The adsorption and electronic properties of isolated cobalt phthalocyanine (CoPc) molecule on an ultrathin layer of NaC1 have been investigated. High-resolution STM images give a detailed picture of the lowest unocc...The adsorption and electronic properties of isolated cobalt phthalocyanine (CoPc) molecule on an ultrathin layer of NaC1 have been investigated. High-resolution STM images give a detailed picture of the lowest unoccupied molecular orbital (LUMO) of an isolated CoPc. It is shown that the NaC1 ultrathin layer efficiently decouples the interaction of the molecules from the underneath metal substrate, which makes it an ideal substrate for studying the properties of single molecules. Moreover, strong dependence of the appearance of the molecules on the sample bias in the region of relatively high bias (〉 3.1 V) is ascribed to the image potential states (IPSs) of NaCI/Cu(100), which may provide us with a possible method to fabricate quantum storage devices.展开更多
This paper proposes a comprehensive framework for estimating the regional rooftop photovoltaic(PV)potential.The required rooftop information is extracted from Gao Fen-7 satellite images.In particular,the rooftop area ...This paper proposes a comprehensive framework for estimating the regional rooftop photovoltaic(PV)potential.The required rooftop information is extracted from Gao Fen-7 satellite images.In particular,the rooftop area is obtained using a semantic segmentation network.The azimuth and inclination angles are calculated based on the digital surface model.In addition,to improve the accuracy of the economic evaluation,buildings are divided into commercial and industrial buildings and residential buildings.Based on the difference in the roof inclination,the rooftops can be divided into flat roofs,on which the PV panels are installed with the optimal inclination angle,and sloped rooftops,on which the PV panels are installed in a lay-flat manner.The solar irradiation on the plane-of-array is calculated using the isotropic sky translocation model.Then,the available installed capacity and generation potential of the rooftop PV is obtained.Finally,the net present value,dynamic payback period,and internal rate of return are used to evaluate the economic efficiency of the rooftop PV project.The proposed framework is applied in the Da Xing district of Beijing,China,with a total area of 546.84 km^(2).The results show that the rooftop area and available installed capacity of PV are 25.63 km^(2)and 1487.45 MWp,respectively.The annual rooftop PV generation potential is 2832.23 GWh,with significant economic returns.展开更多
Objective:To elucidate whether DNA aneuploidy was an independent discriminator for carcinoma within oral potentially malignant disorders(OPMDs),and further establish and validate a risk model based on DNA aneuploidy f...Objective:To elucidate whether DNA aneuploidy was an independent discriminator for carcinoma within oral potentially malignant disorders(OPMDs),and further establish and validate a risk model based on DNA aneuploidy for the detection of oral cancer.Methods:A total of 810 consecutive patients with OPMD were prospectively enrolled from March 2013 to December 2018,and divided into a training set(n=608)and a test set(n=202).Brushing and biopsy samples from each patient were processed by DNADNA image cytometry and histopathological examination,respectively.Results:DNA aneuploidy of an outside DNA index≥3.5 in OPMD was an independent marker strongly associated with malignant risk[adjusted odds ratio:13.04;95%confidence interval(CI):5.46-31.14].In the training and test sets,the area under the curve(AUC)was 0.87(95%CI:0.82-0.91)and 0.77(95%CI:0.57-0.97),respectively,for detecting carcinoma in OPMD patients.The independent risk factors of lateral/ventral tongue and non-homogenous type combined with a risk model built with a multivariate logistic regression revealed a more favorable diagnostic efficacy associated with the training set(AUC:0.93;95%CI:0.91-0.96)and test set(AUC:0.94;95%CI:0.90-0.98).The sensitivity and specificity of carcinoma detection within OPMD was improved to 100%and 88.1%,respectively.Conclusions:This large-scale diagnostic study established a risk model based on DNA aneuploidy that consisted of a noninvasive strategy with lateral/ventral tongue and non-homogenous features.The results showed favorable diagnostic efficacy for detecting carcinoma within OPMD,irrespective of the clinical and pathological diagnoses of OPMD.Multicenter validation and longitudinal studies are warranted to evaluate community practices and clinical applications.展开更多
In this work, we modeled and simulated the electric potential generated by point charges in the region of grounded conductor planes for Yukawa potential (e−μ/r) and Coulomb potential (1/r). We show the symb...In this work, we modeled and simulated the electric potential generated by point charges in the region of grounded conductor planes for Yukawa potential (e−μ/r) and Coulomb potential (1/r). We show the symbolic expression for the electric potential and some graphs for it and for the electric field with different values of μ. We observe that the electric potential decreases as the value of μ increases and that does not allow all the charge to be distributed on the surface of the conductor.展开更多
Negative motor evoked potentials after cerebral infarction, indicative of poor recovery of limb motor function, tend to be accompanied by changes in fractional anisotropy values and the cerebral pe-duncle area on the ...Negative motor evoked potentials after cerebral infarction, indicative of poor recovery of limb motor function, tend to be accompanied by changes in fractional anisotropy values and the cerebral pe-duncle area on the affected side, but the characteristics of these changes have not been reported. This study included 57 cases of cerebral infarction whose motor evoked potentials were tested in the 24 hours after the first inspection for diffusion tensor imaging, in which 29 cases were in the negative group and 28 cases in the positive group. Twenty-nine patients with negative motor evoked potentials were divided into two groups according to fractional anisotropy on the affected side of the cerebral peduncle: a fractional anisotropy 〈 0.36 group and a fractional anisotropy 〉 0.36 group. All patients underwent a regular magnetic resonance imaging and a diffusion tensor imaging examina- tion at 1 week, 1, 3, 6 and 12 months after cerebral infarction. The FugI-Meyer scores of their hemiplegic limbs were tested before the magnetic resonance and diffusion tensor imaging exami-nations. In the negative motor evoked potential group, fractional anisotropy in the affected cerebral peduncle declined progressively, which was most obvious in the first 1-3 months after the onset of cerebral infarction. The areas and area asymmetries of the cerebral peduncle on the affected side were significantly decreased at 6 and 12 months after onset. At 12 months after onset, the area asymmetries of the cerebral peduncle on the affected side were lower than the normal lower limit value of 0.83. FugI-Meyer scores in the fractional anisotropy ≥0.36 group were significantly higher than in the fractional anisotropy 〈 0.36 group at 3-12 months after onset. The fractional anisotropy of the cerebral peduncle in the positive motor evoked potential group decreased in the first 1 month after onset, and stayed unchanged from 3-12 months; there was no change in the area of the cerebral peduncle in the first 1-12 months after cerebral infarction. These findings confirmed that if the fractional anisotropy of the cerebral peduncle on the affected side is 〈 0.36 and the area asym-metries 〈 0.83 in patients with negative motor evoked potential after cerebral infarction, then poor hemiplegic limb motor function recovery may occur.展开更多
Recently, non-invasive, real-time and multi-point measurement of neural activities has become possible by using a multi-electrode array (MEA). Another method for multi-point measurement is the fluorescent imaging tech...Recently, non-invasive, real-time and multi-point measurement of neural activities has become possible by using a multi-electrode array (MEA). Another method for multi-point measurement is the fluorescent imaging technique using voltage indicator dyes or calcium indicator dyes. Especially, calcium imaging using fluorescent calcium indicator dyes is often more useful, because they exhibit larger changes in the fluorescence intensity than voltage indicator dyes and their fluorescence changes can be detect easily. Additionally, calcium signals play key roles in the brain function, such as the long-term potentiation (LTP) in the hippocampus, and calcium imaging can be a powerful tool to elucidate the brain function. In this study, we constructed a measurement apparatus combining the MEA system and laser confocal calcium imaging and simultaneously measured electric signals and calcium signals in acute mouse hippocampal slices. The obtained results showed the availability of the present method.展开更多
<p> For a point charge between two grounded conductor planes forming a 60<span style="white-space:nowrap;">°</span> angle, the potential and electric field generated by point charge fo...<p> For a point charge between two grounded conductor planes forming a 60<span style="white-space:nowrap;">°</span> angle, the potential and electric field generated by point charge for Yukawa’s potential (<span style="white-space:nowrap;">e<sup><span style="white-space:nowrap;">-</span><em>μr</em></sup>/<em>r</em></span>) and Coulomb’s potential (1/<em>r</em>) are modeled and simulated. The expression for the potential that generalizes the cases discussed in López-Mari<span style="white-space:nowrap;"><span style="white-space:nowrap;">ñ</span></span>o, M. and Trujillo Caballero, J. (2017) Point Charges and Conducting Planes for Yukawa’s Potential and Coulomb’s Potential. <em>Journal of Electromagnetic Analysis and Applications</em>, 9, 135-146. </p> <p> <a href="https://doi.org/10.4236/jemaa.2017.910012" target="_blank">https://doi.org/10.4236/jemaa.2017.910012</a> is presented. Graphs for the potential and electric field for both cases are showed using Maple, that of Coulomb and that of Yukawa for different values of <span style="white-space:nowrap;"><em>μ</em></span> . The purpose of this work is to offer students a practical guide for problem analysis of electrostatics using Maple’s capabilities as a computational tool. </p>展开更多
Motor imagery is the mental representation of an action without overt movement or muscle activation. However, the effects of motor imagery on stroke-induced hand dysfunction and brain neural networks are still unknown...Motor imagery is the mental representation of an action without overt movement or muscle activation. However, the effects of motor imagery on stroke-induced hand dysfunction and brain neural networks are still unknown. We conducted a randomized controlled trial in the China Rehabilitation Research Center. Twenty stroke patients, including 13 males and 7 females, 32–51 years old, were recruited and randomly assigned to the traditional rehabilitation treatment group(PP group, n = 10) or the motor imagery training combined with traditional rehabilitation treatment group(MP group, n = 10). All patients received rehabilitation training once a day, 45 minutes per session, five times per week, for 4 consecutive weeks. In the MP group, motor imagery training was performed for 45 minutes after traditional rehabilitation training, daily. Action Research Arm Test and the Fugl-Meyer Assessment of the upper extremity were used to evaluate hand functions before and after treatment. Transcranial magnetic stimulation was used to analyze motor evoked potentials in the affected extremity. Diffusion tensor imaging was used to assess changes in brain neural networks. Compared with the PP group, the MP group showed better recovery of hand function, higher amplitude of the motor evoked potential in the abductor pollicis brevis, greater fractional anisotropy of the right dorsal pathway, and an increase in the fractional anisotropy of the bilateral dorsal pathway. Our findings indicate that 4 weeks of motor imagery training combined with traditional rehabilitation treatment improves hand function in stroke patients by enhancing the dorsal pathway. This trial has been registered with the Chinese Clinical Trial Registry(registration number: Chi CTR-OCH-12002238).展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.21203239 and 21311120059)RFBR(Grant No.13-02-91180)
文摘The adsorption and electronic properties of isolated cobalt phthalocyanine (CoPc) molecule on an ultrathin layer of NaC1 have been investigated. High-resolution STM images give a detailed picture of the lowest unoccupied molecular orbital (LUMO) of an isolated CoPc. It is shown that the NaC1 ultrathin layer efficiently decouples the interaction of the molecules from the underneath metal substrate, which makes it an ideal substrate for studying the properties of single molecules. Moreover, strong dependence of the appearance of the molecules on the sample bias in the region of relatively high bias (〉 3.1 V) is ascribed to the image potential states (IPSs) of NaCI/Cu(100), which may provide us with a possible method to fabricate quantum storage devices.
基金supported by the Global Energy Interconnection Group Co.,Ltd.,Science and Technology Project(SGGEIG00JYJS2100032)。
文摘This paper proposes a comprehensive framework for estimating the regional rooftop photovoltaic(PV)potential.The required rooftop information is extracted from Gao Fen-7 satellite images.In particular,the rooftop area is obtained using a semantic segmentation network.The azimuth and inclination angles are calculated based on the digital surface model.In addition,to improve the accuracy of the economic evaluation,buildings are divided into commercial and industrial buildings and residential buildings.Based on the difference in the roof inclination,the rooftops can be divided into flat roofs,on which the PV panels are installed with the optimal inclination angle,and sloped rooftops,on which the PV panels are installed in a lay-flat manner.The solar irradiation on the plane-of-array is calculated using the isotropic sky translocation model.Then,the available installed capacity and generation potential of the rooftop PV is obtained.Finally,the net present value,dynamic payback period,and internal rate of return are used to evaluate the economic efficiency of the rooftop PV project.The proposed framework is applied in the Da Xing district of Beijing,China,with a total area of 546.84 km^(2).The results show that the rooftop area and available installed capacity of PV are 25.63 km^(2)and 1487.45 MWp,respectively.The annual rooftop PV generation potential is 2832.23 GWh,with significant economic returns.
基金supported by the National Natural Science Foundation of China(Grant No.82074502)the Science and Technology Commission of Shanghai Municipality(Grant No.20Y11903700)+3 种基金the Shanghai Hospital Development Center(Grant No.SHDC2020CR4082)the Shanghai Municipal Health Committee(Grant No.202040457)the Innovative Research Team of High-level Local Universities in Shanghai(Grant No.SSMU-ZDCX20180901)the SHIPM-mu Fund from the Shanghai Institute of Precision Medicine(Grant No.JC201807)。
文摘Objective:To elucidate whether DNA aneuploidy was an independent discriminator for carcinoma within oral potentially malignant disorders(OPMDs),and further establish and validate a risk model based on DNA aneuploidy for the detection of oral cancer.Methods:A total of 810 consecutive patients with OPMD were prospectively enrolled from March 2013 to December 2018,and divided into a training set(n=608)and a test set(n=202).Brushing and biopsy samples from each patient were processed by DNADNA image cytometry and histopathological examination,respectively.Results:DNA aneuploidy of an outside DNA index≥3.5 in OPMD was an independent marker strongly associated with malignant risk[adjusted odds ratio:13.04;95%confidence interval(CI):5.46-31.14].In the training and test sets,the area under the curve(AUC)was 0.87(95%CI:0.82-0.91)and 0.77(95%CI:0.57-0.97),respectively,for detecting carcinoma in OPMD patients.The independent risk factors of lateral/ventral tongue and non-homogenous type combined with a risk model built with a multivariate logistic regression revealed a more favorable diagnostic efficacy associated with the training set(AUC:0.93;95%CI:0.91-0.96)and test set(AUC:0.94;95%CI:0.90-0.98).The sensitivity and specificity of carcinoma detection within OPMD was improved to 100%and 88.1%,respectively.Conclusions:This large-scale diagnostic study established a risk model based on DNA aneuploidy that consisted of a noninvasive strategy with lateral/ventral tongue and non-homogenous features.The results showed favorable diagnostic efficacy for detecting carcinoma within OPMD,irrespective of the clinical and pathological diagnoses of OPMD.Multicenter validation and longitudinal studies are warranted to evaluate community practices and clinical applications.
文摘In this work, we modeled and simulated the electric potential generated by point charges in the region of grounded conductor planes for Yukawa potential (e−μ/r) and Coulomb potential (1/r). We show the symbolic expression for the electric potential and some graphs for it and for the electric field with different values of μ. We observe that the electric potential decreases as the value of μ increases and that does not allow all the charge to be distributed on the surface of the conductor.
基金supported by a grant from the Bureau of Science and Technology of Zhongshan,China,No.20102C146
文摘Negative motor evoked potentials after cerebral infarction, indicative of poor recovery of limb motor function, tend to be accompanied by changes in fractional anisotropy values and the cerebral pe-duncle area on the affected side, but the characteristics of these changes have not been reported. This study included 57 cases of cerebral infarction whose motor evoked potentials were tested in the 24 hours after the first inspection for diffusion tensor imaging, in which 29 cases were in the negative group and 28 cases in the positive group. Twenty-nine patients with negative motor evoked potentials were divided into two groups according to fractional anisotropy on the affected side of the cerebral peduncle: a fractional anisotropy 〈 0.36 group and a fractional anisotropy 〉 0.36 group. All patients underwent a regular magnetic resonance imaging and a diffusion tensor imaging examina- tion at 1 week, 1, 3, 6 and 12 months after cerebral infarction. The FugI-Meyer scores of their hemiplegic limbs were tested before the magnetic resonance and diffusion tensor imaging exami-nations. In the negative motor evoked potential group, fractional anisotropy in the affected cerebral peduncle declined progressively, which was most obvious in the first 1-3 months after the onset of cerebral infarction. The areas and area asymmetries of the cerebral peduncle on the affected side were significantly decreased at 6 and 12 months after onset. At 12 months after onset, the area asymmetries of the cerebral peduncle on the affected side were lower than the normal lower limit value of 0.83. FugI-Meyer scores in the fractional anisotropy ≥0.36 group were significantly higher than in the fractional anisotropy 〈 0.36 group at 3-12 months after onset. The fractional anisotropy of the cerebral peduncle in the positive motor evoked potential group decreased in the first 1 month after onset, and stayed unchanged from 3-12 months; there was no change in the area of the cerebral peduncle in the first 1-12 months after cerebral infarction. These findings confirmed that if the fractional anisotropy of the cerebral peduncle on the affected side is 〈 0.36 and the area asym-metries 〈 0.83 in patients with negative motor evoked potential after cerebral infarction, then poor hemiplegic limb motor function recovery may occur.
文摘Recently, non-invasive, real-time and multi-point measurement of neural activities has become possible by using a multi-electrode array (MEA). Another method for multi-point measurement is the fluorescent imaging technique using voltage indicator dyes or calcium indicator dyes. Especially, calcium imaging using fluorescent calcium indicator dyes is often more useful, because they exhibit larger changes in the fluorescence intensity than voltage indicator dyes and their fluorescence changes can be detect easily. Additionally, calcium signals play key roles in the brain function, such as the long-term potentiation (LTP) in the hippocampus, and calcium imaging can be a powerful tool to elucidate the brain function. In this study, we constructed a measurement apparatus combining the MEA system and laser confocal calcium imaging and simultaneously measured electric signals and calcium signals in acute mouse hippocampal slices. The obtained results showed the availability of the present method.
文摘<p> For a point charge between two grounded conductor planes forming a 60<span style="white-space:nowrap;">°</span> angle, the potential and electric field generated by point charge for Yukawa’s potential (<span style="white-space:nowrap;">e<sup><span style="white-space:nowrap;">-</span><em>μr</em></sup>/<em>r</em></span>) and Coulomb’s potential (1/<em>r</em>) are modeled and simulated. The expression for the potential that generalizes the cases discussed in López-Mari<span style="white-space:nowrap;"><span style="white-space:nowrap;">ñ</span></span>o, M. and Trujillo Caballero, J. (2017) Point Charges and Conducting Planes for Yukawa’s Potential and Coulomb’s Potential. <em>Journal of Electromagnetic Analysis and Applications</em>, 9, 135-146. </p> <p> <a href="https://doi.org/10.4236/jemaa.2017.910012" target="_blank">https://doi.org/10.4236/jemaa.2017.910012</a> is presented. Graphs for the potential and electric field for both cases are showed using Maple, that of Coulomb and that of Yukawa for different values of <span style="white-space:nowrap;"><em>μ</em></span> . The purpose of this work is to offer students a practical guide for problem analysis of electrostatics using Maple’s capabilities as a computational tool. </p>
基金supported by the National Natural Science Foundation of China,No.U1613228a grant from the Sub-Project under National “Twelfth Five-Year” Plan for Science & Technology Support Project in China,No.2011BAI08B11+1 种基金a grant from the Beijing Municipal Science & Technology Commission in China,No.Z161100002616018the Special Fund for Basic Scientific Research Business of Central Public Scientific Research Institutes in China,No.2014CZ-5,2015CZ-30
文摘Motor imagery is the mental representation of an action without overt movement or muscle activation. However, the effects of motor imagery on stroke-induced hand dysfunction and brain neural networks are still unknown. We conducted a randomized controlled trial in the China Rehabilitation Research Center. Twenty stroke patients, including 13 males and 7 females, 32–51 years old, were recruited and randomly assigned to the traditional rehabilitation treatment group(PP group, n = 10) or the motor imagery training combined with traditional rehabilitation treatment group(MP group, n = 10). All patients received rehabilitation training once a day, 45 minutes per session, five times per week, for 4 consecutive weeks. In the MP group, motor imagery training was performed for 45 minutes after traditional rehabilitation training, daily. Action Research Arm Test and the Fugl-Meyer Assessment of the upper extremity were used to evaluate hand functions before and after treatment. Transcranial magnetic stimulation was used to analyze motor evoked potentials in the affected extremity. Diffusion tensor imaging was used to assess changes in brain neural networks. Compared with the PP group, the MP group showed better recovery of hand function, higher amplitude of the motor evoked potential in the abductor pollicis brevis, greater fractional anisotropy of the right dorsal pathway, and an increase in the fractional anisotropy of the bilateral dorsal pathway. Our findings indicate that 4 weeks of motor imagery training combined with traditional rehabilitation treatment improves hand function in stroke patients by enhancing the dorsal pathway. This trial has been registered with the Chinese Clinical Trial Registry(registration number: Chi CTR-OCH-12002238).