Study on the anti-inflammatory and analgesic effects of white peony root and mucuna pruriens and their combinations in vivo

Objective:This study investigates the in vivo anti-inflammatory and analgesic pharmacological effects of white peony root and mucuna pruriens and their combinations.Methods:In this study,the corresponding solutions were administered in groups,and after 14 days of gavage,xylene-induced ear swelling test,acetic acid torsion test and hot plate pain test were performed.Results:It was found that both Paeonia lactiflora root and Kapok had anti-inflammatory and analgesic effects(P<0.05),with the 2:1 group having the best experimental effect(P<0.05).Conclusion:Paeonia lactiflora root and Kapok and its combination have good anti-inflammatory and analgesic effects in vivo,and the 2:1 group showed significant anti-inflammatory and analgesic effects compared with other groups.

白芍提取物通过多巴胺D2受体治疗大鼠高泌乳素血症

目的研究白芍水提取物对高泌乳素血症大鼠及体外细胞的药效学作用。方法注射盐酸甲氧氯普胺注射液制备高泌乳素血症大鼠,观察白芍提取物对模型大鼠血清泌乳素(PRL)、雌二醇(E_2)、孕酮(P)、促卵泡激素(FSH)和黄体生成素(LH)水平的影响。研究白芍提取物对大鼠垂体瘤(MMQ)细胞、垂体腺瘤(GH3)细胞和嗜铬细胞瘤(PC12)细胞株的PRL分泌、多巴胺D2受体和多巴胺转运体(DAT)的影响。结果与模型组比较,高[28.8 g/(kg·d)]、中剂量[14.4 g/(kg·d)]的白芍提取物能显著降低高泌乳素血症大鼠的PRL水平(P<0.01)。在给药24 h后,与正常组比较,5 mg/m L和10 mg/m L的白芍提取物显著抑制了MMQ细胞PRL的分泌(P<0.01),但并不影响缺乏多巴胺D2受体表达的GH3细胞PRL的分泌;4、8 mg/m L的白芍提取物显著增加了PC12细胞多巴胺D2受体和DAT的表达(P<0.05,P<0.01)。结论白芍提取物介由多巴胺D2受体治疗高泌乳素血症,且疗效显著。