目的:运用网状Meta分析的方法评估中成药联合糖皮质激素(glucocorticoid, GC)治疗原发性肾病综合征(primary nephrotic syndrome, PNS)的疗效。方法:检索中成药联合GC治疗PNS的随机对照试验。在筛选文献、提取资料和评价偏倚风险后,对...目的:运用网状Meta分析的方法评估中成药联合糖皮质激素(glucocorticoid, GC)治疗原发性肾病综合征(primary nephrotic syndrome, PNS)的疗效。方法:检索中成药联合GC治疗PNS的随机对照试验。在筛选文献、提取资料和评价偏倚风险后,对所纳入的指标进行网状Meta分析。结果:共纳入31篇文献,2275例PNS患者。结果显示,在提高总有效率、降低24 h尿蛋白定量方面,5种中成药联合GC治疗成人PNS优于单纯GC治疗。概率排序显示,在提高总有效率方面,昆仙胶囊排第一位;在升高血浆白蛋白方面,雷公藤制剂排第一位;在降低尿素氮方面,黄葵胶囊排第一位。结论:中成药联合GC的方案可提高PNS的治疗效果。Objective: To evaluate the efficacy of different Chinese patent medicines combined with glucocorticoid in treatment of primary nephrotic syndrome (PNS) by Network Meta analysis. Methods: Randomized controlled trial of Chinese patent medicine combined with glucocorticoid in treatment of PNS was retrieved. After screening the literature, extracting data and evaluating bias risk, the included indicators were analyzed by Network Meta analysis. Results: A total of 31 articles were included, involving 2275 patients with PNS. The results showed that in terms of improving the total effective rate and reducing 24-hour urinary protein, five kinds of Chinese patent medicines combined with glucocorticoid were better than glucocorticoid alone in the treatment of adult PNS. SUCRA showed that in terms of improving the total effective rate, Kunxian capsule ranks first;in terms of increasing the level of albumin, Tripterygium pharmaceutical preparation ranks first;in terms of reducing urea nitrogen, Huangkui Capsule ranks first. Conclusion: Chinese patent medicine combined with glucocorticoid can improve the therapeutic effect of PNS.展开更多
目的:比较并评价中成药治疗非ST段抬高型急性冠脉综合征的疗效差异和在不同评价指标间的治疗优势。方法:选择中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、...目的:比较并评价中成药治疗非ST段抬高型急性冠脉综合征的疗效差异和在不同评价指标间的治疗优势。方法:选择中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase等主流医学数据库检索中成药治疗非ST段抬高型急性冠脉综合征随机对照试验,以中医证候积分疗效、心电图疗效、硝酸甘油减停率作为评价指标,并选用GRADEpro软件和Cochrane偏倚风险评估工具进行质量评估,GeMTC和Stata14.0软件进行网状Meta分析。结果:共纳入27篇随机对照试验和22种中成药。网状Meta分析结果显示,心脉通贴散联合芪参益气滴丸和常规西药、解毒通脉胶囊联合常规西药对于中医证候积分疗效较好;心痛舒胶囊联合常规西药对于改善心电图疗效较好;解毒通脉胶囊联合常规西药、养阴活血颗粒联合常规西药对于硝酸甘油减停率效果较好。结论:心脉通贴散、芪参益气滴丸、解毒通脉胶囊、心痛舒胶囊、养阴活血颗粒在非ST段抬高型急性冠脉综合征不同评价指标中具有一定治疗优势,但因受到文献质量限制,今后仍需高质量临床研究提供证据支持。展开更多
文摘目的:运用网状Meta分析的方法评估中成药联合糖皮质激素(glucocorticoid, GC)治疗原发性肾病综合征(primary nephrotic syndrome, PNS)的疗效。方法:检索中成药联合GC治疗PNS的随机对照试验。在筛选文献、提取资料和评价偏倚风险后,对所纳入的指标进行网状Meta分析。结果:共纳入31篇文献,2275例PNS患者。结果显示,在提高总有效率、降低24 h尿蛋白定量方面,5种中成药联合GC治疗成人PNS优于单纯GC治疗。概率排序显示,在提高总有效率方面,昆仙胶囊排第一位;在升高血浆白蛋白方面,雷公藤制剂排第一位;在降低尿素氮方面,黄葵胶囊排第一位。结论:中成药联合GC的方案可提高PNS的治疗效果。Objective: To evaluate the efficacy of different Chinese patent medicines combined with glucocorticoid in treatment of primary nephrotic syndrome (PNS) by Network Meta analysis. Methods: Randomized controlled trial of Chinese patent medicine combined with glucocorticoid in treatment of PNS was retrieved. After screening the literature, extracting data and evaluating bias risk, the included indicators were analyzed by Network Meta analysis. Results: A total of 31 articles were included, involving 2275 patients with PNS. The results showed that in terms of improving the total effective rate and reducing 24-hour urinary protein, five kinds of Chinese patent medicines combined with glucocorticoid were better than glucocorticoid alone in the treatment of adult PNS. SUCRA showed that in terms of improving the total effective rate, Kunxian capsule ranks first;in terms of increasing the level of albumin, Tripterygium pharmaceutical preparation ranks first;in terms of reducing urea nitrogen, Huangkui Capsule ranks first. Conclusion: Chinese patent medicine combined with glucocorticoid can improve the therapeutic effect of PNS.
文摘目的:比较并评价中成药治疗非ST段抬高型急性冠脉综合征的疗效差异和在不同评价指标间的治疗优势。方法:选择中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase等主流医学数据库检索中成药治疗非ST段抬高型急性冠脉综合征随机对照试验,以中医证候积分疗效、心电图疗效、硝酸甘油减停率作为评价指标,并选用GRADEpro软件和Cochrane偏倚风险评估工具进行质量评估,GeMTC和Stata14.0软件进行网状Meta分析。结果:共纳入27篇随机对照试验和22种中成药。网状Meta分析结果显示,心脉通贴散联合芪参益气滴丸和常规西药、解毒通脉胶囊联合常规西药对于中医证候积分疗效较好;心痛舒胶囊联合常规西药对于改善心电图疗效较好;解毒通脉胶囊联合常规西药、养阴活血颗粒联合常规西药对于硝酸甘油减停率效果较好。结论:心脉通贴散、芪参益气滴丸、解毒通脉胶囊、心痛舒胶囊、养阴活血颗粒在非ST段抬高型急性冠脉综合征不同评价指标中具有一定治疗优势,但因受到文献质量限制,今后仍需高质量临床研究提供证据支持。
