓丹 +3 位作者 芮章茹 李文宏 代留玲 陈浩 《中国中西医结合肾病杂志》 2024年第8期683-687,I0004,共6页
目的:探讨糖皮质激素联合环磷酰胺的不同治疗方案对IgA肾病伴新月体形成合并肾衰竭患者的疗效和安全性及肾组织肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)的表达差异。方法:将收治于我院的59位IgA肾病伴有新月体形成的肾衰竭患者根据治疗方... 目的:探讨糖皮质激素联合环磷酰胺的不同治疗方案对IgA肾病伴新月体形成合并肾衰竭患者的疗效和安全性及肾组织肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)的表达差异。方法:将收治于我院的59位IgA肾病伴有新月体形成的肾衰竭患者根据治疗方案的不同纳入以下4组:对照组、糖皮质激素(G)组、G+环磷酰胺(C)组和G冲击+C组,观察24周各组的疗效和安全性。此外,免疫组织化学染色观察TWEAK在肾组织中的表达和分析其与临床指标的相关性。结果:G组、G+C组和G冲击+C组治疗后的24 h尿蛋白定量、血肌酐、eGFR水平均优于对照组(P<0.05)。对临床疗效进行比较,发现G组(47.06%)、G+C组(50.00%)和G冲击+C组(58.33%)总有效率均高于对照组(7.14%),差异具有统计学意义(P<0.05)。对药物安全性进行比较,3个治疗组不良反应发生率差异无统计学意义(P>0.05)。免疫组织化学分析结果显示总体有效组TWEAK表达和分布均低于无效组(P<0.05)。且TWEAK的表达量与尿红细胞数无明显相关性(P>0.05),但与尿蛋白定量、血肌酐存在正相关(P<0.05),与eGFR存在负相关(P<0.05)。结论:单用半量糖皮质激素的治疗方案是IgA肾病伴新月体形成合并肾衰竭安全有效的方案,且临床应用更具优势,并且我们发现IgA肾病患者肾组织中TWEAK的表达可能与更差的肾脏预后相关。 展开更多
关键词 IGA肾病 新月体形成 肾衰竭 糖皮质激素 环磷酰胺 肿瘤坏死因子样凋亡微弱诱导剂
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Weakly Supervised Network with Scribble-Supervised and Edge-Mask for Road Extraction from High-Resolution Remote Sensing Images
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作者 Supeng Yu Fen Huang Chengcheng Fan 《Computers, Materials & Continua》 SCIE EI 2024年第4期549-562,共14页
Significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous human... Significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous humaneffort to label the image. Within this field, other research endeavors utilize weakly supervised methods. Theseapproaches aim to reduce the expenses associated with annotation by leveraging sparsely annotated data, such asscribbles. This paper presents a novel technique called a weakly supervised network using scribble-supervised andedge-mask (WSSE-net). This network is a three-branch network architecture, whereby each branch is equippedwith a distinct decoder module dedicated to road extraction tasks. One of the branches is dedicated to generatingedge masks using edge detection algorithms and optimizing road edge details. The other two branches supervise themodel’s training by employing scribble labels and spreading scribble information throughout the image. To addressthe historical flaw that created pseudo-labels that are not updated with network training, we use mixup to blendprediction results dynamically and continually update new pseudo-labels to steer network training. Our solutiondemonstrates efficient operation by simultaneously considering both edge-mask aid and dynamic pseudo-labelsupport. The studies are conducted on three separate road datasets, which consist primarily of high-resolutionremote-sensing satellite photos and drone images. The experimental findings suggest that our methodologyperforms better than advanced scribble-supervised approaches and specific traditional fully supervised methods. 展开更多
关键词 Semantic segmentation road extraction weakly supervised learning scribble supervision remote sensing image
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Characterizations of m-weak group inverses
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作者 Zhou Yukun Chen Jianlong 《Journal of Southeast University(English Edition)》 EI CAS 2024年第3期313-318,共6页
To characterize m-weak group inverses,several algebraic methods are used,such as the use of idempotents,one-side principal ideals,and units.Consider an element a within a unitary ring that possesses Drazin invertibili... To characterize m-weak group inverses,several algebraic methods are used,such as the use of idempotents,one-side principal ideals,and units.Consider an element a within a unitary ring that possesses Drazin invertibility and an involution.This paper begins by outlining the conditions necessary for the existence of the m-weak group inverse of a.Moreover,it explores the criteria under which a can be considered pseudo core invertible and weak group invertible.In the context of a weak proper*-ring,it is proved that a is weak group invertible if,and only if,a D can serve as the weak group inverse of au,where u represents a specially invertible element closely associated with a D.The paper also introduces a counterexample to illustrate that a D cannot universally serve as the pseudo core inverse of another element.This distinction underscores the nuanced differences between pseudo core inverses and weak group inverses.Ultimately,the discussion expands to include the commuting properties of weak group inverses,extending these considerations to m-weak group inverses.Several new conditions on commuting properties of generalized inverses are given.These results show that pseudo core inverses,weak group inverses,and m-weak group inverses are not only closely linked but also have significant differences that set them apart. 展开更多
关键词 m-weak group inverse weak group inverse Drazin inverse commuting property
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Macro-micro behaviors and failure mechanism of frozen weakly cemented mudstone
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作者 Xianzhou Lyu Jijie Du +2 位作者 Hao Fu Dawei Lyu Weiming Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1337-1347,共11页
Understanding the mechanical properties and multiscale failure mechanism of frozen soft rock is an important prerequisite for the construction safety of tunnels,artificially frozen ground and other infrastructure in c... Understanding the mechanical properties and multiscale failure mechanism of frozen soft rock is an important prerequisite for the construction safety of tunnels,artificially frozen ground and other infrastructure in cold regions.In this study,the triaxial compression test are performed on mudstone in the weakly cemented soft rock strata in the mining area of western China,and the mechanical characteristics and failure mechanism of weakly cemented mudstone are systematically investigated under the combined action of freezing and loading.Furthermore,the quantitative relationship between the microstructural parameters and the macroscopic strength and deformation parameters is established based on fractal theory.Thus,the failure mechanism of frozen weakly cemented mudstone is revealed on both micro- and macro-scales.The results show that temperature and confining pressure significantly affects the elastic modulus and peak strength of weakly cemented mudstone.With decreasing temperature,the compressive strength increases,while the corresponding peak strain decreases gradually.On the deformation curve,the plastic deformation stage is shortened,and the brittle fracture feature at the post-peak stage is more prominent,and the elastic modulus correspondingly increases with decreasing temperature.Under low-temperature conditions,most of the weakly cemented mudstone undergoes microscopic shear failure along the main fracture surface.The micro-fracture morphology characteristics of weakly cemented mudstone under different temperatures are quantified via the fractal dimension,and an approximately exponential relationship can be obtained among the fractal dimension and the temperature,compressive strength and elastic modulus. 展开更多
关键词 weakly cemented mudstone Artificial freezing Mechanical properties Linkage destruction mechanism Fractal dimension
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Design of weak current measurement system and research on temperature impact
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作者 Chu-Xiang Zhao San-Gang Li +8 位作者 Rong-Rong Su Li Yang Ming-Zhe Liu Qing-Yue Xue Shan Liao Zhi Zhou Qing-Shan Tan Xian-Guo Tuo Yi Cheng 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第4期46-56,共11页
A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization chamber.This system incorporates a second-order low-pass filter circuit and the Kalman filterin... A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization chamber.This system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement results.Testing conducted under normal temperature conditions has demonstrated the system's high precision performance.However,it was observed that temperature variations can affect the measurement performance.Data were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this issue.The feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature correction.The research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents. 展开更多
关键词 weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model
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Oscillation of Dzyaloshinskii–Moriya interaction driven by weak electric fields
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作者 陈润泽 曹安妮 +3 位作者 王馨苒 柳洋 杨洪新 赵巍胜 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期487-491,共5页
Dzyaloshinskii–Moriya interaction(DMI) is under extensive investigation considering its crucial status in chiral magnetic orders, such as Néel-type domain wall(DW) and skyrmions. It has been reported that the in... Dzyaloshinskii–Moriya interaction(DMI) is under extensive investigation considering its crucial status in chiral magnetic orders, such as Néel-type domain wall(DW) and skyrmions. It has been reported that the interfacial DMI originating from Rashba spin–orbit coupling(SOC) can be linearly tuned with strong external electric fields. In this work, we experimentally demonstrate that the strength of DMI exhibits rapid fluctuations, ranging from 10% to 30% of its original value, as a function of applied electric fields in Pt/Co/MgO heterostructures within the small field regime(< 10-2V/nm). Brillouin light scattering(BLS) experiments have been performed to measure DMI, and first-principles calculations show agreement with this observation, which can be explained by the variation in orbital hybridization at the Co/MgO interface in response to the weak electric fields. Our results on voltage control of DMI(VCDMI) suggest that research related to the voltage control of magnetic anisotropy for spin–orbit torque or the motion control of skyrmions might also have to consider the role of the external electric field on DMI as small voltages are generally used for the magnetoresistance detection. 展开更多
关键词 Dzyaloshinskii-Moriya interaction weak electric field control effect Rashba spin-orbit coupling interfacial orbital hybridization
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Protected simultaneous quantum remote state preparation scheme by weak and reversal measurements in noisy environments
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作者 Mandal Manoj Kumar Choudhury Binayak S. Samanta Soumen 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期169-177,共9页
We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is know... We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform. 展开更多
关键词 multi-qubit entangled channel quantum remote state preparation noisy environments weak and reversal measurements
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Risk factors for intensive-care-unit-acquired weakness
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作者 Ming Liu Yu-Tong Chen +1 位作者 Guang-Liang Wang Xue-Mei Wu 《World Journal of Clinical Cases》 SCIE 2024年第21期4853-4855,共3页
Wang et al reported 1063 cases from the initial 14 d of intensive care unit(ICU)stay,and analyzed relevant data such as age,comorbidities,recent dosages,vapor pressure dosages,duration of mechanical ventilation,length... Wang et al reported 1063 cases from the initial 14 d of intensive care unit(ICU)stay,and analyzed relevant data such as age,comorbidities,recent dosages,vapor pressure dosages,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,which are closely related to ICU-acquired weakness(ICUAW).It is suggested that the length of ICU stay and the duration of mechanical ventilation are the main factors.ICU-AW is the most common neuromuscular injury in the ICU,which affects clinical progression and outcomes of patients.This manuscript helps to improve the early recognition of ICU-AW,thereby reducing mortality and improving prognosis. 展开更多
关键词 Risk factors Intensive care unit Acquired weakness Prognosis Neuromuscular injury
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