BACKGROUND:To investigate the eff ects of early standardized enteral nutrition(EN)on the crosssectional area of erector spine muscle(ESMcsa),plasma growth diff erentiation factor-15(GDF-15),and 28-day mortality of acu...BACKGROUND:To investigate the eff ects of early standardized enteral nutrition(EN)on the crosssectional area of erector spine muscle(ESMcsa),plasma growth diff erentiation factor-15(GDF-15),and 28-day mortality of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with invasive mechanical ventilation(MV).METHODS:A total of 97 AECOPD patients with invasive MV were screened in the ICUs of the First People's Hospital of Lianyungang.The conventional EN group(stage Ⅰ)and early standardized EN group(stage Ⅱ)included 46 and 51 patients,respectively.ESMcsa loss and GDF-15 levels on days 1 and 7 of ICU admission and 28-day survival rates were analyzed.RESULTS:On day 7,the ESMcsa of the early standardized EN group was significantly higher than that of the conventional EN group,while the plasma GDF-15 levels were significantly lower than those in the conventional EN group(ESMcsa:28.426±6.130 cm^(2) vs.25.205±6.127 cm^(2);GDF-15:1661.608±558.820 pg/mL vs.2541.000±634.845 pg/mL;all P<0.001).The 28-day survival rates of the patients in the early standardized EN group and conventional EN group were 80.40%and 73.90%,respectively(P=0.406).CONCLUSION:ESMcsa loss in AECOPD patients with MV was correlated with GDF-15 levels,both of which indicated acute muscular atrophy and skeletal muscle dysfunction.Early standardized EN may prevent acute muscle loss and intensive care unit-acquired weakness(ICU-AW)in AECOPD patients.展开更多
针对王坡煤矿复杂软弱煤层钻孔排渣难、成孔率低等难题,研究了高速螺旋复合钻进技术,并结合选用的ZDY6000LR型高转速坑道钻机性能特点,分别设计了φ110/63.5 mm、φ95/60.3mm及φ88/50 mm 3种不同规格螺旋钻杆及配套三翼锥形刮刀PDC钻头...针对王坡煤矿复杂软弱煤层钻孔排渣难、成孔率低等难题,研究了高速螺旋复合钻进技术,并结合选用的ZDY6000LR型高转速坑道钻机性能特点,分别设计了φ110/63.5 mm、φ95/60.3mm及φ88/50 mm 3种不同规格螺旋钻杆及配套三翼锥形刮刀PDC钻头;重点对不同钻具组合情况下,高速螺旋复合钻进的给进速度、钻杆转速及风量等关键参数进行研究,明确了钻进过程中参数范围。在王坡煤矿3206工作面完成的现场工业性试验表明:设计的3种组合钻强度高、刚度好,钻孔保直性较好,排渣效率高,钻杆及钻头使用寿命长;高速螺旋复合钻进技术及配套机具能够有效解决施工过程中存在的排渣难、喷孔顶钻等问题,提高了深孔钻进成孔率,百米以上钻孔成孔率超过70%,为矿井本煤层瓦斯抽采提供了重要支撑;采用φ95/60.3 mm螺旋钻杆及配套钻头成孔效果最优,平均孔深111.2 m,成孔率90.9%。展开更多
基金funded by the Social Development Project of Jiangsu Provincial Department of Science and Technology(BE2020670)the Social Development Project of Lianyungang Science and Technology(SF2117).
文摘BACKGROUND:To investigate the eff ects of early standardized enteral nutrition(EN)on the crosssectional area of erector spine muscle(ESMcsa),plasma growth diff erentiation factor-15(GDF-15),and 28-day mortality of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with invasive mechanical ventilation(MV).METHODS:A total of 97 AECOPD patients with invasive MV were screened in the ICUs of the First People's Hospital of Lianyungang.The conventional EN group(stage Ⅰ)and early standardized EN group(stage Ⅱ)included 46 and 51 patients,respectively.ESMcsa loss and GDF-15 levels on days 1 and 7 of ICU admission and 28-day survival rates were analyzed.RESULTS:On day 7,the ESMcsa of the early standardized EN group was significantly higher than that of the conventional EN group,while the plasma GDF-15 levels were significantly lower than those in the conventional EN group(ESMcsa:28.426±6.130 cm^(2) vs.25.205±6.127 cm^(2);GDF-15:1661.608±558.820 pg/mL vs.2541.000±634.845 pg/mL;all P<0.001).The 28-day survival rates of the patients in the early standardized EN group and conventional EN group were 80.40%and 73.90%,respectively(P=0.406).CONCLUSION:ESMcsa loss in AECOPD patients with MV was correlated with GDF-15 levels,both of which indicated acute muscular atrophy and skeletal muscle dysfunction.Early standardized EN may prevent acute muscle loss and intensive care unit-acquired weakness(ICU-AW)in AECOPD patients.