In order to solve the problems of the fine division of sedimentary sequence cycles and their change in two-dimensional space as well as lateral extension contrast, we developed a method of wavelet depth-frequency anal...In order to solve the problems of the fine division of sedimentary sequence cycles and their change in two-dimensional space as well as lateral extension contrast, we developed a method of wavelet depth-frequency analysis. The single signal and composite signal of different Milankovitch cycles are obtained by numerical simulation. The simulated composite signal can be separated into single signals of a single frequency cycle. We also develop a well-seismic calibration insertion technology which helps to realize the calibration from the spectrum characteristics of a single well to the seismic profile. And then we determine the change and distribution characteristics of spectrum cycles in the two-dimensional space. It points out the direction in determining the variations of the regional sedimentary sequence cycles, underground strata structure and the contact relationship.展开更多
Aimed at the serious mismatch between the synthetic seismogram and the real data of the Sinian Dengying Formation and the Lower Cambrian Qiongzhusi Formation in the GS1 well area, Sichuan Basin, four aspects of intern...Aimed at the serious mismatch between the synthetic seismogram and the real data of the Sinian Dengying Formation and the Lower Cambrian Qiongzhusi Formation in the GS1 well area, Sichuan Basin, four aspects of internal multiples identification and suppression were studied. Firstly, a forward modeling method of internal multiple based on reflectivity method was developed. Through eight means such as post-stack and pre-stack forward modeling of internal multiple, and combined with VSP data, it was demonstrated that well-seismic mismatching in this area is mainly caused by the internal multiples. Secondly, the simulation results of internal multiple forward modeling using the stripping method combined with the internal multiple periodicity analysis showed that four groups of overburden layers with velocity inversion were the main sources of the internal multiples. Thirdly, by identifying internal multiples accurately and using suppression technology based on pattern recognition, an effective and replicable suppression scheme suitable for these formations was established, overcoming the difficulty of the small speed difference between internal multiple and primary reflection wave which makes the current methods ineffective. Fourthly, an evaluation index of internal multiple intensity was proposed, and the internal multiple intensity distribution diagram of the fourth member of Dengying Formation(Deng-4 Member) in Gaoshiti-Moxi area was compiled. This scheme greatly improved the well-seismic match, and the strata sedimentary features are clearer on the new seismic profiles with higher lateral resolution, with which smaller faults and geological anomalies can be identified and a series of the bead reflections in the Dengying Formation are first discovered. The coincidence rate of reservoir prediction based on seismic waveform classification was increased from 60% to 90%, and that of hydrocarbon detection based on dual phase medium theory was increased from 70% to 100%.展开更多
A simple method for the synthesis of new bithienylethenes bearing a functional group on the cyclopentene moi- ety is developed. Three new photochromic compounds (4a, 4b, 4c) have been successfully synthesized throug...A simple method for the synthesis of new bithienylethenes bearing a functional group on the cyclopentene moi- ety is developed. Three new photochromic compounds (4a, 4b, 4c) have been successfully synthesized through this simple method, and exhibit good photochromic properties with alternate irradiation of ultraviolet and visible light. Furthermore, the fluorescence of compound 4a, which bears a quinoline unit on the cyclopentene, can be modulated via optic and proton dual inputs. Upon excitation by 320 nm light, 4a emits a strong fluorescence at 404 nm. After irradiation with 254 nm light, the emission intensity is reduced due to the fluorescence resonance energy transfers (FRET) from quinoline unit to bithienylethene unit. Moreover, on addition of H~, the fluorescence is quenched completely due to the protonation of the quinoline. In addition, both the FRET and protonation process are reversi- ble, which indicates a potential application in molecular switches and logic gates.展开更多
Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have ...Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents.In light of this,a receptor for advanced glycation end products(RAGE)inhibitor,4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide(FPS-ZM1),was loaded into a cobalt(Co)-based MOF(zeolitic imidazolate framework-67,ZIF-67)to fabricate FPS-ZM1 encapsulated ZIF-67(FZ@ZIF-67)nanoparticles(NPs).As a result,FZ@ZIF-67 NPs could dually deliver Co ions and FPS-ZM1 in a controlled manner for over 14 days.Our in vitro study showed that FZ@ZIF-67 NPs not only enhanced angiogenesis by delivering Co ions but also released FPS-ZM1 to promote M2 macrophage polarization and attenuated high glucose(HG)-and/or inflammation-induced impairment of angiogenesis through RAGE inhibition.Moreover,in an in vivo study,FZ@ZIF-67 NPs markedly improved re-epithelialization,collagen deposition,neovascularization,and relieved inflammation in diabetic wounds in rats.This study not only provides a low-cost,effective,and synergistic proangiogenic bioactive agent but also demonstrates that targeting diabetes-related pathological signaling pathways is necessary to ameliorate vascularization impairment during diabetic wound healing.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.2011YYL128)the CNPC Innovation Foundation(GrantNo.2012D-5006-0103)the Ministry of Land and Resources special funds for scientific research on public cause(Grant No.201311107)
文摘In order to solve the problems of the fine division of sedimentary sequence cycles and their change in two-dimensional space as well as lateral extension contrast, we developed a method of wavelet depth-frequency analysis. The single signal and composite signal of different Milankovitch cycles are obtained by numerical simulation. The simulated composite signal can be separated into single signals of a single frequency cycle. We also develop a well-seismic calibration insertion technology which helps to realize the calibration from the spectrum characteristics of a single well to the seismic profile. And then we determine the change and distribution characteristics of spectrum cycles in the two-dimensional space. It points out the direction in determining the variations of the regional sedimentary sequence cycles, underground strata structure and the contact relationship.
基金Supported by the CNPC Geophysical Major Technology Field Examination and Integrated Support Project(2017D-3503)Scientific Research and Technological Development Project of PetroChina Company Ltd.(kt2018-10-02)
文摘Aimed at the serious mismatch between the synthetic seismogram and the real data of the Sinian Dengying Formation and the Lower Cambrian Qiongzhusi Formation in the GS1 well area, Sichuan Basin, four aspects of internal multiples identification and suppression were studied. Firstly, a forward modeling method of internal multiple based on reflectivity method was developed. Through eight means such as post-stack and pre-stack forward modeling of internal multiple, and combined with VSP data, it was demonstrated that well-seismic mismatching in this area is mainly caused by the internal multiples. Secondly, the simulation results of internal multiple forward modeling using the stripping method combined with the internal multiple periodicity analysis showed that four groups of overburden layers with velocity inversion were the main sources of the internal multiples. Thirdly, by identifying internal multiples accurately and using suppression technology based on pattern recognition, an effective and replicable suppression scheme suitable for these formations was established, overcoming the difficulty of the small speed difference between internal multiple and primary reflection wave which makes the current methods ineffective. Fourthly, an evaluation index of internal multiple intensity was proposed, and the internal multiple intensity distribution diagram of the fourth member of Dengying Formation(Deng-4 Member) in Gaoshiti-Moxi area was compiled. This scheme greatly improved the well-seismic match, and the strata sedimentary features are clearer on the new seismic profiles with higher lateral resolution, with which smaller faults and geological anomalies can be identified and a series of the bead reflections in the Dengying Formation are first discovered. The coincidence rate of reservoir prediction based on seismic waveform classification was increased from 60% to 90%, and that of hydrocarbon detection based on dual phase medium theory was increased from 70% to 100%.
文摘A simple method for the synthesis of new bithienylethenes bearing a functional group on the cyclopentene moi- ety is developed. Three new photochromic compounds (4a, 4b, 4c) have been successfully synthesized through this simple method, and exhibit good photochromic properties with alternate irradiation of ultraviolet and visible light. Furthermore, the fluorescence of compound 4a, which bears a quinoline unit on the cyclopentene, can be modulated via optic and proton dual inputs. Upon excitation by 320 nm light, 4a emits a strong fluorescence at 404 nm. After irradiation with 254 nm light, the emission intensity is reduced due to the fluorescence resonance energy transfers (FRET) from quinoline unit to bithienylethene unit. Moreover, on addition of H~, the fluorescence is quenched completely due to the protonation of the quinoline. In addition, both the FRET and protonation process are reversi- ble, which indicates a potential application in molecular switches and logic gates.
基金supported by grants from the National Natural Science Foundation of China(Nos.81930069,81772338,81974331,and 81802156)supported by the Major Scientific Research and Innovation Project of Shanghai Municipal Education Commission(No.2019-01-07-00-02-E00043).
文摘Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents.In light of this,a receptor for advanced glycation end products(RAGE)inhibitor,4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide(FPS-ZM1),was loaded into a cobalt(Co)-based MOF(zeolitic imidazolate framework-67,ZIF-67)to fabricate FPS-ZM1 encapsulated ZIF-67(FZ@ZIF-67)nanoparticles(NPs).As a result,FZ@ZIF-67 NPs could dually deliver Co ions and FPS-ZM1 in a controlled manner for over 14 days.Our in vitro study showed that FZ@ZIF-67 NPs not only enhanced angiogenesis by delivering Co ions but also released FPS-ZM1 to promote M2 macrophage polarization and attenuated high glucose(HG)-and/or inflammation-induced impairment of angiogenesis through RAGE inhibition.Moreover,in an in vivo study,FZ@ZIF-67 NPs markedly improved re-epithelialization,collagen deposition,neovascularization,and relieved inflammation in diabetic wounds in rats.This study not only provides a low-cost,effective,and synergistic proangiogenic bioactive agent but also demonstrates that targeting diabetes-related pathological signaling pathways is necessary to ameliorate vascularization impairment during diabetic wound healing.