白质纤维束分割方法通过识别连接不同脑区的白质通路,为脑连接分析提供了重要的神经通路参考信息。然而,传统的白质纤维束分割方法主要依赖于弥散磁共振图像(Diffusion magnetic resonance imaging,dMRI),由于获取弥散磁共振图像比较耗...白质纤维束分割方法通过识别连接不同脑区的白质通路,为脑连接分析提供了重要的神经通路参考信息。然而,传统的白质纤维束分割方法主要依赖于弥散磁共振图像(Diffusion magnetic resonance imaging,dMRI),由于获取弥散磁共振图像比较耗时,这极大地限制了其在临床中的应用。为解决此问题,提出了一种基于T1加权图像的白质纤维束分割方法,通过计算T1加权图像的结构张量来提示可能的纤维走向,进而提高白质纤维束的分割精度。此外,本文在模型训练期间引入弥散磁共振图像的特权信息来指导模型学习,从而提升白质束分割模型性能,具有挑战性的束分割效果提升明显,其中左穹窿(Left fornix,FX_left)的Dice得分提高了5%,右穹窿(Right fornix,FX_right)的Dice得分提高了6%。。本研究弥补了在缺少弥散磁共振图像的场景下无法进行神经通路分析的不足,扩展了神经通路分析的应用场景。展开更多
The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain chara...The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ function.Therefore, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.展开更多
基金supported by The National Key Research and Development Program of China (2016YFC1306200)the National Natural Science Foundation of China (91132750)+1 种基金Major Projects of the National Social Science Foundation of China (14ZDB161)the Key Research and Development Program of Jiangsu Province, China (BE2016616)
文摘The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ function.Therefore, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.
